Research Topics
Genomes and Genes | R H SchwartzSummaryAffiliation: National Institutes of Health Country: USA Publications
| Collaborators
|
Detail Information
Publications
Historical overview of immunological toleranceRonald H Schwartz
Laboratory of Cellular and Molecular Immunology, NIAID, National Institutes of Health, Bethesda, Maryland 20892 0420, USA
Cold Spring Harb Perspect Biol 4:a006908. 2012..quot;..
T cell clonal anergyR H Schwartz
Laboratory of Cellular and Molecular Immunology, National Institutes of Health, Bethesda, MD 20892 0420, USA
Curr Opin Immunol 9:351-7. 1997..Second, repressor molecules (Nil-2-a and a molecule related to AP-1) have been characterized that dominantly inhibit IL-2 gene transcription...- T cell anergyRonald H Schwartz
Laboratory of Cellular and Molecular Immunology, National Institutes of Health, Bethesda, Maryland 20892 0420, USA
Annu Rev Immunol 21:305-34. 2003..Aspects of both of the anergic states are found in regulatory T cells, possibly preventing them from dominating initial immune responses to foreign antigens and shutting down such responses prematurely... - CTLA-4 engagement acts as a brake on CD4+ T cell proliferation and cytokine production but is not required for tuning T cell reactivity in adaptive toleranceManabu Inobe
Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 173:7239-48. 2004..Removal of this braking function in CTLA-4-deficient mice following Ag stimulation may explain their lymphoproliferative dysregulation... 
Host resistance and immune deviation in pigeon cytochrome c T-cell receptor transgenic mice infected with Toxoplasma gondiiC M Collazo
Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Infect Immun 68:2713-9. 2000..gondii infection...- Epithelial cell-specific laminin 5 is required for survival of early thymocytesM G Kim
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 165:192-201. 2000..These results suggest that the interaction between double negative thymoctyes and laminin 5 made by subcapsular epithelial cells is required for the survival and differentiation of mouse thymocytes... - The -180 site of the IL-2 promoter is the target of CREB/CREM binding in T cell anergyJ D Powell
Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
J Immunol 163:6631-9. 1999..These findings suggest that the -180 region of the IL-2 promoter is the target of a CREB/CREM transcriptional inhibitor that contributes to the repression of IL-2 production in T cell anergy... 
The strength of persistent antigenic stimulation modulates adaptive tolerance in peripheral CD4+ T cellsNevil J Singh
Laboratory of Cellular and Molecular Immunology, NIAID NIH, Building 4, Room 111, 4 Center Drive MSC 0420, Bethesda, MD 20892, USA
J Exp Med 198:1107-17. 2003....- IL-2 secretion by CD4+ T cells in vivo is rapid, transient, and influenced by TCR-specific competitionDorothy K Sojka
Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 172:6136-43. 2004.... - Adaptive tolerance of CD4+ T cells in vivo: multiple thresholds in response to a constant level of antigen presentationC Tanchot
Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 167:2030-9. 2001..Both the readjustment in sensitivity and the reversal without Ag convincingly demonstrate for the first time a truly adaptive tolerance process in CD4+ T cells in vivo... - Biallelic expression of the IL-2 locus under optimal stimulation conditionsL Chiodetti
National Institutes of Health, National Institute of Allergy and Infectious Diseases, Laboratory of Cellular and Molecular Immunology, Bethesda 20892 0420, USA
Eur J Immunol 30:2157-63. 2000..These data strongly argue that the IL-2 locus can be expressed biallelically under optimum stimulation conditions... - TCR engagement in the absence of cell cycle progression leads to T cell anergy independent of p27(Kip1)J D Powell
Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 0420, USA
Eur J Immunol 31:3737-46. 2001..Overall, our data serve to disassociate the ability of IL-2 to down-regulate p27(Kip1) and its ability to prevent or reverse anergy... - A distinct region of the murine IFN-gamma promoter is hypomethylated from early T cell development through mature naive and Th1 cell differentiation, but is hypermethylated in Th2 cellsBenjamin R Winders
Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 173:7377-84. 2004..Our experiments support a new model of IFN-gamma chromatin structural changes in murine T cell development that differs from what has been previously published for human T cells... - Spatial, a gene expressed in thymic stromal cells, depends on three-dimensional thymus organization for its expressionF A Flomerfelt
Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 0420, USA
Genes Immun 1:391-401. 2000..Paracortical subcapsular cells of unknown function were also stained in the LN. Both forms of Spatial fused to the green fluorescent protein (GFP) localize to the nucleus in transfected cells... - Cloning and chromosomal mapping of a gene isolated from thymic stromal cells encoding a new mouse type II membrane serine protease, epithin, containing four LDL receptor modules and two CUB domainsM G Kim
Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 0420, USA
Immunogenetics 49:420-8. 1999..This gene, Prss14 (protease, serine, 14), was mapped to mouse chromosome 9 and is closely linked to the Fli1 (Friend leukemia integration 1) gene... - A putative 12 transmembrane domain cotransporter expressed in thymic cortical epithelial cellsM G Kim
Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda MD 20892, USA
J Immunol 164:3185-92. 2000..TSCOT represents a new member of this superfamily that is highly expressed in thymic cortical epithelial cells... - Adaptive tolerance and clonal anergy are distinct biochemical statesLynda Chiodetti
Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
J Immunol 176:2279-91. 2006..These results demonstrate that T cell adaptive tolerance and clonal anergy are distinct biochemical states, possibly providing T cells with two molecular mechanisms to curtail responsiveness in different biological circumstances... - Primer: mechanisms of immunologic toleranceNevil J Singh
Laboratory of Cellular and Molecular Immunology at the National Institute of Allergy and Infectious Diseases of the National Institutes of Health, Bethesda, MD 20892-0420, USA
Nat Clin Pract Rheumatol 2:44-52. 2006..The combined action of these processes ensures that the organism does not suffer autoimmune pathology, even if autoreactive receptors are generated and maintained in the immune system... - The impact of T cell intrinsic antigen adaptation on peripheral immune toleranceNevil J Singh
Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
PLoS Biol 4:e340. 2006..These extrinsic mechanisms prevented the effector differentiation of the autoreactive T cells and reduced their precursor frequency, in vivo... - Biphasic regulation of Il2 transcription in CD4+ T cells: roles for TNF-alpha receptor signaling and chromatin structureSusan C McKarns
Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 181:1272-81. 2008..This is provided, at least partially, by TNFR signaling during priming, but not during recall... - Tbata modulates thymic stromal cell proliferation and thymus functionFrancis A Flomerfelt
Experimental Transplantation Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
J Exp Med 207:2521-32. 2010..These findings suggest that Tbata modulates thymus function by regulating stromal cell proliferation via the Nedd8 pathway... - TLR ligands differentially modulate T cell responses to acute and chronic antigen presentationNevil J Singh
Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 179:7999-8008. 2007..These data suggest a novel process by which TLR ligands modulate T cell responses to acute Ags, without disrupting the induction of tolerance to persistent self Ags... - Dual effects of Sprouty1 on TCR signaling depending on the differentiation state of the T cellHeonsik Choi
Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 176:6034-45. 2006..Thus, Spry1 uses a novel mechanism to bring about differential effects on TCR signaling through the same receptor, depending on the differentiation state of the T cell... - Natural regulatory T cells and self-toleranceRonald H Schwartz
Ronald H Schwartz is with the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Nat Immunol 6:327-30. 2005..This perspective discusses why such a mechanism might have evolved and the problems it presents for self-non-self discrimination... - Distinct effects of TGF-beta 1 on CD4+ and CD8+ T cell survival, division, and IL-2 production: a role for T cell intrinsic Smad3Susan C McKarns
Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 174:2071-83. 2005..Collectively, these findings firmly establish for the first time that TGF-beta1 discriminately regulates CD4+ and CD8+ T cell expansion by signaling through distinct intracellular pathways... - Smad3 is essential for TGF-beta 1 to suppress IL-2 production and TCR-induced proliferation, but not IL-2-induced proliferationSusan C McKarns
Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824 USA
J Immunol 172:4275-84. 2004..Thus, we establish that TGF-beta1 signals through multiple pathways to suppress T cell proliferation... - The lymphopenic mouse in immunology: from patron to pariahNevil J Singh
Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases (NIAID, National Institutes of Health, 4 / 111 Center Drive, MSC-0420, Bethesda, Maryland 20892, USA
Immunity 25:851-5. 2006..Here we discuss this skepticism in a broader historical context... - A new fractionation assay, based on the size of formaldehyde-crosslinked, mildly sheared chromatin, delineates the chromatin structure at promoter regionsSatoru Ishihara
Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Nucleic Acids Res 38:e124. 2010..Thus, this new chromatin fractionation technique has revealed a change in chromatin structure that has not been previously characterized... - Molecular mechanisms for adaptive tolerance and other T cell anergy modelsSeeyoung Choi
National Institutes of Health, LCMI, NIAID, Bethesda, MD 20892 0420, USA
Semin Immunol 19:140-52. 2007..In this review we will detail our own work on the in vivo model referred to as adaptive tolerance and then attempt to compare this biochemical state to the multitude of other states that have been described in the literature... - Anergy and cytokine-mediated suppression as distinct superantigen-induced tolerance mechanisms in vivoC Miller
Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 0420, USA
J Exp Med 190:53-64. 1999..These experiments show that complex in vivo interactions of multiple peripheral tolerance mechanisms can now be dissected at both the cellular and molecular levels... - The destabilization of IL-2 mRNA by a premature stop codon and its differential stabilization by trans-acting inhibitors of protein synthesis do not support a role for active translation in mRNA stabilityJ A Ragheb
Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
J Immunol 163:3321-30. 1999..Finally, CHX was able to superinduce IL-2 mRNA levels in anti-TCR Ab-stimulated cells but not in CD28-costimulated cells, suggesting that CHX may also act by other mechanisms... - Selective, stable demethylation of the interleukin-2 gene enhances transcription by an active processDenis Bruniquel
Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-0420, USA
Nat Immunol 4:235-40. 2003..These results imply that this demethylation process proceeds by an active enzymatic mechanism... - Characterization of the mouse gene, human promoter and human cDNA of TSCOT reveals strong interspecies homologyC Chen
Laboratory of Cellular and Molecular Immunology, Room 111, Building 4, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 0420, USA
Biochim Biophys Acta 1493:159-69. 2000.... - Regulation of interleukin 2 gene expression by CD28 costimulation in mouse T-cell clones: both nuclear and cytoplasmic RNAs are regulated with complex kineticsS W Umlauf
Laboratory of Cellular and Molecular Immunology, National Institutes of Health, Bethesda, Maryland 20892, USA
Mol Cell Biol 15:3197-205. 1995..This complexity suggests the existence of two interesting molecular mechanisms by which CD28 costimulates lymphokine gene expression... - Egr-2 and Egr-3 are negative regulators of T cell activationMeredith Safford
The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Nat Immunol 6:472-80. 2005..These data support the idea that Egr-2 and Egr-3 are involved in promoting a T cell receptor-induced negative regulatory genetic program... - Non-parametric, hypothesis-based analysis of microarrays for comparison of several phenotypesJeanne Kowalski
Department of Oncology, Johns Hopkins University, Baltimore, MD 21205, USA
Bioinformatics 20:364-73. 2004.... - Low-dose radiation plus rapamycin promotes long-term bone marrow chimerismJonathan D Powell
Department of Oncology, Johns Hopkins School of Medicine, Baltimore, MD, USA
Transplantation 80:1541-5. 2005..This strategy may prove useful in nonmalignant disorders such as hemoglobinopathies in which moderate levels of donor chimerism could prove curative...