P J Schmidt

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Stressful life events, personal losses, and perimenopause-related depression
    P J Schmidt
    Department of Health and Human Services, Behavioral Endocrinology Branch, National Institutes of Health, Bethesda, MD 20892 1276, USA
    Arch Womens Ment Health 7:19-26. 2004
  2. ncbi request reprint The effects of pharmacologically induced hypogonadism on mood in healthy men
    Peter J Schmidt
    Behavioral Endocrinology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 1276, USA
    Arch Gen Psychiatry 61:997-1004. 2004
  3. ncbi request reprint Basal plasma hormone levels in depressed perimenopausal women
    P J Schmidt
    NIMH, Building 10, Room 3N 238, 10 Center Drive MSC 1276, Bethesda, MD 20892 1276, USA
    Psychoneuroendocrinology 27:907-20. 2002
  4. ncbi request reprint Cerebrospinal fluid and behavioral changes after methyltestosterone administration: preliminary findings
    R C Daly
    Behavioral Endocrinology Branch, National Institute of Mental Health, Bldg 10, Room 3N242, 10 Center Dr, MSC 1277, Bethesda, MD 20892 1277, USA
    Arch Gen Psychiatry 58:172-7. 2001
  5. ncbi request reprint Effects of gonadal steroids on peripheral benzodiazepine receptor density in women with PMS and controls
    R C Daly
    Behavioral Endocrinology Branch, National Institute of Mental Health, Bldg 10, Room 3N238, 10 Center Dr MSC 1276, Bethesda, MD 20892 1276, USA
    Psychoneuroendocrinology 26:539-49. 2001
  6. ncbi request reprint Gonadotropin-releasing hormone-stimulated gonadotropin levels in women with premenstrual dysphoria
    M J Smith
    Behavioral Endocrinology Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    Gynecol Endocrinol 19:335-43. 2004
  7. pmc Modulation of cognition-specific cortical activity by gonadal steroids: a positron-emission tomography study in women
    K F Berman
    Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 94:8836-41. 1997
  8. ncbi request reprint Effects of the menstrual cycle on measures of personality in women with premenstrual syndrome: a preliminary study
    R E Berlin
    Behavioral Endocrinology Branch, National Institute of Mental Health, Bethesda, MD 20892-1276, USA
    J Clin Psychiatry 62:337-42. 2001
  9. ncbi request reprint Neuroendocrine and behavioral effects of high-dose anabolic steroid administration in male normal volunteers
    R C Daly
    Behavioural Endocrinology Branch, National Institute of Mental Health, Building 10, Room 3N238, 10 Center Drive MSC 1277, Bethesda, MD 20892 1277, USA
    Psychoneuroendocrinology 28:317-31. 2003
  10. ncbi request reprint Premenstrual symptoms and perimenopausal depression
    Misty Richards
    Behavioral Endocrinology Branch, NIMH, NIH, U S Department of Health and Human Services, Bethesda, MD, USA
    Am J Psychiatry 163:133-7. 2006

Detail Information

Publications38

  1. ncbi request reprint Stressful life events, personal losses, and perimenopause-related depression
    P J Schmidt
    Department of Health and Human Services, Behavioral Endocrinology Branch, National Institutes of Health, Bethesda, MD 20892 1276, USA
    Arch Womens Ment Health 7:19-26. 2004
    ..Nevertheless, independent of the presence of hot flushes, perimenopausal depressed women are more likely to report both negative life events and diminished self esteem...
  2. ncbi request reprint The effects of pharmacologically induced hypogonadism on mood in healthy men
    Peter J Schmidt
    Behavioral Endocrinology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 1276, USA
    Arch Gen Psychiatry 61:997-1004. 2004
    ..The effects of declining androgen secretion on mood regulation and the potential psychotropic efficacy of androgen replacement in men are largely undetermined...
  3. ncbi request reprint Basal plasma hormone levels in depressed perimenopausal women
    P J Schmidt
    NIMH, Building 10, Room 3N 238, 10 Center Drive MSC 1276, Bethesda, MD 20892 1276, USA
    Psychoneuroendocrinology 27:907-20. 2002
    ..An association between abnormal changes in reproductive endocrine function during the perimenopause and the onset of depression in some women has been suggested but remains controversial...
