N A Sans

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint A developmental change in NMDA receptor-associated proteins at hippocampal synapses
    N Sans
    Laboratory of Neurochemistry, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 20:1260-71. 2000
  2. ncbi request reprint Aberrant formation of glutamate receptor complexes in hippocampal neurons of mice lacking the GluR2 AMPA receptor subunit
    Nathalie Sans
    Laboratory of Neurochemistry, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland 20892 8027, USA
    J Neurosci 23:9367-73. 2003
  3. ncbi request reprint NMDA receptor trafficking through an interaction between PDZ proteins and the exocyst complex
    Nathalie Sans
    Laboratory of Neurochemistry, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Building 50, Room 4146, 50 South Drive, Bethesda, MD 20892 8027, USA
    Nat Cell Biol 5:520-30. 2003
  4. ncbi request reprint Synapse-associated protein 97 selectively associates with a subset of AMPA receptors early in their biosynthetic pathway
    N Sans
    Laboratory of Neurochemistry, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland 20892 8027, USA
    J Neurosci 21:7506-16. 2001
  5. ncbi request reprint Postnatal developmental changes in AMPA and NMDA receptors in the rat vestibular nuclei
    N A Sans
    INSERM U432, Neurobiologie et Développement du Système Vestibulaire, Universite de Montpellier II, CP089, 34095 Cedex 5, Montpellier, France
    Brain Res Dev Brain Res 123:41-52. 2000
  6. ncbi request reprint Glutamate receptor targeting in the postsynaptic spine involves mechanisms that are independent of myosin Va
    R S Petralia
    Laboratory of Neurochemistry, NIDCD NIH, 36 5D08, 36 CONVENT DR MSC 4162, Bethesda MD 20892 4162, USA
    Eur J Neurosci 13:1722-32. 2001
  7. ncbi request reprint PDZ domain suppression of an ER retention signal in NMDA receptor NR1 splice variants
    S Standley
    Laboratory of Neurochemistry, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892, USA
    Neuron 28:887-98. 2000
  8. ncbi request reprint Early events in the trafficking of N-methyl-D-aspartate (NMDA) receptors
    R J Wenthold
    Laboratory of Neurochemistry, NIDCD, NIH, Building 50, Room 4140, Bethesda, MD 20892, USA
    Biochem Soc Trans 31:885-8. 2003
  9. ncbi request reprint The role of the PDZ protein GIPC in regulating NMDA receptor trafficking
    Zhaohong Yi
    Laboratory of Neurochemistry, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 27:11663-75. 2007
  10. ncbi request reprint mPins modulates PSD-95 and SAP102 trafficking and influences NMDA receptor surface expression
    Nathalie Sans
    Laboratory of Neurochemistry, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Building 50, Room 4146, 50 South Drive, Bethesda, MD 20892 8027, USA
    Nat Cell Biol 7:1179-90. 2005

