Research Topics
Genomes and GenesSpecies | A SchatzkinSummaryAffiliation: National Institutes of Health Country: USA Publications
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Publications
Prospective study of physical activity and lung cancer by histologic type in current, former, and never smokersMichael F Leitzmann
Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA
Am J Epidemiol 169:542-53. 2009..The inverse findings among former and current smokers in combination with the null results for physical activity among never smokers may point toward residual confounding by cigarette smoking as an explanation for the relations observed...
Non-steroidal anti-inflammatory drugs and risk of gastric and oesophageal adenocarcinomas: results from a cohort study and a meta-analysisC C Abnet
Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852, USA
Br J Cancer 100:551-7. 2009..64 (0.52-0.80), 0.82 (0.65-1.04), and 0.64 (0.52-0.79), respectively. The corresponding numbers for other NSAIDs were 0.68 (0.57-0.81), 0.80 (0.67-0.95), and 0.65 (0.50-0.85), respectively...
Effect of smoking status on total energy expenditureDavid P Bradley
Department of Nutritional Sciences, University of Wisconsin, Madison, WI, USA
Nutr Metab (Lond) 7:81. 2010..Using doubly labeled water, we found no evidence of increased energy expenditure among smokers, however, it should be noted that BMI differences in this cohort also did not differ by smoking status...
Can we use biomarkers in combination with self-reports to strengthen the analysis of nutritional epidemiologic studies?Laurence S Freedman
Biostatistics Unit, Gertner Institute for Epidemiology, Tel Hashomer 52161, Israel
Epidemiol Perspect Innov 7:2. 2010....
Nonsteroidal anti-inflammatory drugs and breast cancer risk in the National Institutes of Health-AARP Diet and Health StudyGretchen L Gierach
Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Blvd, Suite 550, Rockville, MD 20852 7234, USA
Breast Cancer Res 10:R38. 2008..Epidemiologic evidence for a protective role of NSAIDs in breast cancer, however, is equivocal...
Prospective study of physical activity and risk of postmenopausal breast cancerMichael F Leitzmann
Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
Breast Cancer Res 10:R92. 2008..To prospectively examine the relation of total, vigorous and non-vigorous physical activity to postmenopausal breast cancer risk...
A prospective study of physical activity and the risk of pancreatic cancer among women (United States)Brook A Calton
Division of Cancer Epidemiology and Genetics, NCI NIH, Rockville, MD, USA
BMC Cancer 8:63. 2008..Several epidemiologic studies have examined the association between physical activity and pancreatic cancer risk; however, the results of these studies are not consistent...
Prospective study of dietary fiber, whole grain foods, and small intestinal cancerArthur Schatzkin
Department of Health and Human Services, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20852, USA
Gastroenterology 135:1163-7. 2008..We conducted a prospective cohort study to determine the relationship between intake of dietary fiber/whole grains and the incidence of small intestinal cancer...
A comparison of a food frequency questionnaire with a 24-hour recall for use in an epidemiological cohort study: results from the biomarker-based Observing Protein and Energy Nutrition (OPEN) studyArthur Schatzkin
Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA
Int J Epidemiol 32:1054-62. 2003..We use data from the Observing Protein and Energy Nutrition (OPEN) study to compare the performance of a FFQ with that of a 24-hour recall (24HR)...
Mendelian randomization: how it can--and cannot--help confirm causal relations between nutrition and cancerArthur Schatzkin
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA
Cancer Prev Res (Phila) 2:104-13. 2009..We conclude that Mendelian randomization is not universally applicable, but, under the right conditions, can complement evidence for causal associations from conventional epidemiologic studies...
The promise and peril of surrogate end points in cancer researchArthur Schatzkin
Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892 7232, USA
Nat Rev Cancer 2:19-27. 2002..Surrogate end points--markers of preclinical cancer or of imminent recurrence--are therefore an attractive alternative. But how can we be sure that a study with a surrogate outcome gives us the right answer about the true end point?..
Design and serendipity in establishing a large cohort with wide dietary intake distributions : the National Institutes of Health-American Association of Retired Persons Diet and Health StudyA Schatzkin
National Cancer Institute, Bethesda, MD 20892 7232, USA
Am J Epidemiol 154:1119-25. 2001..The large size and wide intake range of the cohort will provide ample power for examining a number of important diet and cancer hypotheses...
Dietary fiber and whole-grain consumption in relation to colorectal cancer in the NIH-AARP Diet and Health StudyArthur Schatzkin
Division of Cancer Epidemiology, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
Am J Clin Nutr 85:1353-60. 2007..Whether the intake of dietary fiber can protect against colorectal cancer is a long-standing question of considerable public health import, but the epidemiologic evidence has been inconsistent...
