Research Topics
Species | A ScuteriSummaryAffiliation: National Institutes of Health Country: USA Publications
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Detail Information
Publications
Metabolic syndrome amplifies the age-associated increases in vascular thickness and stiffnessAngelo Scuteri
Laboratory of Cardiovascular Science, Laboratory of Clinical Investigation, Gerontology Research Center, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224 6825, USA
J Am Coll Cardiol 43:1388-95. 2004..We sought to evaluate whether the clustering of multiple components of the metabolic syndrome (MS) has a greater impact on these vascular parameters than individual components of MS...- Prevalence of specific variant carotid geometric patterns and incidence of cardiovascular events in older persons. The Cardiovascular Health Study (CHS E-131)Angelo Scuteri
Laboratory of Cardiovascular Sciences, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
J Am Coll Cardiol 43:187-93. 2004..We hypothesized that variant geometric patterns of the common carotid artery (CCA) predict the incidence of cardiovascular disease (CVD), after accounting for CCA intima-medial thickness (IMT)... - Effect of estrogen and progestin replacement on arterial stiffness indices in postmenopausal womenA Scuteri
Gerontology Research Center, National Institute on Aging National Institutes of Health, Baltimore, Maryland 21224, USA
Aging (Milano) 13:122-30. 2001..In conclusion, ERT in postmenopausal women can beneficially affect the vascular system, by reducing BP and the age-associated increase in arterial stiffness. The addition of progestins to ERT may reduce these beneficial effects... - Association of high resting end tidal CO2 with carotid artery thickness in women, but not menD E Anderson
Laboratory of Cardiovascular Science, National Institute on Aging, Baltimore, Maryland 21224, USA
J Hypertens 19:459-63. 2001..CONCLUSIONS: This study indicates that PetCO2 can play a role in cardiovascular structure, as well as function, in women, and that the relationship is independent of the association of PetCO2 with blood pressure... - Functional correlates of central arterial geometric phenotypesA Scuteri
Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
Hypertension 38:1471-5. 2001..The interplay among these factors, particularly circumferential wall and FSS, likely determines the CGP; conversely, the resultant CGP may modulate the FSS and wall stress for a given pressure and flow... - Is the apoE4 allele an independent predictor of coronary events?A Scuteri
Laboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
Am J Med 110:28-32. 2001..Although the apolipoprotein E genotype epsilon4 (apoE4) has been associated with high cholesterol levels, whether it is an independent predictor of coronary events is not certain... - Anger inhibition potentiates the association of high end-tidal CO2 with blood pressure in womenA Scuteri
Laboratory of Cardiovascular Sciences, National Institute on Aging, Baltimore, Maryland 21224, USA
Psychosom Med 63:470-5. 2001..Additional studies are needed to determine the origins of the observed gender differences and the psychophysiological pathways by which high resting PetCO2 contributes to elevated resting blood pressure in women... - Improved arterial compliance by a novel advanced glycation end-product crosslink breakerD A Kass
Division of Cardiology, The Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
Circulation 104:1464-70. 2001..We tested whether ALT-711, a novel nonenzymatic breaker of advanced glycation end-product crosslinks, selectively improves arterial compliance and lowers pulse pressure in older individuals with vascular stiffening... - Racial differences in resting end-tidal CO2 and circulating sodium pump inhibitorD E Anderson
Laboratory of Cardiovascular Science, National Institute on Aging, Baltimore, Maryland 21224, USA
Am J Hypertens 14:761-7. 2001.... - Age-related changes in cognitive domains. A population-based studyAngelo Scuteri
Centro Nazionale di Epidemiologia, Sorveglianza e Promozione della Salute, Istituto Superiore di Sanita, Roma, Italy
Aging Clin Exp Res 17:367-73. 2005.... 
