R A Seder

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Differential roles for IL-12 in the maintenance of immune responses in infectious versus autoimmune disease
    R A Seder
    Laboratory of Clinical Investigation, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 157:2745-8. 1996
  2. ncbi request reprint Are differentiated human T helper cells reversible?
    R A Seder
    Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Int Arch Allergy Immunol 113:163-6. 1997
  3. ncbi request reprint Factors involved in the differentiation of TGF-beta-producing cells from naive CD4+ T cells: IL-4 and IFN-gamma have opposing effects, while TGF-beta positively regulates its own production
    R A Seder
    Lymphokine Regulation Unit, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 160:5719-28. 1998
  4. ncbi request reprint The potency and durability of DNA- and protein-based vaccines against Leishmania major evaluated using low-dose, intradermal challenge
    S Mendez
    Laboratory of Parasitic Diseases and Laboratory of Clinical Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 166:5122-8. 2001
  5. ncbi request reprint CD40 ligand trimer and IL-12 enhance peripheral blood mononuclear cells and CD4+ T cell proliferation and production of IFN-gamma in response to p24 antigen in HIV-infected individuals: potential contribution of anergy to HIV-specific unresponsiveness
    M Dybul
    Laboratory of Immunoregulation and Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, and Warren Magneson Clinical Research Center, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 165:1685-91. 2000
  6. pmc The role of antigen and IL-12 in sustaining Th1 memory cells in vivo: IL-12 is required to maintain memory/effector Th1 cells sufficient to mediate protection to an infectious parasite challenge
    L Stobie
    Clinical Immunology Section, Laboratory of Clinical Investigation, Howard Hughes Medical Institute, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 97:8427-32. 2000
  7. ncbi request reprint Perforin is required for primary immunity to Histoplasma capsulatum
    P Zhou
    Clinical Immunology Section, Laboratory of Clinical Investigation, and Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 166:1968-74. 2001
  8. ncbi request reprint Differential requirement of IFN consensus sequence binding protein for the production of IL-12 and induction of Th1-type cells in response to IFN-gamma
    C Y Wu
    Clinical Immunology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    J Immunol 162:807-12. 1999
  9. ncbi request reprint Factors involved in regulating primary and secondary immunity to infection with Histoplasma capsulatum: TNF-alpha plays a critical role in maintaining secondary immunity in the absence of IFN-gamma
    P Zhou
    Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    J Immunol 160:1359-68. 1998
  10. pmc CD40 ligand is not essential for induction of type 1 cytokine responses or protective immunity after primary or secondary infection with histoplasma capsulatum
    P Zhou
    Clinical Immunology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Exp Med 187:1315-24. 1998

