Pamela L Schwartzberg

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc SAP regulates T cell-mediated help for humoral immunity by a mechanism distinct from cytokine regulation
    Jennifer L Cannons
    National Human Genome Research Institute, National Institutes of Health NIH, Bethesda, MD 20892, USA
    J Exp Med 203:1551-65. 2006
  2. pmc Advantages of q-PCR as a method of screening for gene targeting in mammalian cells using conventional and whole BAC-based constructs
    Julio Gomez-Rodriguez
    Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Nucleic Acids Res 36:e117. 2008
  3. doi request reprint SLAM receptors and SAP influence lymphocyte interactions, development and function
    Pamela L Schwartzberg
    National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Rev Immunol 9:39-46. 2009
  4. ncbi request reprint Formin the way
    Pamela L Schwartzberg
    National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 26:139-41. 2007
  5. ncbi request reprint TEC-family kinases: regulators of T-helper-cell differentiation
    Pamela L Schwartzberg
    National Human Genome Research Institute, National Institutes of Health, 4A38 49 Convent Drive, Bethesda, Maryland 20892, USA
    Nat Rev Immunol 5:284-95. 2005
  6. pmc Optimal germinal center responses require a multistage T cell:B cell adhesion process involving integrins, SLAM-associated protein, and CD84
    Jennifer L Cannons
    National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 32:253-65. 2010
  7. ncbi request reprint SAP regulates T(H)2 differentiation and PKC-theta-mediated activation of NF-kappaB1
    Jennifer L Cannons
    National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 21:693-706. 2004
  8. pmc Biochemical and genetic evidence for a SAP-PKC-theta interaction contributing to IL-4 regulation
    Jennifer L Cannons
    National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 185:2819-27. 2010
  9. pmc A role for Ly108 in the induction of promyelocytic zinc finger transcription factor in developing thymocytes
    Mala Dutta
    National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 190:2121-8. 2013
  10. pmc Requirements for selection of conventional and innate T lymphocyte lineages
    Reiko Horai
    National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 27:775-85. 2007

Detail Information

Publications65

  1. pmc SAP regulates T cell-mediated help for humoral immunity by a mechanism distinct from cytokine regulation
    Jennifer L Cannons
    National Human Genome Research Institute, National Institutes of Health NIH, Bethesda, MD 20892, USA
    J Exp Med 203:1551-65. 2006
    ..Thus, SAP affects expression of key molecules required for T-B cell collaboration by mechanisms that are distinct from its role in cytokine regulation...
  2. pmc Advantages of q-PCR as a method of screening for gene targeting in mammalian cells using conventional and whole BAC-based constructs
    Julio Gomez-Rodriguez
    Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Nucleic Acids Res 36:e117. 2008
    ..Our results demonstrate the utility of q-PCR as a screening tool for gene targeting and further highlight potential problems with the use of whole BAC-based constructs for homologous recombination...
  3. doi request reprint SLAM receptors and SAP influence lymphocyte interactions, development and function
    Pamela L Schwartzberg
    National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Rev Immunol 9:39-46. 2009
    ..These data have revealed that SLAM family members and SAP have crucial roles in regulating lymphocyte interactions and adhesion, which are required for the normal development, homeostasis and function of the immune system...
  4. ncbi request reprint Formin the way
    Pamela L Schwartzberg
    National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 26:139-41. 2007
    ..In this issue of Immunity, the functions of two classes of actin nucleators are examined in T lymphocytes, giving insight into the regulation of T cell polarity (Gomez et al., 2007)...
  5. ncbi request reprint TEC-family kinases: regulators of T-helper-cell differentiation
    Pamela L Schwartzberg
    National Human Genome Research Institute, National Institutes of Health, 4A38 49 Convent Drive, Bethesda, Maryland 20892, USA
    Nat Rev Immunol 5:284-95. 2005
    ..Here, we review studies of signalling pathways that involve TEC kinases and how these pathways might contribute to the regulation of T-helper-cell differentiation and function...
  6. pmc Optimal germinal center responses require a multistage T cell:B cell adhesion process involving integrins, SLAM-associated protein, and CD84
    Jennifer L Cannons
    National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 32:253-65. 2010
    ..Our results reveal insight into the dynamic regulation of T cell:B cell interactions and identify SLAM family members as critical components of sustained T cell:B cell adhesion required for productive humoral immunity...
