Research Topics
| P J SchmidtSummaryAffiliation: National Institutes of Health Country: USA Publications
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Detail Information
Publications
Stressful life events, personal losses, and perimenopause-related depressionP J Schmidt
Department of Health and Human Services, Behavioral Endocrinology Branch, National Institutes of Health, Bethesda, MD 20892 1276, USA
Arch Womens Ment Health 7:19-26. 2004..Nevertheless, independent of the presence of hot flushes, perimenopausal depressed women are more likely to report both negative life events and diminished self esteem...- The effects of pharmacologically induced hypogonadism on mood in healthy menPeter J Schmidt
Behavioral Endocrinology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 1276, USA
Arch Gen Psychiatry 61:997-1004. 2004..The effects of declining androgen secretion on mood regulation and the potential psychotropic efficacy of androgen replacement in men are largely undetermined... - Basal plasma hormone levels in depressed perimenopausal womenP J Schmidt
NIMH, Building 10, Room 3N 238, 10 Center Drive MSC 1276, Bethesda, MD 20892 1276, USA
Psychoneuroendocrinology 27:907-20. 2002..An association between abnormal changes in reproductive endocrine function during the perimenopause and the onset of depression in some women has been suggested but remains controversial... - Cerebrospinal fluid and behavioral changes after methyltestosterone administration: preliminary findingsR C Daly
Behavioral Endocrinology Branch, National Institute of Mental Health, Bldg 10, Room 3N242, 10 Center Dr, MSC 1277, Bethesda, MD 20892 1277, USA
Arch Gen Psychiatry 58:172-7. 2001..Anabolic androgen steroid abuse is associated with multiple psychiatric symptoms and is a significant public health problem. The biological mechanisms underlying behavioral symptom development are poorly understood... - Effects of gonadal steroids on peripheral benzodiazepine receptor density in women with PMS and controlsR C Daly
Behavioral Endocrinology Branch, National Institute of Mental Health, Bldg 10, Room 3N238, 10 Center Dr MSC 1276, Bethesda, MD 20892 1276, USA
Psychoneuroendocrinology 26:539-49. 2001..Alterations in PBR density have been observed in association with several psychiatric disorders... - Gonadotropin-releasing hormone-stimulated gonadotropin levels in women with premenstrual dysphoriaM J Smith
Behavioral Endocrinology Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
Gynecol Endocrinol 19:335-43. 2004..These data are consistent with prior findings of normal basal reproductive hormone levels in women with PMD. Our data suggest the absence in women with PMD of an abnormality of dynamic ovarian function as measured by GnRH stimulation... 
Modulation of cognition-specific cortical activity by gonadal steroids: a positron-emission tomography study in womenK F Berman
Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 94:8836-41. 1997..These data directly demonstrate that the hormonal milieu modulates cognition-related neural activity in humans...- Effects of the menstrual cycle on measures of personality in women with premenstrual syndrome: a preliminary studyR E Berlin
Behavioral Endocrinology Branch, National Institute of Mental Health, Bethesda, MD 20892-1276, USA
J Clin Psychiatry 62:337-42. 2001..These findings suggest that personality disorder in women with PMS may have both state- and trait-related components... - Neuroendocrine and behavioral effects of high-dose anabolic steroid administration in male normal volunteersR C Daly
Behavioural Endocrinology Branch, National Institute of Mental Health, Building 10, Room 3N238, 10 Center Drive MSC 1277, Bethesda, MD 20892 1277, USA
Psychoneuroendocrinology 28:317-31. 2003.... - Premenstrual symptoms and perimenopausal depressionMisty Richards
Behavioral Endocrinology Branch, NIMH, NIH, U.S. Department of Health and Human Services, Bethesda, MD, USA
Am J Psychiatry 163:133-7. 2006..However, neither menses-related symptom cyclicity nor premenstrual dysphoria was an invariant accompaniment of perimenopausal depression. Additionally, the rate of premenstrual dysphoria was not predicted by initial self-reports... - Mood, depression, and reproductive hormones in the menopausal transitionPeter J Schmidt
Behavioral Endocrinology Branch, National Institute of Mental Health, National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland 20892 1276, USA
Am J Med 118:54-8. 2005.... - Magnesium (mg) retention and mood effects after intravenous mg infusion in premenstrual dysphoric disorderKhursheed Khine
Behavioral Endocrinology Branch, National Institute of Mental Health, National Institute of Health, Department of Health and Human Services, Bethesda, Maryland 20892 1277, USA
