Silvia Santamarina-Fojo

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Complete genomic sequence of the human ABCA1 gene: analysis of the human and mouse ATP-binding cassette A promoter
    S Santamarina-Fojo
    National Heart, Lung, and Blood Institute, and Clinical Center, Clinical Pathology Department, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 97:7987-92. 2000
  2. ncbi request reprint Lecithin-cholesterol acyltransferase: role in lipoprotein metabolism, reverse cholesterol transport and atherosclerosis
    S Santamarina-Fojo
    Molecular Disease Branch, National Heart, Lung, and Blood Institute, National Institute of Health, Bethesda, Maryland, USA
    Curr Opin Lipidol 11:267-75. 2000
  3. ncbi request reprint Regulation and intracellular trafficking of the ABCA1 transporter
    S Santamarina-Fojo
    Molecular Disease Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Lipid Res 42:1339-45. 2001
  4. ncbi request reprint Hepatic lipase, lipoprotein metabolism, and atherogenesis
    Silvia Santamarina-Fojo
    Molecular Disease Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Arterioscler Thromb Vasc Biol 24:1750-4. 2004
  5. ncbi request reprint Hepatic ABCG5 and ABCG8 overexpression increases hepatobiliary sterol transport but does not alter aortic atherosclerosis in transgenic mice
    Justina E Wu
    Molecular Disease Branch, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 279:22913-25. 2004
  6. pmc The ATP binding cassette transporter A1 (ABCA1) modulates the development of aortic atherosclerosis in C57BL/6 and apoE-knockout mice
    Charles W Joyce
    Molecular Disease Branch, National Heart, Lung, and Blood Institute, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 99:407-12. 2002
  7. pmc Hepatic lipase expression in macrophages contributes to atherosclerosis in apoE-deficient and LCAT-transgenic mice
    Zengxuan Nong
    Molecular Disease Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, Maryland 20892, USA
    J Clin Invest 112:367-78. 2003
  8. ncbi request reprint The ligand-binding function of hepatic lipase modulates the development of atherosclerosis in transgenic mice
    Herminia Gonzalez-Navarro
    Molecular Disease Branch, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 279:45312-21. 2004
  9. ncbi request reprint ABCA1 overexpression in the liver of LDLr-KO mice leads to accumulation of pro-atherogenic lipoproteins and enhanced atherosclerosis
    Charles W Joyce
    Molecular Disease Section, NHLBI, National Institutes of Health, Bethesda, MD 20892, USA
    J Biol Chem 281:33053-65. 2006
  10. ncbi request reprint The ABCA1 transporter functions on the basolateral surface of hepatocytes
    Edward B Neufeld
    Molecular Disease Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, 10 7N115, 10 Center Drive, 20892, Bethesda, MD 20892, USA
    Biochem Biophys Res Commun 297:974-9. 2002

