Enrique F Schisterman

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Optimal cut-point and its corresponding Youden Index to discriminate individuals using pooled blood samples
    Enrique F Schisterman
    Division of Epidemiology, Statistics and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, DHHS, Bethesda, Maryland, USA
    Epidemiology 16:73-81. 2005
  2. pmc Effects of low-dose aspirin in in-vitro fertilization
    Enrique F Schisterman
    Division of Epidemiology, Statistics, and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland, USA
    Curr Opin Obstet Gynecol 21:275-8. 2009
  3. pmc Overadjustment bias and unnecessary adjustment in epidemiologic studies
    Enrique F Schisterman
    Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Rockville, MD 20852, USA
    Epidemiology 20:488-95. 2009
  4. ncbi request reprint Invited commentary: simple models for a complicated reality
    Enrique F Schisterman
    Epidemiology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD
    Am J Epidemiol 164:312-4; discussion 315-6. 2006
  5. pmc Z-scores and the birthweight paradox
    Enrique F Schisterman
    Epidemiology Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Paediatr Perinat Epidemiol 23:403-13. 2009
  6. pmc Invited commentary: causation or "noitasuac"?
    Enrique Schisterman
    Epidemiology Branch, Division of Epidemiology, Statistics, and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland 20854, USA
    Am J Epidemiol 173:984-7; reply 988-9. 2011
  7. pmc Hybrid pooled-unpooled design for cost-efficient measurement of biomarkers
    Enrique F Schisterman
    Division of Epidemiology, Statistics and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH DHHS, Rockville, MD 20852, USA
    Stat Med 29:597-613. 2010
  8. pmc The limitations due to exposure detection limits for regression models
    Enrique F Schisterman
    Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, 6100 Executive Boulevard, Rm 7B03, Rockville, MD 20852, USA
    Am J Epidemiol 163:374-83. 2006
  9. pmc Lipid adjustment in the analysis of environmental contaminants and human health risks
    Enrique F Schisterman
    Division of Epidemiology, Statistics and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland 20852, USA
    Environ Health Perspect 113:853-7. 2005
  10. pmc Estimation of the correlation coefficient using the Bayesian Approach and its applications for epidemiologic research
    Enrique F Schisterman
    Division of Epidemiology, Statistics and Prevention National Institute of Child Health and Human Development National Institute of Health, Bethesda, MD, USA
    BMC Med Res Methodol 3:5. 2003

Detail Information

Publications101 found, 100 shown here

  1. ncbi request reprint Optimal cut-point and its corresponding Youden Index to discriminate individuals using pooled blood samples
    Enrique F Schisterman
    Division of Epidemiology, Statistics and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, DHHS, Bethesda, Maryland, USA
    Epidemiology 16:73-81. 2005
    ..In conclusion, pooling can result in a substantial cost reduction while preserving the effectiveness of estimators, especially when the pool size is not very large...
  2. pmc Effects of low-dose aspirin in in-vitro fertilization
    Enrique F Schisterman
    Division of Epidemiology, Statistics, and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland, USA
    Curr Opin Obstet Gynecol 21:275-8. 2009
    ..It is hypothesized that this effect on blood flow will improve success rates...
  3. pmc Overadjustment bias and unnecessary adjustment in epidemiologic studies
    Enrique F Schisterman
    Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Rockville, MD 20852, USA
    Epidemiology 20:488-95. 2009
    ..Overadjustment bias is not a finite sample bias, while inefficiencies due to control for unnecessary variables are a function of sample size...
  4. ncbi request reprint Invited commentary: simple models for a complicated reality
    Enrique F Schisterman
    Epidemiology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD
    Am J Epidemiol 164:312-4; discussion 315-6. 2006
  5. pmc Z-scores and the birthweight paradox
    Enrique F Schisterman
    Epidemiology Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Paediatr Perinat Epidemiol 23:403-13. 2009
    ....
  6. pmc Invited commentary: causation or "noitasuac"?
    Enrique Schisterman
    Epidemiology Branch, Division of Epidemiology, Statistics, and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland 20854, USA
    Am J Epidemiol 173:984-7; reply 988-9. 2011
    ..This creates a complex causal system that requires careful scrutiny. The methods presented here may be applicable to a wide range of studies that involve time-varying exposures and time-varying confounders...
  7. pmc Hybrid pooled-unpooled design for cost-efficient measurement of biomarkers
    Enrique F Schisterman
    Division of Epidemiology, Statistics and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH DHHS, Rockville, MD 20852, USA
    Stat Med 29:597-613. 2010
    ..Monte Carlo simulation and biomarker data from a study on coronary heart disease are used to demonstrate the proposed methodology...
  8. pmc The limitations due to exposure detection limits for regression models
    Enrique F Schisterman
    Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, 6100 Executive Boulevard, Rm 7B03, Rockville, MD 20852, USA
    Am J Epidemiol 163:374-83. 2006
    ..These results may inform decisions regarding analytical plans for future studies and provide a possible explanation for some amount of the discordance seen in extant literature...
  9. pmc Lipid adjustment in the analysis of environmental contaminants and human health risks
    Enrique F Schisterman
    Division of Epidemiology, Statistics and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland 20852, USA
    Environ Health Perspect 113:853-7. 2005
    ..g., nonfasting blood samples), laboratory measurement, and other underlying modeling assumptions when devising a statistical plan for assessing health outcomes in relation to environmental exposures...
