Research Topics
Genomes and GenesSpecies | J SavitzSummaryAffiliation: National Institutes of Health Country: USA Publications
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Detail Information
Publications
Catechol-o-methyltransferase genotype and childhood trauma may interact to impact schizotypal personality traitsJonathan Savitz
MRC UCT Human Genetics Research Unit, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa
Behav Genet 40:415-23. 2010..We raise the possibility that genetically-driven variation in COMT may interact with childhood trauma to contribute to the risk of developing schizotypal personality traits...
The relationship between childhood abuse and dissociation. Is it influenced by catechol-O-methyltransferase (COMT) activity?Jonathan B Savitz
MRC UCT Human Genetics Research Unit, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa
Int J Neuropsychopharmacol 11:149-61. 2008..The current findings support the involvement of the COMT Val158Met polymorphism in mediating the relationship between trauma and psychopathology...
Neurocognitive function in an extended Afrikaner-ancestry family with affective illnessJonathan Savitz
Division of Human Genetics, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa
J Psychiatry Neurosci 32:116-20. 2007..To characterize the neuropsychological profile of an extended family with unipolar depression (UPD) and other forms of affective illness...- Lateralization of hand skill in bipolar affective disorderJ Savitz
Division of Human Genetics, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa
Genes Brain Behav 6:698-705. 2007..Relative hand skill was significantly associated with a functional variant in the catechol-O-methyltransferase gene. We speculate that this polymorphism may influence brain lateralization... - Genotype and childhood sexual trauma moderate neurocognitive performance: a possible role for brain-derived neurotrophic factor and apolipoprotein E variantsJonathan Savitz
MRC UCT Human Genetics Research Unit, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa
Biol Psychiatry 62:391-9. 2007..We predicted that memory would be affected by sexual trauma and that a number of functional polymorphisms previously implicated in BPD and cognition would moderate the effect of psychological trauma on memory... - Neuropsychological task performance in bipolar spectrum illness: genetics, alcohol abuse, medication and childhood traumaJonathan B Savitz
Division of Human Genetics, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa
Bipolar Disord 10:479-94. 2008.... - Personality endophenotypes for bipolar affective disorder: a family-based genetic association analysisJ Savitz
UCT MRC Human Genetics Research Unit, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa
Genes Brain Behav 7:869-76. 2008..We raise the possibility that the 10R allele of the SLC6A3 repeat polymorphism and the short allele of the SLC6A4 promoter variant constitute risk factors for irritable-aggressive and anxious-dysthymic subtypes of BD, respectively... - Neuropsychological status of bipolar I disorder: impact of psychosisJonathan Savitz
Division of Human Genetics, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa
Br J Psychiatry 194:243-51. 2009.... - Imaging phenotypes of major depressive disorder: genetic correlatesJ B Savitz
Mood and Anxiety Disorders Program, NIH NIMH, Bethesda, MD 20892, USA
Neuroscience 164:300-30. 2009..Further advances are likely as epigenetic, copy-number variant, gene-gene interaction, and genome-wide association (GWA) approaches are brought to bear on imaging data... - Bipolar and major depressive disorder: neuroimaging the developmental-degenerative divideJonathan Savitz
Section on Neuroimaging in Mood and Anxiety Disorders, Mood and Anxiety Disorders Program, National Institute of Mental Health NIH, Bethesda, MD 20892, USA
Neurosci Biobehav Rev 33:699-771. 2009..Imaging genetic approaches hold out promise for advancing our understanding of affective illness... - 5-HT(1A) receptor function in major depressive disorderJonathan Savitz
Section on Neuroimaging in Mood and Anxiety Disorders, Mood and Anxiety Disorders Program, NIH NIMH, Bethesda, MD 20892, United States
Prog Neurobiol 88:17-31. 2009..Conversely, the C allele has been associated with better response to AD drugs. We raise the possibility that 5-HT(1A) receptor dysfunction represents one potential mechanism underpinning MDD and other stress-related disorders... - Amygdala volume in depressed patients with bipolar disorder assessed using high resolution 3T MRI: the impact of medicationJonathan Savitz
Section on Neuroimaging in Mood and Anxiety Disorders, NIH NIMH MAP, Bethesda, MD 20892, USA
Neuroimage 49:2966-76. 2010..Here we extend these results to the amygdala. We raise the possibility that neuroplastic changes in the amygdala associated with BD are moderated by some mood stabilizing medications... - Dysthymic and anxiety-related personality traits in bipolar spectrum illnessJonathan Savitz
Division of Human Genetics, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, USA
J Affect Disord 109:305-11. 2008..While dysthymic temperament traits conform relatively well to the quantitative genetic model of affective illness, anxious traits as defined by the AT scale, are equally salient in BPD and unipolar depression... - The molecular genetics of cognition: dopamine, COMT and BDNFJ Savitz
