Marco L Schito
Affiliation: National Institutes of Health
- Opportunities and challenges for cost-efficient implementation of new point-of-care diagnostics for HIV and tuberculosisMarco Schito
Division of AIDS, Henry M Jackson Foundation for Advancement of Military Medicine, National Institutes of Health, Bethesda, Maryland 20892 7628, USA
J Infect Dis 205:S169-80. 2012..In this fashion, the global community can best harness the tremendous capacity of novel diagnostics in fighting these 2 scourges...
- Challenges for rapid molecular HIV diagnosticsMarco L Schito
Henry Jackson Foundation for the Advancement of Military Medicine, Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20817, USA
J Infect Dis 201:S1-6. 2010..The way forward requires sound scientific judgment and an ability to further develop and implement these tests despite a variety of technical, social, and operational hurdles, to declare success...
- In vivo antiviral activity of novel human immunodeficiency virus type 1 nucleocapsid p7 zinc finger inhibitors in a transgenic murine modelMarco L Schito
Chemical Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland 20892, USA
AIDS Res Hum Retroviruses 19:91-101. 2003..Thus, these thioesters may provide an effective means for inhibiting the expression of human immunodeficiency virus from integrated viral reservoirs...
- Cutting edge: in vivo induction of integrated HIV-1 expression by mycobacteria is critically dependent on Toll-like receptor 2Andre Bafica
Immunobiology Section, National Institute of Allergy and Infectious Diseases and Chemical Immunology Section, Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 171:1123-7. 2003..Together, these results argue that TLR2 plays a crucial role in the activation of HIV-1 expression by mycobacterial coinfections...
- Wip1 phosphatase-deficient mice exhibit defective T cell maturation due to sustained p53 activationMarco L Schito
Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 176:4818-25. 2006..In contrast, the abnormal thymic phenotype of Wip1-deficient mice was reversed in the absence of p53. These data suggest that Wip1 down-regulates p53 activation in the thymus and is required for normal alphabeta T cell development...
- Preclinical evaluation of a zinc finger inhibitor targeting lentivirus nucleocapsid protein in SIV-infected monkeysMarco L Schito
Laboratory of Cell Biology, National Cancer Institute, National Institute of Health, Bethesda, Maryland 20892, USA
Curr HIV Res 4:379-86. 2006..Further studies directed at optimizing SAMT bioavailability and pharmacokinetics likely will result in enhanced therapeutic efficacy of this promising HIV therapeutic...
- Small-molecule inactivation of HIV-1 NCp7 by repetitive intracellular acyl transferLisa M Miller Jenkins
Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
Nat Chem Biol 6:887-9. 2010..The thiol produced by SAMT reaction with NCp7 is acetylated by cellular enzymes to regenerate active SAMTs via a recycling mechanism unique among small-molecule inhibitors of HIV...
- Topical microbicides: a promising approach for controlling the AIDS pandemic via retroviral zinc finger inhibitorsJim A Turpin
Preventions Sciences Program, Division of AIDS, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA
Adv Pharmacol 56:229-56. 2008