  10. pmc Estimation of the correlation coefficient using the Bayesian Approach and its applications for epidemiologic research
    Enrique F Schisterman
    Division of Epidemiology, Statistics and Prevention National Institute of Child Health and Human Development National Institute of Health, Bethesda, MD, USA
    BMC Med Res Methodol 3:5. 2003
    ..The purpose of this paper is to illustrate the utility of the Bayesian approach for estimating correlations using prior knowledge...
  11. ncbi request reprint Minimal and best linear combination of oxidative stress and antioxidant biomarkers to discriminate cardiovascular disease
    E F Schisterman
    Department of Social and Preventive Medicine, University at Buffalo, Buffalo, NY 14214, USA
    Nutr Metab Cardiovasc Dis 12:259-66. 2002
    ..However, limited knowledge is available on how to combine these biomarkers to best discriminate between individuals with and without CHD...
  12. pmc Influence of endogenous reproductive hormones on F2-isoprostane levels in premenopausal women: the BioCycle Study
    Enrique F Schisterman
    Epidemiology Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, 6100 Executive Boulevard, 7B03M, Rockville, MD 20852, USA
    Am J Epidemiol 172:430-9. 2010
    ..If F(2)-isoprostanes are specific markers of oxidative stress, these results call into question the commonly held hypothesis that endogenous estradiol reduces oxidative stress...
  13. pmc To pool or not to pool, from whether to when: applications of pooling to biospecimens subject to a limit of detection
    Enrique F Schisterman
    Division of Epidemiology, Statistics and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, Rockville, MD 20852, USA
    Paediatr Perinat Epidemiol 22:486-96. 2008
    ..e. DT). Several Monte Carlo simulations and an example based on actual biomarker data illustrate the results of the article...
  14. pmc Energy-containing beverages: reproductive hormones and ovarian function in the BioCycle Study
    Karen C Schliep
    Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, USA
    Am J Clin Nutr 97:621-30. 2013
    ..Energy-containing beverages are widely consumed among premenopausal women, but their association with reproductive hormones is not well understood...
  15. pmc Relation of blood cadmium, lead, and mercury levels to biomarkers of lipid peroxidation in premenopausal women
    Anna Z Pollack
    Epidemiology Branch, Division of Epidemiology, Statistics, and PreventionResearch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, 6100 Executive Blvd, Rockville, MD 20852, USA
    Am J Epidemiol 175:645-52. 2012
    ..In this population of healthy premenopausal women with low exposure levels, cadmium, lead, and mercury were not associated with elevated lipid peroxidation biomarkers...
  16. pmc Habitual dietary isoflavone intake is associated with decreased C-reactive protein concentrations among healthy premenopausal women
    Amanda C Filiberto
    Division of Epidemiology, Statistics, and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Rockville, MD, USA
    J Nutr 143:900-6. 2013
    ..S. population are associated with decreased serum CRP concentrations, a factor associated with beneficial effects on inflammation, and subsequently may have the potential to improve health status among young women...
  17. pmc Heavy metals and couple fecundity, the LIFE Study
    Germaine M Buck Louis
    Division of Epidemiology, Statistics and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Rockville, MD 20852, United States
    Chemosphere 87:1201-7. 2012
    ..80; 95% CI 0.64, 1.00). This prospective couple based cohort with longitudinal capture of time to pregnancy is suggestive of cadmium and lead's reproductive toxicity at environmentally relevant concentrations...
  18. pmc The utility of menstrual cycle length as an indicator of cumulative hormonal exposure
    Sunni L Mumford
    Epidemiology Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, 6100 Executive Boulevard, 7B03, Rockville, Maryland 20852, USA
    J Clin Endocrinol Metab 97:E1871-9. 2012
    ..Associations between menstrual cycle length and chronic diseases are hypothesized to be due to differences in underlying hormonal patterns...
  19. doi request reprint Realignment and multiple imputation of longitudinal data: an application to menstrual cycle data
    Sunni L Mumford
    Division of Epidemiology, Statistics, and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Rockville, MD 20852, USA
    Paediatr Perinat Epidemiol 25:448-59. 2011
    ..Our method has applications in settings where missing data may occur over time, where daily blood sampling for hormonal measurements is not feasible, and in other areas where timing is essential...
  20. pmc Cholesterol, endocrine and metabolic disturbances in sporadic anovulatory women with regular menstruation
    Sunni L Mumford
    Epidemiology Branch, Division of Epidemiology, Statistics and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, DHHS, 6100 Executive Boulevard 7B03, Rockville, MD 20852, USA
    Hum Reprod 26:423-30. 2011
    ..The objective was to evaluate the association between lipoprotein cholesterol levels and endocrine and metabolic disturbances and incident anovulation among ovulatory and anovulatory women reporting regular menstruation...
  21. pmc Endogenous reproductive hormones and C-reactive protein across the menstrual cycle: the BioCycle Study
    Audrey J Gaskins
    Division of Epidemiology, Statistics, and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland, USA
    Am J Epidemiol 175:423-31. 2012
    ..4, 31.5). These results support the hypothesis that endogenous estradiol might have antiinflammatory effects and highlight the need for standardization of CRP measurement to menstrual cycle phase in reproductive-aged women...