  4. ncbi request reprint Cerebrospinal fluid and behavioral changes after methyltestosterone administration: preliminary findings
    R C Daly
    Behavioral Endocrinology Branch, National Institute of Mental Health, Bldg 10, Room 3N242, 10 Center Dr, MSC 1277, Bethesda, MD 20892 1277, USA
    Arch Gen Psychiatry 58:172-7. 2001
    ..Anabolic androgen steroid abuse is associated with multiple psychiatric symptoms and is a significant public health problem. The biological mechanisms underlying behavioral symptom development are poorly understood...
  5. ncbi request reprint Effects of gonadal steroids on peripheral benzodiazepine receptor density in women with PMS and controls
    R C Daly
    Behavioral Endocrinology Branch, National Institute of Mental Health, Bldg 10, Room 3N238, 10 Center Dr MSC 1276, Bethesda, MD 20892 1276, USA
    Psychoneuroendocrinology 26:539-49. 2001
    ..Alterations in PBR density have been observed in association with several psychiatric disorders...
  6. ncbi request reprint Gonadotropin-releasing hormone-stimulated gonadotropin levels in women with premenstrual dysphoria
    M J Smith
    Behavioral Endocrinology Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    Gynecol Endocrinol 19:335-43. 2004
    ..These data are consistent with prior findings of normal basal reproductive hormone levels in women with PMD. Our data suggest the absence in women with PMD of an abnormality of dynamic ovarian function as measured by GnRH stimulation...
  7. pmc Modulation of cognition-specific cortical activity by gonadal steroids: a positron-emission tomography study in women
    K F Berman
    Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 94:8836-41. 1997
    ..These data directly demonstrate that the hormonal milieu modulates cognition-related neural activity in humans...
  8. ncbi request reprint Effects of the menstrual cycle on measures of personality in women with premenstrual syndrome: a preliminary study
    R E Berlin
    Behavioral Endocrinology Branch, National Institute of Mental Health, Bethesda, MD 20892-1276, USA
    J Clin Psychiatry 62:337-42. 2001
    ..These findings suggest that personality disorder in women with PMS may have both state- and trait-related components...
  9. ncbi request reprint Neuroendocrine and behavioral effects of high-dose anabolic steroid administration in male normal volunteers
    R C Daly
    Behavioural Endocrinology Branch, National Institute of Mental Health, Building 10, Room 3N238, 10 Center Drive MSC 1277, Bethesda, MD 20892 1277, USA
    Psychoneuroendocrinology 28:317-31. 2003
    ....
  10. ncbi request reprint Premenstrual symptoms and perimenopausal depression
    Misty Richards
    Behavioral Endocrinology Branch, NIMH, NIH, U S Department of Health and Human Services, Bethesda, MD, USA
    Am J Psychiatry 163:133-7. 2006
    ..Premenstrual mood symptoms were evaluated in women with perimenopause-related depression...
  11. ncbi request reprint Mood, depression, and reproductive hormones in the menopausal transition
    Peter J Schmidt
    Behavioral Endocrinology Branch, National Institute of Mental Health, National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland 20892 1276, USA
    Am J Med 118:54-8. 2005
    ....
  12. pmc Magnesium (mg) retention and mood effects after intravenous mg infusion in premenstrual dysphoric disorder
    Khursheed Khine
    Behavioral Endocrinology Branch, National Institute of Mental Health, National Institute of Health, Department of Health and Human Services, Bethesda, Maryland 20892 1277, USA
    Biol Psychiatry 59:327-33. 2006
    ..Conflicting data exist regarding the presence of magnesium (Mg) deficiency and the therapeutic efficacy of Mg in premenstrual syndrome or premenstrual dysphoric disorder (PMDD)...
  13. ncbi request reprint Monoamines and neurosteroids in sexual function during induced hypogonadism in healthy men
    Miki Bloch
    Behavioral Endocrinology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
    Arch Gen Psychiatry 63:450-6. 2006
    ..Although the behavioral effects of high-dose androgen administration may involve alterations in serotonergic activity, few studies have investigated the impact of androgen withdrawal on the central nervous system in humans...
  14. ncbi request reprint Gonadal steroid regulation of mood: the lessons of premenstrual syndrome
    David R Rubinow
    Behavioral Endocrinology Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 1276, USA
    Front Neuroendocrinol 27:210-6. 2006
    ....
  15. ncbi request reprint Reproductive ageing, sex steroids and depression
    Peter J Schmidt
    Behavioral Endocrinology Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 1276, USA
    J Br Menopause Soc 12:178-85. 2006
    ..Future studies of perimenopausal depression should identify the number of women affected, individual risk factors and the role of hormonal therapies in this condition...
