R H Schwartz

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc The strength of persistent antigenic stimulation modulates adaptive tolerance in peripheral CD4+ T cells
    Nevil J Singh
    Laboratory of Cellular and Molecular Immunology, NIAID NIH, Building 4, Room 111, 4 Center Drive MSC 0420, Bethesda, MD 20892, USA
    J Exp Med 198:1107-17. 2003
  2. doi Historical overview of immunological tolerance
    Ronald H Schwartz
    Laboratory of Cellular and Molecular Immunology, NIAID, National Institutes of Health, Bethesda, Maryland 20892 0420, USA
    Cold Spring Harb Perspect Biol 4:a006908. 2012
  3. ncbi T cell clonal anergy
    R H Schwartz
    Laboratory of Cellular and Molecular Immunology, National Institutes of Health, Bethesda, MD 20892 0420, USA
    Curr Opin Immunol 9:351-7. 1997
  4. ncbi T cell anergy
    Ronald H Schwartz
    Laboratory of Cellular and Molecular Immunology, National Institutes of Health, Bethesda, Maryland 20892 0420, USA
    Annu Rev Immunol 21:305-34. 2003
  5. ncbi Characterization of the mouse gene, human promoter and human cDNA of TSCOT reveals strong interspecies homology
    C Chen
    Laboratory of Cellular and Molecular Immunology, Room 111, Building 4, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 0420, USA
    Biochim Biophys Acta 1493:159-69. 2000
  6. ncbi Adaptive tolerance of CD4+ T cells in vivo: multiple thresholds in response to a constant level of antigen presentation
    C Tanchot
    Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 167:2030-9. 2001
  7. ncbi CTLA-4 engagement acts as a brake on CD4+ T cell proliferation and cytokine production but is not required for tuning T cell reactivity in adaptive tolerance
    Manabu Inobe
    Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 173:7239-48. 2004
  8. ncbi Epithelial cell-specific laminin 5 is required for survival of early thymocytes
    M G Kim
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 165:192-201. 2000
  9. pmc Host resistance and immune deviation in pigeon cytochrome c T-cell receptor transgenic mice infected with Toxoplasma gondii
    C M Collazo
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Infect Immun 68:2713-9. 2000
  10. ncbi Spatial, a gene expressed in thymic stromal cells, depends on three-dimensional thymus organization for its expression
    F A Flomerfelt
    Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 0420, USA
    Genes Immun 1:391-401. 2000

