Research Topics

Genomes and Genes


Iain Scott


Affiliation: National Institutes of Health
Country: USA


  1. Scott I. Degradation of RIG-I following cytomegalovirus infection is independent of apoptosis. Microbes Infect. 2009;11:973-9 pubmed publisher
    ..This process occurs in a non-apoptotic manner, and provides new evidence that HCMV may have evolved a unique strategy to evade RIG-I-mediated immune responses. ..
  2. Scott I. Mitochondrial factors in the regulation of innate immunity. Microbes Infect. 2009;11:729-36 pubmed publisher
    ..Recent research has identified the mitochondrial protein MAVS as a key component of one intracellular pathway, definitively linking mitochondria to the mammalian antiviral defence system for the first time. ..
  3. Scott I. The role of mitochondria in the mammalian antiviral defense system. Mitochondrion. 2010;10:316-20 pubmed publisher
    ..This review summarizes the novel mitochondrial proteins, such as MAVS and NLRX1, involved in this process and attempts to reconcile this new mitochondrial function with our previous knowledge of the organelle. ..