Promises and perils of validating biomarkers for cancer riskArthur Schatzkin
Nutritional Epidemiology, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20852, USA
J Nutr 136:2671S-2S. 2006
Can biomarkers help us understand the nutritional and lifestyle factors important in cancer prognosis?Arthur Schatzkin
Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20815, USA
J Nutr 137:249S-252S. 2007....
Implementation of a 4-y, high-fiber, high-fruit-and-vegetable, low-fat dietary intervention: results of dietary changes in the Polyp Prevention TrialE Lanza
National Cancer Institute, Bethesda, MD, USA
Am J Clin Nutr 74:387-401. 2001..30 g/MJ), high-fruit-and-vegetable (0.84 servings/MJ), low-fat (20% of energy from fat) diet on the recurrence of adenomatous polyps in the large bowel...
Interleukin-6 as a potential indicator for prevention of high-risk adenoma recurrence by dietary flavonols in the polyp prevention trialGerd Bobe
Center for Cancer Research, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, Maryland, USA
Cancer Prev Res (Phila) 3:764-75. 2010..Our results suggest that serum IL-6 may serve as a risk indicator and as a response indicator to dietary flavonols for colorectal cancer prevention...
Alcohol and risk of breast cancer by histologic type and hormone receptor status in postmenopausal women: the NIH-AARP Diet and Health StudyJasmine Q Lew
Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, Rockville, MD 20852, USA
Am J Epidemiol 170:308-17. 2009..13 (95% CI: 0.73, 1.77) for >20 g versus 0 g/day, and 1.21 (95% CI: 0.79, 1.84) for >20 g versus 0 g/day, respectively. Moderate consumption of alcohol was associated with breast cancer, specifically hormone receptor-positive tumors...
Effects of dietary fat and fiber on plasma and urine androgens and estrogens in men: a controlled feeding studyJ F Dorgan
Division of Cancer Prevention and Control, National Cancer Institute, Bethesda, MD 20892 7326, USA
Am J Clin Nutr 64:850-5. 1996..01). Results of this study suggest that diet may alter endogenous sex hormone metabolism in men...
Evaluation of 2 brief instruments and a food-frequency questionnaire to estimate daily number of servings of fruit and vegetablesF E Thompson
National Cancer Institute, Bethesda, MD, 20892 7344, USA
Am J Clin Nutr 71:1503-10. 2000..Measurement of fruit and vegetable intake is important in the surveillance of populations and in epidemiologic studies that examine the relations between diet and disease. Some situations require the use of brief dietary assessment tools...
The effect of strict adherence to a high-fiber, high-fruit and -vegetable, and low-fat eating pattern on adenoma recurrenceLeah B Sansbury
Division of Cancer Control and Population Sciences, 6130 Executive Boulevard, Room 5106, Mail Stop Code 7324, Bethesda, MD 20892, USA
Am J Epidemiol 170:576-84. 2009..65, 95% confidence interval: 0.47, 0.92). Findings suggest that high compliance with a low-fat, high-fiber diet is associated with reduced risk of adenoma recurrence...
Evaluation of alternative approaches to assign nutrient values to food groups in food frequency questionnairesA F Subar
National Cancer Institute, Bethesda, MD 20892 7344, USA
Am J Epidemiol 152:279-86. 2000..Mean methods for assigning nutrients to food groups were superior to median approaches for all measurements. Among the mean methods, no single variation was consistently better...
Self-rated quality of life measures: effect of change to a low-fat, high-fiber, fruit and vegetable enriched dietD K Corle
National Cancer Institute, Bethesda, MD 20892-7354, USA
Ann Behav Med 23:198-207. 2001..021), and health action (p < .001) domains significantly higher and the social domain significantly lower (p <.001) than control participants. These changes were consistent through Years 2, 3, and 4. This study..
Dietary fatty acids and pancreatic cancer in the NIH-AARP diet and health studyAnne C M Thiebaut
Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
J Natl Cancer Inst 101:1001-11. 2009..Previous research relating dietary fat, a modifiable risk factor, to pancreatic cancer has been inconclusive...
Hormone replacement therapy and colorectal adenoma recurrence among women in the Polyp Prevention TrialK Woodson
Cancer Prevention Studies Branch, Division of Clinical Sciences, National Cancer Institute NIH, 6006 Executive Blvd, MSC 7058, Bethesda, MD 20892 7058, USA
J Natl Cancer Inst 93:1799-805. 2001....
