James R Sellers
Affiliation: National Institutes of Health
Ecsédi P, Billington N, Pálfy G, Gogl G, Kiss B, Bulyáki É, et al
. Multiple S100 protein isoforms and C-terminal phosphorylation contribute to the paralog-selective regulation of nonmuscle myosin 2 filaments. J Biol Chem. 2018;293:14850-14867 pubmed publisher
Sellers J, Knight P. Folding and regulation in myosins II and V. J Muscle Res Cell Motil. 2007;28:363-70 pubmed publisher
..In myosin V the key feature is an interaction between the heads and the globular tail domain. ..
Heissler S, Chinthalapudi K, Sellers J. Kinetic characterization of the sole nonmuscle myosin-2 from the model organism Drosophila melanogaster. FASEB J. 2015;29:1456-66 pubmed publisher
..3 Â± 4.1 ÂµM. Together, these data show that Drosophila nonmuscle myosin-2 is a bona fide molecular motor and establish an important link between switch-2 and blebbistatin sensitivity. ..
Billington N, Beach J, Heissler S, Remmert K, Guzik Lendrum S, Nagy A, et al
. Myosin 18A coassembles with nonmuscle myosin 2 to form mixed bipolar filaments. Curr Biol. 2015;25:942-8 pubmed publisher
..Given the numerous, fundamental cellular and developmental roles attributed to NM2, our results have far-reaching biological implications. ..
Heissler S, Chinthalapudi K, Sellers J. Kinetic signatures of myosin-5B, the motor involved in microvillus inclusion disease. J Biol Chem. 2017;292:18372-18385 pubmed publisher