Thomas D Sargent

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Transcriptional regulation at the neural plate border
    Thomas D Sargent
    Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA
    Adv Exp Med Biol 589:32-44. 2006
  2. pmc Myosin-X is required for cranial neural crest cell migration in Xenopus laevis
    Yoo seok Hwang
    Laboratory of Molecular Genetics, NICHD, NIH, Bethesda, Maryland 20892, USA
    Dev Dyn 238:2522-9. 2009
  3. ncbi request reprint Msx1 and Msx2 have shared essential functions in neural crest but may be dispensable in epidermis and axis formation in Xenopus
    Deepak Khadka
    Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda MD 20892, USA
    Int J Dev Biol 50:499-502. 2006
  4. ncbi request reprint Inca: a novel p21-activated kinase-associated protein required for cranial neural crest development
    Ting Luo
    Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Development 134:1279-89. 2007
  5. ncbi request reprint Regulatory targets for transcription factor AP2 in Xenopus embryos
    Ting Luo
    Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 2790, USA
    Dev Growth Differ 47:403-13. 2005
  6. pmc Induction of neural crest in Xenopus by transcription factor AP2alpha
    Ting Luo
    Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 100:532-7. 2003
  7. ncbi request reprint PCNS: a novel protocadherin required for cranial neural crest migration and somite morphogenesis in Xenopus
    Janaki Rangarajan
    Laboratory of Molecular Genetics, NICHD, NIH, Bethesda, MD 20892, USA
    Dev Biol 295:206-18. 2006
  8. ncbi request reprint Expression of TFAP2beta and TFAP2gamma genes in Xenopus laevis
    Yanhui Zhang
    Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bldg 6B, Room 412, Bethesda, MD 20892, USA
    Gene Expr Patterns 6:589-95. 2006
  9. ncbi request reprint Transcription factor AP-2 is an essential and direct regulator of epidermal development in Xenopus
    Ting Luo
    Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, Bethesda, MD 20892, USA
    Dev Biol 245:136-44. 2002
  10. doi request reprint Maternal pak4 expression is required for primitive myelopoiesis in zebrafish
    Sheran H W Law
    Section on Vertebrate Development, Program on Genomics of Differentiation, Eunice Kennedy Shriver National Institute of Child Health and Development, National Institutes of Health, Bethesda, MD, USA
    Mech Dev 130:181-94. 2013

Collaborators

  • Sheran H W Law
  • Thomas Schilling
  • GUILLERMO C OLIVER
  • Ting Luo
  • Yanhui Zhang
  • Jae H Lim
  • Janaki Rangarajan
  • Deepak Khadka
  • Yoo seok Hwang
  • Yanhua Xu
  • Justin R Fallon
  • Natasha Saint-Germain
  • Young Hoon Lee
  • Jean Pierre Saint-Jeannet
  • Tailin Zhang
  • Trevor L Hoffman
  • Yasuhide Furuta
  • Anne B Booker
  • Ken W Y Cho
  • Trevor Williams
  • Oleg Lagutin
  • Mami Matsuo-Takasaki
  • Megan L Thomas
  • Daniel L Weeks