Body mass index and risk of ovarian cancerMichael F Leitzmann
Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
Cancer 115:812-22. 2009..However, to the authors' knowledge, data addressing whether the relation between BMI and ovarian cancer differs by MHT use are very sparse...
Body size and renal cell cancer incidence in a large US cohort studyKenneth F Adams
Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD, USA
Am J Epidemiol 168:268-77. 2008..Waist-to hip ratio was positively associated with RCC in women and with height at age 18 years in both men and women...
Fruit and vegetable intake and esophageal cancer in a large prospective cohort studyNeal D Freedman
Cancer Prevention Fellowship Program, Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
Int J Cancer 121:2753-60. 2007..A significant inverse association between EAC and Chenopodiaceae (spinach) intake was observed. Results from our study suggest that the relation of fruit and vegetable intake and esophageal cancer risk may vary by histologic type...
Physical activity and risk of ovarian cancer: a prospective cohort study in the United StatesLindsay M Hannan
Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, 6120 Executive Boulevard, EPS-MSC 7232, Bethesda, MD 20892, USA
Cancer Epidemiol Biomarkers Prev 13:765-70. 2004..13). In this prospective cohort study among U.S. women, we found no overall significant association between physical activity and risk of ovarian cancer, although the results are suggestive of an inverse association...
Lack of effect of a low-fat, high-fruit, -vegetable, and -fiber diet on serum prostate-specific antigen of men without prostate cancer: results from a randomized trialMoshe Shike
Memorial Sloan Kettering Cancer Center, New York, NY, and National Cancer Institute, Bethesda, MD
J Clin Oncol 20:3592-8. 2002..To determine whether a diet low in fat and high in fruits, vegetables, and fiber may be protective against prostate cancer by having an impact on serial levels of serum prostate-specific antigen (PSA)...
Polyps and vegetables (and fat, fibre): the polyp prevention trialA Schatzkin
National Cancer Institute, Bethesda, MD 20814, USA
IARC Sci Publ 156:463-6. 2002
A prospective study of tobacco, alcohol, and the risk of esophageal and gastric cancer subtypesNeal D Freedman
Cancer Prevention Fellowship Program, Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
Am J Epidemiol 165:1424-33. 2007..93, 95% CI: 2.69, 9.03) but not risk for esophageal, gastric cardia, or gastric noncardia adenocarcinoma...
Reproductive factors, exogenous hormone use and bladder cancer risk in a prospective studyMarie M Cantwell
Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
Int J Cancer 119:2398-401. 2006..62-2.43) and 0.57 (95% CI = 0.14-2.34), respectively, compared with nonusers (p = 0.50). Findings from this study are not consistent with the hypothesis that hormone-related factors in women are associated with bladder cancer...
The polyp prevention trial continued follow-up study: no effect of a low-fat, high-fiber, high-fruit, and -vegetable diet on adenoma recurrence eight years after randomizationElaine Lanza
Laboratory for Cancer Prevention, Centre for Cancer Research, National Cancer Institute, 6116 Executive Boulevard, Room 7206, Bethesda, MD 20892 8325, USA
Cancer Epidemiol Biomarkers Prev 16:1745-52. 2007..04 (0.98-1.09). This study failed to show any effect of a low-fat, high-fiber, high-fruit and -vegetable eating pattern on adenoma recurrence even with 8 years of follow-up. (Cancer Epidemiol Biomarkers Prev 2007;16(9):1745-52)...
Male predominance of upper gastrointestinal adenocarcinoma cannot be explained by differences in tobacco smoking in men versus womenN D Freedman
Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Rockville, MD, USA
Eur J Cancer 46:2473-8. 2010..As smoking is a well-established risk factor, we investigated the role of tobacco smoking in the male predominance of UGI adenocarcinomas in the United States NIH-AARP Diet and Health Study...
Dietary fat, fat subtypes, and breast cancer in postmenopausal women: a prospective cohort studyE Velie
Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA
J Natl Cancer Inst 92:833-9. 2000..To extend the prospective epidemiologic evidence on this question, we examined the association between adult dietary intake of fat, fat subtypes, and breast cancer in a large, prospective cohort of postmenopausal women...
Accelerometer-measured physical activity in Chinese adultsTricia M Peters
National Cancer Institute, Bethesda, Maryland, USA
Am J Prev Med 38:583-91. 2010..Following adoption of a Western lifestyle, China is experiencing a decline in physical activity levels, which is projected to contribute to future increases in the burden of chronic diseases...