Collaborators

Detail Information

Publications18

  1. ncbi request reprint A developmental change in NMDA receptor-associated proteins at hippocampal synapses
    N Sans
    Laboratory of Neurochemistry, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 20:1260-71. 2000
    ..These studies suggest that there is a preference for complexes of NR2A/PSD-93/95 and NR2B/SAP-102. These results indicate that individual receptor-associated proteins may have specific functions that are critical to synapse development...
  2. ncbi request reprint Aberrant formation of glutamate receptor complexes in hippocampal neurons of mice lacking the GluR2 AMPA receptor subunit
    Nathalie Sans
    Laboratory of Neurochemistry, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland 20892 8027, USA
    J Neurosci 23:9367-73. 2003
    ..Therefore, GluR1 may have a greater preference for GluR2 than it does for GluR3...
  3. ncbi request reprint NMDA receptor trafficking through an interaction between PDZ proteins and the exocyst complex
    Nathalie Sans
    Laboratory of Neurochemistry, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Building 50, Room 4146, 50 South Drive, Bethesda, MD 20892 8027, USA
    Nat Cell Biol 5:520-30. 2003
    ..Furthermore, they suggest that an exocyst-SAP102-NMDAR complex is an important component of NMDAR trafficking...
  4. ncbi request reprint Synapse-associated protein 97 selectively associates with a subset of AMPA receptors early in their biosynthetic pathway
    N Sans
    Laboratory of Neurochemistry, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland 20892 8027, USA
    J Neurosci 21:7506-16. 2001
    ..We also show that internalization of GluR1, as triggered by NMDAR activation, does not require SAP97. These results implicate GluR1-SAP97 interactions in mechanisms underlying AMPA receptor targeting...
  5. ncbi request reprint Postnatal developmental changes in AMPA and NMDA receptors in the rat vestibular nuclei
    N A Sans
    INSERM U432, Neurobiologie et Développement du Système Vestibulaire, Universite de Montpellier II, CP089, 34095 Cedex 5, Montpellier, France
    Brain Res Dev Brain Res 123:41-52. 2000
    ..This may be related to the postsynaptic regulation of receptor subunits associated with the synaptic plasticity of the vestibular neuron connections during specific sequences of postnatal development...
  6. ncbi request reprint Glutamate receptor targeting in the postsynaptic spine involves mechanisms that are independent of myosin Va
    R S Petralia
    Laboratory of Neurochemistry, NIDCD NIH, 36 5D08, 36 CONVENT DR MSC 4162, Bethesda MD 20892 4162, USA
    Eur J Neurosci 13:1722-32. 2001
    ..Other possible mechanisms include diffusion along the extrasynaptic membrane and delivery via other motors running along the spine's actin cytoskeleton...
  7. ncbi request reprint PDZ domain suppression of an ER retention signal in NMDA receptor NR1 splice variants
    S Standley
    Laboratory of Neurochemistry, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892, USA
    Neuron 28:887-98. 2000
    ..This site suppresses ER retention of the C1 cassette and leads to surface expression. These findings suggest a role for PDZ proteins in facilitating the transition of receptors from an intracellular pool to the surface of the neuron...
  8. ncbi request reprint Early events in the trafficking of N-methyl-D-aspartate (NMDA) receptors
    R J Wenthold
    Laboratory of Neurochemistry, NIDCD, NIH, Building 50, Room 4140, Bethesda, MD 20892, USA
    Biochem Soc Trans 31:885-8. 2003
    ....
  9. ncbi request reprint The role of the PDZ protein GIPC in regulating NMDA receptor trafficking
    Zhaohong Yi
    Laboratory of Neurochemistry, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 27:11663-75. 2007
    ..Our results suggest that GIPC may be preferentially associated with extrasynaptic NMDA receptors and may play a role in the organization and trafficking of this population of receptors...
  10. ncbi request reprint mPins modulates PSD-95 and SAP102 trafficking and influences NMDA receptor surface expression
    Nathalie Sans
    Laboratory of Neurochemistry, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Building 50, Room 4146, 50 South Drive, Bethesda, MD 20892 8027, USA
    Nat Cell Biol 7:1179-90. 2005
    ..mPins changes the number and morphology of dendritic spines and these effects depend on its Galphai interaction domain, thus implicating G-protein signalling in the regulation of postsynaptic structure and trafficking of GluRs...
  11. pmc The synaptic localization of NR2B-containing NMDA receptors is controlled by interactions with PDZ proteins and AP-2
    Kate Prybylowski
    Laboratory of Neurochemistry, National Institute on Deafness and Other Communication Disorders, Room 4148 Bldg 50, National Institutes of Health, Bethesda Maryland 20892, USA
    Neuron 47:845-57. 2005
    ..This study identifies a dynamic regulation of synaptic NR2B-containing NMDARs through PDZ protein-mediated stabilization and AP-2-mediated internalization that is modulated by phosphorylation by Fyn kinase...
  12. ncbi request reprint Synapse associated protein 102 is a novel binding partner to the cytoplasmic terminus of neurone-glial related cell adhesion molecule
    Fleur Davey
    Bute Medical Building, School of Biology, University of St Andrews, UK
    J Neurochem 94:1243-53. 2005
    ..This is the first interaction reported for NrCAM, and its association with SAP102 suggests that it is part of a larger complex which can interact with many different signalling pathways...
  13. pmc Ontogeny of postsynaptic density proteins at glutamatergic synapses
    Ronald S Petralia
    Laboratory of Neurochemistry, NIDCD NIH, 50 4142, 50 South Drive MSC 8027, Bethesda, MD 20892 8027, USA
    Mol Cell Neurosci 29:436-52. 2005
    ..Development was marked by substantial decreases in NR2B and SAP102 and increases in NR2A, PSD-95, AMPA receptors, and CaMKII. Other components showed more moderate changes...
  14. ncbi request reprint Loss of GLUR2 alpha-amino-3-hydroxy-5-methyl-4-isoxazoleproprionic acid receptor subunit differentially affects remaining synaptic glutamate receptors in cerebellum and cochlear nuclei
    Ronald S Petralia
    Laboratory of Neurochemistry, NIDCD NIH, 50 4142, 50 South Drive MSC 8027, Bethesda, MD 20892 8027, USA
    Eur J Neurosci 19:2017-29. 2004
    ....
  15. ncbi request reprint Trafficking of NMDA receptors
    Robert J Wenthold
    Laboratory of Neurochemistry, NIDCD, NIH, Bethesda, Maryland 20892, USA
    Annu Rev Pharmacol Toxicol 43:335-58. 2003
    ..This review addresses recent advances in our understanding of NMDAR trafficking and its synaptic delivery and maintenance...
  16. ncbi request reprint Asymmetric localization of Vangl2 and Fz3 indicate novel mechanisms for planar cell polarity in mammals
    Mireille Montcouquiol
    Section on Developmental Neuroscience, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 26:5265-75. 2006
    ..Together, our data support the idea that protein asymmetry plays an important role in the development of PCP, but the colocalization and interaction of Fz3 and Vangl2 suggests that novel PCP mechanisms exist in vertebrates...
  17. ncbi request reprint Calcium-binding proteins map the postnatal development of rat vestibular nuclei and their vestibular and cerebellar projections
    Julien Puyal
    INSERM U432, Neurobiologie et Développement du Système Vestibulaire, Universite de Montpellier II, CP089, Montpellier 34095 Cedex 5, France
    J Comp Neurol 451:374-91. 2002
    ....
  18. doi request reprint Scrib regulates PAK activity during the cell migration process
    Sebastien Nola
    INSERM, U891, Centre de Recherche en Cancerologie de Marseille, Pharmacologie Moléculaire, Marseille, France
    Hum Mol Genet 17:3552-65. 2008
    ..These data underscore the role of Scrib in cell migration and show the strong impact of Scrib in the function of PAK and Rac, two key molecules implicated in this process...