  7. ncbi request reprint SAP regulates T(H)2 differentiation and PKC-theta-mediated activation of NF-kappaB1
    Jennifer L Cannons
    National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 21:693-706. 2004
    ..SLAM engagement amplified PKC-theta recruitment in wt but not SAP- or Fyn-deficient cells, arguing that a SAP/Fyn-mediated pathway enhances PKC-theta/NF-kappaB1 activation and suggesting a role for this pathway in T(H)2 regulation...
  8. pmc Biochemical and genetic evidence for a SAP-PKC-theta interaction contributing to IL-4 regulation
    Jennifer L Cannons
    National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 185:2819-27. 2010
    ....
  9. pmc A role for Ly108 in the induction of promyelocytic zinc finger transcription factor in developing thymocytes
    Mala Dutta
    National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 190:2121-8. 2013
    ..Moreover, mice lacking Ly108 showed decreased numbers of PLZF-expressing CD4(+) T cells. Together, these results support a potential role for Ly108 in the induction of PLZF...
  10. pmc Requirements for selection of conventional and innate T lymphocyte lineages
    Reiko Horai
    National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 27:775-85. 2007
    ....
  11. pmc The major component in schistosome eggs responsible for conditioning dendritic cells for Th2 polarization is a T2 ribonuclease (omega-1)
    Svenja Steinfelder
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 206:1681-90. 2009
    ..Based on this evidence, we hypothesize that S. mansoni omega-1 acts by limiting the interaction of DCs with CD4(+) T lymphocytes, thereby lowering the strength of the activation signal delivered...
  12. pmc Itk-mediated integration of T cell receptor and cytokine signaling regulates the balance between Th17 and regulatory T cells
    Julio Gomez-Rodriguez
    National Human Genome Research Institute, 2 National Institute of Allergy and Infectious Diseases, 3 National Institute of Arthritis and Musculoskeletal and Skin Diseases, and 4 National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892
    J Exp Med 211:529-43. 2014
    ..Our results demonstrate that Itk helps orchestrate positive feedback loops integrating multiple T cell signaling pathways, suggesting Itk as a potential target for altering the balance between Th17 and Treg cells...
  13. pmc Differential expression of interleukin-17A and -17F is coupled to T cell receptor signaling via inducible T cell kinase
    Julio Gomez-Rodriguez
    National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 31:587-97. 2009
    ..Our results suggest that Itk specifically couples TCR signaling to Il17a expression and the differential regulation of Th17 cell cytokines through NFATc1...
  14. pmc SAP-controlled T-B cell interactions underlie germinal centre formation
    Hai Qi
    Lymphocyte Biology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 455:764-9. 2008
    ..These results offer an explanation for the germinal centre defect due to SAP deficiency and provide new insights into the bi-directional communication between cognate T and B cells in vivo...
  15. ncbi request reprint Altered development of CD8+ T cell lineages in mice deficient for the Tec kinases Itk and Rlk
    Christine Broussard
    National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Immunity 25:93-104. 2006
    ..Our results suggest that Tec kinases differentially regulate development of conventional versus nonconventional lymphocytes...
  16. pmc A novel ICOS-independent, but CD28- and SAP-dependent, pathway of T cell-dependent, polysaccharide-specific humoral immunity in response to intact Streptococcus pneumoniae versus pneumococcal conjugate vaccine
    Quanyi Chen
    Department of Pathology, Uniformed Services University of the Health Sciences, National Institutes of Health, Bethesda, MD 20814, USA
    J Immunol 181:8258-66. 2008
    ..These data define a novel T cell-, SAP-, and B7-dependent, but ICOS-independent, extrafollicular pathway of Ig induction...
  17. ncbi request reprint A critical role for IL-21 in regulating immunoglobulin production
    Katsutoshi Ozaki
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1674, USA
    Science 298:1630-4. 2002
    ..This suggests that these gammac-dependent cytokines may be those whose inactivation is primarily responsible for the B cell defect in humans with XSCID...
  18. pmc Positive and negative signaling through SLAM receptors regulate synapse organization and thresholds of cytolysis
    Fang Zhao
    Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 36:1003-16. 2012
    ..Hence, SAP and SLAM receptors regulate positive and negative signals required for organizing the T cell:B cell synapse and setting thresholds for cytotoxicity against distinct cellular targets...
