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Species | Y ShahamSummaryAffiliation: National Institutes of Health Country: USA Publications
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The role of neuroadaptations in relapse to drug seekingYavin Shaham
Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, 5500 Nathan Shock Drive, Baltimore, Maryland 21224, USA
Nat Neurosci 8:1437-9. 2005..Persistent neuroadaptations are thought to underlie aspects of addiction, including relapse. This commentary assesses the degree to which these neuroadaptations, primarily identified in preclinical studies on cocaine, induce relapse...- Clonidine blocks stress-induced reinstatement of heroin seeking in rats: an effect independent of locus coeruleus noradrenergic neuronsY Shaham
Behavioural Neuroscience Branch, IRP NIDA NIH, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
Eur J Neurosci 12:292-302. 2000.... - The reinstatement model of drug relapse: history, methodology and major findingsYavin Shaham
Behavioral Neuroscience Branch, NIDA IRP, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
Psychopharmacology (Berl) 168:3-20. 2003..Finally, there appears to be a good correspondence between the events that induce reinstatement in laboratory animals and those that provoke relapse in humans... - Stress-induced relapse to heroin and cocaine seeking in rats: a reviewY Shaham
Behavioral Neuroscience Branch, IRP NIDA NIH, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
Brain Res Brain Res Rev 33:13-33. 2000..Finally, we consider the mechanisms that might underlie stress-induced relapse to drug seeking and the possible implications of the findings for the treatment of relapse to drug use in humans... - Repeated lofexidine treatment attenuates stress-induced, but not drug cues-induced reinstatement of a heroin-cocaine mixture (speedball) seeking in ratsD Highfield
Behavioral Neuroscience Branch, IRP/NIDA, Baltimore, MD 21224, USA
Neuropsychopharmacology 25:320-31. 2001..The present data also suggest that the neurochemical events underlying stress- and drug cues-induced relapse are not identical... - Leptin attenuates acute food deprivation-induced relapse to heroin seekingU Shalev
Behavioral Neuroscience Branch, National Institute on Drug Abuse/Intramural Research Program, Baltimore, Maryland 21224, USA
J Neurosci 21:RC129. 2001..These data indicate that food deprivation can provoke relapse to heroin seeking via a leptin-dependent mechanism, which is not involved in relapse induced by footshock stress or reexposure to heroin... - Time-dependent changes in extinction behavior and stress-induced reinstatement of drug seeking following withdrawal from heroin in ratsU Shalev
Behavioral Neuroscience Branch, IRP/NIDA/NIH, Baltimore, MD 21224, USA
Psychopharmacology (Berl) 156:98-107. 2001..Finally, the time-dependent changes in footshock stress-induced reinstatement following withdrawal from heroin were not correlated with alterations in CRF mRNA in the CeA and BNST... 
Effect of pharmacological manipulations of neuropeptide Y and corticotropin-releasing factor neurotransmission on incubation of conditioned fearC L Pickens
Department of Health and Human Services, Behavioral Neuroscience Branch, Intramural Research Program National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21218, USA
Neuroscience 164:1398-406. 2009..Results also suggest that CRF receptors are not involved in cue-induced fear in the conditioned suppression procedure...- Differential effects of the hypocretin 1 receptor antagonist SB 334867 on high-fat food self-administration and reinstatement of food seeking in ratsS G Nair
Behavioral Neuroscience Branch, NIDA IRP NIH DHHS, Baltimore, MD 21224, USA
Br J Pharmacol 154:406-16. 2008..However, the role of these receptors in operant food self-administration or relapse to food seeking in animal models is unknown... - Differential long-term neuroadaptations of glutamate receptors in the basolateral and central amygdala after withdrawal from cocaine self-administration in ratsLin Lu
Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, National Institute on Health, Department of Health and Human Services, Baltimore, MD 21224, USA
J Neurochem 94:161-8. 2005..These results indicate that cocaine self-administration and subsequent withdrawal induces long-lasting and differential neuroadaptations in basolateral and central amygdala glutamate receptors... - Activation of group II metabotropic glutamate receptors in the nucleus accumbens shell attenuates context-induced relapse to heroin seekingJennifer M Bossert
Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, NIH DHHS, Baltimore, MD 21224, USA
Neuropsychopharmacology 31:2197-209. 2006..0 microg) 1.5 mm dorsal from the NAc core into the caudate-putamen were ineffective. Results suggest an important role of glutamate transmission in the NAc shell in context-induced reinstatement of heroin seeking... - The anxiogenic drug yohimbine reinstates palatable food seeking in a rat relapse model: a role of CRF1 receptorsUdi E Ghitza
