J M Sanders

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Carcinogenesis studies of cresols in rats and mice
    J M Sanders
    National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, United States
    Toxicology 257:33-9. 2009
  2. pmc Disposition of 2,2',4,4',5,5'-hexabromodiphenyl ether (BDE153) and its interaction with other polybrominated diphenyl ethers (PBDEs) in rodents
    J M Sanders
    Laboratory of Pharmacology and Chemistry, National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Xenobiotica 36:824-37. 2006
  3. ncbi request reprint Metabolism and disposition of 2,2',4,4'- tetrabromodiphenyl ether following administration of single or multiple doses to rats and mice
    J M Sanders
    Laboratory of Pharmacology and Chemistry, National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Xenobiotica 36:103-17. 2006
  4. ncbi request reprint Differential expression of CYP1A, 2B, and 3A genes in the F344 rat following exposure to a polybrominated diphenyl ether mixture or individual components
    J M Sanders
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences NIEHS, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 88:127-33. 2005
  5. ncbi request reprint Metabolism and disposition of 2,2',4,4',5-pentabromodiphenyl ether (BDE99) following a single or repeated administration to rats or mice
    L J Chen
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Xenobiotica 36:515-34. 2006
  6. ncbi request reprint Comparative metabolism and disposition of ethoxyquin in rat and mouse. I. Disposition
    J M Sanders
    Chemistry Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Xenobiotica 26:583-95. 1996
  7. ncbi request reprint Comparative metabolism and disposition of ethoxyquin in rat and mouse. II. Metabolism
    L T Burka
    Chemistry Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Xenobiotica 26:597-611. 1996
  8. ncbi request reprint Comparative xenobiotic metabolism between Tg.AC and p53+/- genetically altered mice and their respective wild types
    J M Sanders
    Laboratory of Pharmacology and Chemistry, National Toxicology Program, National Institute of Environmental Health Sciences, MD C3 02, P O Box 12233, Research Triangle Park, North Carolina 27709 2233, USA
    Toxicol Sci 61:54-61. 2001
  9. ncbi request reprint Metabolism and disposition of luminol in the rat
    J M Sanders
    Laboratory of Pharmacology and Chemistry, National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Xenobiotica 30:263-72. 2000
  10. ncbi request reprint Comparative metabolism and disposition of ethyl carbamate (urethane) in male Fischer 344 rats and male B6C3F1 mice
    A A Nomeir
    Systemic Toxicology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709
    Toxicol Appl Pharmacol 97:203-15. 1989

