Dustin E Schones

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Chromatin signatures in multipotent human hematopoietic stem cells indicate the fate of bivalent genes during differentiation
    Kairong Cui
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Cell Stem Cell 4:80-93. 2009
  2. pmc Genome-wide mapping of HATs and HDACs reveals distinct functions in active and inactive genes
    Zhibin Wang
    Laboratory of Molecular Immunology, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Cell 138:1019-31. 2009
  3. pmc Monovalent and unpoised status of most genes in undifferentiated cell-enriched Drosophila testis
    Qiang Gan
    Department of Biology, The Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218, USA
    Genome Biol 11:R42. 2010
  4. pmc Determination of enriched histone modifications in non-genic portions of the human genome
    Jeffrey A Rosenfeld
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    BMC Genomics 10:143. 2009
  5. doi request reprint Genome-wide approaches to studying chromatin modifications
    Dustin E Schones
    Laboratory of Molecular Immunology, The National Heart, Lung and Blood Institute, National Institutes of Health, Building 10, Room 7B05, 9, 000 Rockville Pike, Bethesda, Maryland 20892, USA
    Nat Rev Genet 9:179-91. 2008
  6. pmc Genomic profiling of HMGN1 reveals an association with chromatin at regulatory regions
    Suresh Cuddapah
    Laboratory of Molecular Immunology, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Cell Biol 31:700-9. 2011
  7. pmc Regulation of nucleosome landscape and transcription factor targeting at tissue-specific enhancers by BRG1
    Gangqing Hu
    Laboratory of Molecular Immunology, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Genome Res 21:1650-8. 2011
  8. pmc Chromatin poises miRNA- and protein-coding genes for expression
    Artem Barski
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Genome Res 19:1742-51. 2009
  9. pmc Combinatorial patterns of histone acetylations and methylations in the human genome
    Zhibin Wang
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, US National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Genet 40:897-903. 2008
  10. doi request reprint Dynamic regulation of nucleosome positioning in the human genome
    Dustin E Schones
    Laboratory of Molecular Immunology, The National Heart, Lung and Blood Institute, NIH, Bethesda, MD 20892, USA
    Cell 132:887-98. 2008

