William P Schiemann

Summary

Affiliation: National Jewish Medical and Research Center
Country: USA

Publications

  1. pmc Cloning of a novel signaling molecule, AMSH-2, that potentiates transforming growth factor beta signaling
    Nieves Ibarrola
    McKusick Nathans Institute of Genetic Medicine and Department of Biological Chemistry, Johns Hopkins University, Baltimore, MD 21205, USA
    BMC Cell Biol 5:2. 2004
  2. ncbi request reprint Transforming growth factor-beta (TGF-beta)-resistant B cells from chronic lymphocytic leukemia patients contain recurrent mutations in the signal sequence of the type I TGF-beta receptor
    William P Schiemann
    Department of Pediatrics, Program in Cell Biology, National Jewish Medical and Research Center, Goodman Building, K1011, 1400 Jackson Street, Denver, CO 80206, USA
    Cancer Detect Prev 28:57-64. 2004
  3. ncbi request reprint Context-specific effects of fibulin-5 (DANCE/EVEC) on cell proliferation, motility, and invasion. Fibulin-5 is induced by transforming growth factor-beta and affects protein kinase cascades
    William P Schiemann
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    J Biol Chem 277:27367-77. 2002
  4. pmc SPARC inhibits epithelial cell proliferation in part through stimulation of the transforming growth factor-beta-signaling system
    Barbara J Schiemann
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    Mol Biol Cell 14:3977-88. 2003
  5. ncbi request reprint Fibulin-5 antagonizes vascular endothelial growth factor (VEGF) signaling and angiogenic sprouting by endothelial cells
    Allan R Albig
    Program in Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado, USA
    DNA Cell Biol 23:367-79. 2004
  6. pmc Transcriptional and translational regulation of TGF-beta production in response to apoptotic cells
    Yi Qun Xiao
    Program in Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Immunol 181:3575-85. 2008
  7. pmc Identification and characterization of regulator of G protein signaling 4 (RGS4) as a novel inhibitor of tubulogenesis: RGS4 inhibits mitogen-activated protein kinases and vascular endothelial growth factor signaling
    Allan R Albig
    Program in Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    Mol Biol Cell 16:609-25. 2005
  8. ncbi request reprint Fibulin-5 function during tumorigenesis
    Allan R Albig
    Department of Pediatrics, National Jewish Medical and Research Center, Goodman Building K1011, 1400 Jackson Street, Denver, CO 80206, USA
    Future Oncol 1:23-35. 2005
  9. ncbi request reprint Fibulins 3 and 5 antagonize tumor angiogenesis in vivo
    Allan R Albig
    Program in Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    Cancer Res 66:2621-9. 2006
  10. pmc The use of cystatin C to inhibit epithelial-mesenchymal transition and morphological transformation stimulated by transforming growth factor-beta
    Jonathan P Sokol
    Program in Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO, USA
    Breast Cancer Res 7:R844-53. 2005