Collaborators

Detail Information

Publications15

  1. pmc Carcinogenesis studies of cresols in rats and mice
    J M Sanders
    National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, United States
    Toxicology 257:33-9. 2009
    ..However, given the minimal chemical-related neoplastic response in these studies, it was concluded that there was no clear evidence of carcinogenicity in male rats or female mice exposed to the cresol mixture...
  2. pmc Disposition of 2,2',4,4',5,5'-hexabromodiphenyl ether (BDE153) and its interaction with other polybrominated diphenyl ethers (PBDEs) in rodents
    J M Sanders
    Laboratory of Pharmacology and Chemistry, National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Xenobiotica 36:824-37. 2006
    ..BDE153 was probably retained in the liver due to minimal metabolism and elimination after 'first-pass' distribution to the tissue following gavage...
  3. ncbi request reprint Metabolism and disposition of 2,2',4,4'- tetrabromodiphenyl ether following administration of single or multiple doses to rats and mice
    J M Sanders
    Laboratory of Pharmacology and Chemistry, National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Xenobiotica 36:103-17. 2006
    ..BDE47 appears to induce its own metabolism. Increased formation of reactive metabolites over time may correlate with toxicological effects in BDE47-treated rodents...
  4. ncbi request reprint Differential expression of CYP1A, 2B, and 3A genes in the F344 rat following exposure to a polybrominated diphenyl ether mixture or individual components
    J M Sanders
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences NIEHS, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 88:127-33. 2005
    ..These results indicate that in vivo PBDE-mediated toxicity would be better categorized by AhR-independent mechanisms, rather than the well-characterized AhR-dependent mechanism associated with exposure to dioxin-like chemicals...
  5. ncbi request reprint Metabolism and disposition of 2,2',4,4',5-pentabromodiphenyl ether (BDE99) following a single or repeated administration to rats or mice
    L J Chen
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Xenobiotica 36:515-34. 2006
    ..BDE99 undergoes more extensive metabolism than does BDE47. Half of the absorbed oral dose in male rats was excreted in 10 days mostly as metabolites derived from arene oxide intermediates...
  6. ncbi request reprint Comparative metabolism and disposition of ethoxyquin in rat and mouse. I. Disposition
    J M Sanders
    Chemistry Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Xenobiotica 26:583-95. 1996
    ..Repeated high dose administration may overcome delayed gastric emptying (observed following single dose administration of 250 mg/kg) and/or lead to auto-induction of EQ metabolism...
  7. ncbi request reprint Comparative metabolism and disposition of ethoxyquin in rat and mouse. II. Metabolism
    L T Burka
    Chemistry Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Xenobiotica 26:597-611. 1996
    ..Two of the biliary metabolites are glutathione conjugates of ethoxyquin 3,4-epoxide; the third appears to be a conjugate of either ethoxyquin 7,8-epoxide or 2,2,4-trimethylquinol-6-one...
  8. ncbi request reprint Comparative xenobiotic metabolism between Tg.AC and p53+/- genetically altered mice and their respective wild types
    J M Sanders
    Laboratory of Pharmacology and Chemistry, National Toxicology Program, National Institute of Environmental Health Sciences, MD C3 02, P O Box 12233, Research Triangle Park, North Carolina 27709 2233, USA
    Toxicol Sci 61:54-61. 2001
    ....
  9. ncbi request reprint Metabolism and disposition of luminol in the rat
    J M Sanders
    Laboratory of Pharmacology and Chemistry, National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Xenobiotica 30:263-72. 2000
    ..If the fate of LMN is similar between species, this compound should have little potential for either dermal absorption, bioaccumulation in tissues following other routes of exposure or chronic toxicity in humans...
  10. ncbi request reprint Comparative metabolism and disposition of ethyl carbamate (urethane) in male Fischer 344 rats and male B6C3F1 mice
    A A Nomeir
    Systemic Toxicology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709
    Toxicol Appl Pharmacol 97:203-15. 1989
    ..This work indicates that a number of studies of EC carcinogenicity have used doses that exceed the capacity of rats and mice to metabolize this chemical in a linear fashion...
  11. ncbi request reprint Role of cytochrome P-450 2E1 in methacrylonitrile metabolism and disposition
    B I Ghanayem
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
    J Pharmacol Exp Ther 289:1054-9. 1999
    ..It is therefore concluded that MAN oxidative metabolites such as the epoxide intermediate have greater reactivity than parent MAN...
  12. ncbi request reprint Determination of tamoxifen and metabolites in mouse fetal tissue using nonaqueous capillary electrophoresis
    J M Sanders
    Laboratory of Pharmacology and Chemistry, National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709 2233, USA
    Electrophoresis 23:502-5. 2002
    ..This work demonstrates both transplacental transport of TAM in CD-1 mice and a sensitive analytical technique for detecting low concentrations of TAM and similar compounds in biological tissues...
  13. ncbi request reprint AP-3 adaptor functions in targeting P-selectin to secretory granules in endothelial cells
    B L Daugherty
    Department of Cell Biology, UVA Health System, School of Medicine, PO Box 800732, Charlottesville, VA 22908-0732, USA
    Traffic 2:406-13. 2001
    ..These observations establish that AP-3 adaptor functions in assembly of conventional secretory granules, in addition to lysosomes and the 'lysosome-like' secretory granules of platelets and melanocytes...
  14. ncbi request reprint P-selectin and ICAM-1 mediate endotoxin-induced neutrophil recruitment and injury to the lung and liver
    M Kamochi
    Department of Internal Medicine, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA
    Am J Physiol 277:L310-9. 1999
    ..These data suggest that P-selectin and ICAM-1 significantly contribute to lung and liver injury after systemic endotoxemia...
  15. ncbi request reprint Adenosine A(2A) receptor stimulation reduces inflammation and neointimal growth in a murine carotid ligation model
    J A McPherson
    Cardiovascular Division, Department of Medicine, University of Virginia Health System, Charlottesville 22908, USA
    Arterioscler Thromb Vasc Biol 21:791-6. 2001
    ..These data demonstrate that novel stimulation of adenosine A(2A) receptors can inhibit early inflammatory processes that are important in neointimal formation after vascular injury...