Genomes and Genes
Affiliation: National Institutes of Health
- Association of host genetic risk factors with the course of cytomegalovirus retinitis in patients infected with human immunodeficiency virusEfe Sezgin
Laboratory of Genomic Diversity, National Cancer Institute, Frederick, MD 21702, USA
Am J Ophthalmol 151:999-1006.e4. 2011....
- Effect of host genetics on incidence of HIV neuroretinal disorder in patients with AIDSEfe Sezgin
Laboratory of Genomic Diversity, National Cancer Institute, Frederick, MD 21702 1201, USA
J Acquir Immune Defic Syndr 54:343-51. 2010..Clearly, further studies are warrented...
- Effect of host genetics on the development of cytomegalovirus retinitis in patients with AIDSEfe Sezgin
Laboratory of Genomic Diversity, SAIC Frederick, National Cancer Institute, Frederick, Maryland 21702 1201, USA
J Infect Dis 202:606-13. 2010..The ubiquitous CMV pathogen contains a human interleukin-10 (IL-10) homolog in its genome and utilizes it to evade host immune reactions through an IL-10 receptor mediated immune-suppression pathway...
- Examination of disease-based selection, demographic history and population structure in European Y-chromosome haplogroup IEfe Sezgin
Laboratory of Genomic Diversity, National Cancer Institute at Frederick, Frederick, MD 21702 1201, USA
J Hum Genet 55:613-20. 2010..Clearly, further studies on Y-chromosome candidate loci sequencing to discover functional variants and discern the roles of evolutionary factors are warranted...
- Genome-wide association study implicates PARD3B-based AIDS restrictionJennifer L Troyer
Laboratory of Genomic Diversity, SAIC Frederick, Inc, Frederick, MD 21702, USA
J Infect Dis 203:1491-502. 2011..Here we used clinically well-characterized subjects from 5 pretreatment HIV/AIDS cohorts for a genome-wide association study to identify gene associations with rate of AIDS progression...
- Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progressionSher L Hendrickson
Laboratory of Genomic Diversity, National Cancer Institute, Frederick, Maryland, USA
PLoS ONE 5:e12862. 2010..Mitochondrial pathogenesis occurs in HIV patients and genetically, mitochondrial DNA haplogroups with presumed functional differences have been associated with differential AIDS progression...
- Role of exonic variation in chemokine receptor genes on AIDS: CCRL2 F167Y association with pneumocystis pneumoniaPing An
Basic Research Laboratory, SAIC Frederick, National Cancer Institute Frederick, Frederick, Maryland, USA
PLoS Genet 7:e1002328. 2011..28-6.31) among four major AIDS-defining conditions. Considering the newly defined role of CCRL2 in lung dendritic cell trafficking, this atypical chemokine receptor may affect PCP through immune regulation and inducing inflammation...
- Mitochondrial DNA haplogroups influence AIDS progressionSher L Hendrickson
Laboratory of Genomic Diversity, National Cancer Institute, Frederick, Maryland 21702 1201, USA
AIDS 22:2429-39. 2008....
- The principal genetic determinants for nasopharyngeal carcinoma in China involve the HLA class I antigen recognition grooveMinzhong Tang
College of Life Science and Bio engineering, Beijing University of Technology, Beijing, China
PLoS Genet 8:e1003103. 2012....
- Association of Y chromosome haplogroup I with HIV progression, and HAART outcomeEfe Sezgin
NCI Frederick, MD 21702, USA
Hum Genet 125:281-94. 2009..Our results suggest that one or more loci on the Y chromosome found on haplogroup Y-I have an effect on AIDS progression and treatment responses in European Americans...