Heritability of cardiovascular and personality traits in 6,148 SardiniansGiuseppe Pilia
Istituto di Neurogenetica e Neurofarmacologia, Consiglio Nazionale delle Ricerche, Ospedale Microcitemico, Cagliari, Italy
PLoS Genet 2:e132. 2006..Evidence for heterogeneity by age and sex suggests that models allowing for these differences will be important in mapping quantitative traits...- Aortic correlates of clinical markers of large artery structure and function. Effects of aging and hypertensionAngelo Scuteri
UO Geriatria, INRCA IRCCS, Via Cassia 1167, 00189 Roma, Italy
Aging Clin Exp Res 18:452-61. 2006..However, neither their relations with aorta properties nor the effects of aging and hypertension on those relations are yet clear... - Slowing arterial aging: how far have we progressed?Angelo Scuteri
J Hypertens 25:509-10. 2007 - Carotid intima-media thickness, carotid distensibility and mitral, aortic valve calcification: a useful diagnostic parameter of systemic atherosclerotic diseaseLuca Sgorbini
Unit of Cardiology, INRCA IRCCS Hospital, Rome, Italy
J Cardiovasc Med (Hagerstown) 8:342-7. 2007..Common carotid intima-media thickness (cIMT) and distensibility (cDIST) are also independent predictors of adverse cardiovascular outcomes. We examined the relationship between the degree of MAC-AVC and cIMT and cDIST... - Pulse pressure is inversely related to aortic root diameter implications for the pathogenesis of systolic hypertensionS Morteza Farasat
Laboratory of Cardiovascular Science, Clinical Research Branch, National Institute on Aging, National Institutes of Health, 3001 South Hanover St, Baltimore, MD 21225, USA
Hypertension 51:196-202. 2008..40; P=0.01; model R(2)=0.61). Thus, AoD is inversely associated with PP, suggesting that a small AoD may contribute to the pathogenesis of systolic hypertension. Longitudinal studies are needed to examine this possibility... - Endothelial function and arterial stiffness in normotensive normoglycemic first-degree relatives of diabetic patients are independent of the metabolic syndromeAngelo Scuteri
UO Geriatria, INRCA IRCCS, Via Cassia 1167, 00189 Rome, Italy
Nutr Metab Cardiovasc Dis 18:349-56. 2008.... - Ethnic variation in hypertension among premenopausal and perimenopausal women: Study of Women's Health Across the NationDonald M Lloyd-Jones
Division of Cardiology, Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
Hypertension 46:689-95. 2005..Treatment and control rates vary considerably across ethnicities. Greater efforts must be made to improve hypertension awareness, treatment, and control in all middle-aged women, particularly those in ethnic minority groups... - Pulse wave velocity is an independent predictor of the longitudinal increase in systolic blood pressure and of incident hypertension in the Baltimore Longitudinal Study of AgingSamer S Najjar
Laboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21225, USA
J Am Coll Cardiol 51:1377-83. 2008..This study sought to evaluate whether pulse wave velocity (PWV), a noninvasive index of arterial stiffness, is a predictor of the longitudinal changes in systolic blood pressure (SBP) and of incident hypertension... - Arterial stiffness is an independent risk factor for cognitive impairment in the elderly: a pilot studyAngelo Scuteri
UO Geriatria, INRCA IRCCS, Roma, Italy
J Hypertens 23:1211-6. 2005.... - Nitric oxide inhibition as a mechanism for blood pressure increase during salt loading in normotensive postmenopausal womenAngelo Scuteri
Laboratory of Cardiovascular Science, National Institute on Aging, NIH, Baltimore, Maryland, USA
J Hypertens 21:1339-46. 2003..We determined whether changes in endothelium-dependent vasodilation (EDD) and plasma ADMA predict changes in blood pressure (BP) after salt loading in normotensive postmenopausal women (PMW)... - Blood pressure, arterial function, structure, and aging: the role of hormonal replacement therapy in postmenopausal womenAngelo Scuteri
Unita Operativa di Geriatria, INRCA, Rome, Italy
J Clin Hypertens (Greenwich) 5:219-25. 2003.... 
