Research Topics
Genomes and Genes | William P SchiemannSummaryAffiliation: National Jewish Medical and Research Center Country: USA Publications
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Detail Information
Publications
Cloning of a novel signaling molecule, AMSH-2, that potentiates transforming growth factor beta signalingNieves Ibarrola
McKusick Nathans Institute of Genetic Medicine and Department of Biological Chemistry, Johns Hopkins University, Baltimore, MD 21205, USA
BMC Cell Biol 5:2. 2004..Signaling by these factors is mediated chiefly by the Smad family of latent transcription factors...
Transforming growth factor-beta (TGF-beta)-resistant B cells from chronic lymphocytic leukemia patients contain recurrent mutations in the signal sequence of the type I TGF-beta receptorWilliam P Schiemann
Department of Pediatrics, Program in Cell Biology, National Jewish Medical and Research Center, Goodman Building, K1011, 1400 Jackson Street, Denver, CO 80206, USA
Cancer Detect Prev 28:57-64. 2004..Our results demonstrate that TGF-beta-resistant B-CLL is linked to signal sequence mutations within the TbetaR-I gene, and may eventually be employed as a prognostic indicator in B-CLL...- Context-specific effects of fibulin-5 (DANCE/EVEC) on cell proliferation, motility, and invasion. Fibulin-5 is induced by transforming growth factor-beta and affects protein kinase cascadesWilliam P Schiemann
Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
J Biol Chem 277:27367-77. 2002..Our findings also indicate that aberrant FBLN-5 expression likely contributes to tumor development in humans... 
SPARC inhibits epithelial cell proliferation in part through stimulation of the transforming growth factor-beta-signaling systemBarbara J Schiemann
Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
Mol Biol Cell 14:3977-88. 2003....- Fibulin-5 antagonizes vascular endothelial growth factor (VEGF) signaling and angiogenic sprouting by endothelial cellsAllan R Albig
Program in Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado, USA
DNA Cell Biol 23:367-79. 2004..Collectively, our findings establish FBLN-5 as a novel antagonist of angiogenesis and endothelial cell activities, and offer new insights into why tumorigenesis downregulates FBLN-5 expression... - Transcriptional and translational regulation of TGF-beta production in response to apoptotic cellsYi Qun Xiao
Program in Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
J Immunol 181:3575-85. 2008..Strikingly, these induction pathways for TGF-beta production were different from those initiated in the same cells responding to LPS or PMA... - Identification and characterization of regulator of G protein signaling 4 (RGS4) as a novel inhibitor of tubulogenesis: RGS4 inhibits mitogen-activated protein kinases and vascular endothelial growth factor signalingAllan R Albig
Program in Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
Mol Biol Cell 16:609-25. 2005.... - Fibulin-5 function during tumorigenesisAllan R Albig
Department of Pediatrics, National Jewish Medical and Research Center, Goodman Building K1011, 1400 Jackson Street, Denver, CO 80206, USA
Future Oncol 1:23-35. 2005..Here, the tumor suppressing activities of fibulin-5 are reviewed, and the potential use and targeting of fibulin-5 to combat growth and metastasis of human malignancies is discussed... - Fibulins 3 and 5 antagonize tumor angiogenesis in vivoAllan R Albig
Program in Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
Cancer Res 66:2621-9. 2006.... - The use of cystatin C to inhibit epithelial-mesenchymal transition and morphological transformation stimulated by transforming growth factor-betaJonathan P Sokol
Program in Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO, USA
Breast Cancer Res 7:R844-53. 2005..We hypothesized that the oncogenic activities of TGF-beta, particularly its stimulation of mammary epithelial-mesenchymal transition (EMT), can be prevented by CystC... - Cystatin C antagonizes transforming growth factor beta signaling in normal and cancer cellsJonathan P Sokol
Program in Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
Mol Cancer Res 2:183-95. 2004..Collectively, our findings have identified CystC as a novel TGF-beta receptor antagonist, as well as a novel CystC-mediated feedback loop that inhibits TGF-beta signaling... - p130Cas is required for mammary tumor growth and transforming growth factor-beta-mediated metastasis through regulation of Smad2/3 activityMichael K Wendt
Department of Pharmacology, University of Colorado, Denver, Anschutz Medical Campus, Aurora, Colorado 80045, USA
J Biol Chem 284:34145-56. 2009.... - Pigment epithelium-derived factor in idiopathic pulmonary fibrosis: a role in aberrant angiogenesisGregory P Cosgrove
Pulmonary Division, Department of Medicine, National Jewish Medical and Research Center and Program in Cell Biology, Department of Pediatrics, University of Colorado Health Sciences Center, Denver, Colorado CO 80206, USA