Behavioral Neuroscience Branch, NIDA/IRP/NIH/DHHS, Baltimore, MD 21224, USA
Neuropsychopharmacology 31:2188-96. 2006..These data suggest that CRF is involved in stress-induced relapse to palatable food seeking, and that CRF1 antagonists should be considered for the treatment of maladaptive eating habits... - Effects of dexfenfluramine and 5-HT3 receptor antagonists on stress-induced reinstatement of alcohol seeking in ratsANH DZUNG LE
Department of Neuroscience, Centre for Addiction and Mental Health, 33 Russell Street, Toronto, Ontario, M5S 2S1, Canada
Psychopharmacology (Berl) 186:82-92. 2006.... - Effect of methamphetamine self-administration on tyrosine hydroxylase and dopamine transporter levels in mesolimbic and nigrostriatal dopamine pathways of the ratJack D Shepard
Cellular Neurobiology Research Branch, IRP/NIDA/NIH, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
Psychopharmacology (Berl) 185:505-13. 2006..CONCLUSIONS: Results suggest that extended daily access to self-administered methamphetamine results in a transient, short-lasting effect on mesolimbic and nigrostriatal dopamine neurons of the rat brain... - Systemic and central amygdala injections of the mGluR(2/3) agonist LY379268 attenuate the expression of incubation of cocaine cravingLin Lu
Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland, USA
Biol Psychiatry 61:591-8. 2007.... - Neurobiology of relapse to heroin and cocaine seeking: an update and clinical implicationsJennifer M Bossert
Behavioral Neuroscience Branch, IRP/NIDA/NIH/DHHS, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
Eur J Pharmacol 526:36-50. 2005.... - Withdrawal from cocaine self-administration produces long-lasting deficits in orbitofrontal-dependent reversal learning in ratsDonna J Calu
Program in Neuroscience, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
Learn Mem 14:325-8. 2007..We found robust time-dependent increases in cue-induced cocaine seeking in the two extinction tests (incubation of craving) and severe reversal-learning impairments... - A conflict rat model of cue-induced relapse to cocaine seekingAyelet Cooper
Department of Neurobiology, The Weizmann Institute of Science, Rehovot 76100, Israel
Psychopharmacology (Berl) 194:117-25. 2007..In this paper, we describe a conflict model of cue-induced relapse in rats that approximate the human condition... - A role for BDNF in cocaine reward and relapseGeoffrey Schoenbaum
Nat Neurosci 10:935-6. 2007 - The CRF1 receptor antagonist antalarmin attenuates yohimbine-induced increases in operant alcohol self-administration and reinstatement of alcohol seeking in ratsPeter W Marinelli
Department of Neuroscience, Neurobiology of Alcohol Laboratory, Centre for Addiction and Mental Health, Toronto, ON, Canada
Psychopharmacology (Berl) 195:345-55. 2007..In this study, we assess whether these effects of yohimbine are attenuated by systemic injections of the corticotrotropin-releasing factor 1 (CRF1) receptor antagonist antalarmin... - Toward a model of drug relapse: an assessment of the validity of the reinstatement procedureDavid H Epstein
Clinical Pharmacology and Therapeutics Research Branch, IRP NIDA NIH DHHS, Baltimore, MD 21224, USA
Psychopharmacology (Berl) 189:1-16. 2006..The model's construct validity faces more substantial challenges and is yet to be established, but we argue that some of the criticisms of the model in this regard may have been overstated... - Differential effects of blockade of dopamine D1-family receptors in nucleus accumbens core or shell on reinstatement of heroin seeking induced by contextual and discrete cuesJennifer M Bossert
Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health Department of Health and Human Services, Baltimore, Maryland 21224, USA
J Neurosci 27:12655-63. 2007..Results also demonstrate novel dissociable roles of accumbens core and shell in context- versus discrete-cue-induced reinstatement of heroin seeking... - Formation of accumbens GluR2-lacking AMPA receptors mediates incubation of cocaine cravingKELLY L CONRAD
Department of Neuroscience, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, Illinois 60064, USA
Nature 454:118-21. 2008.... - Review. Context-induced relapse to drug seeking: a reviewHans S Crombag
Department of Psychology, Behavioural and Clinical Neuroscience Group, School of Life Sciences, The University of Sussex, Brighton, UK
Philos Trans R Soc Lond B Biol Sci 363:3233-43. 2008..We conclude by discussing the clinical implications of rat studies on context-induced reinstatement of drug seeking... - Cocaine experience establishes control of midbrain glutamate and dopamine by corticotropin-releasing factor: a role in stress-induced relapse to drug seekingBin Wang
Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, USA
J Neurosci 25:5389-96. 2005..Similar neuroadaptations may be important for the comorbidity between addiction and other stress-related psychiatric disorders... - Central amygdala ERK signaling pathway is critical to incubation of cocaine cravingLin Lu
Behavioral Neuroscience Branch, Intramural Research Program/National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, 5500 Nathan Shock Drive, Baltimore, Maryland 21224, USA
Nat Neurosci 8:212-9. 2005..Results suggest that the incubation of cocaine craving is mediated by time-dependent increases in the responsiveness of the central amygdala ERK pathway to cocaine cues... - Reinstatement of cocaine seeking in 129X1/SvJ mice: effects of cocaine priming, cocaine cues and food deprivationDavid A Highfield
Behavioral Neuroscience Branch, IRP/NIDA/NIH, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
Psychopharmacology (Berl) 161:417-24. 2002..CONCLUSIONS: The present data suggest that factors contributing to relapse to drugs can be studied in the reinstatement model using the common 129X1/SvJ mouse inbred strain... - Effects of acute and prolonged opiate abstinence on extinction behaviour in ratsKim G C Hellemans
Department of Psychology, Queen's University, Kingston, Ontario, K7L 3N6
Can J Exp Psychol 56:241-52. 2002..Results suggest that heroin abstinence has different effects on drug-seeking and drug-taking and that these effects do not temporally coincide with somatic measures of opioid withdrawal... - Time-dependent increases in brain-derived neurotrophic factor protein levels within the mesolimbic dopamine system after withdrawal from cocaine: implications for incubation of cocaine cravingJeffrey W Grimm
Behavioral Neuroscience Branch, Intramural Research Program/National Institute on Drug Abuse/National Institutes of Health/Department of Health and Human Services, Baltimore, Maryland 21224, USA
J Neurosci 23:742-7. 2003..Time-dependent increases in BDNF levels may lead to synaptic modifications that underlie enhanced responsiveness to cocaine cues after prolonged withdrawal periods... - Molecular neuroadaptations in the accumbens and ventral tegmental area during the first 90 days of forced abstinence from cocaine self-administration in ratsLin Lu
Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse/National Institutes of Health/Department of Health and Human Services, Baltimore, Maryland 21224, USA
J Neurochem 85:1604-13. 2003..Cocaine self-administration produces long-lasting molecular neuroadaptations in the VTA and accumbens that may underlie cocaine relapse during periods of abstinence... - The role of corticosterone in food deprivation-induced reinstatement of cocaine seeking in the ratUri Shalev
Behavioral Neuroscience Branch, IRP NIDA NIH, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
Psychopharmacology (Berl) 168:170-6. 2003..Here we studied whether food deprivation would reinstate cocaine seeking and whether the stress hormone, corticosterone, is involved in this effect... - Effect of environmental stressors on opiate and psychostimulant reinforcement, reinstatement and discrimination in rats: a reviewLin Lu
Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, NIH/DHHS, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
Neurosci Biobehav Rev 27:457-91. 2003..The broader implications of the data reviewed here for future research and for the treatment of opiate and psychostimulant addiction are briefly discussed... - Renewal of drug seeking by contextual cues after prolonged extinction in ratsHans S Crombag
Behavioral Neuroscience Branch, National Institute on Drug Abuse, Intramural Research Program, Baltimore, Maryland 21224, USA
Behav Neurosci 116:169-73. 2002..The authors suggest that the renewal procedure can be used to study mechanisms underlying relapse to drug seeking elicited by drug-associated contextual stimuli... - Selective induction of c-Fos immunoreactivity in the prelimbic cortex during reinstatement of heroin seeking induced by acute food deprivation in ratsUri Shalev
Behavioral Neuroscience Branch, IRP/NIDA/NIH/DHHS, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
Behav Brain Res 145:79-88. 2003..These results raise the possibility that the prelimbic cortex is involved in food deprivation-induced reinstatement of heroin seeking... - Drug onset cues, conditioned withdrawal, and drug relapse: comment on McDonald and Siegel (2004)Jennifer M Bossert
Behavioral Neuroscience Branch, Intramural Research Program (IRP, National Institute on Drug Abuse (NIDA, National Institutes of Health (NIH, Baltimore, MD 21224, USA
Exp Clin Psychopharmacol 12:15-7; discussion 23-6. 2004..The authors of this comment discuss the degree to which the literature supports this hypothesis... - A single infusion of brain-derived neurotrophic factor into the ventral tegmental area induces long-lasting potentiation of cocaine seeking after withdrawalLin Lu
Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224, USA
J Neurosci 24:1604-11. 2004..These data suggest that BDNF-mediated neuroadaptations in mesolimbic areas are involved in the persistent cocaine seeking induced by exposure to drug cues after withdrawal... - Cocaine seeking over extended withdrawal periods in rats: different time courses of responding induced by cocaine cues versus cocaine priming over the first 6 monthsLin Lu
Behavioral Neuroscience Branch, IRP/NIDA/NIH/DHHS, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
Psychopharmacology (Berl) 176:101-8. 2004..Results also indicate that while the incubation of responsiveness to cocaine cues is a long lasting phenomenon, it is not permanent... - Neurobiology of relapse to heroin and cocaine seeking: a reviewUri Shalev
Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, USA
Pharmacol Rev 54:1-42. 2002..The data reviewed also suggest that the neuronal events mediating drug-induced reinstatement are to some degree dissociable from those mediating drug reinforcement... - Cocaine-experienced rats exhibit learning deficits in a task sensitive to orbitofrontal cortex lesionsGeoffrey Schoenbaum
University of Maryland School of Medicine, Department of Anatomy and Neurobiology, 685 West Baltimore Street, HSF 1 Rm 280K, Baltimore, MD 21201, USA
Eur J Neurosci 19:1997-2002. 2004.... - The cystine-glutamate transporter in the accumbens: a novel role in cocaine relapseLin Lu
Behavioral Neuroscience Branch, IRP, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, MD 21224, USA
Trends Neurosci 27:74-6. 2004..These data also suggest the cystine-glutamate transporter as a novel target for medication that could prevent cocaine relapse... - The anxiogenic drug yohimbine reinstates methamphetamine seeking in a rat model of drug relapseJack D Shepard
Cellular Neurobiology Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health/Department of Health and Human Services, Baltimore, Maryland 21224, USA
Biol Psychiatry 55:1082-9. 2004..In contrast, no significant time-dependent changes in yohimbine-induced reinstatement were observed. CONCLUSIONS: Results indicate that yohimbine is a potent stimulus for reinstatement of methamphetamine seeking in a rat relapse model... - Incubation of cocaine craving after withdrawal: a review of preclinical dataLin Lu
Behavioral Neuroscience Branch, IRP/NIDA/NIH/DHHS, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
Neuropharmacology 47:214-26. 2004..4. Incubation of cocaine craving after withdrawal is associated with increases in the levels of brain-derived neurotrophic factor (BDNF) in mesolimbic dopamine areas... - A role of ventral tegmental area glutamate in contextual cue-induced relapse to heroin seekingJennifer M Bossert
Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224, USA
J Neurosci 24:10726-30. 2004..Results indicate that glutamate transmission in the VTA plays an important role in contextual cue-induced relapse to heroin seeking... - Effect of dopamine receptor antagonists on renewal of cocaine seeking by reexposure to drug-associated contextual cuesHans S Crombag
Behavioral Neuroscience Branch, The National Institute on Drug Abuse, Intramural Research Program, Baltimore, MD 21224, USA
Neuropsychopharmacology 27:1006-15. 2002..These data suggest that activation of dopamine receptors is involved in reinstatement of cocaine seeking induced by exposure to the drug self-administration context... - Peptide YY3-36 decreases reinstatement of high-fat food seeking during dieting in a rat relapse modelUdi E Ghitza
Behavioral Neuroscience Branch, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224, USA
J Neurosci 27:11522-32. 2007.... - Role of ERK in cocaine addictionLin Lu
Department of Neuropharmacology, National Institute on Drug Dependence, Peking University, Beijing 100083, China
Trends Neurosci 29:695-703. 2006..Pharmacological manipulations that decrease the extent to which cocaine and cocaine cues induce ERK activity might therefore be considered as potential treatments for cocaine addiction... - Rodent BDNF genes, novel promoters, novel splice variants, and regulation by cocaineQing Rong Liu
Molecular Neurobiology Branch, National Institute on Drug Abuse Intramural Research Program NIDA IRP, NIH, Department of Health and Human Services DHHS, Box 5180, Baltimore, MD 21224, USA
Brain Res 1067:1-12. 2006..These data suggest a role of specific BDNF promoter regions and regulatory sequences in stimulant-induced alterations in BDNF expression, and in the alterations that changed BDNF expression is likely to confer in the brain... - The role of orbitofrontal cortex in drug addiction: a review of preclinical studiesGeoffrey Schoenbaum
Department of Anatomy and Neurobiology, University of Maryland, School of Medicine, Baltimore, Maryland 21201, USA
Biol Psychiatry 63:256-62. 2008....