  22. pmc Validation of different instruments for caffeine measurement among premenopausal women in the BioCycle study
    Karen C Schliep
    Epidemiology Branch, Division of Epidemiology, Statistics, and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Rockville, MD 20852, USA
    Am J Epidemiol 177:690-9. 2013
    ..Although caffeine and coffee exposures were highly correlated, absolute intakes differed significantly between measurement tools. These results highlight the importance of considering potential misclassification of caffeine exposure...
  23. pmc Menstrual bleeding patterns among regularly menstruating women
    Sonya S Dasharathy
    Epidemiology Branch, Division of Epidemiology, Statistics, and PreventionResearch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Rockville, MD 20852, USA
    Am J Epidemiol 175:536-45. 2012
    ..6 vs. 47.2 mL; P = 0.07). Study findings suggest that detailed characterizations of bleeding patterns may provide more insight than previously thought as noninvasive markers for endocrine status in a given cycle...
  24. pmc Effect of daily fiber intake on reproductive function: the BioCycle Study
    Audrey J Gaskins
    Division of Epidemiology, Statistics, and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, USA
    Am J Clin Nutr 90:1061-9. 2009
    ..The influence of fiber on aspects of reproduction, which include ovulation, has not been well studied in premenopausal women...
  25. pmc BioCycle study: design of the longitudinal study of the oxidative stress and hormone variation during the menstrual cycle
    Jean Wactawski-Wende
    Department of Social and Preventive Medicine, School of Public Health and Health Professions, University at Buffalo, Buffalo, NY 14214, USA
    Paediatr Perinat Epidemiol 23:171-84. 2009
    ..This report describes the study design, baseline characteristics and visit completion rate for the BioCycle study...
  26. pmc Longitudinal study of insulin resistance and sex hormones over the menstrual cycle: the BioCycle Study
    Edwina H Yeung
    Eunice Kennedy Shriver National Institute of Child Health and Human Development, Division of Epidemiology, Statistics, and Prevention Research, Epidemiology Branch, 6100 Executive Boulevard, Room 7B03, MSC 7510, Bethesda, Maryland 20892, USA
    J Clin Endocrinol Metab 95:5435-42. 2010
    ..Conflicting findings have been reported regarding the effect of menstrual cycle phase and sex hormones on insulin sensitivity...
  27. pmc Whole grains are associated with serum concentrations of high sensitivity C-reactive protein among premenopausal women
    Audrey J Gaskins
    Division of Epidemiology, Statistics, and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD 20852, USA
    J Nutr 140:1669-76. 2010
    ....
  28. doi request reprint Effect of daily fiber intake on luteinizing hormone levels in reproductive-aged women
    Audrey J Gaskins
    Division of Epidemiology, Statistics, and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, 6100 Executive Blvd, Rockville, MD 20852, USA
    Eur J Nutr 51:249-53. 2012
    ..To evaluate whether the association between fiber intake and LH levels is driven by the association between fiber and estradiol, or whether there is an independent association...
  29. pmc Maximum likelihood ratio tests for comparing the discriminatory ability of biomarkers subject to limit of detection
    Albert Vexler
    Division of Epidemiology, Statistics and Prevention Research, NICHD, NIH, Rockville, Maryland 20852, USA
    Biometrics 64:895-903. 2008
    ..We propose and examine the likelihood ratio tests with operating characteristics that are easily obtained by classical maximum likelihood methodology...
  30. pmc Adherence to a Mediterranean diet and plasma concentrations of lipid peroxidation in premenopausal women
    Audrey J Gaskins
    Division of Epidemiology, Statistics, and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, USA
    Am J Clin Nutr 92:1461-7. 2010
    ..A possible mechanism is through a decrease in lipid peroxidation (LPO); however, evidence linking the Mediterranean diet with lower LPO in premenopausal women is sparse...
  31. doi request reprint Designing prospective cohort studies for assessing reproductive and developmental toxicity during sensitive windows of human reproduction and development--the LIFE Study
    Germaine M Buck Louis
    Division of Epidemiology, Statistics and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Rockville, MD20852, USA
    Paediatr Perinat Epidemiol 25:413-24. 2011
    ..However, appropriately sized sampling frameworks are critical, given the small percentage of couples contacted found eligible and reportedly planning pregnancy at any point in time...
  32. pmc Effect of dietary fiber intake on lipoprotein cholesterol levels independent of estradiol in healthy premenopausal women
    Sunni L Mumford
    Epidemiology Branch, Division of Epidemiology, Statistics and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Rockville, Maryland, USA
    Am J Epidemiol 173:145-56. 2011
    ..These analyses suggested that estradiol mediates at least part of the association between fiber and cholesterol among premenopausal women. More research is needed to elucidate the biologic mechanisms driving these associations...
  33. pmc Youden Index and optimal cut-point estimated from observations affected by a lower limit of detection
    Marcus D Ruopp
    Division of Epidemiology, Statistics and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, DHHS, 6100 Executive Blvd, 7B03, Rockville Bethesda, MD, USA
    Biom J 50:419-30. 2008
    ..We address the limitations and usefulness of each method in order to give researchers guidance in constructing appropriate estimates of biomarkers' true discriminating capabilities...
