Y Shaham

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint The role of neuroadaptations in relapse to drug seeking
    Yavin Shaham
    Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, 5500 Nathan Shock Drive, Baltimore, Maryland 21224, USA
    Nat Neurosci 8:1437-9. 2005
  2. pmc Ventral medial prefrontal cortex neuronal ensembles mediate context-induced relapse to heroin
    Jennifer M Bossert
    Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, US National Institutes of Health Department of Health and Human Services, Baltimore, Maryland, USA
    Nat Neurosci 14:420-2. 2011
  3. pmc The use of the reinstatement model to study relapse to palatable food seeking during dieting
    Donna J Calu
    Behavioral Neuroscience Branch, Intramural Research Program, NIDA NIH, Baltimore, MD, USA Electronic address
    Neuropharmacology 76:395-406. 2014
  4. ncbi request reprint The reinstatement model of drug relapse: history, methodology and major findings
    Yavin Shaham
    Behavioral Neuroscience Branch, NIDA IRP, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 168:3-20. 2003
  5. ncbi request reprint Clonidine blocks stress-induced reinstatement of heroin seeking in rats: an effect independent of locus coeruleus noradrenergic neurons
    Y Shaham
    Behavioural Neuroscience Branch, IRP NIDA NIH, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Eur J Neurosci 12:292-302. 2000
  6. ncbi request reprint Stress-induced relapse to heroin and cocaine seeking in rats: a review
    Y Shaham
    Behavioral Neuroscience Branch, IRP NIDA NIH, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Brain Res Brain Res Rev 33:13-33. 2000
  7. ncbi request reprint Repeated lofexidine treatment attenuates stress-induced, but not drug cues-induced reinstatement of a heroin-cocaine mixture (speedball) seeking in rats
    D Highfield
    Behavioral Neuroscience Branch, IRP/NIDA, Baltimore, MD 21224, USA
    Neuropsychopharmacology 25:320-31. 2001
  8. ncbi request reprint Leptin attenuates acute food deprivation-induced relapse to heroin seeking
    U Shalev
    Behavioral Neuroscience Branch, National Institute on Drug Abuse/Intramural Research Program, Baltimore, Maryland 21224, USA
    J Neurosci 21:RC129. 2001
  9. ncbi request reprint Time-dependent changes in extinction behavior and stress-induced reinstatement of drug seeking following withdrawal from heroin in rats
    U Shalev
    Behavioral Neuroscience Branch, IRP/NIDA/NIH, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 156:98-107. 2001
  10. pmc Differential effects of the hypocretin 1 receptor antagonist SB 334867 on high-fat food self-administration and reinstatement of food seeking in rats
    S G Nair
    Behavioral Neuroscience Branch, NIDA IRP NIH DHHS, Baltimore, MD 21224, USA
    Br J Pharmacol 154:406-16. 2008

Collaborators

Detail Information

Publications50

  1. ncbi request reprint The role of neuroadaptations in relapse to drug seeking
    Yavin Shaham
    Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, 5500 Nathan Shock Drive, Baltimore, Maryland 21224, USA
    Nat Neurosci 8:1437-9. 2005
    ..Persistent neuroadaptations are thought to underlie aspects of addiction, including relapse. This commentary assesses the degree to which these neuroadaptations, primarily identified in preclinical studies on cocaine, induce relapse...
  2. pmc Ventral medial prefrontal cortex neuronal ensembles mediate context-induced relapse to heroin
    Jennifer M Bossert
    Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, US National Institutes of Health Department of Health and Human Services, Baltimore, Maryland, USA
    Nat Neurosci 14:420-2. 2011
    ....
  3. pmc The use of the reinstatement model to study relapse to palatable food seeking during dieting
    Donna J Calu
    Behavioral Neuroscience Branch, Intramural Research Program, NIDA NIH, Baltimore, MD, USA Electronic address
    Neuropharmacology 76:395-406. 2014
    ..This article is part of a Special Issue entitled 'NIDA 40th Anniversary Issue'...