Collaborators

Detail Information

Publications26

  1. pmc Complete genomic sequence of the human ABCA1 gene: analysis of the human and mouse ATP-binding cassette A promoter
    S Santamarina-Fojo
    National Heart, Lung, and Blood Institute, and Clinical Center, Clinical Pathology Department, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 97:7987-92. 2000
    ..These combined findings provide insights into ABCA1-mediated regulation of cellular cholesterol metabolism and will facilitate the identification of new pharmacologic agents for the treatment of atherosclerosis in humans...
  2. ncbi request reprint Lecithin-cholesterol acyltransferase: role in lipoprotein metabolism, reverse cholesterol transport and atherosclerosis
    S Santamarina-Fojo
    Molecular Disease Branch, National Heart, Lung, and Blood Institute, National Institute of Health, Bethesda, Maryland, USA
    Curr Opin Lipidol 11:267-75. 2000
    ..Analysis of LCAT transgenic animals has established the importance of evaluating HDL function, as well as HDL plasma levels, to predict atherogenic risk...
  3. ncbi request reprint Regulation and intracellular trafficking of the ABCA1 transporter
    S Santamarina-Fojo
    Molecular Disease Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Lipid Res 42:1339-45. 2001
    ..Given the key role that ABCA1 plays in cholesterol homeostasis, it is likely that there are multiple mechanisms for controlling the overall transporter activity of ABCA1...
  4. ncbi request reprint Hepatic lipase, lipoprotein metabolism, and atherogenesis
    Silvia Santamarina-Fojo
    Molecular Disease Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Arterioscler Thromb Vasc Biol 24:1750-4. 2004
    ....
  5. ncbi request reprint Hepatic ABCG5 and ABCG8 overexpression increases hepatobiliary sterol transport but does not alter aortic atherosclerosis in transgenic mice
    Justina E Wu
    Molecular Disease Branch, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 279:22913-25. 2004
    ..These findings demonstrate that overexpression of ABCG5/G8 in the liver profoundly alters hepatic but not intestinal sterol transport, identifying distinct roles for liver and intestinal ABCG5/G8 in modulating sterol metabolism...
  6. pmc The ATP binding cassette transporter A1 (ABCA1) modulates the development of aortic atherosclerosis in C57BL/6 and apoE-knockout mice
    Charles W Joyce
    Molecular Disease Branch, National Heart, Lung, and Blood Institute, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 99:407-12. 2002
    ....
  7. pmc Hepatic lipase expression in macrophages contributes to atherosclerosis in apoE-deficient and LCAT-transgenic mice
    Zengxuan Nong
    Molecular Disease Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, Maryland 20892, USA
    J Clin Invest 112:367-78. 2003
    ....
  8. ncbi request reprint The ligand-binding function of hepatic lipase modulates the development of atherosclerosis in transgenic mice
    Herminia Gonzalez-Navarro
    Molecular Disease Branch, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 279:45312-21. 2004
    ....
  9. ncbi request reprint ABCA1 overexpression in the liver of LDLr-KO mice leads to accumulation of pro-atherogenic lipoproteins and enhanced atherosclerosis
    Charles W Joyce
    Molecular Disease Section, NHLBI, National Institutes of Health, Bethesda, MD 20892, USA
    J Biol Chem 281:33053-65. 2006
    ....
  10. ncbi request reprint The ABCA1 transporter functions on the basolateral surface of hepatocytes
    Edward B Neufeld
    Molecular Disease Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, 10 7N115, 10 Center Drive, 20892, Bethesda, MD 20892, USA
    Biochem Biophys Res Commun 297:974-9. 2002
    ..These findings suggest an important role for hepatocyte basolateral membrane ABCA1 in the regulation of the levels of intracellular hepatic cholesterol, as well as plasma HDL...
  11. ncbi request reprint Study of ABCA1 function in transgenic mice
    Charles Joyce
    Molecular Disease Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Arterioscler Thromb Vasc Biol 23:965-71. 2003
    ..The present review summarizes the most recent studies and discusses insights provided by these transgenic mouse models...
  12. ncbi request reprint The E-box motif in the proximal ABCA1 promoter mediates transcriptional repression of the ABCA1 gene
    Xiao Ping Yang
    Molecular Disease Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1666, USA
    J Lipid Res 43:297-306. 2002
    ..These combined studies identify a novel site in the human ABCA1 promoter involved in the regulation of ABCA1 gene expression...
  13. ncbi request reprint Role of the hepatic ABCA1 transporter in modulating intrahepatic cholesterol and plasma HDL cholesterol concentrations
    Federica Basso
    Molecular Disease Branch, NHLBI, National Institutes of Health, Bethesda, MD 20862, USA
    J Lipid Res 44:296-302. 2003
    ..These combined results demonstrate that ABCA1 plays a key role in hepatic cholesterol efflux, inducing pathways that modulate cholesterol homeostasis in the liver, and establish the liver as a major source of plasma HDL-C...
  14. ncbi request reprint Identification of mouse and human macrophages as a site of synthesis of hepatic lipase
    Herminia Gonzalez-Navarro
    Molecular Disease Branch, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Lipid Res 43:671-5. 2002
    ..These combined findings establish that HL is synthesized de novo by macrophages as well as liver, and raises the possibility that HL may have a direct role in the pathogenesis of atherosclerosis...
