Affiliation: National Institutes of Health
- Genetic and epigenetic biomarkers in cancer : improving diagnosis, risk assessment, and disease stratificationMukesh Verma
Analytic Epidemiology Research Branch, Epidemiology and Genetics Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, Rockville, Maryland 20852, USA
Mol Diagn Ther 10:1-15. 2006..The current status and the challenges in the field of genetic and epigenetic markers in cancer diagnosis, risk assessment, and disease stratification are discussed...
- The Breast Cancer Family Registry: an infrastructure for cooperative multinational, interdisciplinary and translational studies of the genetic epidemiology of breast cancerEsther M John
Clinical and Genetic Epidemiology Research Branch, Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, Maryland, USA
Breast Cancer Res 6:R375-89. 2004....
- The emergence of networks in human genome epidemiology: challenges and opportunitiesDaniela Seminara
Epidemiology and Genetics Research Branch, Division of Cancer Control and Population Sciences, National Cancer Institute, NIH, EPN Bldg, Rm 5142, MSC 7393, 6130 Executive Blvd, Bethesda, MD 20892, USA
Epidemiology 18:1-8. 2007
- Frontiers in cancer epidemiology: a challenge to the research community from the Epidemiology and Genomics Research Program at the National Cancer InstituteMuin J Khoury
Epidemiology and Genomics Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, Maryland, USA
Cancer Epidemiol Biomarkers Prev 21:999-1001. 2012..grants.cancer.gov/ to develop priorities and the next generation of high-impact studies...
- Cancer risk prediction models: a workshop on development, evaluation, and applicationAndrew N Freedman
Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, MD 20892 7344, USA
J Natl Cancer Inst 97:715-23. 2005....
- Oral contraceptives, postmenopausal hormones, and risk of asynchronous bilateral breast cancer: the WECARE Study GroupJane C Figueiredo
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
J Clin Oncol 26:1411-8. 2008..To investigate whether oral contraceptive (OC) use and postmenopausal hormones (PMH) are associated with an increased risk of developing asynchronous bilateral breast cancer among women diagnosed with breast cancer younger than 55 years...
- A road map for efficient and reliable human genome epidemiologyJohn P A Ioannidis
Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, and Biomedical Research Institute, Foundation for Research and Technology Hellas, Ioannina 45110, Greece
Nat Genet 38:3-5. 2006..Systematic reviews will be expanded to include more meta-analyses of individual-level data and prospective meta-analyses. Field synopses will offer regularly updated overviews...
- A network of investigator networks in human genome epidemiologyJohn P A Ioannidis
Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
Am J Epidemiol 162:302-4. 2005....
- A combined genomewide linkage scan of 1,233 families for prostate cancer-susceptibility genes conducted by the international consortium for prostate cancer geneticsJianfeng Xu
Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC, USA
Am J Hum Genet 77:219-29. 2005....
- Lower cancer incidence in Amsterdam-I criteria families without mismatch repair deficiency: familial colorectal cancer type XNoralane M Lindor
Department of Medical Genetics, Mayo Clinic, Rochester, Minn, USA
JAMA 293:1979-85. 2005..Cancer incidence in AC-I families with MMR gene mutations is reported to be very high, but cancer incidence for individuals in AC-I families with no evidence of an MMR defect is unknown...
- Variants in the ATM gene associated with a reduced risk of contralateral breast cancerPatrick Concannon
Department of Biochemistry and Molecular Genetics and Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia 22908 0733, USA
Cancer Res 68:6486-91. 2008..1-0.6; c.6348-54T>C RR, 0.2; 95% CI, 0.1-0.8]. These data suggest that some alleles of ATM may exert an antineoplastic effect, perhaps by altering the activity of ATM as an initiator of DNA damage responses or a regulator of p53...
- Colon Cancer Family Registry: an international resource for studies of the genetic epidemiology of colon cancerPolly A Newcomb
Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
Cancer Epidemiol Biomarkers Prev 16:2331-43. 2007..Family studies have served as a cornerstone of genetic research on colorectal cancer...