  4. ncbi request reprint The reinstatement model of drug relapse: history, methodology and major findings
    Yavin Shaham
    Behavioral Neuroscience Branch, NIDA IRP, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 168:3-20. 2003
    ....
  5. ncbi request reprint Clonidine blocks stress-induced reinstatement of heroin seeking in rats: an effect independent of locus coeruleus noradrenergic neurons
    Y Shaham
    Behavioural Neuroscience Branch, IRP NIDA NIH, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Eur J Neurosci 12:292-302. 2000
    ....
  6. ncbi request reprint Stress-induced relapse to heroin and cocaine seeking in rats: a review
    Y Shaham
    Behavioral Neuroscience Branch, IRP NIDA NIH, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Brain Res Brain Res Rev 33:13-33. 2000
    ..Finally, we consider the mechanisms that might underlie stress-induced relapse to drug seeking and the possible implications of the findings for the treatment of relapse to drug use in humans...
  7. ncbi request reprint Repeated lofexidine treatment attenuates stress-induced, but not drug cues-induced reinstatement of a heroin-cocaine mixture (speedball) seeking in rats
    D Highfield
    Behavioral Neuroscience Branch, IRP/NIDA, Baltimore, MD 21224, USA
    Neuropsychopharmacology 25:320-31. 2001
    ..The present data also suggest that the neurochemical events underlying stress- and drug cues-induced relapse are not identical...
  8. ncbi request reprint Leptin attenuates acute food deprivation-induced relapse to heroin seeking
    U Shalev
    Behavioral Neuroscience Branch, National Institute on Drug Abuse/Intramural Research Program, Baltimore, Maryland 21224, USA
    J Neurosci 21:RC129. 2001
    ..These data indicate that food deprivation can provoke relapse to heroin seeking via a leptin-dependent mechanism, which is not involved in relapse induced by footshock stress or reexposure to heroin...
  9. ncbi request reprint Time-dependent changes in extinction behavior and stress-induced reinstatement of drug seeking following withdrawal from heroin in rats
    U Shalev
    Behavioral Neuroscience Branch, IRP/NIDA/NIH, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 156:98-107. 2001
    ..Finally, the time-dependent changes in footshock stress-induced reinstatement following withdrawal from heroin were not correlated with alterations in CRF mRNA in the CeA and BNST...
  10. pmc Differential effects of the hypocretin 1 receptor antagonist SB 334867 on high-fat food self-administration and reinstatement of food seeking in rats
    S G Nair
    Behavioral Neuroscience Branch, NIDA IRP NIH DHHS, Baltimore, MD 21224, USA
    Br J Pharmacol 154:406-16. 2008
    ..However, the role of these receptors in operant food self-administration or relapse to food seeking in animal models is unknown...
  11. pmc Effect of pharmacological manipulations of neuropeptide Y and corticotropin-releasing factor neurotransmission on incubation of conditioned fear
    C L Pickens
    Department of Health and Human Services, Behavioral Neuroscience Branch, Intramural Research Program National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21218, USA
    Neuroscience 164:1398-406. 2009
    ..Results also suggest that CRF receptors are not involved in cue-induced fear in the conditioned suppression procedure...
  12. ncbi request reprint Systemic and central amygdala injections of the mGluR(2/3) agonist LY379268 attenuate the expression of incubation of cocaine craving
    Lin Lu
    Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland, USA
    Biol Psychiatry 61:591-8. 2007
    ....
  13. ncbi request reprint Effect of methamphetamine self-administration on tyrosine hydroxylase and dopamine transporter levels in mesolimbic and nigrostriatal dopamine pathways of the rat
    Jack D Shepard
    Cellular Neurobiology Research Branch, IRP NIDA NIH, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 185:505-13. 2006
    ..We studied the effect of methamphetamine self-administration on two key regulators of dopamine transmission, tyrosine hydroxylase (TH), and dopamine transporter (DAT), in components of the mesolimbic and nigrostriatal dopamine pathways...
