William Samuel

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Mitogen-activated protein kinase pathway mediates N-(4-hydroxyphenyl)retinamide-induced neuronal differentiation in the ARPE-19 human retinal pigment epithelial cell line
    William Samuel
    Laboratory of Retinal Cell and Molecular Biology, National Eye Institute, Bethesda, Maryland, USA
    J Neurochem 106:591-602. 2008
  2. ncbi request reprint N-(4-hydroxyphenyl)retinamide induces apoptosis in human retinal pigment epithelial cells: retinoic acid receptors regulate apoptosis, reactive oxygen species generation, and the expression of heme oxygenase-1 and Gadd153
    William Samuel
    Biochemistry Section, Laboratory of Retinal Cell and Molecular Biology, National Eye Institute, 7 Memorial Drive, Bethesda, MD 20892, USA
    J Cell Physiol 209:854-65. 2006
  3. pmc Decreased expression of insulin-like growth factor binding protein-5 during N-(4-hydroxyphenyl)retinamide-induced neuronal differentiation of ARPE-19 human retinal pigment epithelial cells: regulation by CCAAT/enhancer-binding protein
    William Samuel
    Laboratory of Retinal Cell and Molecular Biology, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892 0706, USA
    J Cell Physiol 224:827-36. 2010
  4. pmc MicroRNA expression in human retinal pigment epithelial (ARPE-19) cells: increased expression of microRNA-9 by N-(4-hydroxyphenyl)retinamide
    R Krishnan Kutty
    Laboratory of Retinal Cell and Molecular Biology, Bldg 6, Room 112, National Eye Institute, National Institutes of Health, 6 Center Dr, MSC 0608, Bethesda, MD 20892, USA
    Mol Vis 16:1475-86. 2010
  5. pmc Differential regulation of microRNA-146a and microRNA-146b-5p in human retinal pigment epithelial cells by interleukin-1β, tumor necrosis factor-α, and interferon-γ
    R Krishnan Kutty
    Laboratory of Retinal Cell and Molecular Biology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Vis 19:737-50. 2013
  6. ncbi request reprint Differentiation of human retinal pigment epithelial cells into neuronal phenotype by N-(4-hydroxyphenyl)retinamide
    Shanyi Chen
    Biochemistry Section, Laboratory of Retinal Cell and Molecular Biology, National Eye Institute, National Institutes of Health, 6 Center Drive, MSC 2740, Bethesda, MD 20892, USA
    J Neurochem 84:972-81. 2003
  7. ncbi request reprint Transforming growth factor-beta induces expression of vascular endothelial growth factor in human retinal pigment epithelial cells: involvement of mitogen-activated protein kinases
    Chandrasekharam N Nagineni
    National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Cell Physiol 197:453-62. 2003
  8. ncbi request reprint Cell density-dependent nuclear/cytoplasmic localization of NORPEG (RAI14) protein
    R Krishnan Kutty
    Section on Biochemistry, Laboratory of Retinal Cell and Molecular Biology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Biochem Biophys Res Commun 345:1333-41. 2006
  9. ncbi request reprint Immunofluorescence analysis of the expression of Norpeg (Rai14) in retinal Müller and ganglion cells
    R Krishnan Kutty
    Section on Biochemistry, Laboratory of Retinal Cell and Molecular Biology, 7 329, National Eye Institute, National Institutes of Health, Bethesda, MD 20892 0706, USA
    Neurosci Lett 404:294-8. 2006
  10. pmc Fenretinide induces ubiquitin-dependent proteasomal degradation of stearoyl-CoA desaturase in human retinal pigment epithelial cells
    William Samuel
    Laboratory of Retinal Cell and Molecular Biology, National Eye Institute, National Institutes of Health, Bethesda, Maryland
    J Cell Physiol 229:1028-38. 2014

