Thomas D Sargent

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi Transcriptional regulation at the neural plate border
    Thomas D Sargent
    Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA
    Adv Exp Med Biol 589:32-44. 2006
  2. ncbi Induction of neural crest in Xenopus by transcription factor AP2alpha
    Ting Luo
    Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 100:532-7. 2003
  3. ncbi Inca: a novel p21-activated kinase-associated protein required for cranial neural crest development
    Ting Luo
    Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Development 134:1279-89. 2007
  4. ncbi Regulatory targets for transcription factor AP2 in Xenopus embryos
    Ting Luo
    Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892-2790, USA
    Dev Growth Differ 47:403-13. 2005
  5. ncbi Transcription factor AP-2 is an essential and direct regulator of epidermal development in Xenopus
    Ting Luo
    Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, Bethesda, MD 20892, USA
    Dev Biol 245:136-44. 2002
  6. ncbi Myosin-X is required for cranial neural crest cell migration in Xenopus laevis
    Yoo seok Hwang
    Laboratory of Molecular Genetics, NICHD, NIH, Bethesda, Maryland 20892, USA
    Dev Dyn 238:2522-9. 2009
  7. ncbi Msx1 and Msx2 have shared essential functions in neural crest but may be dispensable in epidermis and axis formation in Xenopus
    Deepak Khadka
    Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda MD 20892, USA
    Int J Dev Biol 50:499-502. 2006
  8. ncbi PCNS: a novel protocadherin required for cranial neural crest migration and somite morphogenesis in Xenopus
    Janaki Rangarajan
    Laboratory of Molecular Genetics, NICHD, NIH, Bethesda, MD 20892, USA
    Dev Biol 295:206-18. 2006
  9. ncbi AP-2alpha selectively regulates fragile X mental retardation-1 gene transcription during embryonic development
    Jae H Lim
    Department of Neuroscience, Brown University, Providence, RI 02912, USA
    Hum Mol Genet 14:2027-34. 2005
  10. ncbi Specification of the otic placode depends on Sox9 function in Xenopus
    Natasha Saint-Germain
    Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, 3800 Spruce Street, Philadelphia, PA 19104, USA
    Development 131:1755-63. 2004

Collaborators

  • Thomas Schilling
  • GUILLERMO C OLIVER
  • Ting Luo
  • Jae H Lim
  • Janaki Rangarajan
  • Deepak Khadka
  • Yoo seok Hwang
  • Yanhua Xu
  • Justin R Fallon
  • Yanhui Zhang
  • Natasha Saint-Germain
  • Jean-Pierre Saint-Jeannet
  • Young-Hoon Lee
  • Tailin Zhang
  • Trevor L Hoffman
  • Ken W Y Cho
  • Anne B Booker
  • Yasuhide Furuta
  • Oleg Lagutin
  • Trevor Williams
  • Young Hoon Lee
  • Jean Pierre Saint-Jeannet
  • Daniel L Weeks
  • Mami Matsuo-Takasaki
  • Megan L Thomas

Detail Information

Publications11

  1. ncbi Transcriptional regulation at the neural plate border
    Thomas D Sargent
    Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA
    Adv Exp Med Biol 589:32-44. 2006
  2. ncbi Induction of neural crest in Xenopus by transcription factor AP2alpha
    Ting Luo
    Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 100:532-7. 2003
    ..We propose a model in which AP2alpha expression, along with inactivation of NC inhibitory factors such as Dlx3, establish a feedback loop comprising AP2alpha, Sox9, and Slug, leading to and maintaining NC specification...
  3. ncbi Inca: a novel p21-activated kinase-associated protein required for cranial neural crest development
    Ting Luo
    Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Development 134:1279-89. 2007
    ..These results suggest that Inca and PAK5 cooperate in restructuring cytoskeletal organization and in the regulation of cell adhesion in the early embryo and in NC cells during craniofacial development...
  4. ncbi Regulatory targets for transcription factor AP2 in Xenopus embryos
    Ting Luo
    Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892-2790, USA
    Dev Growth Differ 47:403-13. 2005
    ..These results provide further support for the importance of TFAP2alpha in ectoderm development, and also highlight the molecular linkage between the epidermis and neural crest in the Xenopus embryo...
  5. ncbi Transcription factor AP-2 is an essential and direct regulator of epidermal development in Xenopus
    Ting Luo
    Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, Bethesda, MD 20892, USA
    Dev Biol 245:136-44. 2002
    ..These treatments also result in gastrulation failure. Thus, AP-2 is a critical regulator of ectodermal determination that is required for normal epidermal development and morphogenesis in the frog embryo...
  6. ncbi Myosin-X is required for cranial neural crest cell migration in Xenopus laevis
    Yoo seok Hwang
    Laboratory of Molecular Genetics, NICHD, NIH, Bethesda, Maryland 20892, USA
    Dev Dyn 238:2522-9. 2009
    ..These data support the conclusion that MyoX has an essential function in CNC migration in the vertebrate embryo...
  7. ncbi Msx1 and Msx2 have shared essential functions in neural crest but may be dispensable in epidermis and axis formation in Xenopus
    Deepak Khadka
    Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda MD 20892, USA
    Int J Dev Biol 50:499-502. 2006
    ..If Msx genes have important functions in epidermis or axial mesoderm induction, these functions must be shared with other regulatory proteins...
  8. ncbi PCNS: a novel protocadherin required for cranial neural crest migration and somite morphogenesis in Xenopus
    Janaki Rangarajan
    Laboratory of Molecular Genetics, NICHD, NIH, Bethesda, MD 20892, USA
    Dev Biol 295:206-18. 2006
    ..Somites and axial muscles also failed to undergo normal morphogenesis in these embryos. Thus, PCNS has essential functions in these two important developmental processes in Xenopus...
  9. ncbi AP-2alpha selectively regulates fragile X mental retardation-1 gene transcription during embryonic development
    Jae H Lim
    Department of Neuroscience, Brown University, Providence, RI 02912, USA
    Hum Mol Genet 14:2027-34. 2005
    ..We conclude that AP-2alpha associates with the Fmr1 promoter in vivo and selectively regulates Fmr1 transcription during embryonic development...
  10. ncbi Specification of the otic placode depends on Sox9 function in Xenopus
    Natasha Saint-Germain
    Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, 3800 Spruce Street, Philadelphia, PA 19104, USA
    Development 131:1755-63. 2004
    ..We propose that Sox9 is one of the key regulators of inner ear specification in Xenopus...
  11. ncbi Developmental expression of Xenopus fragile X mental retardation-1 gene
    Jae H Lim
    Department of Neuroscience, Brown University, Providence, RI 02912, USA
    Int J Dev Biol 49:981-4. 2005
    ..Further, our findings indicate that Xenopus will serve as an excellent model to study the developmental basis of this disease...