  14. ncbi request reprint Effects of dexfenfluramine and 5-HT3 receptor antagonists on stress-induced reinstatement of alcohol seeking in rats
    ANH DZUNG LE
    Department of Neuroscience, Centre for Addiction and Mental Health, 33 Russell Street, Toronto, Ontario, M5S 2S1, Canada
    Psychopharmacology (Berl) 186:82-92. 2006
    ....
  15. pmc The anxiogenic drug yohimbine reinstates palatable food seeking in a rat relapse model: a role of CRF1 receptors
    Udi E Ghitza
    Behavioral Neuroscience Branch, NIDA IRP NIH DHHS, Baltimore, MD 21224, USA
    Neuropsychopharmacology 31:2188-96. 2006
    ..These data suggest that CRF is involved in stress-induced relapse to palatable food seeking, and that CRF1 antagonists should be considered for the treatment of maladaptive eating habits...
  16. ncbi request reprint Neurobiology of relapse to heroin and cocaine seeking: an update and clinical implications
    Jennifer M Bossert
    Behavioral Neuroscience Branch, IRP NIDA NIH DHHS, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Eur J Pharmacol 526:36-50. 2005
    ....
  17. pmc Activation of group II metabotropic glutamate receptors in the nucleus accumbens shell attenuates context-induced relapse to heroin seeking
    Jennifer M Bossert
    Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, NIH DHHS, Baltimore, MD 21224, USA
    Neuropsychopharmacology 31:2197-209. 2006
    ..0 microg) 1.5 mm dorsal from the NAc core into the caudate-putamen were ineffective. Results suggest an important role of glutamate transmission in the NAc shell in context-induced reinstatement of heroin seeking...
  18. pmc Toward a model of drug relapse: an assessment of the validity of the reinstatement procedure
    David H Epstein
    Clinical Pharmacology and Therapeutics Research Branch, IRP NIDA NIH DHHS, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 189:1-16. 2006
    ..The reinstatement model is widely used to study relapse to drug addiction. However, the model's validity is open to question...
  19. pmc A conflict rat model of cue-induced relapse to cocaine seeking
    Ayelet Cooper
    Department of Neurobiology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Psychopharmacology (Berl) 194:117-25. 2007
    ..In this paper, we describe a conflict model of cue-induced relapse in rats that approximate the human condition...
  20. pmc A role for BDNF in cocaine reward and relapse
    Geoffrey Schoenbaum
    Nat Neurosci 10:935-6. 2007
  21. ncbi request reprint The CRF1 receptor antagonist antalarmin attenuates yohimbine-induced increases in operant alcohol self-administration and reinstatement of alcohol seeking in rats
    Peter W Marinelli
    Department of Neuroscience, Neurobiology of Alcohol Laboratory, Centre for Addiction and Mental Health, Toronto, ON, Canada
    Psychopharmacology (Berl) 195:345-55. 2007
    ..In this study, we assess whether these effects of yohimbine are attenuated by systemic injections of the corticotrotropin-releasing factor 1 (CRF1) receptor antagonist antalarmin...
  22. pmc Differential effects of blockade of dopamine D1-family receptors in nucleus accumbens core or shell on reinstatement of heroin seeking induced by contextual and discrete cues
    Jennifer M Bossert
    Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health Department of Health and Human Services, Baltimore, Maryland 21224, USA
    J Neurosci 27:12655-63. 2007
    ..Results also demonstrate novel dissociable roles of accumbens core and shell in context- versus discrete-cue-induced reinstatement of heroin seeking...
  23. pmc Formation of accumbens GluR2-lacking AMPA receptors mediates incubation of cocaine craving
    KELLY L CONRAD
    Department of Neuroscience, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, Illinois 60064, USA
    Nature 454:118-21. 2008
    ....