  34. pmc A longitudinal study of serum lipoproteins in relation to endogenous reproductive hormones during the menstrual cycle: findings from the BioCycle study
    Sunni L Mumford
    Epidemiology Branch, Division of Epidemiology, Statistics, and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland 20852, USA
    J Clin Endocrinol Metab 95:E80-5. 2010
    ..Exogenous estrogens have been shown to affect the lipid profile, leading to the hypothesis that endogenous estrogens may have similar effects...
  35. pmc Generalized ROC curve inference for a biomarker subject to a limit of detection and measurement error
    Neil J Perkins
    Division of Epidemiology, Statistics and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, DHHS, 6100 Executive Blvd, Rm 7B03, Bethesda, MD 20852, U S A
    Stat Med 28:1841-60. 2009
    ..Our method is evaluated via simulation study and applied to two potential discriminators of women with and without preeclampsia...
  36. ncbi request reprint ROC analysis for markers with mass at zero
    Enrique F Schisterman
    Division of Epidemiology, Statistics and Prevention, NICHD, NIH, USA
    Stat Med 25:623-38. 2006
    ..We motivate this problem and illustrate the modelling approach using data on the coronary calcium score, measured by electron beam tomography, which is a marker for atherosclerosis...
  37. pmc Persistent environmental pollutants and couple fecundity: the LIFE study
    Germaine M Buck Louis
    Division of Epidemiology, Statistics and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland, USA
    Environ Health Perspect 121:231-6. 2013
    ..Evidence suggesting that persistent environmental pollutants may be reproductive toxicants underscores the need for prospective studies of couples for whom exposures are measured...
  38. pmc The impact of dietary folate intake on reproductive function in premenopausal women: a prospective cohort study
    Audrey J Gaskins
    Division of Epidemiology, Statistics, and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Rockville, Maryland, USA
    PLoS ONE 7:e46276. 2012
    ..Our objective was to evaluate the association between dietary folate intake, hormone levels, and sporadic anovulation in healthy, regularly menstruating women...
  39. pmc Caffeinated beverage intake and reproductive hormones among premenopausal women in the BioCycle Study
    Karen C Schliep
    Division of Epidemiology, Statistics, and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, USA
    Am J Clin Nutr 95:488-97. 2012
    ..Caffeinated beverages are widely consumed among women of reproductive age, but their association with reproductive hormones, and whether race modifies any such associations, is not well understood...
  40. pmc Cadmium, lead, and mercury in relation to reproductive hormones and anovulation in premenopausal women
    Anna Z Pollack
    Eunice Kennedy Shriver National Institute of Child Health and Human Development, Epidemiology Branch, Rockville, Maryland, USA
    Environ Health Perspect 119:1156-61. 2011
    ..Metals can interfere with hormonal functioning by binding at the receptor site and through indirect mechanisms; thus, they may be associated with hormonal changes in premenopausal women...
  41. ncbi request reprint Pooling biospecimens and limits of detection: effects on ROC curve analysis
    Sunni L Mumford
    Division of Epidemiology, Statistics and Prevention, NICHD, NIH, DHHS, Bethesda, MD 20892, USA
    Biostatistics 7:585-98. 2006
    ..In conclusion, pooling is the most efficient cost-cutting strategy when the LOD affects less than 50% of the data. However, when much more than 50% of the data are affected, utilization of the pooling design is not recommended...
  42. pmc Maternal serum granulocyte colony-stimulating factor levels and spontaneous preterm birth
    Brian W Whitcomb
    Epidemiology Branch, DESPR, NICHD, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Rockville, Maryland
    J Womens Health (Larchmt) 18:73-8. 2009
    ..G-CSF, a hematopoietic cytokine, mediates the increase in leukocytes in pregnancy and may play a role in placentation. We evaluated the association between maternal serum G-CSF in the first and second trimesters and PTB...
  43. pmc Energy expenditure and plasma F2-isoprostanes across the menstrual cycle
    Carole B Rudra
    Department of Social and Preventive Medicine, School of Public Health and Health Professions, University at Buffalo, Buffalo, NY 14214, USA
    Med Sci Sports Exerc 43:785-92. 2011
    ..Sparse evidence suggests that hormones that fluctuate during the menstrual cycle, particularly estrogens, may influence concentrations of oxidative biomarkers and their relation to energy expenditure...
  44. pmc Analytical and biological variation of biomarkers of oxidative stress during the menstrual cycle
    Richard W Browne
    Department of Biotechnical and Clinical Laboratory Sciences, University at Buffalo, State University of New York, NY 14214, USA
    Biomarkers 13:160-83. 2008
    ..These results provide important initial information on the variability of biomarkers of oxidative stress, antioxidant defence and micronutrients across the menstrual cycle...
  45. pmc Circulating levels of cytokines during pregnancy: thrombopoietin is elevated in miscarriage
    Brian W Whitcomb
    Epidemiology Branch, Division of Epidemiology, Statistics and Prevention Research, National Institute of Child Health and Human Development, National Insttutes of Health, Bethesda, Maryland 20852, USA
    Fertil Steril 89:1795-802. 2008
    ..To evaluate the hypothesis that cytokine levels are associated with miscarriage risk using serum samples collected before report of miscarriage...
