Nicholas Seneca

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Brain and whole-body imaging in nonhuman primates with [11C]MeS-IMPY, a candidate radioligand for beta-amyloid plaques
    Nicholas Seneca
    Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 2035, USA
    Nucl Med Biol 34:681-9. 2007
  2. pmc Occupancy of dopamine D2/3 receptors in rat brain by endogenous dopamine measured with the agonist positron emission tomography radioligand [11C]MNPA
    Nicholas Seneca
    Molecular Imaging Branch, National Institute of Mental Health, Bethesda, Maryland 20892 2035, USA
    Synapse 62:756-63. 2008
  3. pmc Kinetic brain analysis and whole-body imaging in monkey of [11C]MNPA: a dopamine agonist radioligand
    Nicholas Seneca
    Molecular Imaging Branch, National Institute of Mental Health, Building 31, Bethesda, MD 20892, USA
    Synapse 62:700-9. 2008
  4. ncbi request reprint Atomoxetine occupies the norepinephrine transporter in a dose-dependent fashion: a PET study in nonhuman primate brain using (S,S)-[18F]FMeNER-D2
    Nicholas Seneca
    Department of Clinical Neuroscience, Psychiatry Section, Karolinska Institutet, Karolinska Hospital, S 17176, Stockholm, Sweden
    Psychopharmacology (Berl) 188:119-27. 2006
  5. ncbi request reprint Whole-body biodistribution, radiation dosimetry estimates for the PET norepinephrine transporter probe (S,S)-[18F]FMeNER-D2 in non-human primates
    Nicholas Seneca
    Karolinska Institutet, Department of Clinical Neuroscience, Karolinska Hospital, Stockholm, Sweden
    Nucl Med Commun 26:695-700. 2005
  6. pmc Dopamine beta-hydroxylase-deficient mice have normal densities of D(2) dopamine receptors in the high-affinity state based on in vivo PET imaging and in vitro radioligand binding
    Mette Skinbjerg
    Molecular Imaging Branch, National Institute of Mental Health, Bethesda, Maryland 20892 2035, USA
    Synapse 64:699-703. 2010
  7. ncbi request reprint Effect of amphetamine on dopamine D2 receptor binding in nonhuman primate brain: a comparison of the agonist radioligand [11C]MNPA and antagonist [11C]raclopride
    Nicholas Seneca
    Department of Clinical Neuroscience, Psychiatry Section, Karolinska Institutet, Karolinska Hospital, S 17176 Stockholm, Sweden
    Synapse 59:260-9. 2006
  8. pmc Human brain imaging and radiation dosimetry of 11C-N-desmethyl-loperamide, a PET radiotracer to measure the function of P-glycoprotein
    Nicholas Seneca
    National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA
    J Nucl Med 50:807-13. 2009
  9. pmc P-glycoprotein function at the blood-brain barrier imaged using 11C-N-desmethyl-loperamide in monkeys
    Jeih San Liow
    Molecular Imaging Branch, PET Department, Clinical Center, National Institutes of Health, Bethesda, Maryland 20892 2035, USA
    J Nucl Med 50:108-15. 2009
  10. pmc D2 dopamine receptor internalization prolongs the decrease of radioligand binding after amphetamine: a PET study in a receptor internalization-deficient mouse model
    Mette Skinbjerg
    Molecular Imaging Branch, National Institute of Mental Health, Bethesda, MD, USA
    Neuroimage 50:1402-7. 2010

Detail Information

Publications25

  1. ncbi request reprint Brain and whole-body imaging in nonhuman primates with [11C]MeS-IMPY, a candidate radioligand for beta-amyloid plaques
    Nicholas Seneca
    Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 2035, USA
    Nucl Med Biol 34:681-9. 2007
    ..Calculated dosimetry results are comparable with those for other (11)C-labeled brain imaging radioligands...