  19. pmc Functional and epigenetic studies reveal multistep differentiation and plasticity of in vitro-generated and in vivo-derived follicular T helper cells
    Kristina T Lu
    National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 35:622-32. 2011
    ..ChIP-Seq analyses revealed positive epigenetic markings on Tbx21, Gata3, and Rorc in Tfh-like and ex vivo Tfh cells and on Bcl6 in non-Tfh cells, supporting the concept of plasticity between Tfh and other Th cell populations...
  20. pmc Cbl enforces an SLP76-dependent signaling pathway for T cell differentiation
    Y Jeffrey Chiang
    Experimental Immunology Branch, NCI, and NIA, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 284:4429-38. 2009
    ..Thus, our data demonstrate that Cbl suppresses activation of a bypass signaling pathway and thereby enforces SLP76 dependence of early T cell development...
  21. pmc The immunity-related GTPase Irgm1 promotes the expansion of activated CD4+ T cell populations by preventing interferon-gamma-induced cell death
    Carl G Feng
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Immunol 9:1279-87. 2008
    ..Our studies identify a feedback mechanism in the T helper type 1 response that limits the detrimental effects of IFN-gamma on effector T lymphocyte survival while promoting the antimicrobial functions of IFN-gamma...
  22. pmc A role for thymic stromal lymphopoietin in CD4(+) T cell development
    Amin Al-Shami
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 200:159-68. 2004
    ..Thus, as compared with other known cytokines, TSLP is distinctive in exhibiting a lineage preference for the expansion and survival of CD4(+) T cells...
  23. pmc Early Th1 cell differentiation is marked by a Tfh cell-like transition
    Shingo Nakayamada
    Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 35:919-31. 2011
    ..Our data argue that Tfh and Th1 cells share a transitional stage through the signal mediated by STAT4, which promotes both phenotypes. However, T-bet represses Tfh cell functionalities, promoting full Th1 cell differentiation...
  24. pmc Impaired in vitro regulatory T cell function associated with Wiskott-Aldrich syndrome
    Marsilio Adriani
    Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, 49 Convent Dr, Blg 49, Rm 3A20, Bethesda, MD 20892 4442, USA
    Clin Immunol 124:41-8. 2007
    ..These findings may provide insights into the complex pathophysiology and paradoxical phenotypes of WAS and suggest new therapeutic modalities for autoimmunity in these patients...
  25. ncbi request reprint Kinase-independent functions for Itk in TCR-induced regulation of Vav and the actin cytoskeleton
    Derek Dombroski
    National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 174:1385-92. 2005
    ..These data suggest a kinase-independent scaffolding function for Itk in the regulation of Vav localization and TCR-induced actin polarization...
  26. ncbi request reprint Fine-tuning lymphocyte regulation: what's new with tyrosine kinases and phosphatases?
    Jennifer L Cannons
    National Human Genome Research Institute, 49 4A38, 49 Convent Drive, National Institutes of Health, Bethesda, MD 20892, USA
    Curr Opin Immunol 16:296-303. 2004
    ....
  27. pmc Type I IFN induces binding of STAT1 to Bcl6: divergent roles of STAT family transcription factors in the T follicular helper cell genetic program
    Shingo Nakayamada
    Lymphocyte Biology Section, Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892
    J Immunol 192:2156-66. 2014
    ..These data suggest that type I IFNs (IFN-α/β) and STAT1 can contribute to some features of TFH cells but are inadequate in inducing complete programming of this subset. ..
  28. pmc T follicular helper cell diversity and plasticity
    Jennifer L Cannons
    National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Trends Immunol 34:200-7. 2013
    ..In this review, we highlight advances in our understanding of Tfh cell development, cytokine production, and the potential plasticity that allows Tfh cells to possess characteristics of other effector Th cell populations...
  29. ncbi request reprint Tec kinases regulate TCR-mediated recruitment of signaling molecules and integrin-dependent cell adhesion
    Lisa D Finkelstein
    National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 175:5923-30. 2005
    ..Thus, Tec kinases play key roles in regulating TCR-mediated polarization of integrins and signaling molecules to the site of TCR stimulation as well as the up-regulation of integrin adhesion...