  46. pmc Perceived stress and severity of perimenstrual symptoms: the BioCycle Study
    Audra L Gollenberg
    Division of Epidemiology, Statistics and Prevention Research, NICHD, NIH, DHHS, Bethesda, Maryland, USA
    J Womens Health (Larchmt) 19:959-67. 2010
    ..To examine the longitudinal relation between perceived stress in the previous month and perimenstrual symptom severity across two cycles among regularly menstruating, healthy women (n = 259)...
  47. pmc Linear regression with an independent variable subject to a detection limit
    Lei Nie
    Division of Biometrics IV, Office of Biometrics OTS CDER FDA, Silver Spring, MD, USA
    Epidemiology 21:S17-24. 2010
    ..2003;157:355-363), and Schisterman et al (Am J Epidemiol. 2006;163:374-383)...
  48. ncbi request reprint Efficient design and analysis of biospecimens with measurements subject to detection limit
    Albert Vexler
    Division of Epidemiology, Statistics and Prevention Research, National Institute of Child Health and Human Development, NIH DHHS, 6100 Executive Blvd, Rockville, MD 20852, USA
    Biom J 48:780-91. 2006
    ..Our investigation of three sampling strategies shows that, for a range of values of the detection limit, pooling is the most efficient sampling procedure. For certain other values of the detection limit, pooling can perform poorly...
  49. pmc Serum uric acid in relation to endogenous reproductive hormones during the menstrual cycle: findings from the BioCycle study
    Sunni L Mumford
    Epidemiology Branch, Division of Epidemiology, Statistics and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, DHHS, 6100 Executive Blvd 7B03, Rockville, MD 20852, USA
    Hum Reprod 28:1853-62. 2013
    ..Do uric acid levels across the menstrual cycle show associations with endogenous estradiol (E2) and reproductive hormone concentrations in regularly menstruating women?..
  50. doi request reprint ROC curve inference for best linear combination of two biomarkers subject to limits of detection
    Neil J Perkins
    Eunice Kennedy Shriver National Institute of Child Health and Human Development, Rockville, MD 20852, USA
    Biom J 53:464-76. 2011
    ..An example using polychlorinated biphenyl (PCB) levels to classify women with and without endometriosis illustrates the potential benefits of our methods...
  51. pmc Youden Index and the optimal threshold for markers with mass at zero
    Enrique F Schisterman
    Division of Epidemiology, Statistics and Prevention, NICHD, NIH, Rockville, MD, USA
    Stat Med 27:297-315. 2008
    ..We show how this modeling approach can be adjusted to take covariate information into account. This approach is applied to data on the Coronary Calcium Score, a marker for atherosclerosis...
  52. pmc Stress reduces conception probabilities across the fertile window: evidence in support of relaxation
    Germaine M Buck Louis
    Division of Epidemiology, Statistics, and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Rockville, Maryland 20852, USA
    Fertil Steril 95:2184-9. 2011
    ..To assess salivary stress biomarkers (cortisol and α-amylase) and female fecundity...
  53. ncbi request reprint Pregnancy outcomes in smokers who develop pre-eclampsia
    Lauren A Beste
    Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Paediatr Perinat Epidemiol 19:12-8. 2005
    ..In conclusion, among women who developed pre-eclampsia, smoking during pregnancy was not associated with disease severity. We found no evidence that pre-eclampsia and smoking act synergistically to restrict fetal growth...
  54. ncbi request reprint The Youden Index and the optimal cut-point corrected for measurement error
    Neil J Perkins
    Division of Epidemiology, Statistics and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
    Biom J 47:428-41. 2005
    ..This result may lead to biomarkers that were once naively considered ineffective becoming useful diagnostic devices...
  55. ncbi request reprint Two-stage elevation of cell-free fetal DNA in maternal sera before onset of preeclampsia
    Richard J Levine
    Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development, Department of Health and Human Services, Bethesda, MD, USA
    Am J Obstet Gynecol 190:707-13. 2004
    ..The purpose was to determine whether preeclampsia (PE) is caused by microfragments of syncytial trophoblast shed into the maternal circulation that stimulate an exaggerated inflammatory response...
  56. ncbi request reprint Receiver operating characteristic curve inference from a sample with a limit of detection
    Neil J Perkins
    Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
    Am J Epidemiol 165:325-33. 2007
    ..An example using polychlorinated biphenyl levels to classify women with and without endometriosis illustrates the potential benefits of these methods...
  57. pmc Nonparametric sequential evaluation of diagnostic biomarkers
    Aiyi Liu
    Biometry and Mathematical Statistics Branch, National Institute of Child Health and Human Development, Department of Health and Human Services, 6100 Executive Blvd, Rockville, MD 20852, U S A
    Stat Med 27:1667-78. 2008
    ..These procedures rely on the construction of a two-dimensional statistic of Whitehead (Statist. Med. 1999; 18:2271-2286) so that design methods based on Brownian motion can be applied...
  58. doi request reprint Pooling designs for outcomes under a Gaussian random effects model
    Yaakov Malinovsky
    Division of Epidemiology, Statistics, and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland 20892, USA
    Biometrics 68:45-52. 2012
    ..The design methodology is illustrated with a longitudinal study of premenopausal women focusing on assessing the reproducibility of F2-isoprostane, a biomarker of oxidative stress, over the menstrual cycle...