  2. pmc Occupancy of dopamine D2/3 receptors in rat brain by endogenous dopamine measured with the agonist positron emission tomography radioligand [11C]MNPA
    Nicholas Seneca
    Molecular Imaging Branch, National Institute of Mental Health, Bethesda, Maryland 20892 2035, USA
    Synapse 62:756-63. 2008
    ....
  3. pmc Kinetic brain analysis and whole-body imaging in monkey of [11C]MNPA: a dopamine agonist radioligand
    Nicholas Seneca
    Molecular Imaging Branch, National Institute of Mental Health, Building 31, Bethesda, MD 20892, USA
    Synapse 62:700-9. 2008
    ..4 muSv/MBq (23.5 mrem/mCi). In conclusion, brain uptake of [(11)C]MNPA reflected the density of D(2/3) receptors, quantified relative to serial arterial measurements, and caused moderate to low radiation exposure...
  4. ncbi request reprint Atomoxetine occupies the norepinephrine transporter in a dose-dependent fashion: a PET study in nonhuman primate brain using (S,S)-[18F]FMeNER-D2
    Nicholas Seneca
    Department of Clinical Neuroscience, Psychiatry Section, Karolinska Institutet, Karolinska Hospital, S 17176, Stockholm, Sweden
    Psychopharmacology (Berl) 188:119-27. 2006
    ..Previous positron emission tomography (PET) studies had failed to demonstrate the feasibility of measuring a dose-dependent and saturable NET occupancy in human brain using [11C]MeNER...
  5. ncbi request reprint Whole-body biodistribution, radiation dosimetry estimates for the PET norepinephrine transporter probe (S,S)-[18F]FMeNER-D2 in non-human primates
    Nicholas Seneca
    Karolinska Institutet, Department of Clinical Neuroscience, Karolinska Hospital, Stockholm, Sweden
    Nucl Med Commun 26:695-700. 2005
    ..In this work, we quantified the biodistribution over time and radiation exposure to multiple organs with (S,S)-[F]FMeNER-D2...
  6. pmc Dopamine beta-hydroxylase-deficient mice have normal densities of D(2) dopamine receptors in the high-affinity state based on in vivo PET imaging and in vitro radioligand binding
    Mette Skinbjerg
    Molecular Imaging Branch, National Institute of Mental Health, Bethesda, Maryland 20892 2035, USA
    Synapse 64:699-703. 2010
    ..In summary, our results suggest that DBH knockout mice have normal levels of D(2) receptors in the high-affinity state and that additional mechanisms contribute to their behavioral sensitivity to psychostimulants...
  7. ncbi request reprint Effect of amphetamine on dopamine D2 receptor binding in nonhuman primate brain: a comparison of the agonist radioligand [11C]MNPA and antagonist [11C]raclopride
    Nicholas Seneca
    Department of Clinical Neuroscience, Psychiatry Section, Karolinska Institutet, Karolinska Hospital, S 17176 Stockholm, Sweden
    Synapse 59:260-9. 2006
    ....
  8. pmc Human brain imaging and radiation dosimetry of 11C-N-desmethyl-loperamide, a PET radiotracer to measure the function of P-glycoprotein
    Nicholas Seneca
    National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA
    J Nucl Med 50:807-13. 2009
    ..The purposes of this study were to determine whether (11)C-dLop is a substrate for P-gp at the blood-brain barrier in humans and to measure the distribution of radioactivity in the entire body to estimate radiation exposure...
  9. pmc P-glycoprotein function at the blood-brain barrier imaged using 11C-N-desmethyl-loperamide in monkeys
    Jeih San Liow
    Molecular Imaging Branch, PET Department, Clinical Center, National Institutes of Health, Bethesda, Maryland 20892 2035, USA
    J Nucl Med 50:108-15. 2009
    ..Should further demethylation of 11C-dLop occur, radiometabolites with low entry into the brain are generated. Therefore, we evaluated the ability of 11C-dLop to quantify the function of P-gp at the blood-brain barrier in monkeys...
