T W Schulte

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Expression of PAX3 in Ewing's sarcoma family of tumors
    T W Schulte
    Clinical Pharmacology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Biochem Mol Med 60:121-6. 1997
  2. pmc Destabilization of Raf-1 by geldanamycin leads to disruption of the Raf-1-MEK-mitogen-activated protein kinase signalling pathway
    T W Schulte
    Clinical Pharmacology Branch, National Cancer Institute, Bethesda, Maryland 20892, USA
    Mol Cell Biol 16:5839-45. 1996
  3. ncbi request reprint Geldanamycin-induced destabilization of Raf-1 involves the proteasome
    T W Schulte
    Medicine Branch, National Cancer Institute, Bethesda, Maryland 20892, USA
    Biochem Biophys Res Commun 239:655-9. 1997
  4. pmc Antibiotic radicicol binds to the N-terminal domain of Hsp90 and shares important biologic activities with geldanamycin
    T W Schulte
    Medicine Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Cell Stress Chaperones 3:100-8. 1998
  5. ncbi request reprint The benzoquinone ansamycin 17-allylamino-17-demethoxygeldanamycin binds to HSP90 and shares important biologic activities with geldanamycin
    T W Schulte
    Medicine Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 1928, USA
    Cancer Chemother Pharmacol 42:273-9. 1998

Detail Information

Publications5

  1. ncbi request reprint Expression of PAX3 in Ewing's sarcoma family of tumors
    T W Schulte
    Clinical Pharmacology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Biochem Mol Med 60:121-6. 1997
    ..We found expression of PAX3 in most, but not all, of the specimens analyzed, including cell lines and patient material...
  2. pmc Destabilization of Raf-1 by geldanamycin leads to disruption of the Raf-1-MEK-mitogen-activated protein kinase signalling pathway
    T W Schulte
    Clinical Pharmacology Branch, National Cancer Institute, Bethesda, Maryland 20892, USA
    Mol Cell Biol 16:5839-45. 1996
    ..Thus, we demonstrate that interaction between HSP90 and Raf-1 is a sine qua non for Raf stability and function as a signal transducer and that the effects observed cannot be attributed to a general impairment of protein kinase function...
  3. ncbi request reprint Geldanamycin-induced destabilization of Raf-1 involves the proteasome
    T W Schulte
    Medicine Branch, National Cancer Institute, Bethesda, Maryland 20892, USA
    Biochem Biophys Res Commun 239:655-9. 1997
    ..Signaling through this pathway was inhibited by GA, concomitant with loss of Raf-1 protein, but was restored if Raf-1 was protected from GA-induced degradation by proteasome inhibitors...
  4. pmc Antibiotic radicicol binds to the N-terminal domain of Hsp90 and shares important biologic activities with geldanamycin
    T W Schulte
    Medicine Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Cell Stress Chaperones 3:100-8. 1998
    ..Radicicol thus represents a structurally unique antibiotic, and the first non-benzoquinone ansamycin, capable of binding to Hsp90 and interfering with its function...
  5. ncbi request reprint The benzoquinone ansamycin 17-allylamino-17-demethoxygeldanamycin binds to HSP90 and shares important biologic activities with geldanamycin
    T W Schulte
    Medicine Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 1928, USA
    Cancer Chemother Pharmacol 42:273-9. 1998
    ..We therefore examined the biologic effects of 17-allylamino-17-demethoxygeldanamycin (17-AG), an ansamycin derivative with lower in vivo toxicity than GA...