  30. ncbi request reprint Tec kinases, actin, and cell adhesion
    Julio Gomez-Rodriguez
    National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Immunol Rev 218:45-64. 2007
    ....
  31. ncbi request reprint Improved generation of C57BL/6J mouse embryonic stem cells in a defined serum-free media
    Jun Cheng
    Genetic Diseases Research Branch, National Human Genome Research Institute, Bethesda, Maryland, USA
    Genesis 39:100-4. 2004
    ..Our work suggests that the use of defined serum-free media may facilitate the generation of ES cells from inbred mouse strains...
  32. pmc CBFB-MYH11 hinders early T-cell development and induces massive cell death in the thymus
    Ling Zhao
    Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, 49 Convent Drive, Bethesda, MD 20892, USA
    Blood 109:3432-40. 2007
    ..Our data suggest that Cbfb-MYH11 suppressed Cbfb in several stages of T-cell development and provide a mechanism for CBFB-MYH11 association with myeloid but not lymphoid leukemia...
  33. doi request reprint Dominant-activating germline mutations in the gene encoding the PI(3)K catalytic subunit p110δ result in T cell senescence and human immunodeficiency
    Carrie L Lucas
    1 Molecular Development of the Immune System Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA 2
    Nat Immunol 15:88-97. 2014
    ..Notably, treatment with rapamycin to inhibit mTOR activity in vivo partially restored the abundance of naive T cells, largely 'rescued' the in vitro T cell defects and improved the clinical course. ..
  34. pmc Tec kinases regulate T-lymphocyte development and function: new insights into the roles of Itk and Rlk/Txk
    Julie A Readinger
    National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Immunol Rev 228:93-114. 2009
    ..We review new findings on the Tec kinases with a focus on their roles in T-cell development and mature T-cell differentiation...
  35. ncbi request reprint The expression of Wiskott-Aldrich syndrome protein (WASP) is dependent on WASP-interacting protein (WIP)
    Akihiro Konno
    Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, 49 Convent Drive, Bethesday, MD 20892, USA
    Int Immunol 19:185-92. 2007
    ..These results demonstrate that expression of WIP is necessary for functional WASP expression in human cells and provide a new paradigm for understanding the function of these two molecules...
  36. pmc Acinar cell apoptosis in Serpini2-deficient mice models pancreatic insufficiency
    Stacie K Loftus
    Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA
    PLoS Genet 1:e38. 2005
    ....
  37. ncbi request reprint Requirement for Tec kinases in chemokine-induced migration and activation of Cdc42 and Rac
    Aya Takesono
    National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Curr Biol 14:917-22. 2004
    ..Thus, Tec kinases are critical components of signaling pathways required for actin polarization downstream from both antigen and chemokine receptors in T cells...
  38. ncbi request reprint Tec kinases: shaping T-cell activation through actin
    Lisa D Finkelstein
    National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Trends Cell Biol 14:443-51. 2004
    ..These data, as well as other findings, support roles for Tec kinases in actin cytoskeleton regulation...
  39. pmc Constitutive reductions in mTOR alter cell size, immune cell development, and antibody production
    Shuling Zhang
    Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute NIH, Bethesda, MD 20892, USA
    Blood 117:1228-38. 2011
    ..Thus, mTOR is required for the maturation and differentiation of multiple immune cell lineages. These mice provide a novel platform for studying the consequences of constitutively reduced mTORC1/TORC2 activity...
  40. pmc Tec family kinases Itk and Rlk / Txk in T lymphocytes: cross-regulation of cytokine production and T-cell fates
    Julio Gomez-Rodriguez
    National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    FEBS J 278:1980-9. 2011
    ..Together, these results suggest that the Tec family kinases play critical roles in helping shape immune responses via their effects on the differentiation and function of distinct cytokine-producing, effector T-cell populations...
  41. pmc A mosaic activating mutation in AKT1 associated with the Proteus syndrome
    Marjorie J Lindhurst
    National Human Genome Research Institute, Bethesda, Maryland, USA
    N Engl J Med 365:611-9. 2011
    ..The Proteus syndrome is characterized by the overgrowth of skin, connective tissue, brain, and other tissues. It has been hypothesized that the syndrome is caused by somatic mosaicism for a mutation that is lethal in the nonmosaic state...