  10. pmc D2 dopamine receptor internalization prolongs the decrease of radioligand binding after amphetamine: a PET study in a receptor internalization-deficient mouse model
    Mette Skinbjerg
    Molecular Imaging Branch, National Institute of Mental Health, Bethesda, MD, USA
    Neuroimage 50:1402-7. 2010
    ..In addition, this study demonstrates the utility of small animal PET to study receptor trafficking in vivo in genetically modified mice...
  11. pmc Effects of ketoconazole on the biodistribution and metabolism of [11C]loperamide and [11C]N-desmethyl-loperamide in wild-type and P-gp knockout mice
    Nicholas Seneca
    Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Nucl Med Biol 37:335-45. 2010
    ..We aimed to test whether inhibition of CYP3A4 with ketoconazole might reduce the metabolism of [(11)C]loperamide and [(11)C]dLop in mice, and thereby improve the quality of these radiotracers...
  12. ncbi request reprint Whole-body biodistribution and radiation dosimetry estimates for the PET dopamine transporter probe 18F-FECNT in non-human primates
    Dnyanesh N Tipre
    Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bldg 1 Rm B3 10, 1 Center Drive, Bethesda, MD 20892 0135, USA
    Nucl Med Commun 25:737-42. 2004
    ..The aim of the current study was to quantify the distribution of radioactivity in three rhesus monkeys after the injection of approximately 185 MBq (5 mCi) of 18F-FECNT...
  13. pmc Synthesis and evaluation of [N-methyl-11C]N-desmethyl-loperamide as a new and improved PET radiotracer for imaging P-gp function
    Neva Lazarova
    Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 1103, USA
    J Med Chem 51:6034-43. 2008
    ..11)C]3 is an effective new radiotracer for imaging brain P-gp function and, in favor of future successful quantification, appears free of extensive brain-penetrant radiometabolites...
  14. ncbi request reprint Quantification of brain phosphodiesterase 4 in rat with (R)-[11C]Rolipram-PET
    Masahiro Fujita
    Molecular Imaging Branch, National Institute of Mental Health, Building 1, Room B3 10, 1 Center Drive, MSC 0135, Bethesda, MD 20892 0135, USA
    Neuroimage 26:1201-10. 2005
    ..Phosphodiesterase 4 (PDE4) catabolizes the second messenger 3', 5'-cyclic adenosine monophosphate and may play a critical role in brain diseases. Our aim was to quantify PDE4 in rats with positron emission tomography (PET)...
  15. ncbi request reprint A preliminary PET evaluation of the new dopamine D2 receptor agonist [11C]MNPA in cynomolgus monkey
    Sjoerd J Finnema
    Department of Clinical Neuroscience, Psychiatry Section, Karolinska Institute, Karolinska University Hospital, S 17176 Stockholm, Sweden
    Nucl Med Biol 32:353-60. 2005
    ....
  16. ncbi request reprint Development of new brain imaging agents based upon nocaine-modafinil hybrid monoamine transporter inhibitors
    John L Musachio
    Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Building 10, Room B3 C346, 10 Center Drive, Bethesda, MD 20892 1003, USA
    Bioorg Med Chem Lett 16:3101-4. 2006
    ..Contrary to our expectations, both of these ligands provided brain images that were more typical of those shown by agents binding to the DAT...
  17. pmc P-glycoprotein function at the blood-brain barrier in humans can be quantified with the substrate radiotracer 11C-N-desmethyl-loperamide
    William C Kreisl
    Molecular Imaging Branch, National Institute of Mental Health, Bethesda, Maryland 20892, USA
    J Nucl Med 51:559-66. 2010
    ..We examined the ability of (11)C-dLop to quantify P-gp function in humans after increasing doses of tariquidar, an inhibitor of P-gp...
  18. doi request reprint Palladium mediated ¹¹C-cyanation and characterization in the non-human primate brain of the novel mGluR5 radioligand [¹¹C]AZD9272
    Jan D Andersson
    Karolinska Institutet, Department of Clinical Neuroscience, Stockholm, Sweden
    Nucl Med Biol 40:547-53. 2013
    ....
