N J Sarlis

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Metastatic thyroid cancer unresponsive to conventional therapies: novel management approaches through translational clinical research
    N J Sarlis
    Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Building 10, Rm 8D12C, Bethesda, MD 20892, USA
    Curr Drug Targets Immune Endocr Metabol Disord 1:103-15. 2001
  2. ncbi request reprint Misclassification of cytologic diagnoses in patients with follicular lesions or follicular neoplasms of the thyroid gland: implications for patient care and clinical research
    Nicholas J Sarlis
    Division of Intramural Research, National Institute of Diabetes, Digestive, and Kidney Disorders, National Institutes of Health, Bethesda, Maryland 20892 1758, USA
    Cancer 96:323-4. 2002
  3. ncbi request reprint Increased levothyroxine requirements presenting as "inappropriate" TSH secretion syndrome in a patient with nephrotic syndrome
    M T Collins
    National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA
    J Endocrinol Invest 23:383-92. 2000
  4. ncbi request reprint Assessing the effects of thyroid suppression on benign solitary thyroid nodules. A model for using quantitative research synthesis
    G Csako
    Clinical Pathology Department, Clin Ctr, NIH, Bethesda, MD 20892 1508, USA
    Medicine (Baltimore) 79:9-26. 2000
  5. ncbi request reprint Low concentrations of the histone deacetylase inhibitor, depsipeptide (FR901228), increase expression of the Na(+)/I(-) symporter and iodine accumulation in poorly differentiated thyroid carcinoma cells
    M Kitazono
    Medicine Branch, DCS, National Cancer Institute, Bethesda, Maryland 20892, USA
    J Clin Endocrinol Metab 86:3430-5. 2001
  6. ncbi request reprint A case of spurious hypercalcitoninemia: a cautionary tale on the use of plasma calcitonin assays in the screening of patients with thyroid nodules for neoplasia
    G I Uwaifo
    Developmental Endocrinology Branch, National Institutes of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    J Endocrinol Invest 24:361-9. 2001
  7. ncbi request reprint Somatic mutation of TRbeta can cause a defect in negative regulation of TSH in a TSH-secreting pituitary tumor
    S Ando
    Molecular Regulation and Neuroendocrinology Section, Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Endocrinol Metab 86:5572-6. 2001
  8. ncbi request reprint Exaggerated levothyroxine malabsorption due to calcium carbonate supplementation in gastrointestinal disorders
    G Csako
    Department of Laboratory Medicine, Warren G Magnuson Clinical Center, National Institutes of Health, Bethesda, MD, USA
    Ann Pharmacother 35:1578-83. 2001
  9. ncbi request reprint The spectrum of thyroid diseases in childhood and its evolution during transition to adulthood: natural history, diagnosis, differential diagnosis and management
    C A Koch
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    J Endocrinol Invest 24:659-75. 2001
  10. ncbi request reprint Effectiveness of long-acting octreotide in suppressing hormonogenesis and tumor growth in thyrotropin-secreting pituitary adenomas: report of two cases
    L Gourgiotis
    Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Pituitary 4:135-43. 2001

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Metastatic thyroid cancer unresponsive to conventional therapies: novel management approaches through translational clinical research
    N J Sarlis
    Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Building 10, Rm 8D12C, Bethesda, MD 20892, USA
    Curr Drug Targets Immune Endocr Metabol Disord 1:103-15. 2001
    ....
  2. ncbi request reprint Misclassification of cytologic diagnoses in patients with follicular lesions or follicular neoplasms of the thyroid gland: implications for patient care and clinical research
    Nicholas J Sarlis
    Division of Intramural Research, National Institute of Diabetes, Digestive, and Kidney Disorders, National Institutes of Health, Bethesda, Maryland 20892 1758, USA
    Cancer 96:323-4. 2002
  3. ncbi request reprint Increased levothyroxine requirements presenting as "inappropriate" TSH secretion syndrome in a patient with nephrotic syndrome
    M T Collins
    National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA
    J Endocrinol Invest 23:383-92. 2000
    ..This pattern of extreme dysregulation in thyroid function indices due to urinary loss of thyroid hormones has not been previously described in NS, and, therefore, extends the spectrum of endocrine manifestations of NS...
  4. ncbi request reprint Assessing the effects of thyroid suppression on benign solitary thyroid nodules. A model for using quantitative research synthesis
    G Csako
    Clinical Pathology Department, Clin Ctr, NIH, Bethesda, MD 20892 1508, USA
    Medicine (Baltimore) 79:9-26. 2000
    ..Finally, quantitative assessment of available evidence as described here may be applicable to the review of other controversial issues as well...