Biol Psychiatry 59:327-33. 2006..Conflicting data exist regarding the presence of magnesium (Mg) deficiency and the therapeutic efficacy of Mg in premenstrual syndrome or premenstrual dysphoric disorder (PMDD)... - Monoamines and neurosteroids in sexual function during induced hypogonadism in healthy menMiki Bloch
Behavioral Endocrinology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
Arch Gen Psychiatry 63:450-6. 2006..CONCLUSION: These data suggest that the neurosteroid androsterone contributes to the regulation of sexual function in men... - Gonadal steroid regulation of mood: the lessons of premenstrual syndromeDavid R Rubinow
Behavioral Endocrinology Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 1276, USA
Front Neuroendocrinol 27:210-6. 2006.... - Reproductive ageing, sex steroids and depressionPeter J Schmidt
Behavioral Endocrinology Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 1276, USA
J Br Menopause Soc 12:178-85. 2006..Future studies of perimenopausal depression should identify the number of women affected, individual risk factors and the role of hormonal therapies in this condition... - Differentiation of women with premenstrual dysphoric disorder, recurrent brief depression, and healthy controls by daily mood rating dynamicsSteven M Pincus
J Psychiatr Res 42:337-47. 2008..The statistical methodologies have broad and direct applicability to behavioral studies for many psychiatric disorders, and indeed to similar analyses of associated biological signals across multiple axes... - Facial emotion discrimination across the menstrual cycle in women with premenstrual dysphoric disorder (PMDD) and controlsDavid R Rubinow
Behavioral Endocrinology Branch, National Institute of Mental Health, Bethesda MD 20892 1276, United States
J Affect Disord 104:37-44. 2007..e., state dependent)... - The menopause transition: the next neuroendocrine frontierVeronica Harsh
National Institutes of Health, Behavioral Endocrinology Branch, National Institute of Mental Health, Department of Health and Human Services, Bldg 10-CRC, Room 65340, 10 Center Drive MSC 1276, Bethesda, MD 20892-1276, USA
Expert Rev Neurother 7:S7-10. 2007 - A cross-sectional evaluation of perimenopausal depressionEmma M Steinberg
Behavioral Endocrinology Branch, National Institute of Mental Health, Bethesda, MD 20892 1276, USA
J Clin Psychiatry 69:973-80. 2008.... - Depression, the perimenopause, and estrogen therapyPeter J Schmidt
Behavioral Endocrinology Branch, National Institute of Mental Health, National Institutes of Health, Bldg 10 CRC, Rm 6 5340, 10 Center Dr, MSC 1276, Bethesda, MD 20892 1276, USA
Ann N Y Acad Sci 1052:27-40. 2005..Thus, although depression is not a uniform accompaniment of the menopausal transition, in some women age-related changes in ovarian estrogen production may alter central nervous system function and predispose them to develop depression... - Sex-related differences in stimulated hypothalamic-pituitary-adrenal axis during induced gonadal suppressionCatherine A Roca
Office of Special Populations, National Institute of Mental Health, Rockville, Maryland 20857, USA
J Clin Endocrinol Metab 90:4224-31. 2005..e. in the absence of characteristic differences in reproductive steroids)... - Testosterone suppression of CRH-stimulated cortisol in menDavid R Rubinow
Behavioral Endocrinology Branch, National Institute of Mental Health, Building 10 CRC, 10 Center Drive MSC 1276, Bethesda, MD 20892 1276, USA
Neuropsychopharmacology 30:1906-12. 2005..Our results further demonstrate that the enhanced stimulated HPA axis activity previously described in young men compared with young women cannot be ascribed to an activational upregulation of the axis by testosterone... - Effects of ovarian hormones on human cortical excitabilityMark J Smith
Brain Stimulation Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892-1430, USA
Ann Neurol 51:599-603. 2002..These findings demonstrate an excitatory neuronal effect associated with estradiol and confirm our earlier finding of inhibition associated with progesterone... - Effects of metergoline on symptoms in women with premenstrual dysphoric disorderCatherine A Roca
National Institute of Mental Health, Bethesda, MD 20892 1277, USA
Am J Psychiatry 159:1876-81. 2002..The authors investigated the role of acute serotonergic modulation in the efficacy of selective serotonin reuptake inhibitors (SSRIs) in women with premenstrual dysphoric disorder... - The effects of gender and gonadal steroids on the neuroendocrine and temperature response to m-chlorophenylpiperazine in leuprolide-induced hypogonadism in women and menPeter J Schmidt