  42. doi request reprint SLAM family receptors and SAP adaptors in immunity
    Jennifer L Cannons
    National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Annu Rev Immunol 29:665-705. 2011
    ..In this review, we cover recent findings on the roles of SLAM family receptors and the SAP family of adaptors, with a focus on their regulation of the pathways involved in the pathogenesis of XLP and other immune disorders...
  43. pmc Rheumatologic and autoimmune manifestations of primary immunodeficiency disorders
    Ramona Goyal
    Office of the Clinical Director, NIAMS, National Institutes of Health, Bethesda, Maryland 20892, USA
    Curr Opin Rheumatol 21:78-84. 2009
    ....
  44. pmc Selective targeting of ITK blocks multiple steps of HIV replication
    Julie A Readinger
    Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 105:6684-9. 2008
    ..Our data suggest that inhibition of ITK blocks HIV infection by affecting multiple steps of HIV replication...
  45. pmc Regulation of microRNA expression and abundance during lymphopoiesis
    Stefan Kuchen
    Genomics and Immunity, NIAMS, NIH, Bethesda, MD 20892, USA
    Immunity 32:828-39. 2010
    ..Our data provide a comprehensive map of immunity's microRNome and reveal the underlying epigenetic and transcriptional forces that shape miRNA homeostasis...
  46. pmc Essential role for retinoic acid in the promotion of CD4(+) T cell effector responses via retinoic acid receptor alpha
    Jason A Hall
    Mucosal Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 34:435-47. 2011
    ....
  47. pmc Knockout of Slc25a19 causes mitochondrial thiamine pyrophosphate depletion, embryonic lethality, CNS malformations, and anemia
    Marjorie J Lindhurst
    National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 103:15927-32. 2006
    ....
  48. pmc Balancing selection maintains a form of ERAP2 that undergoes nonsense-mediated decay and affects antigen presentation
    Aida M Andres
    Genome Technology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA
    PLoS Genet 6:e1001157. 2010
    ..Although the precise selective pressure that maintains polymorphism is unknown, the demonstrated differences between the ERAP2 splice forms provide important insights into the potential mechanism for the action of selection...
  49. ncbi request reprint Global analyses of human immune variation reveal baseline predictors of postvaccination responses
    John S Tsang
    Trans NIH Center for Human Immunology, Autoimmunity and Inflammation, National Institutes of Health, Bethesda, MD 20892, USA Systems Genomics and Bioinformatics Unit, Laboratory of Systems Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA Electronic address
    Cell 157:499-513. 2014
    ..Most of the parameters contributing to prediction delineated temporally stable baseline differences across individuals, raising the prospect of immune monitoring before intervention. ..
  50. ncbi request reprint Genetic approaches to tyrosine kinase signaling pathways in the immune system
    Pamela L Schwartzberg
    Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892 4472, USA
    Immunol Res 27:481-8. 2003
    ..As a model system, we are examining the Tec family kinases and their roles in T lymphocyte development and function...
  51. ncbi request reprint Beyond calcium: new signaling pathways for Tec family kinases
    Aya Takesono
    National Human Genome Research Institute, 49 Convent Drive, 49 4A38, National Institutes of Health, Bethesda, MD 20892, USA
    J Cell Sci 115:3039-48. 2002
    ..Their impact on cellular physiology suggests that the Tec kinases help regulate multiple cellular processes beyond Ca(2+) mobilization...
  52. ncbi request reprint The murine NK receptor 2B4 (CD244) exhibits inhibitory function independent of signaling lymphocytic activation molecule-associated protein expression
    Jill M Mooney
    Graduate Program in Immunology, University of Texas Southwestern Medical Center, Dallas 75390, USA
    J Immunol 173:3953-61. 2004
    ..This predominant inhibitory function of murine 2B4 correlates with increased 2B4 long isoform level expression over 2B4 short...
  53. ncbi request reprint Molecular and cellular pathogenesis of X-linked lymphoproliferative disease
    Kim E Nichols
    Pediatric Oncology, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Immunol Rev 203:180-99. 2005
    ..Further studies of SAP and the SLAM family receptors will provide insights into XLP and elucidate the signaling events regulating lymphocyte ontogeny and function...
  54. pmc TNF-alpha is crucial for the development of autoimmune arthritis in IL-1 receptor antagonist-deficient mice
    Reiko Horai
    Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    J Clin Invest 114:1603-11. 2004
    ..These findings suggest that IL-1 receptor antagonist deficiency in T cells disrupts homeostasis of the immune system and that TNF-alpha plays an important role in activating T cells through induction of OX40...
