J Savitz

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Dissociative identity disorder associated with mania and change in handedness
    Jonathan Savitz
    MRC UCT Human Genetics Research Unit, University of Cape Town Medical School, Observatory, 7925, South Africa
    Cogn Behav Neurol 17:233-7. 2004
  2. doi request reprint Catechol-o-methyltransferase genotype and childhood trauma may interact to impact schizotypal personality traits
    Jonathan Savitz
    MRC UCT Human Genetics Research Unit, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa
    Behav Genet 40:415-23. 2010
  3. ncbi request reprint The relationship between childhood abuse and dissociation. Is it influenced by catechol-O-methyltransferase (COMT) activity?
    Jonathan B Savitz
    MRC UCT Human Genetics Research Unit, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa
    Int J Neuropsychopharmacol 11:149-61. 2008
  4. pmc Neurocognitive function in an extended Afrikaner-ancestry family with affective illness
    Jonathan Savitz
    Division of Human Genetics, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa
    J Psychiatry Neurosci 32:116-20. 2007
  5. ncbi request reprint Lateralization of hand skill in bipolar affective disorder
    J Savitz
    Division of Human Genetics, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa
    Genes Brain Behav 6:698-705. 2007
  6. ncbi request reprint Genotype and childhood sexual trauma moderate neurocognitive performance: a possible role for brain-derived neurotrophic factor and apolipoprotein E variants
    Jonathan Savitz
    MRC UCT Human Genetics Research Unit, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa
    Biol Psychiatry 62:391-9. 2007
  7. doi request reprint Neuropsychological task performance in bipolar spectrum illness: genetics, alcohol abuse, medication and childhood trauma
    Jonathan B Savitz
    Division of Human Genetics, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa
    Bipolar Disord 10:479-94. 2008
  8. doi request reprint Personality endophenotypes for bipolar affective disorder: a family-based genetic association analysis
    J Savitz
    UCT MRC Human Genetics Research Unit, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa
    Genes Brain Behav 7:869-76. 2008
  9. doi request reprint Neuropsychological status of bipolar I disorder: impact of psychosis
    Jonathan Savitz
    Division of Human Genetics, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa
    Br J Psychiatry 194:243-51. 2009
  10. pmc Imaging phenotypes of major depressive disorder: genetic correlates
    J B Savitz
    Mood and Anxiety Disorders Program, NIH NIMH, Bethesda, MD 20892, USA
    Neuroscience 164:300-30. 2009

Detail Information

Publications28

  1. ncbi request reprint Dissociative identity disorder associated with mania and change in handedness
    Jonathan Savitz
    MRC UCT Human Genetics Research Unit, University of Cape Town Medical School, Observatory, 7925, South Africa
    Cogn Behav Neurol 17:233-7. 2004
    ..To investigate the overlap between dissociative and bipolar disorders with reference to their neurophysiological foundations...
  2. doi request reprint Catechol-o-methyltransferase genotype and childhood trauma may interact to impact schizotypal personality traits
    Jonathan Savitz
    MRC UCT Human Genetics Research Unit, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa
    Behav Genet 40:415-23. 2010
    ..We raise the possibility that genetically-driven variation in COMT may interact with childhood trauma to contribute to the risk of developing schizotypal personality traits...
  3. ncbi request reprint The relationship between childhood abuse and dissociation. Is it influenced by catechol-O-methyltransferase (COMT) activity?
    Jonathan B Savitz
    MRC UCT Human Genetics Research Unit, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa
    Int J Neuropsychopharmacol 11:149-61. 2008
    ..The current findings support the involvement of the COMT Val158Met polymorphism in mediating the relationship between trauma and psychopathology...
  4. pmc Neurocognitive function in an extended Afrikaner-ancestry family with affective illness
    Jonathan Savitz
    Division of Human Genetics, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa
    J Psychiatry Neurosci 32:116-20. 2007
    ..To characterize the neuropsychological profile of an extended family with unipolar depression (UPD) and other forms of affective illness...
  5. ncbi request reprint Lateralization of hand skill in bipolar affective disorder
    J Savitz
    Division of Human Genetics, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa
    Genes Brain Behav 6:698-705. 2007
    ..Relative hand skill was significantly associated with a functional variant in the catechol-O-methyltransferase gene. We speculate that this polymorphism may influence brain lateralization...
