J R Sellers

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Myosins: a diverse superfamily
    J R Sellers
    National Heart, Lung and Blood Institute, National Institutes of Health, Building 10, Room 8N202, Bethesda, MD 20892, USA
    Biochim Biophys Acta 1496:3-22. 2000
  2. ncbi request reprint Unconventional myosins and the genetics of hearing loss
    T B Friedman
    Laboratory of Molecular Genetics, National Institute on Deafness and Other Communication Disorders, Rockville, MD 20854, USA
    Am J Med Genet 89:147-57. 1999
  3. pmc Xenopus nonmuscle myosin heavy chain isoforms have different subcellular localizations and enzymatic activities
    C A Kelley
    Laboratory of Molecular Cardiology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Cell Biol 134:675-87. 1996
  4. ncbi request reprint Identification and analysis of the myosin superfamily in Drosophila: a database approach
    R A Yamashita
    Laboratory of Molecular Cardiology, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA
    J Muscle Res Cell Motil 21:491-505. 2000
  5. ncbi request reprint Human myosin XVBP is a transcribed pseudogene
    E T Boger
    Laboratory of Molecular Genetics, Section on Human Genetics, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Rockville, Maryland 20850, USA
    J Muscle Res Cell Motil 22:477-83. 2001
  6. pmc Skeletal muscle expression and abnormal function of beta-myosin in hypertrophic cardiomyopathy
    G Cuda
    Laboratory of Molecular Cardiology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892
    J Clin Invest 91:2861-5. 1993
  7. ncbi request reprint In vitro motility assay to study translocation of actin by myosin
    J R Sellers
    National Heart, Lung, and Blood Institute, Bethesda, Maryland, USA
    Curr Protoc Cell Biol . 2001
  8. ncbi request reprint Molecular characterization of myosin V from Drosophila melanogaster
    N Bonafe
    National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1762, USA
    J Muscle Res Cell Motil 19:129-41. 1998
  9. ncbi request reprint Actin-dependent motility of melanosomes from fish retinal pigment epithelial (RPE) cells investigated using in vitro motility assays
    E L McNeil
    Department of Biology, Saint Joseph s University, Philadelphia, Pennsylvania 19131, USA
    Cell Motil Cytoskeleton 58:71-82. 2004
  10. ncbi request reprint Characterization of the human and mouse unconventional myosin XV genes responsible for hereditary deafness DFNB3 and shaker 2
    Y Liang
    Laboratory of Molecular Genetics, National Institute on Deafness and Other Communication Disorders NIDCD, National Institutes of Health NIH, 5 Research Court, Rockville, Maryland, 20850, USA
    Genomics 61:243-58. 1999

Collaborators

  • Thomas B Friedman
  • C A Kelley
  • H M Holden
  • DWG Brown
  • K B Avraham
  • E L McNeil
  • E T Boger
  • R A Yamashita
  • Y Liang
  • B Kachar
  • I Rayment
  • N Bonafe
  • K Klinger
  • D Tacelosky
  • S Deacon
  • N D Epstein
  • H L Ford
  • C Fox
  • P Damiani
  • L Fananapazir
  • P Basciano
  • C King Smith
  • B Stewart
  • B Biallas
  • C Osborn
  • N Petruzzi
  • R Williams
  • K Poetter
  • J B Anderson
  • R A Fridell
  • S L Sullivan
  • T D Barber
  • L Jin
  • W Miller
  • J W Touchman
  • D W Anderson
  • A Wang
  • F J Probst
  • R V Lloyd
  • I A Belyantseva
  • S A Camper
  • S B Zain
  • D L Silver
  • S R Master
  • M C Dalakas
  • G Cuda
  • A Chang
  • H Jiang
  • S Hassanzadeh
  • W S Zhu

