Hana Schmeisser

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Binding Characteristics of IFN-alpha Subvariants to IFNAR2-EC and Influence of the 6-Histidine Tag
    Hana Schmeisser
    NIH, NIAID, Bethesda, MD 20892, USA
    J Interferon Cytokine Res 26:866-76. 2006
  2. pmc Two interferons alpha influence each other during their interaction with the extracellular domain of human type interferon receptor subunit 2
    Hana Schmeisser
    National Institute of Allergy and Infectious Diseases and National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, Maryland 20892, USA
    Biochemistry 46:14638-49. 2007
  3. pmc Type I interferons induce autophagy in certain human cancer cell lines
    Hana Schmeisser
    National Institutes of Health, National Institute of Allergy and Infectious Disease, Cytokine Biology Section, Bethesda, MD, USA
    Autophagy 9:683-96. 2013
  4. ncbi request reprint Human interferons alpha, beta and omega
    Joseph Bekisz
    Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Growth Factors 22:243-51. 2004
  5. pmc Structural variants of IFNα preferentially promote antiviral functions
    Nancy Vazquez
    Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA
    Blood 118:2567-77. 2011
  6. pmc Nucleolin interacts with the dengue virus capsid protein and plays a role in formation of infectious virus particles
    Corey A Balinsky
    Cytokine Biology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    J Virol 87:13094-106. 2013
  7. ncbi request reprint Amino acid substitutions in loop BC and helix C affect antigenic properties of helix D in hybrid IFN-alpha21a/alpha2c molecules
    Hana Schmeisser
    Division of Therapeutic Proteins, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, MD 20892, USA
    J Interferon Cytokine Res 22:463-72. 2002
  8. pmc IRF9 is a key factor for eliciting the antiproliferative activity of IFN-alpha
    Takaya Tsuno
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunother 32:803-16. 2009
  9. pmc Near eradication of clinically relevant concentrations of human tumor cells by interferon-activated monocytes in vitro
    Samuel Baron
    Cytokine Biology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Interferon Cytokine Res 31:569-73. 2011
  10. pmc New function of type I IFN: induction of autophagy
    Hana Schmeisser
    Cytokine Biology Section, National Institutes of Health, National Institute of Allergy and Infectious Disease, Bethesda, Maryland
    J Interferon Cytokine Res 34:71-8. 2014

Collaborators

Detail Information

Publications12

  1. ncbi request reprint Binding Characteristics of IFN-alpha Subvariants to IFNAR2-EC and Influence of the 6-Histidine Tag
    Hana Schmeisser
    NIH, NIAID, Bethesda, MD 20892, USA
    J Interferon Cytokine Res 26:866-76. 2006
    ..This study is the first report that shows that an N-terminal 6-histidine tag on IFN-alpha2c can affect its interaction with receptor and cause a different bioactivity...
  2. pmc Two interferons alpha influence each other during their interaction with the extracellular domain of human type interferon receptor subunit 2
    Hana Schmeisser
    National Institute of Allergy and Infectious Diseases and National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, Maryland 20892, USA
    Biochemistry 46:14638-49. 2007
    ..This study contributes to the understanding of the mutual interaction between multiple IFN-alpha subtypes during the competition for binding to the receptor...
  3. pmc Type I interferons induce autophagy in certain human cancer cell lines
    Hana Schmeisser
    National Institutes of Health, National Institute of Allergy and Infectious Disease, Cytokine Biology Section, Bethesda, MD, USA
    Autophagy 9:683-96. 2013
    ..Taken together, our findings demonstrated a novel function of type I IFN as an inducer of autophagy in multiple cell lines...
  4. ncbi request reprint Human interferons alpha, beta and omega
    Joseph Bekisz
    Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Growth Factors 22:243-51. 2004
    ..The interaction of IFN-alpha/beta with its receptor components results in the activation of a number of signaling pathways. The regulation of specific genes and proteins contributes to the numerous biological functions of Type I IFNs...
  5. pmc Structural variants of IFNα preferentially promote antiviral functions
    Nancy Vazquez
    Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA
    Blood 118:2567-77. 2011
    ..Defining IFN structure and function relative to APOBEC and other antiviral genes may enable design of novel IFN-related molecules preserving beneficial antiviral roles while minimizing negative effects...
  6. pmc Nucleolin interacts with the dengue virus capsid protein and plays a role in formation of infectious virus particles
    Corey A Balinsky
    Cytokine Biology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    J Virol 87:13094-106. 2013
    ..Here, we identify a critical interaction between DENV C protein and NCL that represents a potential new target for the development of antiviral therapeutics. ..
  7. ncbi request reprint Amino acid substitutions in loop BC and helix C affect antigenic properties of helix D in hybrid IFN-alpha21a/alpha2c molecules
    Hana Schmeisser
    Division of Therapeutic Proteins, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, MD 20892, USA
    J Interferon Cytokine Res 22:463-72. 2002
    ..Changes in the structure of constructs affected not only their antiproliferative activity but also their antiviral activity on human cells...
  8. pmc IRF9 is a key factor for eliciting the antiproliferative activity of IFN-alpha
    Takaya Tsuno
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunother 32:803-16. 2009
    ..Thus, this study suggests that IRF9 is the key factor for eliciting the antiproliferative activity of IFN-alpha and TRAIL may be one of the potential mediators...
  9. pmc Near eradication of clinically relevant concentrations of human tumor cells by interferon-activated monocytes in vitro
    Samuel Baron
    Cytokine Biology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Interferon Cytokine Res 31:569-73. 2011
    ..Thus, high concentrations of tumor cells required high concentrations of IFN and monocytes to cause near eradication of tumor cells. These findings may have clinical implications...
  10. pmc New function of type I IFN: induction of autophagy
    Hana Schmeisser
    Cytokine Biology Section, National Institutes of Health, National Institute of Allergy and Infectious Disease, Bethesda, Maryland
    J Interferon Cytokine Res 34:71-8. 2014
    ..This new function of type I IFN may play an important role in viral clearance, antigen presentation, inhibition of proliferation, as well as a positive feedback loop for the production of type I IFN. ..
  11. pmc A novel role for IFN-stimulated gene factor 3II in IFN-γ signaling and induction of antiviral activity in human cells
    Angel N Morrow
    Cytokine Biology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 186:1685-93. 2011
    ....
  12. ncbi request reprint Incidence of autoantibodies against type I and type II interferons in a cohort of systemic lupus erythematosus patients in Slovakia
    Monika Slavikova
    Institute of Virology, Slovak Academy of Sciences, 842 45 Bratislava, Slovakia
    J Interferon Cytokine Res 23:143-7. 2003
    ..Our findings suggest that formation of autoantibodies could reflect humoral immune responses to increased spontaneous production of the respective IFN species in SLE patients...