  6. ncbi request reprint Genotype and childhood sexual trauma moderate neurocognitive performance: a possible role for brain-derived neurotrophic factor and apolipoprotein E variants
    Jonathan Savitz
    MRC UCT Human Genetics Research Unit, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa
    Biol Psychiatry 62:391-9. 2007
    ..We predicted that memory would be affected by sexual trauma and that a number of functional polymorphisms previously implicated in BPD and cognition would moderate the effect of psychological trauma on memory...
  7. doi request reprint Neuropsychological task performance in bipolar spectrum illness: genetics, alcohol abuse, medication and childhood trauma
    Jonathan B Savitz
    Division of Human Genetics, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa
    Bipolar Disord 10:479-94. 2008
    ....
  8. doi request reprint Personality endophenotypes for bipolar affective disorder: a family-based genetic association analysis
    J Savitz
    UCT MRC Human Genetics Research Unit, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa
    Genes Brain Behav 7:869-76. 2008
    ..We raise the possibility that the 10R allele of the SLC6A3 repeat polymorphism and the short allele of the SLC6A4 promoter variant constitute risk factors for irritable-aggressive and anxious-dysthymic subtypes of BD, respectively...
  9. doi request reprint Neuropsychological status of bipolar I disorder: impact of psychosis
    Jonathan Savitz
    Division of Human Genetics, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa
    Br J Psychiatry 194:243-51. 2009
    ....
  10. pmc Imaging phenotypes of major depressive disorder: genetic correlates
    J B Savitz
    Mood and Anxiety Disorders Program, NIH NIMH, Bethesda, MD 20892, USA
    Neuroscience 164:300-30. 2009
    ..Further advances are likely as epigenetic, copy-number variant, gene-gene interaction, and genome-wide association (GWA) approaches are brought to bear on imaging data...
  11. pmc Bipolar and major depressive disorder: neuroimaging the developmental-degenerative divide
    Jonathan Savitz
    Section on Neuroimaging in Mood and Anxiety Disorders, Mood and Anxiety Disorders Program, National Institute of Mental Health NIH, Bethesda, MD 20892, USA
    Neurosci Biobehav Rev 33:699-771. 2009
    ..Imaging genetic approaches hold out promise for advancing our understanding of affective illness...
  12. pmc 5-HT(1A) receptor function in major depressive disorder
    Jonathan Savitz
    Section on Neuroimaging in Mood and Anxiety Disorders, Mood and Anxiety Disorders Program, NIH NIMH, Bethesda, MD 20892, United States
    Prog Neurobiol 88:17-31. 2009
    ..Conversely, the C allele has been associated with better response to AD drugs. We raise the possibility that 5-HT(1A) receptor dysfunction represents one potential mechanism underpinning MDD and other stress-related disorders...
  13. pmc Amygdala volume in depressed patients with bipolar disorder assessed using high resolution 3T MRI: the impact of medication
    Jonathan Savitz
    Section on Neuroimaging in Mood and Anxiety Disorders, NIH NIMH MAP, Bethesda, MD 20892, USA
    Neuroimage 49:2966-76. 2010
    ..Here we extend these results to the amygdala. We raise the possibility that neuroplastic changes in the amygdala associated with BD are moderated by some mood stabilizing medications...
  14. doi request reprint Dysthymic and anxiety-related personality traits in bipolar spectrum illness
    Jonathan Savitz
    Division of Human Genetics, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, USA
    J Affect Disord 109:305-11. 2008
    ..While dysthymic temperament traits conform relatively well to the quantitative genetic model of affective illness, anxious traits as defined by the AT scale, are equally salient in BPD and unipolar depression...
  15. ncbi request reprint The molecular genetics of cognition: dopamine, COMT and BDNF
    J Savitz
    MRC UCT Human Genetics Research Unit, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa
    Genes Brain Behav 5:311-28. 2006
    ..The implications of molecular genetic cognitive research for psychiatry are discussed in light of these data...
  16. pmc The subgenual anterior cingulate cortex in mood disorders
    Wayne C Drevets
    Section on Neuroimaging in Mood and Anxiety Disorders, Molecular Imaging Branch, National Institute of Mental Health, Bethesda, MD, USA
    CNS Spectr 13:663-81. 2008
    ..These data thus hold important implications for the development of neural models of depression that can account for the abnormal motivational, neuroendocrine, autonomic, and emotional manifestations evident in human mood disorders...