  15. pmc Enhanced ABCG1 expression increases atherosclerosis in LDLr-KO mice on a western diet
    Federica Basso
    Lipoprotein Metabolism Section, NHLBI, NIH, 10 Center Drive, 7N102, Bethesda, MD 20892, USA
    Biochem Biophys Res Commun 351:398-404. 2006
    ..2-fold) were also increased in ABCG1xLDLr-KO mice. In summary, these findings suggest that enhanced expression of ABCG1 increases atherosclerosis in LDLr-KO mice, despite its role in promoting cholesterol efflux from cells...
  16. ncbi request reprint The orphan nuclear receptor LRH-1 activates the ABCG5/ABCG8 intergenic promoter
    Lita A Freeman
    Molecular Disease Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA
    J Lipid Res 45:1197-206. 2004
    ....
  17. ncbi request reprint Lipolytic and ligand-binding functions of hepatic lipase protect against atherosclerosis in LDL receptor-deficient mice
    Lita Freeman
    Molecular Disease Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Lipid Res 48:104-13. 2007
    ..These changes, evident even in the presence of apoE, establish an antiatherogenic role of the ligand-binding function of HL in LDLr-deficient mice...
  18. ncbi request reprint The ABCA1 transporter modulates late endocytic trafficking: insights from the correction of the genetic defect in Tangier disease
    Edward B Neufeld
    Molecular Disease Branch, NHLBI, NHLBI Light Microscopy Core Facility, and Laboratory for Cellular Biology and Biochemistry, NIDDK, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 279:15571-8. 2004
    ..The combined results of this study suggest that ABCA1 converts pools of late endocytic lipids that retain NPC1 to pools that can associate with endocytosed apoA-I, and be released from the cell as nascent high density lipoprotein...
  19. ncbi request reprint Synthetic amphipathic helical peptides promote lipid efflux from cells by an ABCA1-dependent and an ABCA1-independent pathway
    Alan T Remaley
    National Institutes of Health Molecular Disease Branch, National Heart, Lung, and Blood Institute, Bethesda, MD 20892, USA
    J Lipid Res 44:828-36. 2003
    ..In addition, unlike apoA-I, synthetic peptides can also efflux lipid by a passive, energy-independent pathway that does not involve ABCA1 but does depend upon their lipid affinity...
  20. pmc Effects of FXR in foam-cell formation and atherosclerosis development
    Grace L Guo
    Laboratory of Metabolism, Bldg 37, Rm 3106B, NCI, NIH, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Biochim Biophys Acta 1761:1401-9. 2006
    ..Our study cautions the use of serum lipid levels as a surrogate marker to determine the efficiency of FXR modulators in treating hyperlipidemia...
  21. ncbi request reprint Comparative genome analysis of potential regulatory elements in the ABCG5-ABCG8 gene cluster
    Alan T Remaley
    National Heart, Lung and Blood Institute, National Institutes of Health, Bldg 10 2C 433, 10 Center Drive, Bethesda, MD 20892, USA
    Biochem Biophys Res Commun 295:276-82. 2002
    ..In summary, several potential regulatory elements were found for the ABCG5 and ABCG8 genes, and the intergenic region was found to act as a bidirectional promoter...
  22. ncbi request reprint New insights into the role of the adenosine triphosphate-binding cassette transporters in high-density lipoprotein metabolism and reverse cholesterol transport
    H Bryan Brewer
    Molecular Disease Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Am J Cardiol 91:3E-11E. 2003
    ..The ABC transporters currently represent excellent targets for the development of new drugs for the treatment of patients with increased risk of premature cardiovascular disease...
  23. ncbi request reprint The human ABCG1 gene: identification of LXR response elements that modulate expression in macrophages and liver
    Steven L Sabol
    Molecular Disease Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Lipid Res 46:2151-67. 2005
    ..These studies clarify the mechanism of transcriptional upregulation of the ABCG1 gene by oxysterols in macrophages and liver, two key tissues where ABCG1 expression may affect cholesterol balance and atherogenesis...
  24. ncbi request reprint Clinical significance of high-density lipoproteins and the development of atherosclerosis: focus on the role of the adenosine triphosphate-binding cassette protein A1 transporter
    H Bryan Brewer
    Molecular Disease Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20894, USA
    Am J Cardiol 92:10K-16K. 2003
    ..Ongoing investigation of mechanisms by which HDL acts to reduce the risk of atherosclerosis will provide several new targets for the development of drugs to decrease the risk of atherosclerosis...
  25. ncbi request reprint Hepatic ABCG5/G8 overexpression reduces apoB-lipoproteins and atherosclerosis when cholesterol absorption is inhibited
    Federica Basso
    Molecular Disease Section, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA
    J Lipid Res 48:114-26. 2007
    ..These findings identify distinct roles for liver and intestinal ABCG5/G8 in modulating sterol metabolism and atherosclerosis...
  26. ncbi request reprint Structural and functional consequences of missense mutations in exon 5 of the lipoprotein lipase gene
    Jonas Peterson
    Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, Box 356426, University of Washington Medical Center, Seattle, WA 98195 6426, USA
    J Lipid Res 43:398-406. 2002
    ..These results stress the importance of conformational evaluation of mutant LPL. Absence of catalytic activity does not necessarily imply that the substituted amino acid plays a specific direct role in catalysis...