Fruit and vegetable intake and head and neck cancer risk in a large United States prospective cohort studyNeal D Freedman
Cancer Prevention Fellowship Program, Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
Int J Cancer 122:2330-6. 2008..Results from this large prospective observational study are consistent with previous case-control studies and support the hypothesis that total fruit and vegetable intake is associated with reduced risk of head and neck cancer...
Physical activity and esophageal and gastric carcinoma in a large prospective studyMichael F Leitzmann
Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
Am J Prev Med 36:112-9. 2009..Few studies have investigated the relationship of physical activity to esophageal and gastric carcinoma according to histology and anatomic site...
Prospective investigation of the cigarette smoking-head and neck cancer association by sexNeal D Freedman
Cancer Prevention Fellowship Program, Division of Cancer Prevention, National Cancer Institute, Rockville, Maryland 20852, USA
Cancer 110:1593-601. 2007..Very few prospective studies have examined the association between cigarette smoking and cancers of the head and neck in women, even though the rates of smoking in women are increasing rapidly worldwide...
Empirical evidence of correlated biases in dietary assessment instruments and its implicationsV Kipnis
Biometry Research Group, Division of Cancer Prevention, National Cancer Institute, Bethesda, MD 20892 7354, USA
Am J Epidemiol 153:394-403. 2001..3 times larger study than would be estimated by the standard approach. The implications of the results for the ability of FFQ-based epidemiologic studies to detect important diet-disease associations are discussed...
Index-based dietary patterns and risk of colorectal cancer: the NIH-AARP Diet and Health StudyJ Reedy
Risk Factor Monitoring and Methods Branch, Applied Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, MD 20892 7344, USA
Am J Epidemiol 168:38-48. 2008..Index-based dietary patterns that are consistent with given dietary guidelines are associated with reduced risk...
Serum cytokine concentrations, flavonol intake and colorectal adenoma recurrence in the Polyp Prevention TrialG Bobe
Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Building 576, Room 101, 1050 Boyles Street, Frederick, MD 21702, USA
Br J Cancer 103:1453-61. 2010..Flavonols, bioactive compounds found in plant-based foods and beverages, may inhibit colorectal neoplasms partly by attenuating inflammation...
Association of genetic variants in the calcium-sensing receptor with risk of colorectal adenomaUlrike Peters
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD, USA
Cancer Epidemiol Biomarkers Prev 13:2181-6. 2004..We assessed the associations between CASR gene variants and risk for colorectal adenoma, a cancer precursor. We further investigated gene-diet interactions between the CASR variants and calcium intake on adenoma risk...
Comparison of estimated renal net acid excretion from dietary intake and body size with urine pHDominique S Michaud
Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute NIH, 6120 Executive Boulevard, EPS 320 MSC 7232, Bethesda, MD 20892 7232, USA
J Am Diet Assoc 103:1001-7; discussion 1007. 2003..The aim of this study was to examine whether estimated net acid excretion (NAE) from two dietary assessment instruments can predict urine pH in healthy volunteers...
Intensity and timing of physical activity in relation to postmenopausal breast cancer risk: the prospective NIH-AARP diet and health studyTricia M Peters
Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 6120 Executive Blvd, Bethesda, MD, USA
BMC Cancer 9:349. 2009..Despite strong evidence of an inverse association of physical activity with postmenopausal breast cancer risk, whether a certain intensity or time of life of physical activity is most effective for lowering breast cancer risk is not known...
Lifetime weight history and endometrial cancer risk by type of menopausal hormone use in the NIH-AARP diet and health studyShih Chen Chang
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Suite 320, Executive Plaza South, MSC7232, Bethesda, MD 20892 7232, USA
Cancer Epidemiol Biomarkers Prev 16:723-30. 2007..We conclude that both current adiposity and adult weight gain are associated with substantial increases in the risk of endometrial cancer, with relations particularly evident among never users of menopausal hormone therapy...
Genomic methylation of leukocyte DNA in relation to colorectal adenoma among asymptomatic womenUnhee Lim
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Rockville, Maryland, USA
Gastroenterology 134:47-55. 2008..We examined genomic methylation of leukocyte DNA in relation to colorectal adenoma (CRA) among asymptomatic women (40-79 years of age) participating in a multicenter colonoscopy screening study (CONCeRN Study, 2000-2002)...
Prospective study of adiposity and weight change in relation to prostate cancer incidence and mortalityMargaret E Wright
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
Cancer 109:675-84. 2007..Adiposity has been linked inconsistently with prostate cancer, and few studies have evaluated whether such associations vary by disease aggressiveness...