  59. ncbi request reprint Potential confounding by exposure history and prior outcomes: an example from perinatal epidemiology
    Penelope P Howards
    Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development, Bethesda, Maryland 20892, USA
    Epidemiology 18:544-51. 2007
    ..There is no single answer as to whether reproductive history should be included in the model; the decision depends on the research question and the underlying DAG...
  60. pmc Racial differences in the association between sex hormone-binding globulin and adiposity in premenopausal women: the BioCycle study
    Edwina H Yeung
    Epidemiology Branch, Division of Epidemiology, Statistics, and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA
    Diabetes Care 33:2274-6. 2010
    ..To assess the associations between measures of adiposity and sex hormone- binding globulin (SHBG) and to evaluate whether such associations differ by race...
  61. pmc Evidence of absence or absence of evidence? A reanalysis of the effects of low-dose aspirin in in vitro fertilization
    Marcus D Ruopp
    Division of Epidemiology, Statistics and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20852, USA
    Fertil Steril 90:71-6. 2008
    ..We present a reanalysis of the effects of low-dose aspirin in IVF and raise methodological questions regarding the analysis by Gelbaya et al...
  62. ncbi request reprint Multistage evaluation of measurement error in a reliability study
    Aiyi Liu
    Division of Epidemiology, Statistics and Prevention Research, National Institute of Child Health and Human Development, NIH DHHS, 6100 Executive Boulevard, Rockville, Maryland 20852, USA
    Biometrics 62:1190-6. 2006
    ..Methods are developed and critical values tabulated for a number of two-stage designs. The methods are exemplified using an example evaluating the reliability of biomarkers associated with oxidative stress...
  63. ncbi request reprint On linear combinations of biomarkers to improve diagnostic accuracy
    Aiyi Liu
    Division of Epidemiology, Statistics and Prevention Research, National Institute of Child Health and Human Development, Department of Health and Human Services, 6100 Executive Blvd, Rockville, MD 20852, USA
    Stat Med 24:37-47. 2005
    ..We then derive alternative linear combinations that have higher sensitivity over a range of high (or low) specificity. The methods are illustrated using data from a study evaluating biomarkers for coronary heart disease...
  64. ncbi request reprint Power and sample size calculation of comparative diagnostic accuracy studies with multiple correlated test results
    Aiyi Liu
    Division of Epidemiology, Statistics and Prevention Research, National Institute of Child Health and Human Development, Department of Health and Human Services, 6100 Executive Blvd, Rockville, MD 20852, USA
    Biom J 47:140-50. 2005
    ..We derive test statistics and obtain power and sample size formulas. The methods are illustrated using an example of comparison of CT and PET scanner for detecting extra-hepatic disease for colorectal cancer...
  65. ncbi request reprint Glucose tolerance and risk of gestational diabetes mellitus in nulliparous women who smoke during pregnancy
    Lucinda J England
    Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development, Department of Health and Human Services, Bethesda, MD, USA
    Am J Epidemiol 160:1205-13. 2004
    ..9, 95% confidence interval: 1.0, 3.6). These findings support an association between smoking and gestational diabetes mellitus...
  66. ncbi request reprint Circulating chemokine levels and miscarriage
    Brian W Whitcomb
    Epidemiology Branch, Division of Epidemiology, Statistics and Prevention Research, National Institute of Child Health and Human Development, Bethesda, MD, USA
    Am J Epidemiol 166:323-31. 2007
    ..The observation regarding ENA-78, which has roles in regulation of angiogenesis and leukocyte recruitment, suggests a possible role for this chemokine as an early indicator of miscarriage risk...
  67. pmc The effect of lipid adjustment on the analysis of environmental contaminants and the outcome of human health risks
    Audrey J Gaskins
    Division of Epidemiology, Statistics and Prevention Research, Eunice Kennedy Schriver National Institute of Child Health and Human Development, NIH, Rockville, MD, USA
    Methods Mol Biol 580:371-81. 2009
    ....
  68. ncbi request reprint Analysis of repeated pregnancy outcomes
    Germaine Buck Louis
    Division of Epidemiology, Statistics and Prevention Research, National Institute of Child Health and Human Development, 6100 Executive Blvd, Room 7B03, Rockville, MD 20852, USA
    Stat Methods Med Res 15:103-26. 2006
    ..We illustrate the issues by analysing a sample from the Collaborative Perinatal Project dataset, demonstrating how the statistical model impacts summary statistics and inferences when assessing etiologic determinants of birth weight...
  69. pmc Estimation of ROC curves based on stably distributed biomarkers subject to measurement error and pooling mixtures
    Albert Vexler
    National Institute of Child Health and Human Development, USA
    Stat Med 27:280-96. 2008
    ..The obtained methods are illustrated by applications to real data studies...
  70. pmc Timing clinic visits to phases of the menstrual cycle by using a fertility monitor: the BioCycle Study
    Penelope P Howards
    Division of Epidemiology, Statistics, and Prevention Research, the Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland, USA
    Am J Epidemiol 169:105-12. 2009
    ..Fertility monitors appear to be useful in timing clinic visits in a compliant population with flexible schedules...
