Marco L Schito

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Topical microbicides: a promising approach for controlling the AIDS pandemic via retroviral zinc finger inhibitors
    Jim A Turpin
    Preventions Sciences Program, Division of AIDS, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA
    Adv Pharmacol 56:229-56. 2008
  2. ncbi request reprint In vivo antiviral activity of novel human immunodeficiency virus type 1 nucleocapsid p7 zinc finger inhibitors in a transgenic murine model
    Marco L Schito
    Chemical Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland 20892, USA
    AIDS Res Hum Retroviruses 19:91-101. 2003
  3. ncbi request reprint Wip1 phosphatase-deficient mice exhibit defective T cell maturation due to sustained p53 activation
    Marco L Schito
    Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 176:4818-25. 2006
  4. ncbi request reprint Preclinical evaluation of a zinc finger inhibitor targeting lentivirus nucleocapsid protein in SIV-infected monkeys
    Marco L Schito
    Laboratory of Cell Biology, National Cancer Institute, National Institute of Health, Bethesda, Maryland 20892, USA
    Curr HIV Res 4:379-86. 2006
  5. pmc Small-molecule inactivation of HIV-1 NCp7 by repetitive intracellular acyl transfer
    Lisa M Miller Jenkins
    Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    Nat Chem Biol 6:887-9. 2010
  6. ncbi request reprint Cutting edge: in vivo induction of integrated HIV-1 expression by mycobacteria is critically dependent on Toll-like receptor 2
    Andre Bafica
    Immunobiology Section, National Institute of Allergy and Infectious Diseases and Chemical Immunology Section, Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 171:1123-7. 2003
  7. pmc Challenges for rapid molecular HIV diagnostics
    Marco L Schito
    Henry Jackson Foundation for the Advancement of Military Medicine, Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20817, USA
    J Infect Dis 201:S1-6. 2010
  8. ncbi request reprint Toll-like receptor 2 (TLR2) and TLR9 signaling results in HIV-long terminal repeat trans-activation and HIV replication in HIV-1 transgenic mouse spleen cells: implications of simultaneous activation of TLRs on HIV replication
    Ozlem Equils
    Division of Pediatric Infectious Diseases, Steven Spielberg Pediatric Research Center, Burns and Allen Research Institute, Cedars Sinai Medical Center, University of California School of Medicine, Los Angeles, CA 90048, USA
    J Immunol 170:5159-64. 2003

Detail Information

Publications8

  1. ncbi request reprint Topical microbicides: a promising approach for controlling the AIDS pandemic via retroviral zinc finger inhibitors
    Jim A Turpin
    Preventions Sciences Program, Division of AIDS, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA
    Adv Pharmacol 56:229-56. 2008
  2. ncbi request reprint In vivo antiviral activity of novel human immunodeficiency virus type 1 nucleocapsid p7 zinc finger inhibitors in a transgenic murine model
    Marco L Schito
    Chemical Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland 20892, USA
    AIDS Res Hum Retroviruses 19:91-101. 2003
    ..Thus, these thioesters may provide an effective means for inhibiting the expression of human immunodeficiency virus from integrated viral reservoirs...
  3. ncbi request reprint Wip1 phosphatase-deficient mice exhibit defective T cell maturation due to sustained p53 activation
    Marco L Schito
    Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 176:4818-25. 2006
    ..In contrast, the abnormal thymic phenotype of Wip1-deficient mice was reversed in the absence of p53. These data suggest that Wip1 down-regulates p53 activation in the thymus and is required for normal alphabeta T cell development...
  4. ncbi request reprint Preclinical evaluation of a zinc finger inhibitor targeting lentivirus nucleocapsid protein in SIV-infected monkeys
    Marco L Schito
    Laboratory of Cell Biology, National Cancer Institute, National Institute of Health, Bethesda, Maryland 20892, USA
    Curr HIV Res 4:379-86. 2006
    ..Further studies directed at optimizing SAMT bioavailability and pharmacokinetics likely will result in enhanced therapeutic efficacy of this promising HIV therapeutic...
  5. pmc Small-molecule inactivation of HIV-1 NCp7 by repetitive intracellular acyl transfer
    Lisa M Miller Jenkins
    Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    Nat Chem Biol 6:887-9. 2010
    ..The thiol produced by SAMT reaction with NCp7 is acetylated by cellular enzymes to regenerate active SAMTs via a recycling mechanism unique among small-molecule inhibitors of HIV...
  6. ncbi request reprint Cutting edge: in vivo induction of integrated HIV-1 expression by mycobacteria is critically dependent on Toll-like receptor 2
    Andre Bafica
    Immunobiology Section, National Institute of Allergy and Infectious Diseases and Chemical Immunology Section, Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 171:1123-7. 2003
    ..Together, these results argue that TLR2 plays a crucial role in the activation of HIV-1 expression by mycobacterial coinfections...
  7. pmc Challenges for rapid molecular HIV diagnostics
    Marco L Schito
    Henry Jackson Foundation for the Advancement of Military Medicine, Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20817, USA
    J Infect Dis 201:S1-6. 2010
    ..The way forward requires sound scientific judgment and an ability to further develop and implement these tests despite a variety of technical, social, and operational hurdles, to declare success...
  8. ncbi request reprint Toll-like receptor 2 (TLR2) and TLR9 signaling results in HIV-long terminal repeat trans-activation and HIV replication in HIV-1 transgenic mouse spleen cells: implications of simultaneous activation of TLRs on HIV replication
    Ozlem Equils
    Division of Pediatric Infectious Diseases, Steven Spielberg Pediatric Research Center, Burns and Allen Research Institute, Cedars Sinai Medical Center, University of California School of Medicine, Los Angeles, CA 90048, USA
    J Immunol 170:5159-64. 2003
    ....