Detail Information

Publications14

  1. ncbi request reprint Transcriptional regulation at the neural plate border
    Thomas D Sargent
    Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA
    Adv Exp Med Biol 589:32-44. 2006
  2. pmc Myosin-X is required for cranial neural crest cell migration in Xenopus laevis
    Yoo seok Hwang
    Laboratory of Molecular Genetics, NICHD, NIH, Bethesda, Maryland 20892, USA
    Dev Dyn 238:2522-9. 2009
    ..These data support the conclusion that MyoX has an essential function in CNC migration in the vertebrate embryo...
  3. ncbi request reprint Msx1 and Msx2 have shared essential functions in neural crest but may be dispensable in epidermis and axis formation in Xenopus
    Deepak Khadka
    Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda MD 20892, USA
    Int J Dev Biol 50:499-502. 2006
    ..If Msx genes have important functions in epidermis or axial mesoderm induction, these functions must be shared with other regulatory proteins...
  4. ncbi request reprint Inca: a novel p21-activated kinase-associated protein required for cranial neural crest development
    Ting Luo
    Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Development 134:1279-89. 2007
    ..These results suggest that Inca and PAK5 cooperate in restructuring cytoskeletal organization and in the regulation of cell adhesion in the early embryo and in NC cells during craniofacial development...
  5. ncbi request reprint Regulatory targets for transcription factor AP2 in Xenopus embryos
    Ting Luo
    Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 2790, USA
    Dev Growth Differ 47:403-13. 2005
    ..These results provide further support for the importance of TFAP2alpha in ectoderm development, and also highlight the molecular linkage between the epidermis and neural crest in the Xenopus embryo...
  6. pmc Induction of neural crest in Xenopus by transcription factor AP2alpha
    Ting Luo
    Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 100:532-7. 2003
    ..We propose a model in which AP2alpha expression, along with inactivation of NC inhibitory factors such as Dlx3, establish a feedback loop comprising AP2alpha, Sox9, and Slug, leading to and maintaining NC specification...
  7. ncbi request reprint PCNS: a novel protocadherin required for cranial neural crest migration and somite morphogenesis in Xenopus
    Janaki Rangarajan
    Laboratory of Molecular Genetics, NICHD, NIH, Bethesda, MD 20892, USA
    Dev Biol 295:206-18. 2006
    ..Somites and axial muscles also failed to undergo normal morphogenesis in these embryos. Thus, PCNS has essential functions in these two important developmental processes in Xenopus...
  8. ncbi request reprint Expression of TFAP2beta and TFAP2gamma genes in Xenopus laevis
    Yanhui Zhang
    Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bldg 6B, Room 412, Bethesda, MD 20892, USA
    Gene Expr Patterns 6:589-95. 2006
    ..All three are induced by Wnt/beta-catenin -- BMP signals and all bind to a consensus TFAP2 recognition site from an epidermal keratin gene...
  9. ncbi request reprint Transcription factor AP-2 is an essential and direct regulator of epidermal development in Xenopus
    Ting Luo
    Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, Bethesda, MD 20892, USA
    Dev Biol 245:136-44. 2002
    ..These treatments also result in gastrulation failure. Thus, AP-2 is a critical regulator of ectodermal determination that is required for normal epidermal development and morphogenesis in the frog embryo...
  10. doi request reprint Maternal pak4 expression is required for primitive myelopoiesis in zebrafish
    Sheran H W Law
    Section on Vertebrate Development, Program on Genomics of Differentiation, Eunice Kennedy Shriver National Institute of Child Health and Development, National Institutes of Health, Bethesda, MD, USA
    Mech Dev 130:181-94. 2013
    ....
  11. pmc The Serine-Threonine Protein Kinase PAK4 Is Dispensable in Zebrafish: Identification of a Morpholino-Generated Pseudophenotype
    Sheran H W Law
    Section on Vertebrate Development, Program on Genomics of Differentiation, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 9:e100268. 2014
    ....
  12. ncbi request reprint AP-2alpha selectively regulates fragile X mental retardation-1 gene transcription during embryonic development
    Jae H Lim
    Department of Neuroscience, Brown University, Providence, RI 02912, USA
    Hum Mol Genet 14:2027-34. 2005
    ..We conclude that AP-2alpha associates with the Fmr1 promoter in vivo and selectively regulates Fmr1 transcription during embryonic development...
  13. ncbi request reprint Developmental expression of Xenopus fragile X mental retardation-1 gene
    Jae H Lim
    Department of Neuroscience, Brown University, Providence, RI 02912, USA
    Int J Dev Biol 49:981-4. 2005
    ..Further, our findings indicate that Xenopus will serve as an excellent model to study the developmental basis of this disease...
  14. ncbi request reprint Specification of the otic placode depends on Sox9 function in Xenopus
    Natasha Saint-Germain
    Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, 3800 Spruce Street, Philadelphia, PA 19104, USA
    Development 131:1755-63. 2004
    ..We propose that Sox9 is one of the key regulators of inner ear specification in Xenopus...