  71. pmc Age at menarche and metabolic markers for type 2 diabetes in premenopausal women: the BioCycle Study
    Liwei Chen
    Department of Epidemiology, School of Public Health, Louisiana State University Health Science Center, New Orleans, Louisiana 70112, USA
    J Clin Endocrinol Metab 96:E1007-12. 2011
    ..Early age at menarche has been linked to an elevated risk of type 2 diabetes. However, the underlying mechanism is unclear...
  72. ncbi request reprint Circulating angiogenic factors and the risk of preeclampsia
    Richard J Levine
    Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development, Department of Health and Human Services, Bethesda, MD 20892, USA
    N Engl J Med 350:672-83. 2004
    ..Limited data suggest that excess circulating soluble fms-like tyrosine kinase 1 (sFlt-1), which binds placental growth factor (PlGF) and vascular endothelial growth factor (VEGF), may have a pathogenic role...
  73. ncbi request reprint Adjusting the generalized ROC curve for covariates
    Enrique F Schisterman
    Division of Epidemiology, Statistics and Prevention, NICHD, NIH, USA
    Stat Med 23:3319-31. 2004
    ..An example of two biomarkers of coronary heart disease for which covariate information on age and gender is available is used to illustrate this methodology...
  74. pmc Assays with lower detection limits: implications for epidemiological investigations
    Brian W Whitcomb
    Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, Rockville, MD 20852, USA
    Paediatr Perinat Epidemiol 22:597-602. 2008
    ....
  75. pmc The use and misuse of matching in case-control studies: the example of polycystic ovary syndrome
    Michael S Bloom
    Epidemiology Branch, Division of Epidemiology Statistics and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, U S Department of Health and Human Services, Bethesda, Maryland 20892, USA
    Fertil Steril 88:707-10. 2007
    ....
  76. pmc Maternal serum polychlorinated biphenyl concentrations across critical windows of human development
    Michael S Bloom
    Epidemiology Branch, Division of Epidemiology, Statistics and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    Environ Health Perspect 115:1320-4. 2007
    ..Few data are available on polychlorinated biphenyl (PCB) concentrations over critical windows of human reproduction and development inclusive of the periconception window...
  77. pmc The inconsistency of "optimal" cutpoints obtained using two criteria based on the receiver operating characteristic curve
    Neil J Perkins
    Division of Epidemiology, Statistics and Prevention Research, National Institute of Child Health and Human Development, Bethesda, MD 20852, USA
    Am J Epidemiol 163:670-5. 2006
    ..In conclusion, the authors urge that great care be taken when establishing a biomarker cutpoint for clinical use...
  78. ncbi request reprint Selecting controls is not selecting "normals": design and analysis issues for studying the etiology of polycystic ovary syndrome
    Michael S Bloom
    Epidemiology Branch, Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development, Bethesda, Maryland, USA
    Fertil Steril 86:1-12. 2006
    ..However, a review of the literature suggested that inconsistency of research findings in relation to the etiology of PCOS might be, in part, due to the different choice of controls for case-control design and application...
  79. ncbi request reprint Environmental PCB exposure and risk of endometriosis
    G M Buck Louis
    Epidemiology Branch, Division of Epidemiology, Statistics and Prevention Research, National Institute of Child Health and Human Development, Rockville, MD 20852, USA
    Hum Reprod 20:279-85. 2005
    ..Hormonally active environmental agents have recently been associated with the development of endometriosis...
  80. pmc Long term cognitive development in children with prolonged crying
    M R Rao
    Epidemiology Branch, Division of Epidemiology, Statistics and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA
    Arch Dis Child 89:989-92. 2004
    ..Long term studies of cognitive development and colic have not differentiated between typical colic and prolonged crying...
  81. ncbi request reprint Oxidative stress and endometriosis
    L W Jackson
    Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Rockville, MD 20852, USA
    Hum Reprod 20:2014-20. 2005
    ..Within a study investigating persistent organic compounds and endometriosis, the authors evaluated the association between oxidative stress and endometriosis...
  82. ncbi request reprint Polychlorinated biphenyls, cytochrome P4501A1 polymorphism, and postmenopausal breast cancer risk
    K B Moysich
    Department of Social and Preventive Medicine, SUNY Buffalo, New York 14214, USA
    Cancer Epidemiol Biomarkers Prev 8:41-4. 1999
    ..These results should be considered preliminary, pending replication by other studies...
  83. ncbi request reprint TBARS and cardiovascular disease in a population-based sample
    E F Schisterman
    Department of Social and Preventive Medicine, School of Medicine and Biomedical Sciences, University at Buffalo, New York, USA
    J Cardiovasc Risk 8:219-25. 2001
    ..However, there is no strong indication that circulating levels of TBARS are increased in patients with atherosclerosis...
  84. ncbi request reprint Statistical inference for the area under the receiver operating characteristic curve in the presence of random measurement error
    E F Schisterman
    Department of Social and Preventive Medicine, University at Buffalo, Buffalo, NY, USA
    Am J Epidemiol 154:174-9. 2001
    ..A simulation study was used to check the validity of the proposed confidence interval. Furthermore, it was shown that not adjusting for measurement error could result in a serious understatement of the effectiveness of the biomarker...