  16. ncbi request reprint Differentiation of women with premenstrual dysphoric disorder, recurrent brief depression, and healthy controls by daily mood rating dynamics
    Steven M Pincus
    J Psychiatr Res 42:337-47. 2008
    ..The statistical methodologies have broad and direct applicability to behavioral studies for many psychiatric disorders, and indeed to similar analyses of associated biological signals across multiple axes...
  17. pmc Facial emotion discrimination across the menstrual cycle in women with premenstrual dysphoric disorder (PMDD) and controls
    David R Rubinow
    Behavioral Endocrinology Branch, National Institute of Mental Health, Bethesda MD 20892 1276, United States
    J Affect Disord 104:37-44. 2007
    ..e., state dependent)...
  18. ncbi request reprint The menopause transition: the next neuroendocrine frontier
    Veronica Harsh
    National Institutes of Health, Behavioral Endocrinology Branch, National Institute of Mental Health, Department of Health and Human Services, Bldg 10 CRC, Room 65340, 10 Center Drive MSC 1276, Bethesda, MD 20892 1276, USA
    Expert Rev Neurother 7:S7-10. 2007
  19. pmc A cross-sectional evaluation of perimenopausal depression
    Emma M Steinberg
    Behavioral Endocrinology Branch, National Institute of Mental Health, Bethesda, MD 20892 1276, USA
    J Clin Psychiatry 69:973-80. 2008
    ....
  20. ncbi request reprint Depression, the perimenopause, and estrogen therapy
    Peter J Schmidt
    Behavioral Endocrinology Branch, National Institute of Mental Health, National Institutes of Health, Bldg 10 CRC, Rm 6 5340, 10 Center Dr, MSC 1276, Bethesda, MD 20892 1276, USA
    Ann N Y Acad Sci 1052:27-40. 2005
    ..Thus, although depression is not a uniform accompaniment of the menopausal transition, in some women age-related changes in ovarian estrogen production may alter central nervous system function and predispose them to develop depression...
  21. ncbi request reprint Sex-related differences in stimulated hypothalamic-pituitary-adrenal axis during induced gonadal suppression
    Catherine A Roca
    Office of Special Populations, National Institute of Mental Health, Rockville, Maryland 20857, USA
    J Clin Endocrinol Metab 90:4224-31. 2005
    ..Sex-related differences in reproductive steroid levels further confound efforts to define the specific role of the sex of the individual in stress axis responsivity...
  22. pmc Testosterone suppression of CRH-stimulated cortisol in men
    David R Rubinow
    Behavioral Endocrinology Branch, National Institute of Mental Health, Building 10 CRC, 10 Center Drive MSC 1276, Bethesda, MD 20892 1276, USA
    Neuropsychopharmacology 30:1906-12. 2005
    ..Our results further demonstrate that the enhanced stimulated HPA axis activity previously described in young men compared with young women cannot be ascribed to an activational upregulation of the axis by testosterone...
  23. ncbi request reprint Effects of ovarian hormones on human cortical excitability
    Mark J Smith
    Brain Stimulation Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1430, USA
    Ann Neurol 51:599-603. 2002
    ..These findings demonstrate an excitatory neuronal effect associated with estradiol and confirm our earlier finding of inhibition associated with progesterone...
  24. ncbi request reprint Effects of metergoline on symptoms in women with premenstrual dysphoric disorder
    Catherine A Roca
    National Institute of Mental Health, Bethesda, MD 20892 1277, USA
    Am J Psychiatry 159:1876-81. 2002
    ..The authors investigated the role of acute serotonergic modulation in the efficacy of selective serotonin reuptake inhibitors (SSRIs) in women with premenstrual dysphoric disorder...
  25. ncbi request reprint The effects of gender and gonadal steroids on the neuroendocrine and temperature response to m-chlorophenylpiperazine in leuprolide-induced hypogonadism in women and men
    Peter J Schmidt
    Behavioral Endocrinology Branch, National Institute of Mental Health, Bethesda, MD 20892 1276, USA
    Neuropsychopharmacology 27:800-12. 2002
    ....