  5. ncbi request reprint Low concentrations of the histone deacetylase inhibitor, depsipeptide (FR901228), increase expression of the Na(+)/I(-) symporter and iodine accumulation in poorly differentiated thyroid carcinoma cells
    M Kitazono
    Medicine Branch, DCS, National Cancer Institute, Bethesda, Maryland 20892, USA
    J Clin Endocrinol Metab 86:3430-5. 2001
    ..These in vitro results suggest that depsipeptide or other histone deacetylase inhibitors might be used clinically in thyroid carcinomas that are unable to trap iodine as an adjunct to radioiodine therapy...
  6. ncbi request reprint A case of spurious hypercalcitoninemia: a cautionary tale on the use of plasma calcitonin assays in the screening of patients with thyroid nodules for neoplasia
    G I Uwaifo
    Developmental Endocrinology Branch, National Institutes of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    J Endocrinol Invest 24:361-9. 2001
    ..Finally, the assay selected should detect only the mature CT molecule...
  7. ncbi request reprint Somatic mutation of TRbeta can cause a defect in negative regulation of TSH in a TSH-secreting pituitary tumor
    S Ando
    Molecular Regulation and Neuroendocrinology Section, Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Endocrinol Metab 86:5572-6. 2001
    ..Our results demonstrate that somatic mutation of TRbeta occurred in a TSHoma and was probably responsible for the defect in negative regulation of TSH by thyroid hormone in the tumor...
  8. ncbi request reprint Exaggerated levothyroxine malabsorption due to calcium carbonate supplementation in gastrointestinal disorders
    G Csako
    Department of Laboratory Medicine, Warren G Magnuson Clinical Center, National Institutes of Health, Bethesda, MD, USA
    Ann Pharmacother 35:1578-83. 2001
    ..To describe a patient with primary hypothyroidism in whom ingestion of levothyroxine with calcium carbonate led to markedly elevated serum thyrotropin concentrations...
  9. ncbi request reprint The spectrum of thyroid diseases in childhood and its evolution during transition to adulthood: natural history, diagnosis, differential diagnosis and management
    C A Koch
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    J Endocrinol Invest 24:659-75. 2001
    ....
  10. ncbi request reprint Effectiveness of long-acting octreotide in suppressing hormonogenesis and tumor growth in thyrotropin-secreting pituitary adenomas: report of two cases
    L Gourgiotis
    Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Pituitary 4:135-43. 2001
    ..CONCLUSION: Our date corroborate earlier reports on the usefulness of SMS-LAR in the medical management of patients with TSPA's who have residual disease after initial pituitary surgery and/or irradiation...
  11. ncbi request reprint Molecular elements of apoptosis-regulating pathways in follicular thyroid cells: mining for novel therapeutic targets in the treatment of thyroid carcinoma
    N J Sarlis
    Division of Intramural Research NJS, National Institutes of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Bldg 10, Rm 8D12C, 10 Center Drive, Bethesda, MD 20892 1758, USA
    Curr Drug Targets Immune Endocr Metabol Disord 4:187-98. 2004
    ..In this review, we outline the main molecular targets that play a role in apoptosis in ThyrCa cells, and discuss various options for promoting apoptosis, either by pharmacologic or gene transfer therapeutic interventions...
  12. ncbi request reprint Outcomes of patients with differentiated thyroid carcinoma following initial therapy
    Jacqueline Jonklaas
    Georgetown University Medical Center, Washington, DC 20007, USA
    Thyroid 16:1229-42. 2006
    ..We were unable to show any impact, positive or negative, of specific therapies in stage I patients...
  13. ncbi request reprint Thyroid carcinoma in the McCune-Albright syndrome: contributory role of activating Gs alpha mutations
    Michael T Collins
    Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 4320, USA
    J Clin Endocrinol Metab 88:4413-7. 2003
    ..These findings suggest that the infrequent development of thyroid carcinoma in MAS patients involves additional mutational or epigenetic events...
  14. ncbi request reprint Role of metastasectomy in the management of thyroid carcinoma: the NIH experience
    Ho Pak
    Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 1758, USA
    J Surg Oncol 82:10-8. 2003
    ..We studied the impact of metatasectomy on disease outcome in 29 advanced nonmedullary thyroid carcinoma (ThyrCa) patients who were operated on between 1969 and 2001 at NIH to further define its role in the management of this malignancy...
