Thaddeus T Schug

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. doi request reprint A new approach to synergize academic and guideline-compliant research: the CLARITY-BPA research program
    Thaddeus T Schug
    National Institute of Environmental Health Sciences National Institutes of Health, Division of Extramural Research, Research Triangle Park, NC 27709, United States
    Reprod Toxicol 40:35-40. 2013
  2. pmc ONE Nano: NIEHS's strategic initiative on the health and safety effects of engineered nanomaterials
    Thaddeus T Schug
    Cellular, Organs and Systems Pathobiology Branch, Division of Extramural Research and Training, National Institute of Environmental Health Sciences NIEHS, National Institutes of Health NIH, Department of Health and Human Services DHHS, Research Triangle Park, North Carolina 27560, USA
    Environ Health Perspect 121:410-4, 414e1-5. 2013
  3. pmc PPTOX III: environmental stressors in the developmental origins of disease--evidence and mechanisms
    Thaddeus T Schug
    Division of Extramural Research and Training, Cellular, Organ and Systems Pathobiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 131:343-50. 2013
  4. doi request reprint Fetal programming and environmental exposures: implications for prenatal care and preterm birth
    Thaddeus T Schug
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Ann N Y Acad Sci 1276:37-46. 2012
  5. pmc Myeloid deletion of SIRT1 induces inflammatory signaling in response to environmental stress
    Thaddeus T Schug
    Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Mol Cell Biol 30:4712-21. 2010
  6. pmc Endocrine disrupting chemicals and disease susceptibility
    Thaddeus T Schug
    National Institute of Environmental Health Sciences, Division of Extramural Research and Training, Cellular, Organ and Systems Pathobiology Branch, Research Triangle Park, NC 27709, USA
    J Steroid Biochem Mol Biol 127:204-15. 2011
  7. pmc SIRT1 performs a balancing act on the tight-rope toward longevity
    Aparna Purushotham
    Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Aging (Albany NY) 1:669-73. 2009
  8. pmc Consortium-based science: the NIEHS's multipronged, collaborative approach to assessing the health effects of bisphenol A
    Linda S Birnbaum
    National Institute of Environmental Health Sciences NIEHS, National Institutes of Health NIH, Department of Health and Human Services DHHS, Research Triangle Park, North Carolina 27709, USA
    Environ Health Perspect 120:1640-4. 2012
  9. pmc Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation
    Aparna Purushotham
    Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Cell Metab 9:327-38. 2009
  10. pmc DYRK1A and DYRK3 promote cell survival through phosphorylation and activation of SIRT1
    Xiumei Guo
    Laboratory of Signal Transduction, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 285:13223-32. 2010

Detail Information

Publications12

  1. doi request reprint A new approach to synergize academic and guideline-compliant research: the CLARITY-BPA research program
    Thaddeus T Schug
    National Institute of Environmental Health Sciences National Institutes of Health, Division of Extramural Research, Research Triangle Park, NC 27709, United States
    Reprod Toxicol 40:35-40. 2013
    ....
  2. pmc ONE Nano: NIEHS's strategic initiative on the health and safety effects of engineered nanomaterials
    Thaddeus T Schug
    Cellular, Organs and Systems Pathobiology Branch, Division of Extramural Research and Training, National Institute of Environmental Health Sciences NIEHS, National Institutes of Health NIH, Department of Health and Human Services DHHS, Research Triangle Park, North Carolina 27560, USA
    Environ Health Perspect 121:410-4, 414e1-5. 2013
    ..Currently, little is known about the health effects of human exposure to these materials...
  3. pmc PPTOX III: environmental stressors in the developmental origins of disease--evidence and mechanisms
    Thaddeus T Schug
    Division of Extramural Research and Training, Cellular, Organ and Systems Pathobiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 131:343-50. 2013
    ..This report summarizes novel findings in developmental toxicity as reported by select invited experts and meeting attendees. Recommendations for the application and improvement of current and future research efforts are also presented...
  4. doi request reprint Fetal programming and environmental exposures: implications for prenatal care and preterm birth
    Thaddeus T Schug
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Ann N Y Acad Sci 1276:37-46. 2012
    ..Speakers went on to discuss many other factors that affect prenatal development, from genetics to parental diet, revealing the extraordinary sensitivity of the developing fetus...
  5. pmc Myeloid deletion of SIRT1 induces inflammatory signaling in response to environmental stress
    Thaddeus T Schug
    Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Mol Cell Biol 30:4712-21. 2010
    ....
  6. pmc Endocrine disrupting chemicals and disease susceptibility
    Thaddeus T Schug
    National Institute of Environmental Health Sciences, Division of Extramural Research and Training, Cellular, Organ and Systems Pathobiology Branch, Research Triangle Park, NC 27709, USA
    J Steroid Biochem Mol Biol 127:204-15. 2011
    ..This review focuses on the mechanisms and modes of action by which EDCs alter hormone signaling. It also includes brief overviews of select disease endpoints associated with endocrine disruption...
  7. pmc SIRT1 performs a balancing act on the tight-rope toward longevity
    Aparna Purushotham
    Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Aging (Albany NY) 1:669-73. 2009
    ..These findings point toward the involvement of other players in SIRT1-regulated hepatic metabolism. Here we discuss our findings, and comment on some of the controversy surrounding this protein in the current literature...
  8. pmc Consortium-based science: the NIEHS's multipronged, collaborative approach to assessing the health effects of bisphenol A
    Linda S Birnbaum
    National Institute of Environmental Health Sciences NIEHS, National Institutes of Health NIH, Department of Health and Human Services DHHS, Research Triangle Park, North Carolina 27709, USA
    Environ Health Perspect 120:1640-4. 2012
    ..However, research gaps have precluded a full understanding of the effects of BPA in humans and engendered controversies surrounding the chemical's potential toxicity...
  9. pmc Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation
    Aparna Purushotham
    Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Cell Metab 9:327-38. 2009
    ..Taken together, our data indicate that SIRT1 plays a vital role in the regulation of hepatic lipid homeostasis and that pharmacological activation of SIRT1 may be important for the prevention of obesity-associated metabolic diseases...
  10. pmc DYRK1A and DYRK3 promote cell survival through phosphorylation and activation of SIRT1
    Xiumei Guo
    Laboratory of Signal Transduction, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 285:13223-32. 2010
    ..These findings may have important implications in understanding the molecular mechanisms of tumorigenesis, Down syndrome, and aging...
  11. pmc Sirtuin 1 in lipid metabolism and obesity
    Thaddeus T Schug
    Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, RTP, NC 27709, USA
    Ann Med 43:198-211. 2011
    ..It includes brief overviews of sirtuin signaling, with emphasis on SIRT1's role in the liver, macrophage, brain, and adipose tissue as it relates to obesity...
  12. pmc The perfect storm for obesity
    Jerrold J Heindel
    Division of Extramural Research and Training, Cellular, Organ and Systems Pathobiology Branch, National Institute of Environmental Sciences, Research Triangle Park, North Carolina, USA
    Obesity (Silver Spring) 21:1079-80. 2013
    ..Emerging research about alternative factors is setting the stage for today's "Perfect Storm" for obesity. ..