Collaborators

Detail Information

Publications27

  1. pmc Cloning of a novel signaling molecule, AMSH-2, that potentiates transforming growth factor beta signaling
    Nieves Ibarrola
    McKusick Nathans Institute of Genetic Medicine and Department of Biological Chemistry, Johns Hopkins University, Baltimore, MD 21205, USA
    BMC Cell Biol 5:2. 2004
    ..Signaling by these factors is mediated chiefly by the Smad family of latent transcription factors...
  2. ncbi request reprint Transforming growth factor-beta (TGF-beta)-resistant B cells from chronic lymphocytic leukemia patients contain recurrent mutations in the signal sequence of the type I TGF-beta receptor
    William P Schiemann
    Department of Pediatrics, Program in Cell Biology, National Jewish Medical and Research Center, Goodman Building, K1011, 1400 Jackson Street, Denver, CO 80206, USA
    Cancer Detect Prev 28:57-64. 2004
    ..Our results demonstrate that TGF-beta-resistant B-CLL is linked to signal sequence mutations within the TbetaR-I gene, and may eventually be employed as a prognostic indicator in B-CLL...
  3. ncbi request reprint Context-specific effects of fibulin-5 (DANCE/EVEC) on cell proliferation, motility, and invasion. Fibulin-5 is induced by transforming growth factor-beta and affects protein kinase cascades
    William P Schiemann
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    J Biol Chem 277:27367-77. 2002
    ..Our findings also indicate that aberrant FBLN-5 expression likely contributes to tumor development in humans...
  4. pmc SPARC inhibits epithelial cell proliferation in part through stimulation of the transforming growth factor-beta-signaling system
    Barbara J Schiemann
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    Mol Biol Cell 14:3977-88. 2003
    ....
  5. ncbi request reprint Fibulin-5 antagonizes vascular endothelial growth factor (VEGF) signaling and angiogenic sprouting by endothelial cells
    Allan R Albig
    Program in Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado, USA
    DNA Cell Biol 23:367-79. 2004
    ..Collectively, our findings establish FBLN-5 as a novel antagonist of angiogenesis and endothelial cell activities, and offer new insights into why tumorigenesis downregulates FBLN-5 expression...
  6. pmc Transcriptional and translational regulation of TGF-beta production in response to apoptotic cells
    Yi Qun Xiao
    Program in Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Immunol 181:3575-85. 2008
    ..Strikingly, these induction pathways for TGF-beta production were different from those initiated in the same cells responding to LPS or PMA...
  7. pmc Identification and characterization of regulator of G protein signaling 4 (RGS4) as a novel inhibitor of tubulogenesis: RGS4 inhibits mitogen-activated protein kinases and vascular endothelial growth factor signaling
    Allan R Albig
    Program in Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    Mol Biol Cell 16:609-25. 2005
    ....
  8. ncbi request reprint Fibulin-5 function during tumorigenesis
    Allan R Albig
    Department of Pediatrics, National Jewish Medical and Research Center, Goodman Building K1011, 1400 Jackson Street, Denver, CO 80206, USA
    Future Oncol 1:23-35. 2005
    ..Here, the tumor suppressing activities of fibulin-5 are reviewed, and the potential use and targeting of fibulin-5 to combat growth and metastasis of human malignancies is discussed...
  9. ncbi request reprint Fibulins 3 and 5 antagonize tumor angiogenesis in vivo
    Allan R Albig
    Program in Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    Cancer Res 66:2621-9. 2006
    ....
  10. pmc The use of cystatin C to inhibit epithelial-mesenchymal transition and morphological transformation stimulated by transforming growth factor-beta
    Jonathan P Sokol
    Program in Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO, USA
    Breast Cancer Res 7:R844-53. 2005
    ..We hypothesized that the oncogenic activities of TGF-beta, particularly its stimulation of mammary epithelial-mesenchymal transition (EMT), can be prevented by CystC...
  11. ncbi request reprint Cystatin C antagonizes transforming growth factor beta signaling in normal and cancer cells
    Jonathan P Sokol
    Program in Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    Mol Cancer Res 2:183-95. 2004
    ..Collectively, our findings have identified CystC as a novel TGF-beta receptor antagonist, as well as a novel CystC-mediated feedback loop that inhibits TGF-beta signaling...
  12. pmc p130Cas is required for mammary tumor growth and transforming growth factor-beta-mediated metastasis through regulation of Smad2/3 activity
    Michael K Wendt
    Department of Pharmacology, University of Colorado, Denver, Anschutz Medical Campus, Aurora, Colorado 80045, USA
    J Biol Chem 284:34145-56. 2009
    ....
  13. ncbi request reprint Pigment epithelium-derived factor in idiopathic pulmonary fibrosis: a role in aberrant angiogenesis
    Gregory P Cosgrove
    Pulmonary Division, Department of Medicine, National Jewish Medical and Research Center and Program in Cell Biology, Department of Pediatrics, University of Colorado Health Sciences Center, Denver, Colorado CO 80206, USA
    Am J Respir Crit Care Med 170:242-51. 2004
    ..Using 3T3-L1 fibroblasts and human lung fibroblasts, we showed that PEDF was indeed a TGF-beta 1 target gene. Collectively, our findings implicate PEDF as a regulator of pulmonary angiogenesis and an important mediator in IPF...