  15. ncbi request reprint Juxtathyroidal neck soft tissue angiosarcoma presenting as an undifferentiated thyroid carcinoma
    Juan Yu
    Division of Intramural Research, National Institute of Child Health and Human Development, Bethesda, Maryland, USA
    Thyroid 12:427-32. 2002
    ....
  16. ncbi request reprint Current controversies in the management of pediatric patients with well-differentiated nonmedullary thyroid cancer: a review
    Wellington Hung
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 1758, USA
    Thyroid 12:683-702. 2002
    ....
  17. ncbi request reprint Molecular signaling in thyroid cancer
    Nicholas J Sarlis
    Department of Endocrine Neoplasia and Hormonal Disorders, The University of Texas M D Anderson Cancer Center, Houston, Texas 77082, USA
    Cancer Treat Res 122:237-64. 2004
  18. ncbi request reprint Inactive pulmonary tuberculosis mimicking metastasis from papillary thyroid carcinoma in diagnostic radioiodine whole-body scintigraphy
    Michalis K Picolos
    Department of Endocrine Neoplasia and Hormonal Disorders, The University of Texas, M D Anderson Cancer Center, Houston, Texas 77030, USA
    Thyroid 15:1105-6. 2005
  19. ncbi request reprint Thyroid and aging
    Mouhammed Habra
    Department of Endocrine Neoplasia and Hormonal Disorders, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Rev Endocr Metab Disord 6:145-54. 2005
  20. ncbi request reprint Successful outcome after surgical management in two cases of the "painful variant" of Hashimoto's thyroiditis
    Loukas Gourgiotis
    Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases NIDDK, National Institutes of Health, Bethesda, Maryland 20892 1758, USA
    Endocr Pract 8:259-65. 2002
    ..To describe two cases of the rare "painful variant" of Hashimoto's thyroiditis (HT) that were refractory to medical management and in which surgical intervention provided the definitive treatment...
  21. ncbi request reprint Regulatory subunit type I-alpha of protein kinase A (PRKAR1A): a tumor-suppressor gene for sporadic thyroid cancer
    Fabiano Sandrini
    Unit on Genetics and Endocrinology, Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 1862, USA
    Genes Chromosomes Cancer 35:182-92. 2002
    ..We conclude that PRKAR1A, the most abundant regulatory subunit of protein kinase A and a principal cyclic AMP-signaling modulator, acts as a tumor-suppressor gene in sporadic thyroid cancer. Published 2002 Wiley-Liss, Inc...
  22. ncbi request reprint In-111 DTPA-octreotide scintigraphy for disease detection in metastatic thyroid cancer: comparison with F-18 FDG positron emission tomography and extensive conventional radiographic imaging
    Nicholas J Sarlis
    Division of Intramural Research, National Institutes of Diabetes, Bethesda, Maryland, USA
    Clin Nucl Med 28:208-17. 2003
    ..The authors compared the sensitivity of In-111-based SRS, F-18 fluorodeoxyglucose (FDG) positron emission tomography (PET), and extensive conventional radiographic imaging (CRI) in this type of cancer...
  23. ncbi request reprint Localization of medullary thyroid carcinoma metastasis in a multiple endocrine neoplasia type 2A patient by 6-[18F]-fluorodopamine positron emission tomography
    Loukas Gourgiotis
    Clinical Endocrinology Branch, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, 20892, USA
    J Clin Endocrinol Metab 88:637-41. 2003
    ....
  24. ncbi request reprint Effects of thyroid hormone suppression therapy on adverse clinical outcomes in thyroid cancer
    Nayahmka J McGriff
    Department of Pharmacy, Warren G Magnuson Clinical Center, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health NIH, Building 10, Room 8D12C, 10 Center Drive, MSC 1758 Bethesda, MD 20892 1758, USA
    Ann Med 34:554-64. 2002
    ..Additionally, the role - if any - of TSH effect at low ambient concentrations upon human thyroid tumorigenesis remains unclear...
  25. doi request reprint Four patients with cutaneous metastases from medullary thyroid cancer
    Libero Santarpia
    Department of Endocrine Neoplasia and Hormonal Disorders, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Thyroid 18:901-5. 2008
    ..The appearing of cutaneous metastasis is a negative prognostic factor since all the patients here described died within one year from the diagnosis of cutaneous metastases...