Detail Information

Publications13

  1. ncbi request reprint Myosins: a diverse superfamily
    J R Sellers
    National Heart, Lung and Blood Institute, National Institutes of Health, Building 10, Room 8N202, Bethesda, MD 20892, USA
    Biochim Biophys Acta 1496:3-22. 2000
    ..This review will focus on myosins from class IV, VI, VII, VIII, X, XI, XII, XIII, XIV and XV. In addition, the function of myosin II in non-muscle cells will also be discussed...
  2. ncbi request reprint Unconventional myosins and the genetics of hearing loss
    T B Friedman
    Laboratory of Molecular Genetics, National Institute on Deafness and Other Communication Disorders, Rockville, MD 20854, USA
    Am J Med Genet 89:147-57. 1999
    ..This review focuses on what we know about the molecular genetics and biochemistry of myosins VI, VIIA and XV as relates to hereditary hearing loss. Am. J. Med. Genet. (Semin. Med. Genet.) 89:147-157, 1999. Published 2000 Wiley-Liss, Inc...
  3. pmc Xenopus nonmuscle myosin heavy chain isoforms have different subcellular localizations and enzymatic activities
    C A Kelley
    Laboratory of Molecular Cardiology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Cell Biol 134:675-87. 1996
    ..The different subcellular localizations of MHC-A and MHC-B, together with the data demonstrating that these myosins have markedly different enzymatic activities, strongly suggests that they have different functions...
  4. ncbi request reprint Identification and analysis of the myosin superfamily in Drosophila: a database approach
    R A Yamashita
    Laboratory of Molecular Cardiology, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA
    J Muscle Res Cell Motil 21:491-505. 2000
    ..In the future comparative genomics will hopefully lead to the placement of these myosins into new classes...
  5. ncbi request reprint Human myosin XVBP is a transcribed pseudogene
    E T Boger
    Laboratory of Molecular Genetics, Section on Human Genetics, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Rockville, Maryland 20850, USA
    J Muscle Res Cell Motil 22:477-83. 2001
    ..Analyses of these myosin XVBP cDNAs revealed numerous additional disablements including translational reading frame shifts resulting in stop codons. From these data we conclude that myosin XVBP is a transcribed, unprocessed pseudogene...
  6. pmc Skeletal muscle expression and abnormal function of beta-myosin in hypertrophic cardiomyopathy
    G Cuda
    Laboratory of Molecular Cardiology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892
    J Clin Invest 91:2861-5. 1993
    ..Thus, single amino acid changes in beta-myosin result in abnormal actomyosin interactions, confirming the primary role of missense mutations in beta-MHC gene in the etiology of hypertrophic cardiomyopathy...
  7. ncbi request reprint In vitro motility assay to study translocation of actin by myosin
    J R Sellers
    National Heart, Lung, and Blood Institute, Bethesda, Maryland, USA
    Curr Protoc Cell Biol . 2001
    ..The system is fast, easy to set up and maintain, uses only small amounts of protein, and yields quantitative results...
  8. ncbi request reprint Molecular characterization of myosin V from Drosophila melanogaster
    N Bonafe
    National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1762, USA
    J Muscle Res Cell Motil 19:129-41. 1998
    ..While vertebrates would need two different myosin V isoforms to accomplish specific functions, we speculate that Drosophila myosin V might provide the equivalent functions by itself...
  9. ncbi request reprint Actin-dependent motility of melanosomes from fish retinal pigment epithelial (RPE) cells investigated using in vitro motility assays
    E L McNeil
    Department of Biology, Saint Joseph s University, Philadelphia, Pennsylvania 19131, USA
    Cell Motil Cytoskeleton 58:71-82. 2004
    ..Immunoblotting using antibodies against myosin VIIa and rab27a revealed that both proteins are enriched on melanosome membranes, suggesting that they could play a role in melanosome transport within apical projections of fish RPE...
  10. ncbi request reprint Characterization of the human and mouse unconventional myosin XV genes responsible for hereditary deafness DFNB3 and shaker 2
    Y Liang
    Laboratory of Molecular Genetics, National Institute on Deafness and Other Communication Disorders NIDCD, National Institutes of Health NIH, 5 Research Court, Rockville, Maryland, 20850, USA
    Genomics 61:243-58. 1999
    ..These results indicate a likely role for myosin XV in the formation or maintenance of the unique actin-rich structures of inner ear sensory hair cells...
  11. ncbi request reprint Effect of Mts1 on the structure and activity of nonmuscle myosin II
    H L Ford
    Department of Biochemistry and Cancer Center, University of Rochester, 601 Elmwood Avenue, Rochester, New York 14642, USA
    Biochemistry 36:16321-7. 1997
    ..The data demonstrate an effect of Mts1 on both myosin structure and function, and suggest a route through which Mts1 affects motility as well as metastasis...
  12. ncbi request reprint Mutations in either the essential or regulatory light chains of myosin are associated with a rare myopathy in human heart and skeletal muscle
    K Poetter
    Inherited Cardiac Diseases Section, NHLBI, NIH Bethesda, Maryland 20892 1650, USA
    Nat Genet 13:63-9. 1996
    ....
  13. pmc Structural interpretation of the mutations in the beta-cardiac myosin that have been implicated in familial hypertrophic cardiomyopathy
    I Rayment
    Institute for Enzyme Research, Graduate School, University of Wisconsin, Madison 53705 4098, USA
    Proc Natl Acad Sci U S A 92:3864-8. 1995
    ..The remaining five mutations are in the myosin rod. The locations of these mutations provide insight into the way they impair the functioning of this molecular motor and also into the mechanism of energy transduction...