Detail Information

Publications14

  1. ncbi request reprint Differential roles for IL-12 in the maintenance of immune responses in infectious versus autoimmune disease
    R A Seder
    Laboratory of Clinical Investigation, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 157:2745-8. 1996
    ..Herein, we discuss the idea that memory responses for certain infections may be IL-12 independent, whereas memory responses for specific autoimmune diseases still require IL-12 to maintain a pathogenic response...
  2. ncbi request reprint Are differentiated human T helper cells reversible?
    R A Seder
    Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Int Arch Allergy Immunol 113:163-6. 1997
    ..These studies may have implications for immune manipulation for established allergic or autoimmune diseases...
  3. ncbi request reprint Factors involved in the differentiation of TGF-beta-producing cells from naive CD4+ T cells: IL-4 and IFN-gamma have opposing effects, while TGF-beta positively regulates its own production
    R A Seder
    Lymphokine Regulation Unit, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 160:5719-28. 1998
    ..Finally, the addition of exogenous TGF-beta to priming cultures significantly enhanced the production of TGF-beta upon restimulation, demonstrating that TGF-beta has a role in self-regulating its own production...
  4. ncbi request reprint The potency and durability of DNA- and protein-based vaccines against Leishmania major evaluated using low-dose, intradermal challenge
    S Mendez
    Laboratory of Parasitic Diseases and Laboratory of Clinical Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 166:5122-8. 2001
    ..These data suggest that under conditions of natural challenge, DNA vaccination has the capacity to confer complete protection against cutaneous leishmaniasis and to prevent the establishment of infection reservoirs...
  5. ncbi request reprint CD40 ligand trimer and IL-12 enhance peripheral blood mononuclear cells and CD4+ T cell proliferation and production of IFN-gamma in response to p24 antigen in HIV-infected individuals: potential contribution of anergy to HIV-specific unresponsiveness
    M Dybul
    Laboratory of Immunoregulation and Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, and Warren Magneson Clinical Research Center, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 165:1685-91. 2000
    ..They also indicate the potential for CD40LT and IL-12 as immune-based therapies for HIV infection...
  6. pmc The role of antigen and IL-12 in sustaining Th1 memory cells in vivo: IL-12 is required to maintain memory/effector Th1 cells sufficient to mediate protection to an infectious parasite challenge
    L Stobie
    Clinical Immunology Section, Laboratory of Clinical Investigation, Howard Hughes Medical Institute, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 97:8427-32. 2000
    ..Taken together, these data show that IL-12 is essential to sustain a sufficient number of memory/effector Th1 cells generated in vivo to mediate long-term protection to an intracellular pathogen...
  7. ncbi request reprint Perforin is required for primary immunity to Histoplasma capsulatum
    P Zhou
    Clinical Immunology Section, Laboratory of Clinical Investigation, and Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 166:1968-74. 2001
    ..Together, these data suggest that CD8(+) T cells can mediate immunity to HC through both perforin-dependent and -independent mechanisms...
  8. ncbi request reprint Differential requirement of IFN consensus sequence binding protein for the production of IL-12 and induction of Th1-type cells in response to IFN-gamma
    C Y Wu
    Clinical Immunology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    J Immunol 162:807-12. 1999
    ..Overall, these results provide evidence that ICSBP is differentially required for the ability of IFN-gamma to regulate type 1 cytokine responses from APCs and CD4+ T cells...
  9. ncbi request reprint Factors involved in regulating primary and secondary immunity to infection with Histoplasma capsulatum: TNF-alpha plays a critical role in maintaining secondary immunity in the absence of IFN-gamma
    P Zhou
    Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    J Immunol 160:1359-68. 1998
    ..It was further shown that enhancement of TNF-alpha production in IFN-gamma(-/-) mice was the major mechanism by which these mice were effective in controlling secondary infection...
  10. pmc CD40 ligand is not essential for induction of type 1 cytokine responses or protective immunity after primary or secondary infection with histoplasma capsulatum
    P Zhou
    Clinical Immunology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Exp Med 187:1315-24. 1998
    ..capsulatum were protected from secondary infection with a lethal dose of H. capsulatum, demonstrating that CD40L is not required for the maintenance of memory immunity...
  11. ncbi request reprint Differential effects of CD40 ligand/trimer stimulation on the ability of dendritic cells to replicate and transmit HIV infection: evidence for CC-chemokine-dependent and -independent mechanisms
    J F McDyer
    Clinical Immunology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 162:3711-7. 1999
    ..Together, these results show that CD40LT stimulation of DCs suppresses HIV replication and transmission to CD4+ T cells by two potentially different mechanisms...
  12. pmc Interleukin-12 modulates the protective immune response in SCID mice infected with Histoplasma capsulatum
    P Zhou
    Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Infect Immun 65:936-42. 1997
    ..This study demonstrates that IL-12 modulates the protective immune response to histoplasmosis in SCID mice and also suggests that IL-12 in combination with AmB may be useful as a treatment for H. capsulatum in immunodeficient hosts...
  13. ncbi request reprint Vaccines against intracellular infections requiring cellular immunity
    R A Seder
    Clinical Immunology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 406:793-8. 2000
    ..We then discuss current approaches for vaccination against diseases in which cellular immune responses are important for protection...
  14. ncbi request reprint IL-12 prevents mortality in mice infected with Histoplasma capsulatum through induction of IFN-gamma
    P Zhou
    Lymphokine Regulation Unit, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 155:785-95. 1995
    ..Responses could be restored by adding inhibitors of IFN-gamma or of nitric oxide to the in vitro cultures. The above observations suggest that IL-12 may be useful in immunologic intervention against this opportunistic pathogen...