Dietary fiber intake: assessing the degree of agreement between food frequency questionnaires and 4-day food recordsTamaro S Hudson
Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-8329, USA
J Am Coll Nutr 25:370-81. 2006....
Hormonal and reproductive factors and risk of postmenopausal thyroid cancer in the NIH-AARP Diet and Health StudyS J Schonfeld
Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Bethesda, MD 20892, USA
Cancer Epidemiol 35:e85-90. 2011..While this suggests a possible etiologic role of female sex hormones, clear associations between hormonal and reproductive factors and thyroid cancer have not been observed. However, few large prospective studies have been conducted...
Meat intake and the recurrence of colorectal adenomasA Mathew
Nutritional Epidemiology Branch, Division of Epidemiologya nd Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
Eur J Cancer Prev 13:159-64. 2004....
Measuring cell proliferation in the rectal mucosa. comparing bromodeoxyuridine (BrdU) and proliferating cell nuclear antigen (PCNA) assaysM Kulldorff
National Cancer Institute, Bethesda, MD, USA
J Clin Epidemiol 53:875-83. 2000..When used in a clinical or epidemiological setting, it is important to take multiple biopsies at multiple time points...
Insulin resistance-related genes and advanced left-sided colorectal adenomaMarc J Gunter
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, Maryland, USA
Cancer Epidemiol Biomarkers Prev 16:703-8. 2007....
High serum selenium and reduced risk of advanced colorectal adenoma in a colorectal cancer early detection programUlrike Peters
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Rockville, Maryland, USA
Cancer Epidemiol Biomarkers Prev 15:315-20. 2006..Although substantial evidence suggests that smoking is a strong effect modifier for other antioxidative nutrients, little is known about smoking-selenium interactions in colorectal tumors...
Body mass index, effect modifiers, and risk of pancreatic cancer: a pooled study of seven prospective cohortsLi Jiao
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
Cancer Causes Control 21:1305-14. 2010..To investigate whether the positive association of body mass index (BMI, kg/m(2)) with risk of pancreatic cancer is modified by age, sex, smoking status, physical activity, and history of diabetes...
Meat, fat, and their subtypes as risk factors for colorectal cancer in a prospective cohort of womenAndrew Flood
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
Am J Epidemiol 158:59-68. 2003..This study provided no evidence of an association between either meat or fat (or any of their subtypes) and colorectal cancer incidence, but the authors cannot rule out the possibility of a modest association...
Dietary fibre and risk of colorectal cancer in the Breast Cancer Detection Demonstration Project (BCDDP) follow-up cohortVolker Mai
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, 20892, USA
Int J Epidemiol 32:234-9. 2003..We investigated the association between dietary fibre intake and risk of CRC in a cohort of women that prospectively answered a food frequency questionnaire (FFQ)...
Adiposity in relation to colorectal adenomas and hyperplastic polyps in womenMichael F Leitzmann
The Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, National Institutes of Health, 6120 Executive Blvd, Bethesda, MD 20892, USA
Cancer Causes Control 20:1497-507. 2009..To examine whether BMI is independently related to colorectal adenomas and hyperplastic polyps...
Vitamin E intake and risk of esophageal and gastric cancers in the NIH-AARP Diet and Health StudySarah Carman
NEB DCEG, National Cancer Institute, Bethesda, MD 20892 7232, USA
Int J Cancer 125:165-70. 2009..An increase of 71 mg/day (half the interquartile range) in supplemental vitamin E had an hazard ratio (95% confidence interval) of 0.92 (0.85-1.00) and the p value for trend in the quartile analysis was 0.015...
Calorie restriction and diet composition modulate spontaneous intestinal tumorigenesis in Apc(Min) mice through different mechanismsVolker Mai
Cancer Prevention Fellowship Program, Division of Cancer Prevention, National Cancer Institute, Bethesda, Maryland 20892 7105, USA
Cancer Res 63:1752-5. 2003..We conclude that dietary interventions can partially offset genetic susceptibility to intestinal carcinogenesis...
Physical activity and risk of endometrial cancer in a prospective cohort study (United States)Lisa H Colbert
Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, Bethesda, MD, USA
Cancer Causes Control 14:559-67. 2003..To examine the physical activity and endometrial cancer relationship in a prospective study of US women enrolled in the Breast Cancer Detection Demonstration Project (BCDDP) Follow-up Study...