  24. pmc Review. Context-induced relapse to drug seeking: a review
    Hans S Crombag
    Department of Psychology, Behavioural and Clinical Neuroscience Group, School of Life Sciences, The University of Sussex, Brighton, UK
    Philos Trans R Soc Lond B Biol Sci 363:3233-43. 2008
    ..We conclude by discussing the clinical implications of rat studies on context-induced reinstatement of drug seeking...
  25. pmc Withdrawal from cocaine self-administration produces long-lasting deficits in orbitofrontal-dependent reversal learning in rats
    Donna J Calu
    Program in Neuroscience, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Learn Mem 14:325-8. 2007
    ..We found robust time-dependent increases in cue-induced cocaine seeking in the two extinction tests (incubation of craving) and severe reversal-learning impairments...
  26. ncbi request reprint Differential long-term neuroadaptations of glutamate receptors in the basolateral and central amygdala after withdrawal from cocaine self-administration in rats
    Lin Lu
    Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, National Institute on Health, Department of Health and Human Services, Baltimore, MD 21224, USA
    J Neurochem 94:161-8. 2005
    ..These results indicate that cocaine self-administration and subsequent withdrawal induces long-lasting and differential neuroadaptations in basolateral and central amygdala glutamate receptors...
  27. ncbi request reprint Cocaine experience establishes control of midbrain glutamate and dopamine by corticotropin-releasing factor: a role in stress-induced relapse to drug seeking
    Bin Wang
    Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, USA
    J Neurosci 25:5389-96. 2005
    ..Similar neuroadaptations may be important for the comorbidity between addiction and other stress-related psychiatric disorders...
  28. ncbi request reprint Selective induction of c-Fos immunoreactivity in the prelimbic cortex during reinstatement of heroin seeking induced by acute food deprivation in rats
    Uri Shalev
    Behavioral Neuroscience Branch, IRP NIDA NIH DHHS, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Behav Brain Res 145:79-88. 2003
    ..These results raise the possibility that the prelimbic cortex is involved in food deprivation-induced reinstatement of heroin seeking...
  29. ncbi request reprint Effect of environmental stressors on opiate and psychostimulant reinforcement, reinstatement and discrimination in rats: a review
    Lin Lu
    Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, NIH DHHS, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Neurosci Biobehav Rev 27:457-91. 2003
    ..The broader implications of the data reviewed here for future research and for the treatment of opiate and psychostimulant addiction are briefly discussed...
  30. ncbi request reprint The role of corticosterone in food deprivation-induced reinstatement of cocaine seeking in the rat
    Uri Shalev
    Behavioral Neuroscience Branch, IRP NIDA NIH, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 168:170-6. 2003
    ..Here we studied whether food deprivation would reinstate cocaine seeking and whether the stress hormone, corticosterone, is involved in this effect...
  31. ncbi request reprint Molecular neuroadaptations in the accumbens and ventral tegmental area during the first 90 days of forced abstinence from cocaine self-administration in rats
    Lin Lu
    Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse National Institutes of Health Department of Health and Human Services, Baltimore, Maryland 21224, USA
    J Neurochem 85:1604-13. 2003
    ..Cocaine self-administration produces long-lasting molecular neuroadaptations in the VTA and accumbens that may underlie cocaine relapse during periods of abstinence...
  32. ncbi request reprint Time-dependent increases in brain-derived neurotrophic factor protein levels within the mesolimbic dopamine system after withdrawal from cocaine: implications for incubation of cocaine craving
    Jeffrey W Grimm
    Behavioral Neuroscience Branch, Intramural Research Program National Institute on Drug Abuse National Institutes of Health Department of Health and Human Services, Baltimore, Maryland 21224, USA
    J Neurosci 23:742-7. 2003
    ..Time-dependent increases in BDNF levels may lead to synaptic modifications that underlie enhanced responsiveness to cocaine cues after prolonged withdrawal periods...