  14. ncbi request reprint TGF-beta in cancer and other diseases
    Jason R Neil
    Department of Pharmacology, University of Colorado Health Sciences Center, Aurora, Colorado 80206, USA
    Future Oncol 2:185-9. 2006
  15. ncbi request reprint Cross-talk between ERK and p38 MAPK mediates selective suppression of pro-inflammatory cytokines by transforming growth factor-beta
    Yi Qun Xiao
    Program in Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    J Biol Chem 277:14884-93. 2002
    ..Our data provide evidence that TGF-beta selectively inhibits inflammatory cytokine production through cross-talk between MAPKs...
  16. pmc Microfibril-associate glycoprotein-2 (MAGP-2) promotes angiogenic cell sprouting by blocking notch signaling in endothelial cells
    Allan R Albig
    Department of Life Sciences, 600 Chestnut St, Indiana State University, Terre Haute, IN 47809, USA
    Microvasc Res 76:7-14. 2008
    ..Collectively, these observations indicate that MAGP-2 promotes angiogenic cell spouting in vitro by antagonizing Notch signaling pathways in ECs...
  17. pmc Grb2 binding to Tyr284 in TbetaR-II is essential for mammary tumor growth and metastasis stimulated by TGF-beta
    Amy J Galliher-Beckley
    Department of Pharmacology, University of Colorado Health Sciences Center, Aurora, CO 80045, USA
    Carcinogenesis 29:244-51. 2008
    ....
  18. ncbi request reprint Transcriptome analysis of endothelial cell gene expression induced by growth on matrigel matrices: identification and characterization of MAGP-2 and lumican as novel regulators of angiogenesis
    Allan R Albig
    Department of Pharmacology, University of Colorado Health Sciences Center, RC1 South Tower, Room L18 6110, 12801 East 17th Avenue, P O Box 6511, Aurora, CO 80045, USA
    Angiogenesis 10:197-216. 2007
    ....
  19. ncbi request reprint Src phosphorylates Tyr284 in TGF-beta type II receptor and regulates TGF-beta stimulation of p38 MAPK during breast cancer cell proliferation and invasion
    Amy J Galliher
    Department of Pharmacology, University of Colorado Health Sciences Center, 12801 East 17th Avenue, Aurora, CO 80045, USA
    Cancer Res 67:3752-8. 2007
    ....
  20. pmc Beta3 integrin and Src facilitate transforming growth factor-beta mediated induction of epithelial-mesenchymal transition in mammary epithelial cells
    Amy J Galliher
    UCHSC, Fitzsimons Campus, Department of Pharmacology, Mail Stop 8303, RC1 South Tower, Rm L18 6110, PO Box 6511, Aurora, CO 80045, USA
    Breast Cancer Res 8:R42. 2006
    ..The molecular mechanisms underlying this conversion of TGF-beta function remain poorly understood but may involve signaling inputs from integrins...
  21. ncbi request reprint Fibulin-5 promotes wound healing in vivo
    Michael J Lee
    Division of Plastic and Reconstructive Surgery, Department of Surgery, Northwestern University, Chicago, IL, USA
    J Am Coll Surg 199:403-10. 2004
    ..Because fibulin-5 expression is induced dramatically in endothelial and smooth muscle cells in response to mechanical injury, my colleagues and I studied its role in dermal wound healing...
  22. ncbi request reprint Fibulin-2 and fibulin-5 alterations in tsk mice associated with disorganized hypodermal elastic fibers and skin tethering
    Raphael Lemaire
    The Arthritis Center, Boston University School of Medicine, Boston, Massachusetts, USA
    J Invest Dermatol 123:1063-9. 2004
    ....
  23. ncbi request reprint Role of transforming growth factor-beta in cancer progression
    Amy J Galliher
    University of Colorado Health Sciences Center, Department of Pharmacology, Aurora, Colorado 80045, USA
    Future Oncol 2:743-63. 2006
    ....
  24. ncbi request reprint Targeted TGF-beta chemotherapies: friend or foe in treating human malignancies?
    William P Schiemann
    Expert Rev Anticancer Ther 7:609-11. 2007
  25. ncbi request reprint Apoptotic cells, through transforming growth factor-beta, coordinately induce anti-inflammatory and suppress pro-inflammatory eicosanoid and NO synthesis in murine macrophages
    Celio G Freire-de-Lima
    Instituto de Biofisica Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro RJ 21944 970, Brazil
    J Biol Chem 281:38376-84. 2006
    ..These results strongly suggest that the apoptotic cell inhibition of pro-inflammatory mediator production is pleiotropic and significantly dependent on the stimulation of TGF-beta production...
  26. pmc Altered TAB1:I kappaB kinase interaction promotes transforming growth factor beta-mediated nuclear factor-kappaB activation during breast cancer progression
    Jason R Neil
    Department of Pharmacology, University of Colorado Health Sciences Center, Aurora, CO 80045, USA
    Cancer Res 68:1462-70. 2008
    ..Collectively, our findings have defined a novel TAB1:TAK1:IKK beta:NF-kappaB signaling axis that forms aberrantly in breast cancer cells and, consequently, enables oncogenic signaling by TGF-beta...
  27. pmc Development of human protein reference database as an initial platform for approaching systems biology in humans
    Suraj Peri
    McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University, Baltimore, Maryland 21287, USA
    Genome Res 13:2363-71. 2003
    ..hprd.org to the academic community. This unified bioinformatics platform will be useful in cataloging and mining the large number of proteomic interactions and alterations that will be discovered in the postgenomic era...