Alcohol consumption and risk of renal cell cancer: the NIH-AARP diet and health studyJ Q Lew
Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Bethesda, MD, USA
Br J Cancer 104:537-41. 2011..The effect of moderate to heavy drinking (>15 g per day) on renal cell cancer (RCC) risk is unclear...
Tea, coffee, carbonated soft drinks and upper gastrointestinal tract cancer risk in a large United States prospective cohort studyJ S Ren
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, United States
Eur J Cancer 46:1873-81. 2010..In summary, hot tea intake was inversely associated with pharyngeal cancer, and coffee was directly associated with gastric cardia cancer, but was inversely associated with EADC during some follow-up periods...
Components of variation in serum carotenoid concentrations: the Polyp Prevention TrialM R Forman
Laboratory of Biosystems and Cancer, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA
Eur J Clin Nutr 63:763-70. 2009..The intra- and interindividual variations and season and center effects were estimated from a series of serum carotenoid concentrations in the Polyp Prevention Trial (PPT) participants...
Epidemiological studies of cereals, fruit and vegetablesA Schatzkin
National Cancer Institute, Bethesda, MD 20814, USA
IARC Sci Publ 156:77. 2002
Smoking duration, intensity, and risk of Parkinson diseaseH Chen
Epidemiology Branch, National Institute of Environmental Health Sciences, 111 T W Alexander Dr, PO Box 12233, Mail Drop A3 05, Research Triangle Park, NC 27709, USA
Neurology 74:878-84. 2010..To evaluate the relative importance of smoking duration vs intensity in reducing the risk of Parkinson disease (PD)...
Waist circumference and mortalityAnnemarie Koster
Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, MD 20892, USA
Am J Epidemiol 167:1465-75. 2008..36). The finding that persons with a normal BMI but a large waist circumference had a higher mortality risk in this study suggests that increased waist circumference should be considered a risk factor for mortality, in addition to BMI...
Using intake biomarkers to evaluate the extent of dietary misreporting in a large sample of adults: the OPEN studyAmy F Subar
Applied Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, MD, USA
Am J Epidemiol 158:1-13. 2003..There was little underreporting of the percentage of energy from protein for men or women. These findings have important implications for nutritional epidemiology and dietary surveillance...
Association of energy intake and energy balance with postmenopausal breast cancer in the prostate, lung, colorectal, and ovarian cancer screening trialShih Chen Chang
Division of Cancer Epidemiology and Genetics, Nutritional Epidemiology Branch, National Cancer Institute, Executive Plaza South, Suite 320, MSC7232, Bethesda, Maryland 20892 7232, USA
Cancer Epidemiol Biomarkers Prev 15:334-41. 2006..In addition, these three aspects of energy balance may act jointly in determining breast cancer risk...
Dopamine D2 receptor polymorphisms and adenoma recurrence in the Polyp Prevention TrialGwen Murphy
Cancer Prevention Fellowship Program, Office of Preventive Oncology, National Cancer Institute, Bethesda, MD 20892, USA
Int J Cancer 124:2148-51. 2009..Increased risk of adenoma recurrence as conferred by DRD2 genotypes may be related to difference in alcohol and fat intake across genotypes...
Cigarette smoking and subsequent risk of lung cancer in men and women: analysis of a prospective cohort studyNeal D Freedman
Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, 6120 ExecutiveBoulevard, MSC 7232, Rockville, MD 20852, USA
Lancet Oncol 9:649-56. 2008..To address this question, we aimed to compare incidence rates of lung cancer by stratum of smoking use in men and women of the National Institutes of Health (NIH)-AARP cohort...
Age-specific physical activity and prostate cancer risk among white men and black menSteven C Moore
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
Cancer 115:5060-70. 2009..The authors investigated physical activity, including activity during different age periods and of various intensities, in relation to prostate cancer incidence among white men and black men...
Physical activity and head and neck cancer riskMichael F Leitzmann
Department of Health and Human Services, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Cancer Causes Control 19:1391-9. 2008..To investigate the relation of physical activity to head and neck cancer...
Physical activity in relation to total, advanced, and fatal prostate cancerSteven C Moore
Division of Cancer Epidemiology, National Cancer Institute, Bethesda, MD 20892, USA
Cancer Epidemiol Biomarkers Prev 17:2458-66. 2008..96; 95% CI, 0.67-1.36; P(trend) = 0.99). Neither vigorous exercise at baseline nor exercise during adolescence was related to risk of total, advanced, or fatal prostate cancer in this large prospective cohort...
Dietary meat intake in relation to colorectal adenoma in asymptomatic womenLeah M Ferrucci
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
Am J Gastroenterol 104:1231-40. 2009....