  26. ncbi request reprint Operationalizing DSM-IV criteria for PMDD: selecting symptomatic and asymptomatic cycles for research
    Mark J Smith
    Behavioral Endocrinology Branch, National Institute of Mental Health, National Institutes of Health, Bldg 10, Room 3N238, 10 Center Dr MSC 1276, Bethesda MD 20892 1276, USA
    J Psychiatr Res 37:75-83. 2003
    ..At the very least, the method for operationalizing DSM-IV criteria should be described in studies of PMDD...
  27. ncbi request reprint Differential menstrual cycle regulation of hypothalamic-pituitary-adrenal axis in women with premenstrual syndrome and controls
    Catherine A Roca
    Behavioral Endocrinology, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Endocrinol Metab 88:3057-63. 2003
    ..These data demonstrate that women with PMS, when symptomatic, appear to have an abnormal response to progesterone and, furthermore, do not display the HPA axis abnormalities characteristic of major depression...
  28. ncbi request reprint Abnormal luteal phase excitability of the motor cortex in women with premenstrual syndrome
    Mark J Smith
    National Institute of Neurological Disorders and Stroke, NIH, Bethesda, Maryland 20892, USA
    Biol Psychiatry 54:757-62. 2003
    ..Here, we studied women with PMS to see if their response to endogenous progesterone differed from that of control subjects...
  29. ncbi request reprint Concordant restoration of ovarian function and mood in perimenopausal depression
    Robert C Daly
    Behavioral Endocrinology Branch, National Institute of Mental Health, Bethesda, MD 20892 1276, USA
    Am J Psychiatry 160:1842-6. 2003
    ..The purpose of this study was to examine changes in mood and pituitary-ovarian axis function in women exhibiting perimenopausal depression...
  30. ncbi request reprint Dehydroepiandrosterone monotherapy in midlife-onset major and minor depression
    Peter J Schmidt
    Behavioral Endocrinology Branch, National Institute of Mental Health, Rockville, MD 20892 1276, USA
    Arch Gen Psychiatry 62:154-62. 2005
    ..The adrenal androgen and neurosteroid dehydroepiandrosterone (DHEA) is available as over-the-counter hormonal therapy and previously has been reported to have antidepressant-like effects...
  31. ncbi request reprint Cortisol response to ovine corticotropin-releasing hormone in a model of pregnancy and parturition in euthymic women with and without a history of postpartum depression
    Miki Bloch
    Department of Psychiatry, Tel Aviv Sourasky Medical Center, Israel 64239
    J Clin Endocrinol Metab 90:695-9. 2005
    ....
  32. ncbi request reprint A longitudinal evaluation of the relationship between reproductive status and mood in perimenopausal women
    Peter J Schmidt
    Behavioral Endocrinology Branch, NIMH, NIH, Department of Health and Human Services, Rm 3N238, Bldg 10, 10 Center Dr, MSC 1276, Bethesda, MD 20892 1276, USA
    Am J Psychiatry 161:2238-44. 2004
    ..Mood and reproductive function were prospectively evaluated in asymptomatic premenopausal women to determine whether the onset of depression was temporally linked to the perimenopause...
  33. ncbi request reprint Estrogen, menopause, and the aging brain: how basic neuroscience can inform hormone therapy in women
    John H Morrison
    Fishberg Department of Neuroscience, Kastor Neurobiology of Aging Laboratories, New York, New York 10029, USA
    J Neurosci 26:10332-48. 2006
  34. pmc Estrogen and progestogen use in postmenopausal women: July 2008 position statement of The North American Menopause Society
    Wulf H Utian
    Menopause 15:584-602. 2008
    ....
  35. pmc Risk for premenstrual dysphoric disorder is associated with genetic variation in ESR1, the estrogen receptor alpha gene
    Liang Huo
    Behavioral Endocrinology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA
    Biol Psychiatry 62:925-33. 2007
    ..Premenstrual dysphoric disorder (PMDD) is a heritable mood disorder that is triggered by gonadal steroids during the luteal phase in susceptible women...
  36. ncbi request reprint Shyness, social anxiety, and impaired self-esteem in Turner syndrome and premature ovarian failure
    Peter J Schmidt
    JAMA 295:1374-6. 2006
  37. pmc Menstrual cycle phase modulates reward-related neural function in women
    Jean Claude Dreher
    Section on Integrative Neuroimaging, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 104:2465-70. 2007
    ....
  38. ncbi request reprint Why study reproductive neuroscience? A clinical perspective
    Peter J Schmidt
    Behavioral Endocrinology Branch, National Institute of Mental Health, Bethesda, Maryland, USA
    J Clin Psychiatry 69:972. 2008