Do hypertensive individuals have enlarged aortic root diameters? Insights from studying the various subtypes of hypertensionS Morteza Farasat
Laboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA
Am J Hypertens 21:558-63. 2008..We assessed whether AoD differs among subjects with the various subtypes of hypertension and nonhypertensive individuals...- Pulse pressure and pulse wave velocity are related to cognitive decline in the Baltimore Longitudinal Study of AgingShari R Waldstein
Department of Psychology, University of Maryland Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250, USA
Hypertension 51:99-104. 2008..Aggressive treatment of risk factors associated with greater arterial stiffness may help preserve cognitive function with individuals' increasing age... - Association of mitral annulus calcification, aortic valve calcification with carotid intima media thicknessLuca Sgorbini
Cardiologic Unit I N R C A I R C C S, Roma, Italy
Cardiovasc Ultrasound 2:19. 2004..Alterations in vascular structure, as indexed by the intima media thickness (IMT), are also recognized as independent predictors of adverse cardiovascular outcomes... - apoE4 allele and the natural history of cardiovascular risk factorsAngelo Scuteri
Laboratory of Cardiovascular Science, NIA NIH, 5600 Nathan Shock Dr, Baltimore, MD 21224, USA
Am J Physiol Endocrinol Metab 289:E322-7. 2005..In conclusion, apoE4 influences fasting plasma glucose and its changes over time. This could explain, in part, the increased CV risk associated with the apoE4 genotype observed in men... - The metabolic syndrome in older individuals: prevalence and prediction of cardiovascular events: the Cardiovascular Health StudyAngelo Scuteri
Laboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, 5600 Nathan Shock Dr, Baltimore, MD 21224, USA
Diabetes Care 28:882-7. 2005..We also compared the prognostic significance of the two definitions of the metabolic syndrome... - Effect of light-to-moderate alcohol consumption on age-associated arterial stiffeningHidetaka Hougaku
Clinical Research Branch, Laboratory of Cardiovascular Science, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21225, USA
Am J Cardiol 95:1006-10. 2005..A U-shaped relation was found between alcohol intake and a stiffness index, with the lowest index in moderate drinkers, which may partially explain the relation between alcohol and cardiovascular disease... - Newly identified loci that influence lipid concentrations and risk of coronary artery diseaseCristen J Willer
Center for Statistical Genetics, Department of Biostatistics, University of Michigan, 1420 Washington Heights, Ann Arbor, Michigan 48109, USA
Nat Genet 40:161-9. 2008..Notably, the 11 independent variants associated with increased LDL cholesterol concentrations in our study also showed increased frequency in a sample of coronary artery disease cases versus controls... - The GLUT9 gene is associated with serum uric acid levels in Sardinia and Chianti cohortsSiguang Li
Laboratory of Genetics, National Institute on Aging, Baltimore, Maryland, United States of America
PLoS Genet 3:e194. 2007..Our results suggest that polymorphisms in GLUT9 could affect glucose metabolism and uric acid synthesis and/or renal reabsorption, influencing serum uric acid levels over a wide range of values... - Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traitsAngelo Scuteri
Unità Operativa Geriatria, Istituto per la Patologia Endocrina e Metabolica, Rome, Italy
PLoS Genet 3:e115. 2007..These changes could have a significant impact on the risk of obesity-related morbidity in the general population... - Arterial stiffness as an independent predictor of longitudinal changes in cognitive function in the older individualAngelo Scuteri
UO Geriatria, INRCA IRCCS, Rome, Italy
J Hypertens 25:1035-40. 2007..The present study aimed to evaluate PWV as a predictor of longitudinal changes in cognitive function in older individuals reporting memory problems... - Arterial aging: is it an immutable cardiovascular risk factor?Samer S Najjar
Laboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, 5600 Nathan Shock Dr, Baltimore, MD 21224, USA
Hypertension 46:454-62. 2005..It is our hope that a greater appreciation of the links between arterial aging and cardiovascular diseases will stimulate further investigation into strategies aimed at preventing or retarding arterial aging... - Transdermal 17 beta-oestradiol reduces salt sensitivity of blood pressure in postmenopausal womenAngelo Scuteri
J Hypertens 21:2419-20. 2003 - Variations in the G6PC2/ABCB11 genomic region are associated with fasting glucose levelsWei Min Chen
Department of Public Health Sciences, University of Virginia, Charlottesville, Virginia, USA
J Clin Invest 118:2620-8. 2008....