Reproductive factors, exogenous hormone use and risk of lymphoid neoplasms among women in the National Institutes of Health-AARP Diet and Health Study CohortLindsay M Morton
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Rockville, MD 20852, USA
Int J Cancer 124:2737-43. 2009..These data do not support an important role for reproductive factors or exogenous hormones in modulating lymphomagenesis...
Endometrial carcinoma risks among menopausal estrogen plus progestin and unopposed estrogen users in a cohort of postmenopausal womenJames V Lacey
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, Maryland, USA
Cancer Epidemiol Biomarkers Prev 14:1724-31. 2005..However, endometrial carcinoma risks among estrogen plus progestin users and among former unopposed estrogen users are not firmly established...
Calcium, dairy foods, and risk of incident and fatal prostate cancer: the NIH-AARP Diet and Health StudyYikyung Park
Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20852, USA
Am J Epidemiol 166:1270-9. 2007..04). Although the authors cannot definitively rule out a weak association for aggressive prostate cancer, their findings do not provide strong support for the hypothesis that calcium and dairy foods increase prostate cancer risk...
Loss of insulin-like growth factor-II imprinting and the presence of screen-detected colorectal adenomas in womenKaren Woodson
Cancer Prevention Studies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
J Natl Cancer Inst 96:407-10. 2004..These findings are intriguing and need to be confirmed in larger studies...
Use of the predictive sugars biomarker to evaluate self-reported total sugars intake in the Observing Protein and Energy Nutrition (OPEN) studyNatasa Tasevska
Applied Research Program, Division of Cancer Control and Population Sciences, Nutritional Epidemiology, Branch, National Cancer Institute, 6130 Executive Blvd, EPN 3121, Bethesda, MD 20892, USA
Cancer Epidemiol Biomarkers Prev 20:490-500. 2011..A predictive biomarker for intake of total sugars was recently developed under controlled conditions. We used this biomarker to assess measurement error (ME) structure in self-reported intake of total sugars in free-living individuals...
Obesity and thyroid cancer risk among U.S. men and women: a pooled analysis of five prospective studiesCari M Kitahara
Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD 20852, USA
Cancer Epidemiol Biomarkers Prev 20:464-72. 2011..Thyroid cancer incidence has risen dramatically in the United States since the early 1980s. Although the prevalence of obesity has doubled during this time period, the relationship between obesity and thyroid cancer is uncertain...
Adenomatous polyp recurrence and physical activity in the Polyp Prevention Trial (United States)Lisa H Colbert
National Institute on Aging, Bethesda, MD, USA
Cancer Causes Control 13:445-53. 2002..To examine prospectively the association between physical activity and adenomatous polyp recurrence...
Adiposity, adult weight change, and postmenopausal breast cancer riskJiyoung Ahn
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, EPS, 6120 Executive Blvd, Bethesda, MD 20892, USA
Arch Intern Med 167:2091-102. 2007..Obesity is a risk factor for postmenopausal breast cancer, but the role of the timing and amount of adult weight change in breast cancer risk is unclear...
Physical activity and postmenopausal breast cancer risk in the NIH-AARP diet and health studyTricia M Peters
Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, 6120 Executive Boulevard, MSC 7232, Bethesda, MD 20892, USA
Cancer Epidemiol Biomarkers Prev 18:289-96. 2009..Although physical activity has been associated with reduced breast cancer risk, whether this association varies across breast cancer subtypes or is modified by reproductive and lifestyle factors is unclear...
Dairy products, calcium intake, and risk of prostate cancer in the prostate, lung, colorectal, and ovarian cancer screening trialJiyoung Ahn
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, 6120 Executive Boulevard, Bethesda, MD 20892, USA
Cancer Epidemiol Biomarkers Prev 16:2623-30. 2007..Furthermore, we found no relationship between calcium intake and circulating vitamin D...
Polymorphisms in the adenomatous polyposis coli (APC) gene and advanced colorectal adenoma riskHui Lee Wong
Department of Health and Human Services, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD, USA
Eur J Cancer 46:2457-66. 2010..Fat intake modified the APC D1822V-adenoma association, but further studies are warranted...
Physical activity and the risk of colon cancer among women: a prospective cohort study (United States)Brook A Calton
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852, USA
Int J Cancer 119:385-91. 2006..The results of this large prospective cohort study among women do not support the hypothesis that physical activity is related to a lower incidence of colon cancer...