Behavioral Endocrinology Branch, National Institute of Mental Health, Bethesda, MD 20892 1276, USA
Neuropsychopharmacology 27:800-12. 2002.... - Operationalizing DSM-IV criteria for PMDD: selecting symptomatic and asymptomatic cycles for researchMark J Smith
Behavioral Endocrinology Branch, National Institute of Mental Health, National Institutes of Health, Bldg. 10, Room 3N238, 10 Center Dr MSC 1276, Bethesda MD 20892-1276, USA
J Psychiatr Res 37:75-83. 2003..At the very least, the method for operationalizing DSM-IV criteria should be described in studies of PMDD... - Differential menstrual cycle regulation of hypothalamic-pituitary-adrenal axis in women with premenstrual syndrome and controlsCatherine A Roca
Behavioral Endocrinology, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
J Clin Endocrinol Metab 88:3057-63. 2003..These data demonstrate that women with PMS, when symptomatic, appear to have an abnormal response to progesterone and, furthermore, do not display the HPA axis abnormalities characteristic of major depression... - Abnormal luteal phase excitability of the motor cortex in women with premenstrual syndromeMark J Smith
National Institute of Neurological Disorders and Stroke, NIH, Bethesda, Maryland 20892, USA
Biol Psychiatry 54:757-62. 2003..Control subjects showed more inhibition in the luteal phase. Women with PMS showed relative facilitation. CONCLUSIONS: This is the first physiological evidence for an abnormal brain response to progesterone in PMS... - Concordant restoration of ovarian function and mood in perimenopausal depressionRobert C Daly
Behavioral Endocrinology Branch, National Institute of Mental Health, Bethesda, MD 20892-1276, USA
Am J Psychiatry 160:1842-6. 2003..2 IU/liter [SD=36.6] and 51.5 IU/liter [SD=34.2]). CONCLUSIONS: Mood variability in women with perimenopausal depression may reflect episodic alterations in ovarian function that are best detected by longitudinal study designs... - Dehydroepiandrosterone monotherapy in midlife-onset major and minor depressionPeter J Schmidt
Behavioral Endocrinology Branch, National Institute of Mental Health, Rockville, MD 20892 1276, USA
Arch Gen Psychiatry 62:154-62. 2005..The adrenal androgen and neurosteroid dehydroepiandrosterone (DHEA) is available as over-the-counter hormonal therapy and previously has been reported to have antidepressant-like effects... - Cortisol response to ovine corticotropin-releasing hormone in a model of pregnancy and parturition in euthymic women with and without a history of postpartum depressionMiki Bloch
Department of Psychiatry, Tel-Aviv Sourasky Medical Center, Israel 64239
J Clin Endocrinol Metab 90:695-9. 2005.... - A longitudinal evaluation of the relationship between reproductive status and mood in perimenopausal womenPeter J Schmidt
Behavioral Endocrinology Branch, NIMH, NIH, Department of Health and Human Services, Rm 3N238, Bldg 10, 10 Center Dr, MSC 1276, Bethesda, MD 20892 1276, USA
Am J Psychiatry 161:2238-44. 2004..Mood and reproductive function were prospectively evaluated in asymptomatic premenopausal women to determine whether the onset of depression was temporally linked to the perimenopause... - Estrogen, menopause, and the aging brain: how basic neuroscience can inform hormone therapy in womenJohn H Morrison
Fishberg Department of Neuroscience, Kastor Neurobiology of Aging Laboratories, New York, New York 10029, USA
J Neurosci 26:10332-48. 2006 - Estrogen and progestogen use in postmenopausal women: July 2008 position statement of The North American Menopause SocietyWulf H Utian
Menopause 15:584-602. 2008..The benefit-risk ratio for menopausal HT is favorable close to menopause but decreases with aging and with time since menopause in previously untreated women... - Risk for premenstrual dysphoric disorder is associated with genetic variation in ESR1, the estrogen receptor alpha geneLiang Huo
Behavioral Endocrinology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA
Biol Psychiatry 62:925-33. 2007..Premenstrual dysphoric disorder (PMDD) is a heritable mood disorder that is triggered by gonadal steroids during the luteal phase in susceptible women... - Shyness, social anxiety, and impaired self-esteem in Turner syndrome and premature ovarian failurePeter J Schmidt
JAMA 295:1374-6. 2006 - Menstrual cycle phase modulates reward-related neural function in womenJean Claude Dreher
Section on Integrative Neuroimaging, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 104:2465-70. 2007.... - Why study reproductive neuroscience? A clinical perspectivePeter J Schmidt
Behavioral Endocrinology Branch, National Institute of Mental Health, Bethesda, Maryland, USA
J Clin Psychiatry 69:972. 2008