Collaborators

Detail Information

Publications19

  1. pmc Chromatin signatures in multipotent human hematopoietic stem cells indicate the fate of bivalent genes during differentiation
    Kairong Cui
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Cell Stem Cell 4:80-93. 2009
    ..Thus, our data suggest that gene expression changes during differentiation are programmed by chromatin modifications present at the HSC/HPC stage and provide a resource for enhancer and promoter identification...
  2. pmc Genome-wide mapping of HATs and HDACs reveals distinct functions in active and inactive genes
    Zhibin Wang
    Laboratory of Molecular Immunology, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Cell 138:1019-31. 2009
    ..Silent genes without any H3K4 methylation signal show no evidence of being bound by HDACs...
  3. pmc Monovalent and unpoised status of most genes in undifferentiated cell-enriched Drosophila testis
    Qiang Gan
    Department of Biology, The Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218, USA
    Genome Biol 11:R42. 2010
    ..Previous studies have been performed using cultured mammalian embryonic stem cells. To a lesser extent, chromatin structure has been delineated in other model organisms, such as Drosophila, to open new avenues for genetic analyses...
  4. pmc Determination of enriched histone modifications in non-genic portions of the human genome
    Jeffrey A Rosenfeld
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    BMC Genomics 10:143. 2009
    ..Chromatin immunoprecipitation followed by high-throughput sequencing (ChIP-seq) has recently been used to identify the modification patterns for the methylation and acetylation of many different histone tails in genes and enhancers...
  5. doi request reprint Genome-wide approaches to studying chromatin modifications
    Dustin E Schones
    Laboratory of Molecular Immunology, The National Heart, Lung and Blood Institute, National Institutes of Health, Building 10, Room 7B05, 9, 000 Rockville Pike, Bethesda, Maryland 20892, USA
    Nat Rev Genet 9:179-91. 2008
    ..Here we review genome-wide approaches to studying epigenomic structure and the exciting findings that have been obtained using these technologies...
  6. pmc Genomic profiling of HMGN1 reveals an association with chromatin at regulatory regions
    Suresh Cuddapah
    Laboratory of Molecular Immunology, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Cell Biol 31:700-9. 2011
    ..Our results suggest that HMGN1 is part of the cellular machinery that modulates transcriptional fidelity by generating, maintaining, or preferentially interacting with specific sites in chromatin...
  7. pmc Regulation of nucleosome landscape and transcription factor targeting at tissue-specific enhancers by BRG1
    Gangqing Hu
    Laboratory of Molecular Immunology, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Genome Res 21:1650-8. 2011
    ..Intriguingly, we find that the nucleosome shifting specifically facilitates binding of TAL1 but not GATA1 and is linked to subsequent transcriptional regulation of target genes...
  8. pmc Chromatin poises miRNA- and protein-coding genes for expression
    Artem Barski
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Genome Res 19:1742-51. 2009
    ..Our data suggest that miRNA- and protein-coding genes share similar mechanisms of regulation by chromatin modifications, which poise inducible genes for activation in response to environmental stimuli...
  9. pmc Combinatorial patterns of histone acetylations and methylations in the human genome
    Zhibin Wang
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, US National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Genet 40:897-903. 2008
    ..Our data suggest that these histone modifications may act cooperatively to prepare chromatin for transcriptional activation...
  10. doi request reprint Dynamic regulation of nucleosome positioning in the human genome
    Dustin E Schones
    Laboratory of Molecular Immunology, The National Heart, Lung and Blood Institute, NIH, Bethesda, MD 20892, USA
    Cell 132:887-98. 2008
    ..Our results suggest that H2A.Z-containing and modified nucleosomes are preferentially lost from the -1 nucleosome position. Our data provide a comprehensive view of the nucleosome landscape and its dynamic regulation in the human genome...
  11. pmc Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4+ T cells
    Gang Wei
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 30:155-67. 2009
    ..Our data suggest an epigenetic mechanism underlying the specificity and plasticity of effector and regulatory T cells and also provide a framework for understanding complexity of CD4(+) T helper cell differentiation...
  12. pmc Global analysis of the insulator binding protein CTCF in chromatin barrier regions reveals demarcation of active and repressive domains
    Suresh Cuddapah
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Genome Res 19:24-32. 2009
    ..Our data indicate that CTCF may play important roles in the barrier activity of insulators, and this study provides a resource for further investigation of the CTCF function in organizing chromatin in the human genome...
  13. pmc High mobility group protein N5 (HMGN5) and lamina-associated polypeptide 2α (LAP2α) interact and reciprocally affect their genome-wide chromatin organization
    Shaofei Zhang
    Protein Section, Laboratory of Metabolism, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 288:18104-9. 2013
    ..Our study identifies a new functional link between chromatin-binding and lamin-binding proteins. ..
  14. pmc Characterization of human epigenomes
    Zhibin Wang
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD 20892, USA
    Curr Opin Genet Dev 19:127-34. 2009
    ....
  15. pmc Native chromatin preparation and illumina/solexa library construction
    Suresh Cuddapah
    Laboratory of Molecular Immunology, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    CSH Protoc 2009:pdb.prot5237. 2009
    ....
  16. pmc Down-regulation of Gfi-1 expression by TGF-beta is important for differentiation of Th17 and CD103+ inducible regulatory T cells
    Jinfang Zhu
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 206:329-41. 2009
    ..Thus, Gfi-1 plays a critical role both in enhancing Th2 cell expansion and in repressing induction of Th17 and CD103(+) iTreg cells...
  17. pmc The chromatin-binding protein HMGN1 regulates the expression of methyl CpG-binding protein 2 (MECP2) and affects the behavior of mice
    Liron Abuhatzira
    Protein Section, Laboratory of Metabolism, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 286:42051-62. 2011
    ..Our results reveal that HMGN1 affects the behavior of mice and suggest that epigenetic changes resulting from altered HMGN1 levels could play a role in the etiology of neurodevelopmental disorders...
  18. pmc Priming for T helper type 2 differentiation by interleukin 2-mediated induction of interleukin 4 receptor alpha-chain expression
    Wei Liao
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Immunol 9:1288-96. 2008
    ..Our results identify a previously unappreciated function for IL-2 in 'priming' T cells for T(H)2 differentiation and in maintaining the expression of Il4ra and other genes in T(H)2-committed cells...
  19. ncbi request reprint High-resolution profiling of histone methylations in the human genome
    Artem Barski
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD 20892, USA
    Cell 129:823-37. 2007
    ..Our data provide new insights into the function of histone methylation and chromatin organization in genome function...