Mark J Schofield

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint DNA mismatch repair: molecular mechanisms and biological function
    Mark J Schofield
    Genetics and Biochemistry Branch, National Institute of Diabetes, and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Annu Rev Microbiol 57:579-608. 2003
  2. ncbi request reprint Formation of a DNA mismatch repair complex mediated by ATP
    Tassadite Selmane
    Genetics and Biochemistry Branch, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 1810, USA
    J Mol Biol 334:949-65. 2003
  3. ncbi request reprint Crystal structure and biochemical analysis of the MutS.ADP.beryllium fluoride complex suggests a conserved mechanism for ATP interactions in mismatch repair
    Eric Alani
    Department of Molecular Biology and Genetics, 459 Biotechnology Building, Cornell University, Ithaca, NY 14853 2703, USA
    J Biol Chem 278:16088-94. 2003
  4. pmc DNA bending and unbending by MutS govern mismatch recognition and specificity
    Hong Wang
    Department of Chemistry and Curriculum in Applied and Materials Sciences, University of North Carolina, Chapel Hill, NC 27599, USA
    Proc Natl Acad Sci U S A 100:14822-7. 2003

Collaborators

Detail Information

Publications4

  1. ncbi request reprint DNA mismatch repair: molecular mechanisms and biological function
    Mark J Schofield
    Genetics and Biochemistry Branch, National Institute of Diabetes, and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Annu Rev Microbiol 57:579-608. 2003
    ..In addition to its role in postreplication repair, the MMR machinery serves to police homologous recombination events and acts as a barrier to genetic exchange between species...
  2. ncbi request reprint Formation of a DNA mismatch repair complex mediated by ATP
    Tassadite Selmane
    Genetics and Biochemistry Branch, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 1810, USA
    J Mol Biol 334:949-65. 2003
    ..However, recruitment of MutL results in the formation of a dynamic ternary complex that we propose is the intermediate that signals subsequent repair steps requiring ATP hydrolysis...
  3. ncbi request reprint Crystal structure and biochemical analysis of the MutS.ADP.beryllium fluoride complex suggests a conserved mechanism for ATP interactions in mismatch repair
    Eric Alani
    Department of Molecular Biology and Genetics, 459 Biotechnology Building, Cornell University, Ithaca, NY 14853 2703, USA
    J Biol Chem 278:16088-94. 2003
    ....
  4. pmc DNA bending and unbending by MutS govern mismatch recognition and specificity
    Hong Wang
    Department of Chemistry and Curriculum in Applied and Materials Sciences, University of North Carolina, Chapel Hill, NC 27599, USA
    Proc Natl Acad Sci U S A 100:14822-7. 2003
    ..Our results provide a structural explanation for the long-standing question of how MutS achieves mismatch repair specificity...