Diet and cancer: future etiologic researchA Schatzkin
Division of Cancer Prevention and Control, National Cancer Institute, Bethesda, Maryland, USA
Environ Health Perspect 103:171-5. 1995..Finally, we briefly review strategies for evaluating promising hypotheses linking diet to cancers of the large bowel, lung, breast, and prostate...
Physical activity, sedentary behaviours, and the prevention of endometrial cancerS C Moore
Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Bethesda, MD 20892, USA
Br J Cancer 103:933-8. 2010..Taken together with the established biological plausibility of this relation, the totality of evidence now convincingly indicates that physical activity prevents or reduces risk of endometrial cancer...
Serum sex hormone levels are related to breast cancer risk in postmenopausal womenJ F Dorgan
Division of Cancer Prevention and Control, National Cancer Institute, Bethesda, Maryland 20892 7326, USA
Environ Health Perspect 105:583-5. 1997..2 (95% CI = 2.0-19.0). Our results lend considerable support to the hypothesis that serum concentrations of estrogens and androgens are related to the subsequent diagnosis of breast cancer in postmenopausal women...
Past body mass index and risk of mortality among womenS C Moore
Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, MD 20892, USA
Int J Obes (Lond) 32:730-9. 2008..Analysis of BMI from an earlier time period may minimize reverse causation without requiring exclusion of participants based on disease or smoking history...
Alcohol intake and risk of thyroid cancer in the NIH-AARP Diet and Health StudyC L Meinhold
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120Executive Boulevard, Rockville, MD 20852, USA
Br J Cancer 101:1630-4. 2009..Certain studies suggest that alcohol may reduce the risk of thyroid cancer in women, but the effect in men remains unclear...
Alcohol and head and neck cancer risk in a prospective studyN D Freedman
Cancer Prevention Fellowship Program, Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Executive Plaza North, Suite 3109, 6130 Executive Boulevard, MSC 7361, Bethesda, MD 20892 7361, USA
Br J Cancer 96:1469-74. 2007..7), men (34.4). In summary, drinking >3 alcoholic beverages per day was associated with increased risk in men and women, but consumption of up to one drink per day may be associated with reduced risk relative to non-drinking...
Fruits and vegetables and ovarian cancer risk in a pooled analysis of 12 cohort studiesAnita Koushik
Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
Cancer Epidemiol Biomarkers Prev 14:2160-7. 2005..Associations for total fruits and vegetables were similar for different histologic types. These results suggest that fruit and vegetable consumption in adulthood has no important association with the risk of ovarian cancer...
Carbohydrate, glycemic index, and glycemic load and colorectal adenomas in the Prostate, Lung, Colorectal, and Ovarian Screening StudyAndrew Flood
University of Minnesota, Minneapolis, MN, Henry Ford Hospital, Detroit, MI, USA
Am J Clin Nutr 84:1184-92. 2006..It is possible that high-glycemic-load diets, through their hyperinsulinemic effects, can increase the risk of colorectal cancer...
Using biomarker data to adjust estimates of the distribution of usual intakes for misreporting: application to energy intake in the US populationRivka Yanetz
Department of Mathematics, Bar Ilan University, Ramat Gan, Israel
J Am Diet Assoc 108:455-64; discussion 464. 2008....
Low energy reporting may increase in intervention participants enrolled in dietary intervention trialsBette Caan
Division of Research, Kaiser Permanente Medical Care Program of Northern California, 2000 Broadway, Oakland, CA 94612, USA
J Am Diet Assoc 104:357-66; quiz 491. 2004..To examine differences in low energy intake reporting between intervention and control groups during a dietary intervention trial...
Diet, nutrition and the prevention of cancerTimothy J Key
Cancer Research UK Epidemiology Unit, University of Oxford, Oxford, UK
Public Health Nutr 7:187-200. 2004..To assess the epidemiological evidence on diet and cancer and make public health recommendations...
Dietary manipulation, ethnicity, and serum PSA levelsJames A Eastham
Department of Urology, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA
Urology 62:677-82. 2003..Serum PSA, a marker often used in early detection programs for prostate cancer, was not associated with manipulation of the amount of fat in the diet, regardless of ethnicity...
Dietary carotenoids and risk of colorectal cancer in a pooled analysis of 11 cohort studiesSatu Mannisto
National Public Health Institute, Helsinki, Finland
Am J Epidemiol 165:246-55. 2007..00). The associations observed were generally similar across studies, for both sexes, and for colon cancer and rectal cancer. These pooled data did not suggest that carotenoids play an important role in the etiology of colorectal cancer...