- Familial aggregation of common sequence variants on 15q24-25.1 in lung cancerPengyuan Liu
Washington University, St Louis, MO 63110, USA
J Natl Cancer Inst 100:1326-30. 2008..67, CI = 2.21 to 14.60, both of which were located in the 15q24-25.1 locus, than among control subjects. Thus, further research to elucidate causal variants in the 15q24-25.1 locus that are associated with lung cancer is warranted...
- Assessment of cumulative evidence on genetic associations: interim guidelinesJohn P A Ioannidis
Clinical and Molecular Epidemiology Unit, University of Ioannina School of Medicine, Ioannina 45110, Greece
Int J Epidemiol 37:120-32. 2008..Future empirical research and consensus development are needed to develop an integrated model for combining epidemiological and biological evidence in the rapidly evolving field of investigation of genetic factors...
- EGFR-T790M is a rare lung cancer susceptibility allele with enhanced kinase activityHaris Vikis
Washington University, St Louis, Missouri, USA
Cancer Res 67:4665-70. 2007..Our observations show that EGFR-T790M provides a proliferative advantage with respect to WT EGFR and suggest that the enhanced kinase activity of this mutant is the basis for rare cases of inherited susceptibility to lung cancer...
- Identification of a novel tumor suppressor gene p34 on human chromosome 6q25.1Min Wang
School of Medicine, Washington University, 660 Euclid Avenue, St Louis, MO, USA
Cancer Res 67:93-9. 2007..Our results suggest that p34 may be a novel tumor suppressor gene involved in sporadic lung cancer but it seems not to be the candidate familial lung cancer susceptibility gene linked to chromosomal region 6q23-25...
- Ascending the learning curve--MSI testing experience of a six-laboratory consortiumNoralane M Lindor
Department of Medical Genetics, Mayo Clinic, Rochester, MN 55905, USA
Cancer Biomark 2:5-9. 2006..The aim of this paper is to share lessons learned and to describe the final concordance rates in scoring MSI markers within this consortium...
- Pooled genome linkage scan of aggressive prostate cancer: results from the International Consortium for Prostate Cancer GeneticsDaniel J Schaid
Harwick 7, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
Hum Genet 120:471-85. 2006..This provides a basis for attempts to identify these genes, with potential clinical utility for men with aggressive prostate cancer and their relatives...
- Pancreatic cancer genetic epidemiology consortiumGloria M Petersen
Mayo Clinic College of Medicine, Rochester, MN 55905, USA
Cancer Epidemiol Biomarkers Prev 15:704-10. 2006..Linkage studies are ongoing. The PACGENE Consortium will be a valuable family-based resource that will greatly enhance genetic epidemiology research in pancreatic cancer...
- The CHEK2*1100delC allelic variant and risk of breast cancer: screening results from the Breast Cancer Family RegistryJonine L Bernstein
Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, 3rd Floor, 307 East 63rd Street, New York, New York 10021, USA
Cancer Epidemiol Biomarkers Prev 15:348-52. 2006..63; 95% CI, 1.25-10.52). These data supporting the biological relevance of CHEK2 in breast carcinogenesis suggest that further studies examining the joint roles of CHEK2*1100delC carrier status and radiation exposure may be warranted...
- Conversion analysis for mutation detection in MLH1 and MSH2 in patients with colorectal cancerGraham Casey
Department of Cancer Biology, Cleveland Clinic Lerner College of Medicine, Cleveland, Ohio 44195, USA
JAMA 293:799-809. 2005..Current data suggest that mismatch repair mutations are highly heterogeneous and that many mutations are not detected when conventional DNA sequencing alone is used...
- Workshop on The Epidemiology of the ATM Gene: Impact on Breast Cancer Risk and Treatment, Present Status and Future Focus, Lillehammer, Norway, 29 June 2002Jonine L Bernstein
Department of Community Medicine, Mount Sinai School of Medicine, New York, USA
Breast Cancer Res 4:249-52. 2002..In the present meeting report, the aims of each project are described...