  33. ncbi request reprint Effects of acute and prolonged opiate abstinence on extinction behaviour in rats
    Kim G C Hellemans
    Department of Psychology, Queen s University, Kingston, Ontario, K7L 3N6
    Can J Exp Psychol 56:241-52. 2002
    ..Results suggest that heroin abstinence has different effects on drug-seeking and drug-taking and that these effects do not temporally coincide with somatic measures of opioid withdrawal...
  34. ncbi request reprint Effect of dopamine receptor antagonists on renewal of cocaine seeking by reexposure to drug-associated contextual cues
    Hans S Crombag
    Behavioral Neuroscience Branch, The National Institute on Drug Abuse, Intramural Research Program, Baltimore, MD 21224, USA
    Neuropsychopharmacology 27:1006-15. 2002
    ..These data suggest that activation of dopamine receptors is involved in reinstatement of cocaine seeking induced by exposure to the drug self-administration context...
  35. ncbi request reprint Reinstatement of cocaine seeking in 129X1/SvJ mice: effects of cocaine priming, cocaine cues and food deprivation
    David A Highfield
    Behavioral Neuroscience Branch, IRP NIDA NIH, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 161:417-24. 2002
    ..Here we describe a reinstatement method for studying relapse to cocaine seeking in mice, a suitable species for studying the effect of genetic manipulations such as gene knockout or gene over-expression on compulsive drug use...
  36. ncbi request reprint Renewal of drug seeking by contextual cues after prolonged extinction in rats
    Hans S Crombag
    Behavioral Neuroscience Branch, National Institute on Drug Abuse, Intramural Research Program, Baltimore, Maryland 21224, USA
    Behav Neurosci 116:169-73. 2002
    ..The authors suggest that the renewal procedure can be used to study mechanisms underlying relapse to drug seeking elicited by drug-associated contextual stimuli...
  37. ncbi request reprint Drug onset cues, conditioned withdrawal, and drug relapse: comment on McDonald and Siegel (2004)
    Jennifer M Bossert
    Behavioral Neuroscience Branch, Intramural Research Program IRP, National Institute on Drug Abuse NIDA, National Institutes of Health NIH, Baltimore, MD 21224, USA
    Exp Clin Psychopharmacol 12:15-7; discussion 23-6. 2004
    ..The authors of this comment discuss the degree to which the literature supports this hypothesis...
  38. ncbi request reprint Neurobiology of relapse to heroin and cocaine seeking: a review
    Uri Shalev
    Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, USA
    Pharmacol Rev 54:1-42. 2002
    ..The data reviewed also suggest that the neuronal events mediating drug-induced reinstatement are to some degree dissociable from those mediating drug reinforcement...
  39. ncbi request reprint Central amygdala ERK signaling pathway is critical to incubation of cocaine craving
    Lin Lu
    Behavioral Neuroscience Branch, Intramural Research Program National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, 5500 Nathan Shock Drive, Baltimore, Maryland 21224, USA
    Nat Neurosci 8:212-9. 2005
    ..Results suggest that the incubation of cocaine craving is mediated by time-dependent increases in the responsiveness of the central amygdala ERK pathway to cocaine cues...
  40. ncbi request reprint A role of ventral tegmental area glutamate in contextual cue-induced relapse to heroin seeking
    Jennifer M Bossert
    Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224, USA
    J Neurosci 24:10726-30. 2004
    ..Results indicate that glutamate transmission in the VTA plays an important role in contextual cue-induced relapse to heroin seeking...
  41. ncbi request reprint Incubation of cocaine craving after withdrawal: a review of preclinical data
    Lin Lu
    Behavioral Neuroscience Branch, IRP NIDA NIH DHHS, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Neuropharmacology 47:214-26. 2004
    ..4. Incubation of cocaine craving after withdrawal is associated with increases in the levels of brain-derived neurotrophic factor (BDNF) in mesolimbic dopamine areas...