Collaborators

Detail Information

Publications37

  1. pmc The strength of persistent antigenic stimulation modulates adaptive tolerance in peripheral CD4+ T cells
    Nevil J Singh
    Laboratory of Cellular and Molecular Immunology, NIAID NIH, Building 4, Room 111, 4 Center Drive MSC 0420, Bethesda, MD 20892, USA
    J Exp Med 198:1107-17. 2003
    ....
  2. doi Historical overview of immunological tolerance
    Ronald H Schwartz
    Laboratory of Cellular and Molecular Immunology, NIAID, National Institutes of Health, Bethesda, Maryland 20892 0420, USA
    Cold Spring Harb Perspect Biol 4:a006908. 2012
    ....
  3. ncbi T cell clonal anergy
    R H Schwartz
    Laboratory of Cellular and Molecular Immunology, National Institutes of Health, Bethesda, MD 20892 0420, USA
    Curr Opin Immunol 9:351-7. 1997
    ..Second, repressor molecules (Nil-2-a and a molecule related to AP-1) have been characterized that dominantly inhibit IL-2 gene transcription...
  4. ncbi T cell anergy
    Ronald H Schwartz
    Laboratory of Cellular and Molecular Immunology, National Institutes of Health, Bethesda, Maryland 20892 0420, USA
    Annu Rev Immunol 21:305-34. 2003
    ..Aspects of both of the anergic states are found in regulatory T cells, possibly preventing them from dominating initial immune responses to foreign antigens and shutting down such responses prematurely...
  5. ncbi Characterization of the mouse gene, human promoter and human cDNA of TSCOT reveals strong interspecies homology
    C Chen
    Laboratory of Cellular and Molecular Immunology, Room 111, Building 4, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 0420, USA
    Biochim Biophys Acta 1493:159-69. 2000
    ....
  6. ncbi Adaptive tolerance of CD4+ T cells in vivo: multiple thresholds in response to a constant level of antigen presentation
    C Tanchot
    Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 167:2030-9. 2001
    ..Both the readjustment in sensitivity and the reversal without Ag convincingly demonstrate for the first time a truly adaptive tolerance process in CD4+ T cells in vivo...
  7. ncbi CTLA-4 engagement acts as a brake on CD4+ T cell proliferation and cytokine production but is not required for tuning T cell reactivity in adaptive tolerance
    Manabu Inobe
    Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 173:7239-48. 2004
    ..Removal of this braking function in CTLA-4-deficient mice following Ag stimulation may explain their lymphoproliferative dysregulation...
  8. ncbi Epithelial cell-specific laminin 5 is required for survival of early thymocytes
    M G Kim
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 165:192-201. 2000
    ..These results suggest that the interaction between double negative thymoctyes and laminin 5 made by subcapsular epithelial cells is required for the survival and differentiation of mouse thymocytes...
  9. pmc Host resistance and immune deviation in pigeon cytochrome c T-cell receptor transgenic mice infected with Toxoplasma gondii
    C M Collazo
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Infect Immun 68:2713-9. 2000
    ..gondii infection...
  10. ncbi Spatial, a gene expressed in thymic stromal cells, depends on three-dimensional thymus organization for its expression
    F A Flomerfelt
    Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 0420, USA
    Genes Immun 1:391-401. 2000
    ..Paracortical subcapsular cells of unknown function were also stained in the LN. Both forms of Spatial fused to the green fluorescent protein (GFP) localize to the nucleus in transfected cells...
  11. ncbi A putative 12 transmembrane domain cotransporter expressed in thymic cortical epithelial cells
    M G Kim
    Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda MD 20892, USA
    J Immunol 164:3185-92. 2000
    ..TSCOT represents a new member of this superfamily that is highly expressed in thymic cortical epithelial cells...
  12. ncbi The -180 site of the IL-2 promoter is the target of CREB/CREM binding in T cell anergy
    J D Powell
    Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    J Immunol 163:6631-9. 1999
    ..These findings suggest that the -180 region of the IL-2 promoter is the target of a CREB/CREM transcriptional inhibitor that contributes to the repression of IL-2 production in T cell anergy...
  13. ncbi IL-2 secretion by CD4+ T cells in vivo is rapid, transient, and influenced by TCR-specific competition
    Dorothy K Sojka
    Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 172:6136-43. 2004
    ....
  14. ncbi Biallelic expression of the IL-2 locus under optimal stimulation conditions
    L Chiodetti
    National Institutes of Health, National Institute of Allergy and Infectious Diseases, Laboratory of Cellular and Molecular Immunology, Bethesda 20892 0420, USA
    Eur J Immunol 30:2157-63. 2000
    ..These data strongly argue that the IL-2 locus can be expressed biallelically under optimum stimulation conditions...
  15. ncbi TCR engagement in the absence of cell cycle progression leads to T cell anergy independent of p27(Kip1)
    J D Powell
    Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 0420, USA
    Eur J Immunol 31:3737-46. 2001
    ..Overall, our data serve to disassociate the ability of IL-2 to down-regulate p27(Kip1) and its ability to prevent or reverse anergy...
  16. ncbi A distinct region of the murine IFN-gamma promoter is hypomethylated from early T cell development through mature naive and Th1 cell differentiation, but is hypermethylated in Th2 cells
    Benjamin R Winders
    Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 173:7377-84. 2004
    ..Our experiments support a new model of IFN-gamma chromatin structural changes in murine T cell development that differs from what has been previously published for human T cells...
  17. ncbi Primer: mechanisms of immunologic tolerance
    Nevil J Singh
    Laboratory of Cellular and Molecular Immunology at the National Institute of Allergy and Infectious Diseases of the National Institutes of Health, Bethesda, MD 20892 0420, USA
    Nat Clin Pract Rheumatol 2:44-52. 2006
    ..The combined action of these processes ensures that the organism does not suffer autoimmune pathology, even if autoreactive receptors are generated and maintained in the immune system...
  18. ncbi Adaptive tolerance and clonal anergy are distinct biochemical states
    Lynda Chiodetti
    Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    J Immunol 176:2279-91. 2006
    ..These results demonstrate that T cell adaptive tolerance and clonal anergy are distinct biochemical states, possibly providing T cells with two molecular mechanisms to curtail responsiveness in different biological circumstances...
  19. ncbi Dual effects of Sprouty1 on TCR signaling depending on the differentiation state of the T cell
    Heonsik Choi
    Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 176:6034-45. 2006