  19. pmc Occupancy of dopamine D₂ and D₃ and serotonin 5-HT₁A receptors by the novel antipsychotic drug candidate, cariprazine (RGH-188), in monkey brain measured using positron emission tomography
    Nicholas Seneca
    Department of Clinical Neuroscience, Psychiatry Section, Karolinska Institutet, Stockholm 171 76, Sweden
    Psychopharmacology (Berl) 218:579-87. 2011
    ..Positron emission tomography (PET) can be used as a tool in drug development to assess the in vivo distribution and pharmacological properties of a drug...
  20. pmc Biodistribution and dosimetry in humans of two inverse agonists to image cannabinoid CB1 receptors using positron emission tomography
    Garth E Terry
    Molecular Imaging Branch, National Institute of Mental Health, 31 Center Drive, Bethesda, MD 20892 2035, USA
    Eur J Nucl Med Mol Imaging 37:1499-506. 2010
    ..We recently reported brain imaging of CB(1) receptors with two PET radioligands: (11)C-MePPEP and (18)F-FMPEP-d (2). Here we describe the biodistribution and dosimetry estimates for these two radioligands...
  21. ncbi request reprint Pharmacological and genetic characterization of two selective serotonin transporter ligands: 2-[2-(dimethylaminomethylphenylthio)]-5-fluoromethylphenylamine (AFM) and 3-amino-4-[2-(dimethylaminomethyl-phenylthio)]benzonitrile (DASB)
    Qian Li
    Laboratory of Clinical Science, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
    J Pharmacol Exp Ther 308:481-6. 2004
    ..In addition, fenfluramine showed a low capability to compete with [(3)H]AFM. The present results suggest that both AFM and DASB are highly selective SERT ligands potentially suitable for use in human PET studies of SERT...
  22. ncbi request reprint Effect of scatter correction on the compartmental measurement of striatal and extrastriatal dopamine D2 receptors using [123I]epidepride SPET
    Masahiro Fujita
    Department of Psychiatry, Yale University School of Medicine and VA Connecticut Healthcare System, West Haven, CT, USA
    Eur J Nucl Med Mol Imaging 31:644-54. 2004
    ..It is concluded that SC is required for accurate quantification of distribution volumes of receptor ligands in SPET studies...
  23. ncbi request reprint Quantification of nicotinic acetylcholine receptors in human brain using [123I]5-I-A-85380 SPET
    Masahiro Fujita
    Molecular Imaging Branch, National Institute of Mental Health, Bethesda, MD 20892 0135, USA
    Eur J Nucl Med Mol Imaging 30:1620-9. 2003
    ..These results demonstrate the feasibility of quantifying high-affinity type nAChRs using [123I]5-I-A-85380 in humans and support the use of VT' measured by bolus studies...
  24. ncbi request reprint Preparation of highly specific radioactivity [18F]flumazenil and its evaluation in cynomolgus monkey by positron emission tomography
    Nikolaj N Ryzhikov
    Institute of Human Brain, Russian Academy of Science, 9, Pavlov str, 197376, Saint Petersburg, Russia
    Nucl Med Biol 32:109-16. 2005
    ..In blocking experiments, almost all radioactivity was inhibited by the addition of unlabeled flumazenil. [18F]Flumazenil is a suitable radioligand for PET assessment of the BZR...
  25. doi request reprint [11C]AZ10419369: a selective 5-HT1B receptor radioligand suitable for positron emission tomography (PET). Characterization in the primate brain
    M Edward Pierson
    AstraZeneca Pharmaceuticals CNS Discovery, 1800 Concord Pike, PO Box 15437, Wilmington, DE 19850 5437, USA
    Neuroimage 41:1075-85. 2008
    ..This radioligand may be useful in future studies evaluating drug-induced receptor occupancy and measurement of brain 5-HT1B receptor levels in patients with psychiatric disorders...