  42. ncbi request reprint The anxiogenic drug yohimbine reinstates methamphetamine seeking in a rat model of drug relapse
    Jack D Shepard
    Cellular Neurobiology Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health Department of Health and Human Services, Baltimore, Maryland 21224, USA
    Biol Psychiatry 55:1082-9. 2004
    ..We studied whether yohimbine, an alpha-2 adrenoceptor antagonist that increases noradrenaline release and induces anxiety-like responses in human and nonhuman subjects, would reinstate methamphetamine seeking in rats...
  43. ncbi request reprint The cystine-glutamate transporter in the accumbens: a novel role in cocaine relapse
    Lin Lu
    Behavioral Neuroscience Branch, IRP, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, MD 21224, USA
    Trends Neurosci 27:74-6. 2004
    ..These data also suggest the cystine-glutamate transporter as a novel target for medication that could prevent cocaine relapse...
  44. ncbi request reprint Cocaine-experienced rats exhibit learning deficits in a task sensitive to orbitofrontal cortex lesions
    Geoffrey Schoenbaum
    University of Maryland School of Medicine, Department of Anatomy and Neurobiology, 685 West Baltimore Street, HSF 1 Rm 280K, Baltimore, MD 21201, USA
    Eur J Neurosci 19:1997-2002. 2004
    ....
  45. ncbi request reprint Cocaine seeking over extended withdrawal periods in rats: different time courses of responding induced by cocaine cues versus cocaine priming over the first 6 months
    Lin Lu
    Behavioral Neuroscience Branch, IRP NIDA NIH DHHS, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 176:101-8. 2004
    ..Here, we studied cocaine seeking induced by re-exposure to cocaine cues or cocaine itself over an extended withdrawal period of 6 months...
  46. ncbi request reprint A single infusion of brain-derived neurotrophic factor into the ventral tegmental area induces long-lasting potentiation of cocaine seeking after withdrawal
    Lin Lu
    Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224, USA
    J Neurosci 24:1604-11. 2004
    ..These data suggest that BDNF-mediated neuroadaptations in mesolimbic areas are involved in the persistent cocaine seeking induced by exposure to drug cues after withdrawal...
  47. pmc Peptide YY3-36 decreases reinstatement of high-fat food seeking during dieting in a rat relapse model
    Udi E Ghitza
    Behavioral Neuroscience Branch, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224, USA
    J Neurosci 27:11522-32. 2007
    ....
  48. ncbi request reprint Rodent BDNF genes, novel promoters, novel splice variants, and regulation by cocaine
    Qing Rong Liu
    Molecular Neurobiology Branch, National Institute on Drug Abuse Intramural Research Program NIDA IRP, NIH, Department of Health and Human Services DHHS, Box 5180, Baltimore, MD 21224, USA
    Brain Res 1067:1-12. 2006
    ..These data suggest a role of specific BDNF promoter regions and regulatory sequences in stimulant-induced alterations in BDNF expression, and in the alterations that changed BDNF expression is likely to confer in the brain...
  49. pmc The role of orbitofrontal cortex in drug addiction: a review of preclinical studies
    Geoffrey Schoenbaum
    Department of Anatomy and Neurobiology, University of Maryland, School of Medicine, Baltimore, Maryland 21201, USA
    Biol Psychiatry 63:256-62. 2008
    ....
  50. ncbi request reprint Role of ERK in cocaine addiction
    Lin Lu
    Department of Neuropharmacology, National Institute on Drug Dependence, Peking University, Beijing 100083, China
    Trends Neurosci 29:695-703. 2006
    ..Pharmacological manipulations that decrease the extent to which cocaine and cocaine cues induce ERK activity might therefore be considered as potential treatments for cocaine addiction...