Am J Respir Crit Care Med 170:242-51. 2004..Using 3T3-L1 fibroblasts and human lung fibroblasts, we showed that PEDF was indeed a TGF-beta 1 target gene. Collectively, our findings implicate PEDF as a regulator of pulmonary angiogenesis and an important mediator in IPF... - TGF-beta in cancer and other diseasesJason R Neil
Department of Pharmacology, University of Colorado Health Sciences Center, Aurora, Colorado 80206, USA
Future Oncol 2:185-9. 2006 - Cross-talk between ERK and p38 MAPK mediates selective suppression of pro-inflammatory cytokines by transforming growth factor-betaYi Qun Xiao
Program in Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
J Biol Chem 277:14884-93. 2002..Our data provide evidence that TGF-beta selectively inhibits inflammatory cytokine production through cross-talk between MAPKs... - Microfibril-associate glycoprotein-2 (MAGP-2) promotes angiogenic cell sprouting by blocking notch signaling in endothelial cellsAllan R Albig
Department of Life Sciences, 600 Chestnut St, Indiana State University, Terre Haute, IN 47809, USA
Microvasc Res 76:7-14. 2008..Collectively, these observations indicate that MAGP-2 promotes angiogenic cell spouting in vitro by antagonizing Notch signaling pathways in ECs... - Grb2 binding to Tyr284 in TbetaR-II is essential for mammary tumor growth and metastasis stimulated by TGF-betaAmy J Galliher-Beckley
Department of Pharmacology, University of Colorado Health Sciences Center, Aurora, CO 80045, USA
Carcinogenesis 29:244-51. 2008.... - Transcriptome analysis of endothelial cell gene expression induced by growth on matrigel matrices: identification and characterization of MAGP-2 and lumican as novel regulators of angiogenesisAllan R Albig
Department of Pharmacology, University of Colorado Health Sciences Center, RC1 South Tower, Room L18 6110, 12801 East 17th Avenue, P O Box 6511, Aurora, CO 80045, USA
Angiogenesis 10:197-216. 2007.... - Src phosphorylates Tyr284 in TGF-beta type II receptor and regulates TGF-beta stimulation of p38 MAPK during breast cancer cell proliferation and invasionAmy J Galliher
Department of Pharmacology, University of Colorado Health Sciences Center, 12801 East 17th Avenue, Aurora, CO 80045, USA
Cancer Res 67:3752-8. 2007.... - Beta3 integrin and Src facilitate transforming growth factor-beta mediated induction of epithelial-mesenchymal transition in mammary epithelial cellsAmy J Galliher
UCHSC, Fitzsimons Campus, Department of Pharmacology, Mail Stop 8303, RC1 South Tower, Rm L18 6110, PO Box 6511, Aurora, CO 80045, USA
Breast Cancer Res 8:R42. 2006..The molecular mechanisms underlying this conversion of TGF-beta function remain poorly understood but may involve signaling inputs from integrins... - Fibulin-5 promotes wound healing in vivoMichael J Lee
Division of Plastic and Reconstructive Surgery, Department of Surgery, Northwestern University, Chicago, IL, USA
J Am Coll Surg 199:403-10. 2004..Our findings also demonstrate a novel role for fibulin-5 and suggest that altering extracellular matrix protein production through gene therapy may provide a novel means to promote wound healing... - Fibulin-2 and fibulin-5 alterations in tsk mice associated with disorganized hypodermal elastic fibers and skin tetheringRaphael Lemaire
The Arthritis Center, Boston University School of Medicine, Boston, Massachusetts, USA
J Invest Dermatol 123:1063-9. 2004.... - Role of transforming growth factor-beta in cancer progressionAmy J Galliher
University of Colorado Health Sciences Center, Department of Pharmacology, Aurora, Colorado 80045, USA
Future Oncol 2:743-63. 2006.... - Targeted TGF-beta chemotherapies: friend or foe in treating human malignancies?William P Schiemann
Expert Rev Anticancer Ther 7:609-11. 2007 - Apoptotic cells, through transforming growth factor-beta, coordinately induce anti-inflammatory and suppress pro-inflammatory eicosanoid and NO synthesis in murine macrophagesCelio G Freire-de-Lima
, Federal University of Rio de Janeiro, Rio de Janeiro RJ 21944-970, Brazil
J Biol Chem 281:38376-84. 2006..These results strongly suggest that the apoptotic cell inhibition of pro-inflammatory mediator production is pleiotropic and significantly dependent on the stimulation of TGF-beta production... - Altered TAB1:I kappaB kinase interaction promotes transforming growth factor beta-mediated nuclear factor-kappaB activation during breast cancer progressionJason R Neil
Department of Pharmacology, University of Colorado Health Sciences Center, Aurora, CO 80045, USA
Cancer Res 68:1462-70. 2008..Collectively, our findings have defined a novel TAB1:TAK1:IKK beta:NF-kappaB signaling axis that forms aberrantly in breast cancer cells and, consequently, enables oncogenic signaling by TGF-beta... - Development of human protein reference database as an initial platform for approaching systems biology in humansSuraj Peri
McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University, Baltimore, Maryland 21287, USA
Genome Res 13:2363-71. 2003..hprd.org to the academic community. This unified bioinformatics platform will be useful in cataloging and mining the large number of proteomic interactions and alterations that will be discovered in the postgenomic era...