Detail Information

Publications12

  1. pmc Mitogen-activated protein kinase pathway mediates N-(4-hydroxyphenyl)retinamide-induced neuronal differentiation in the ARPE-19 human retinal pigment epithelial cell line
    William Samuel
    Laboratory of Retinal Cell and Molecular Biology, National Eye Institute, Bethesda, Maryland, USA
    J Neurochem 106:591-602. 2008
    ....
  2. ncbi request reprint N-(4-hydroxyphenyl)retinamide induces apoptosis in human retinal pigment epithelial cells: retinoic acid receptors regulate apoptosis, reactive oxygen species generation, and the expression of heme oxygenase-1 and Gadd153
    William Samuel
    Biochemistry Section, Laboratory of Retinal Cell and Molecular Biology, National Eye Institute, 7 Memorial Drive, Bethesda, MD 20892, USA
    J Cell Physiol 209:854-65. 2006
    ..Therefore, our results, clearly demonstrate that 4HPR induces apoptosis in ARPE-19 cells and that RARs mediate this process by regulating ROS generation as well as the expression of Gadd153 and HO-1...
  3. pmc Decreased expression of insulin-like growth factor binding protein-5 during N-(4-hydroxyphenyl)retinamide-induced neuronal differentiation of ARPE-19 human retinal pigment epithelial cells: regulation by CCAAT/enhancer-binding protein
    William Samuel
    Laboratory of Retinal Cell and Molecular Biology, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892 0706, USA
    J Cell Physiol 224:827-36. 2010
    ..Thus, our results clearly demonstrate that the IGFBP5 expression is down-regulated during 4HPR-induced neuronal differentiation of human RPE cells through a MAPK signal transduction pathway involving C/EBPbeta...
  4. pmc MicroRNA expression in human retinal pigment epithelial (ARPE-19) cells: increased expression of microRNA-9 by N-(4-hydroxyphenyl)retinamide
    R Krishnan Kutty
    Laboratory of Retinal Cell and Molecular Biology, Bldg 6, Room 112, National Eye Institute, National Institutes of Health, 6 Center Dr, MSC 0608, Bethesda, MD 20892, USA
    Mol Vis 16:1475-86. 2010
    ..The aim of the present study was to investigate the expression of miR-9 in ARPE-19 cells in response to 4HPR treatment, and to identify other miRNAs normally expressed in these cells...
  5. pmc Differential regulation of microRNA-146a and microRNA-146b-5p in human retinal pigment epithelial cells by interleukin-1β, tumor necrosis factor-α, and interferon-γ
    R Krishnan Kutty
    Laboratory of Retinal Cell and Molecular Biology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Vis 19:737-50. 2013
    ..The aim of the present study is to investigate the expression of miR-146a and miR-146b-5p in human RPE cells and their response to proinflammatory cytokines...
  6. ncbi request reprint Differentiation of human retinal pigment epithelial cells into neuronal phenotype by N-(4-hydroxyphenyl)retinamide
    Shanyi Chen
    Biochemistry Section, Laboratory of Retinal Cell and Molecular Biology, National Eye Institute, National Institutes of Health, 6 Center Drive, MSC 2740, Bethesda, MD 20892, USA
    J Neurochem 84:972-81. 2003
    ..Thus, fenretinide, a synthetic retinoid, is able to induce neuronal differentiation of human RPE cells in culture...
  7. ncbi request reprint Transforming growth factor-beta induces expression of vascular endothelial growth factor in human retinal pigment epithelial cells: involvement of mitogen-activated protein kinases
    Chandrasekharam N Nagineni
    National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Cell Physiol 197:453-62. 2003
    ..Since the secretion of VEGF by HRPE is regulated by MAP kinase pathways, MAP kinase inhibitors may have potential use as therapeutic agents for CNV in AMD...
  8. ncbi request reprint Cell density-dependent nuclear/cytoplasmic localization of NORPEG (RAI14) protein
    R Krishnan Kutty
    Section on Biochemistry, Laboratory of Retinal Cell and Molecular Biology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Biochem Biophys Res Commun 345:1333-41. 2006
    ..Deletion and mutation analysis indicated that the identified nuclear localization sequence is indispensable for nuclear targeting...
  9. ncbi request reprint Immunofluorescence analysis of the expression of Norpeg (Rai14) in retinal Müller and ganglion cells
    R Krishnan Kutty
    Section on Biochemistry, Laboratory of Retinal Cell and Molecular Biology, 7 329, National Eye Institute, National Institutes of Health, Bethesda, MD 20892 0706, USA
    Neurosci Lett 404:294-8. 2006
    ..Immunoreactivity was also evident in the radial glial (Müller) cell fibers...
  10. pmc Fenretinide induces ubiquitin-dependent proteasomal degradation of stearoyl-CoA desaturase in human retinal pigment epithelial cells
    William Samuel
    Laboratory of Retinal Cell and Molecular Biology, National Eye Institute, National Institutes of Health, Bethesda, Maryland
    J Cell Physiol 229:1028-38. 2014
    ..Therefore, the effect of fenretinide on SCD should be considered in its potential therapeutic role against cancer, type-2 diabetes, and retinal diseases...
  11. pmc Inflammatory cytokines regulate microRNA-155 expression in human retinal pigment epithelial cells by activating JAK/STAT pathway
    R Krishnan Kutty
    Laboratory of Retinal Cell and Molecular Biology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Biochem Biophys Res Commun 402:390-5. 2010
    ..All these activities were effectively blocked by JAK inhibitor 1. Our results show that the inflammatory cytokines increase miR-155 expression in human retinal pigment epithelial cells by activating the JAK/STAT signaling pathway...
  12. ncbi request reprint Transforming growth factor-beta regulates stearoyl coenzyme A desaturase expression through a Smad signaling pathway
    William Samuel
    Biochemistry Section, Laboratory of Retinal Cell and Molecular Biology, NEI, National Institutes of Health, Bethesda, Maryland 20878 2740, USA
    J Biol Chem 277:59-66. 2002
    ..Thus, a TGF-beta signal transduction pathway involving Smad proteins appears to regulate the cellular expression of the SCD gene, and this regulation may play an important role in lipid metabolism...