  85. pmc Conditioning on intermediates in perinatal epidemiology
    Tyler J VanderWeele
    Departments of Epidemiology and Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA
    Epidemiology 23:1-9. 2012
    ..The various methodologic approaches described in this paper are applicable to a number of similar settings in perinatal epidemiology...
  86. ncbi request reprint Statistical analysis. Receiver operating characteristic (ROC) curve and lipid peroxidation
    Enrique F Schisterman
    Division of Epidemiology, Statistics and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, Rockville, MD, USA
    Methods Mol Biol 196:343-52. 2002
  87. ncbi request reprint An evaluation of proposed frameworks for grouping polychlorinated biphenyl (PCB) congener data into meaningful analytic units
    K B Moysich
    Department of Cancer Prevention, Epidemiology, and Biostatistics, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Am J Ind Med 35:223-31. 1999
    ..However, to date there are no established frameworks for grouping a large number of PCB congeners into meaningful analytic units...
  88. ncbi request reprint Apolipoprotein E genetic polymorphism, serum lipoproteins, and breast cancer risk
    K B Moysich
    Department of Cancer Prevention, Epidemiology, and Biostatistics, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Mol Carcinog 27:2-9. 2000
    ..69; 95% CI=1. 49-14.7). These data suggest that the apoE4 genotype may modify the association between serum triglycerides and breast cancer risk...
  89. ncbi request reprint Environmental organochlorine exposure and postmenopausal breast cancer risk
    K B Moysich
    Department of Social and Preventive Medicine, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, 14214, USA
    Cancer Epidemiol Biomarkers Prev 7:181-8. 1998
    ..Future studies should consider lactation history of participants, as well as use similar epidemiological and laboratory methodologies, to ensure comparability of results across studies...
  90. ncbi request reprint Extreme prematurity and school outcomes
    G M Buck
    Department of Social and Preventive Medicine, School of Medicine and Biomedical Sciences, University at Buffalo, NY 14214, USA
    Paediatr Perinat Epidemiol 14:324-31. 2000
    ..These findings suggest that survivors of extreme prematurity remain at risk of educational underachievement...
  91. ncbi request reprint Misclassification of maternal smoking status and its effects on an epidemiologic study of pregnancy outcomes
    Lucinda J England
    Division of Reproductive Health, Centers for Disease Control and Prevention, Atlanta, GA, USA
    Nicotine Tob Res 9:1005-13. 2007
    ..The potential for this type of bias should be considered when conducting and interpreting epidemiologic studies of smoking and pregnancy outcomes...
  92. ncbi request reprint ROC curve analysis for biomarkers based on pooled assessments
    David Faraggi
    Department of Statistics, University of Haifa, Haifa, Israel
    Stat Med 22:2515-27. 2003
    ..We measure loss of information by means of the change in root mean square error of the estimate of the area under the ROC curve and study the extent of this loss via a simulation study...
  93. ncbi request reprint Statistical correction of the area under the ROC curve in the presence of random measurement error and applications to biomarkers of oxidative stress
    Enrique F Schisterman
    UCLA School of Public Health, Cedars Sinai Medical Center, Los Angeles, CA, USA
    Methods Mol Biol 186:313-7. 2002
  94. ncbi request reprint The association of hormone replacement therapy and coronary calcium as determined by electron beam tomography
    Enrique F Schisterman
    Departments of Imaging Division of Nuclear Medicine, Burns and Allen Research Institute, Cedars Sinai Medical Center, Los Angeles, CA, USA
    J Womens Health Gend Based Med 11:631-8. 2002
    ..Examination of the association between coronary calcium (CC), a marker of atherosclerotic plaque burden, and the use of HRT in postmenopausal women may help address this paradox...
  95. ncbi request reprint The birth weight "paradox" uncovered?
    Sonia Hernandez-Diaz
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Epidemiol 164:1115-20. 2006
    ..An appropriate justification for conditioning on birth weight requires specifying 1) the causal question motivating this analytical approach and 2) the assumptions regarding the proposed underlying biologic mechanisms...
  96. ncbi request reprint Trying to avoid bias in case-control and case-cohort studies
    Enrique F Schisterman
    Fertil Steril 80:1537-8; author reply 1538. 2003
  97. ncbi request reprint Units of analysis-matched pairs, single patient, or cycles?
    Brian W Whitcomb
    Fertil Steril 82:987-8; author reply 988. 2004
  98. ncbi request reprint Gestational age and gestational age-at-delivery: cause, effect, or time-scale?
    Brian W Whitcomb
    Hum Reprod 22:3267. 2007
  99. ncbi request reprint Maternal plasma cellular fibronectin for early prediction of preeclampsia
    Jun Zhang
    Am J Obstet Gynecol 189:1212. 2003
  100. pmc Monitoring quality control: can we get better data?
    Ofer Harel
    Department of Statistics, University of Connecticut, Storrs, CT, USA
    Epidemiology 19:621-7. 2008
    ..The proposed methodology may help investigators to identify data quality problems that can be corrected while data are still being collected, and also to identify biases in data collection that might be adjusted later...
  101. ncbi request reprint Measurement error! Communication between content experts and statisticians
    Enrique F Schisterman
    Fertil Steril 82:514-5; author reply 515; discussion 515-6. 2004