MRC UCT Human Genetics Research Unit, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa
Genes Brain Behav 5:311-28. 2006..The implications of molecular genetic cognitive research for psychiatry are discussed in light of these data... - The subgenual anterior cingulate cortex in mood disordersWayne C Drevets
Section on Neuroimaging in Mood and Anxiety Disorders, Molecular Imaging Branch, National Institute of Mental Health, Bethesda, MD, USA
CNS Spectr 13:663-81. 2008..These data thus hold important implications for the development of neural models of depression that can account for the abnormal motivational, neuroendocrine, autonomic, and emotional manifestations evident in human mood disorders... - Hypomanic, cyclothymic and hostile personality traits in bipolar spectrum illness: a family-based studyJonathan Savitz
Division of Human Genetics, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa
J Psychiatr Res 42:920-9. 2008..To test whether these traits follow a distribution with the most "pathological" scores in the bipolar disorder I (BPD I) group and the least "pathological" scores in the unaffected relatives... - A linkage and family-based association analysis of a potential neurocognitive endophenotype of bipolar disorderJonathan Savitz
Division of Human Genetics, Institute for Infectious Disease and Molecular Medicine, University of Cape Town, South Africa
Neuromolecular Med 9:101-16. 2007..We speculate that polymorphisms at these loci may predispose to a subtype of BPD characterized by memory-related deficits... - Bipolar disorder: emotional dysregulation and neuronal vulnerabilityDan J Stein
Department of Psychiatry and Mental Health at the University of Cape Town, Cape Town, South Africa
CNS Spectr 14:122-6. 2009..Furthermore, there is growing data on the cellular mechanisms contributing to neuronal vulnerability in this mediating circuitry... - Preliminary evidence for linkage to chromosome 1q31-32, 10q23.3, and 16p13.3 in a South African cohort with bipolar disorderJonathan Savitz
Division of Human Genetics, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa
Am J Med Genet B Neuropsychiatr Genet 144:383-7. 2007..Negative results were obtained for the remaining six candidate loci, possibly due to limited statistical power... - Brain-derived neurotrophic factor: the neurotrophin hypothesis of psychopathologyDan J Stein
Department of Psychiatry and Mental Health at the University of Cape Town, Cape Town, South Africa
CNS Spectr 13:945-9. 2008..Nevertheless, the neurotrophin hypothesis has already given impetus to a range of valuable research... - Neuropsychological dysfunction in bipolar affective disorder: a critical opinionJonathan Savitz
MRC UCT Human Genetics Research Unit, University of Cape Town, Cape Town, South Africa
Bipolar Disord 7:216-35. 2005..The philosophical implications of this conclusion for neuropsychology are briefly discussed... - Warriors versus worriers: the role of COMT gene variantsDan J Stein
Department of Mental Health and Psychiatry, University of Cape Town, South Africa
CNS Spectr 11:745-8. 2006..Some evidence suggests that Val158 alleles are associated with schizophrenia, while Met158 alleles are associated with anxiety... - Dissociative identity disorder associated with mania and change in handednessJonathan Savitz
MRC UCT Human Genetics Research Unit, University of Cape Town Medical School, Observatory, 7925, South Africa
Cogn Behav Neurol 17:233-7. 2004..To investigate the overlap between dissociative and bipolar disorders with reference to their neurophysiological foundations... - Apolipoprotein E variants and cognition in healthy individuals: a critical opinionJonathan Savitz
MRC UCT Human Genetics Research Unit, University of Cape Town Medical School, Observatory 7925, South Africa
Brain Res Rev 51:125-35. 2006..We conclude that the neuropsychological dysfunction reported in non-demented epsilon4 carriers is most likely to be the result of incipient AD... - Neurocognitive function as an endophenotype for genetic studies of bipolar affective disorderJonathan B Savitz
MRC/UCT Human Genetics Research Unit, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Werner Beit North, Level 3, Faculty of Health Sciences, University of Cape Town, Observatory 7925, South Africa
Neuromolecular Med 7:275-86. 2005.... - Trends in suicidology: personality as an endophenotype for molecular genetic investigationsJonathan B Savitz
UCT/MRC Human Genetics Research Unit, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa
PLoS Med 3:e107. 2006 - Personality: is it a viable endophenotype for genetic studies of bipolar affective disorder?Jonathan B Savitz
MRC UCT Human Genetics Research Unit, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa
Bipolar Disord 8:322-37. 2006..We conclude that personality profiling of probands and their relatives may facilitate molecular genetic work, but given the fact that personality is itself a complex trait, its use as an endophenotype has certain limitations... - Genetic variants implicated in personality: a review of the more promising candidatesJonathan B Savitz
MRC UCT Human Genetics Research Unit, Divison of Human Genetics, University of Cape Town, Cape Town, South Africa
Am J Med Genet B Neuropsychiatr Genet 131:20-32. 2004....