  55. pmc SH2D1A regulates T-dependent humoral autoimmunity
    Jonathan D Hron
    Washington University School of Medicine, Campus Box 8045, CSRB 6617, 660 S Euclid Ave, St Louis, MO 63110, USA
    J Exp Med 200:261-6. 2004
    ....
  56. ncbi request reprint SAP is required for generating long-term humoral immunity
    Shane Crotty
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Nature 421:282-7. 2003
    ..Thus, SAP has a crucial role in CD4+ T-cell function: it is essential for late B-cell help and the development of long-term humoral immunity but is not required for early B-cell help and class switching...
  57. ncbi request reprint T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3
    Eun Sook Hwang
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Science 307:430-3. 2005
    ..These results provide a novel function for tyrosine phosphorylation of a transcription factor in specifying alternate fates of a common progenitor cell...
  58. ncbi request reprint SAP is required for Th cell function and for immunity to influenza
    Cris Kamperschroer
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Immunol 177:5317-27. 2006
    ..Overall, our results demonstrate that SAP is required in CD4 T cells for their ability to help B cell responses and promote influenza-specific immunity...
  59. ncbi request reprint Binding of SAP SH2 domain to FynT SH3 domain reveals a novel mechanism of receptor signalling in immune regulation
    Sylvain Latour
    Laboratory of Molecular Oncology, Clinical Research Institute of Montreal, Montreal, Quebec, H2W 1R7, Canada
    Nat Cell Biol 5:149-54. 2003
    ..These observations characterize a biologically important signalling mechanism in which an adaptor molecule composed only of an SH2 domain links a receptor devoid of intrinsic catalytic activity to the kinase required for its function...
  60. pmc Itk functions to control actin polymerization at the immune synapse through localized activation of Cdc42 and WASP
    Christine M Labno
    Department of Pathology, University of Chicago, Chicago, IL 60637, USA
    Curr Biol 13:1619-24. 2003
    ..Our results identify Itk as a key element of the pathway leading to localized actin polymerization at the immune synapse...
  61. ncbi request reprint Tec family kinases in T lymphocyte development and function
    Leslie J Berg
    Department of Pathology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Annu Rev Immunol 23:549-600. 2005
    ..Although they quantitatively reduce proximal signaling, mutations that eliminate Tec family kinases in T cells nonetheless qualitatively alter T cell development and differentiation...
  62. ncbi request reprint Perturbation of B cell activation in SLAM-associated protein-deficient mice is associated with changes in gammaherpesvirus latency reservoirs
    In Jeong Kim
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Immunol 178:1692-701. 2007
    ..Furthermore, there were defects in normal latency reservoirs within the germinal center cells and IgD(+)"naive" B cells in SAP-deficient mice, showing a profound effect of the SAP mutation on latency reservoirs...
  63. ncbi request reprint A BAC contig map of the Ly49 gene cluster in 129 mice reveals extensive differences in gene content relative to C57BL/6 mice
    Andrew P Makrigiannis
    Laboratory of Experimental Immunology, Center for Cancer Research, National Cancer Institute Frederick, Frederick, Maryland 21702 1201, USA
    Genomics 79:437-44. 2002
    ..These results indicate that Ly49 gene numbers can be significantly different between inbred mouse strains, analogous to the haplotype differences observed in the human KIR genes...
  64. ncbi request reprint Regulation of NKT cell development by SAP, the protein defective in XLP
    Kim E Nichols
    Pediatric Oncology, Wood, 4th Floor, 3615 Civic Center Boulevard, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Nat Med 11:340-5. 2005
    ..Thus, SAP is a crucial regulator of NKT cell ontogeny in humans and in mice. The absence of NKT cells may contribute to the phenotypes of SAP deficiency, including abnormal antiviral and antitumor immunity and hypogammaglobulinemia...
  65. ncbi request reprint Functional hierarchy of the N-terminal tyrosines of SLP-76
    Martha S Jordan
    Signal Transduction Program, Leonard and Madlyn Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
    J Immunol 176:2430-8. 2006
    ..These studies show that Tyr(145) of SLP-76 is the most critical tyrosine for both T cell function in vitro and T cell development in vivo...