  17. ncbi request reprint Hypomanic, cyclothymic and hostile personality traits in bipolar spectrum illness: a family-based study
    Jonathan Savitz
    Division of Human Genetics, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa
    J Psychiatr Res 42:920-9. 2008
    ..To test whether these traits follow a distribution with the most "pathological" scores in the bipolar disorder I (BPD I) group and the least "pathological" scores in the unaffected relatives...
  18. ncbi request reprint A linkage and family-based association analysis of a potential neurocognitive endophenotype of bipolar disorder
    Jonathan Savitz
    Division of Human Genetics, Institute for Infectious Disease and Molecular Medicine, University of Cape Town, South Africa
    Neuromolecular Med 9:101-16. 2007
    ..We speculate that polymorphisms at these loci may predispose to a subtype of BPD characterized by memory-related deficits...
  19. ncbi request reprint Bipolar disorder: emotional dysregulation and neuronal vulnerability
    Dan J Stein
    Department of Psychiatry and Mental Health at the University of Cape Town, Cape Town, South Africa
    CNS Spectr 14:122-6. 2009
    ..Furthermore, there is growing data on the cellular mechanisms contributing to neuronal vulnerability in this mediating circuitry...
  20. ncbi request reprint Preliminary evidence for linkage to chromosome 1q31-32, 10q23.3, and 16p13.3 in a South African cohort with bipolar disorder
    Jonathan Savitz
    Division of Human Genetics, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa
    Am J Med Genet B Neuropsychiatr Genet 144:383-7. 2007
    ..Negative results were obtained for the remaining six candidate loci, possibly due to limited statistical power...
  21. ncbi request reprint Brain-derived neurotrophic factor: the neurotrophin hypothesis of psychopathology
    Dan J Stein
    Department of Psychiatry and Mental Health at the University of Cape Town, Cape Town, South Africa
    CNS Spectr 13:945-9. 2008
    ..Nevertheless, the neurotrophin hypothesis has already given impetus to a range of valuable research...
  22. ncbi request reprint Neuropsychological dysfunction in bipolar affective disorder: a critical opinion
    Jonathan Savitz
    MRC UCT Human Genetics Research Unit, University of Cape Town, Cape Town, South Africa
    Bipolar Disord 7:216-35. 2005
    ..The philosophical implications of this conclusion for neuropsychology are briefly discussed...
  23. ncbi request reprint Warriors versus worriers: the role of COMT gene variants
    Dan J Stein
    Department of Mental Health and Psychiatry, University of Cape Town, South Africa
    CNS Spectr 11:745-8. 2006
    ..Some evidence suggests that Val158 alleles are associated with schizophrenia, while Met158 alleles are associated with anxiety...
  24. ncbi request reprint Apolipoprotein E variants and cognition in healthy individuals: a critical opinion
    Jonathan Savitz
    MRC UCT Human Genetics Research Unit, University of Cape Town Medical School, Observatory 7925, South Africa
    Brain Res Rev 51:125-35. 2006
    ..We conclude that the neuropsychological dysfunction reported in non-demented epsilon4 carriers is most likely to be the result of incipient AD...
  25. ncbi request reprint Neurocognitive function as an endophenotype for genetic studies of bipolar affective disorder
    Jonathan B Savitz
    MRC UCT Human Genetics Research Unit, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Werner Beit North, Level 3, Faculty of Health Sciences, University of Cape Town, Observatory 7925, South Africa
    Neuromolecular Med 7:275-86. 2005
    ....
  26. pmc Trends in suicidology: personality as an endophenotype for molecular genetic investigations
    Jonathan B Savitz
    UCT MRC Human Genetics Research Unit, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa
    PLoS Med 3:e107. 2006
  27. ncbi request reprint Personality: is it a viable endophenotype for genetic studies of bipolar affective disorder?
    Jonathan B Savitz
    MRC UCT Human Genetics Research Unit, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa
    Bipolar Disord 8:322-37. 2006
    ..We conclude that personality profiling of probands and their relatives may facilitate molecular genetic work, but given the fact that personality is itself a complex trait, its use as an endophenotype has certain limitations...
  28. ncbi request reprint Genetic variants implicated in personality: a review of the more promising candidates
    Jonathan B Savitz
    MRC UCT Human Genetics Research Unit, Divison of Human Genetics, University of Cape Town, Cape Town, South Africa
    Am J Med Genet B Neuropsychiatr Genet 131:20-32. 2004
    ....