    ..Thus, Spry1 uses a novel mechanism to bring about differential effects on TCR signaling through the same receptor, depending on the differentiation state of the T cell...
  20. pmc The impact of T cell intrinsic antigen adaptation on peripheral immune tolerance
    Nevil J Singh
    Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    PLoS Biol 4:e340. 2006
    ..These extrinsic mechanisms prevented the effector differentiation of the autoreactive T cells and reduced their precursor frequency, in vivo...
  21. pmc Tbata modulates thymic stromal cell proliferation and thymus function
    Francis A Flomerfelt
    Experimental Transplantation Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 207:2521-32. 2010
    ..These findings suggest that Tbata modulates thymus function by regulating stromal cell proliferation via the Nedd8 pathway...
  22. ncbi TLR ligands differentially modulate T cell responses to acute and chronic antigen presentation
    Nevil J Singh
    Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 179:7999-8008. 2007
    ..These data suggest a novel process by which TLR ligands modulate T cell responses to acute Ags, without disrupting the induction of tolerance to persistent self Ags...
  23. pmc Biphasic regulation of Il2 transcription in CD4+ T cells: roles for TNF-alpha receptor signaling and chromatin structure
    Susan C McKarns
    Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 181:1272-81. 2008
    ..This is provided, at least partially, by TNFR signaling during priming, but not during recall...
  24. ncbi Natural regulatory T cells and self-tolerance
    Ronald H Schwartz
    Ronald H Schwartz is with the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Immunol 6:327-30. 2005
    ..This perspective discusses why such a mechanism might have evolved and the problems it presents for self-non-self discrimination...
  25. ncbi Distinct effects of TGF-beta 1 on CD4+ and CD8+ T cell survival, division, and IL-2 production: a role for T cell intrinsic Smad3
    Susan C McKarns
    Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 174:2071-83. 2005
    ..Collectively, these findings firmly establish for the first time that TGF-beta1 discriminately regulates CD4+ and CD8+ T cell expansion by signaling through distinct intracellular pathways...
  26. ncbi Smad3 is essential for TGF-beta 1 to suppress IL-2 production and TCR-induced proliferation, but not IL-2-induced proliferation
    Susan C McKarns
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824 USA
    J Immunol 172:4275-84. 2004
    ..Thus, we establish that TGF-beta1 signals through multiple pathways to suppress T cell proliferation...
  27. ncbi The lymphopenic mouse in immunology: from patron to pariah
    Nevil J Singh
    Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health, 4 111 Center Drive, MSC 0420, Bethesda, Maryland 20892, USA
    Immunity 25:851-5. 2006
    ..Here we discuss this skepticism in a broader historical context...
  28. pmc A new fractionation assay, based on the size of formaldehyde-crosslinked, mildly sheared chromatin, delineates the chromatin structure at promoter regions
    Satoru Ishihara
    Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Nucleic Acids Res 38:e124. 2010
    ..Thus, this new chromatin fractionation technique has revealed a change in chromatin structure that has not been previously characterized...
  29. pmc Molecular mechanisms for adaptive tolerance and other T cell anergy models
    Seeyoung Choi
    National Institutes of Health, LCMI, NIAID, Bethesda, MD 20892 0420, USA
    Semin Immunol 19:140-52. 2007
    ..In this review we will detail our own work on the in vivo model referred to as adaptive tolerance and then attempt to compare this biochemical state to the multitude of other states that have been described in the literature...
  30. pmc Anergy and cytokine-mediated suppression as distinct superantigen-induced tolerance mechanisms in vivo
    C Miller
    Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 0420, USA
    J Exp Med 190:53-64. 1999
    ..These experiments show that complex in vivo interactions of multiple peripheral tolerance mechanisms can now be dissected at both the cellular and molecular levels...
  31. ncbi The destabilization of IL-2 mRNA by a premature stop codon and its differential stabilization by trans-acting inhibitors of protein synthesis do not support a role for active translation in mRNA stability
    J A Ragheb
    Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    J Immunol 163:3321-30. 1999
    ..Finally, CHX was able to superinduce IL-2 mRNA levels in anti-TCR Ab-stimulated cells but not in CD28-costimulated cells, suggesting that CHX may also act by other mechanisms...
  32. ncbi Selective, stable demethylation of the interleukin-2 gene enhances transcription by an active process
    Denis Bruniquel
    Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 0420, USA
    Nat Immunol 4:235-40. 2003
    ..These results imply that this demethylation process proceeds by an active enzymatic mechanism...
  33. ncbi Cloning and chromosomal mapping of a gene isolated from thymic stromal cells encoding a new mouse type II membrane serine protease, epithin, containing four LDL receptor modules and two CUB domains
    M G Kim
    Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 0420, USA
    Immunogenetics 49:420-8. 1999
    ..This gene, Prss14 (protease, serine, 14), was mapped to mouse chromosome 9 and is closely linked to the Fli1 (Friend leukemia integration 1) gene...
  34. pmc Regulation of interleukin 2 gene expression by CD28 costimulation in mouse T-cell clones: both nuclear and cytoplasmic RNAs are regulated with complex kinetics
    S W Umlauf
    Laboratory of Cellular and Molecular Immunology, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Cell Biol 15:3197-205. 1995
    ..This complexity suggests the existence of two interesting molecular mechanisms by which CD28 costimulates lymphokine gene expression...
  35. ncbi Egr-2 and Egr-3 are negative regulators of T cell activation
    Meredith Safford
    The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Nat Immunol 6:472-80. 2005
    ..These data support the idea that Egr-2 and Egr-3 are involved in promoting a T cell receptor-induced negative regulatory genetic program...
  36. ncbi Non-parametric, hypothesis-based analysis of microarrays for comparison of several phenotypes
    Jeanne Kowalski
    Department of Oncology, Johns Hopkins University, Baltimore, MD 21205, USA
    Bioinformatics 20:364-73. 2004
    ..The experiment was conducted to elucidate genes involved in pathways leading to T cell clonal anergy...
  37. ncbi Low-dose radiation plus rapamycin promotes long-term bone marrow chimerism
    Jonathan D Powell
    Department of Oncology, Johns Hopkins School of Medicine, Baltimore, MD, USA
    Transplantation 80:1541-5. 2005
    ..Although a number of regimens have been explored, the optimal means of conditioning has not been determined...