Konstantin Salnikow

Summary

Affiliation: National Cancer Institute
Country: USA

Publications

  1. pmc Ascorbate depletion: a critical step in nickel carcinogenesis?
    Konstantin Salnikow
    Laboratory of Comparative Carcinogenesis, Building 538, Room 205 E, National Cancer Institute at Frederick NIH, Frederick, MD 21702, USA
    Environ Health Perspect 113:577-84. 2005
  2. ncbi request reprint Depletion of intracellular ascorbate by the carcinogenic metals nickel and cobalt results in the induction of hypoxic stress
    Konstantin Salnikow
    NCI Frederick, National Institutes of Health, Frederick, Maryland 21702, USA
    J Biol Chem 279:40337-44. 2004
  3. pmc Regulation of hypoxia-inducible genes by ETS1 transcription factor
    Konstantin Salnikow
    Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, Frederick, MD 21702, USA
    Carcinogenesis 29:1493-9. 2008
  4. ncbi request reprint Effect of nickel and iron co-exposure on human lung cells
    Konstantin Salnikow
    Nelson Institute of Environmental Medicine, EPA PM Health Effects Research Center and NIEHS Environmental Health Sciences Center, New York University School of Medicine, New York, NY 10016, USA
    Toxicol Appl Pharmacol 196:258-65. 2004
  5. ncbi request reprint Ascorbate depletion mediates up-regulation of hypoxia-associated proteins by cell density and nickel
    Aldona Karaczyn
    Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, Frederick, Maryland 21702, USA
    J Cell Biochem 97:1025-35. 2006
  6. pmc Metal ions-stimulated iron oxidation in hydroxylases facilitates stabilization of HIF-1 alpha protein
    Monika Kaczmarek
    Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, Frederick, Maryland 21702, USA
    Toxicol Sci 107:394-403. 2009
  7. pmc The role of hypoxia-inducible signaling pathway in nickel carcinogenesis
    Konstantin Salnikow
    Nelson Institute of Environmental Medicine, NIEHS Center and Kaplan Comprehensive Cancer Center, New York University School of Medicine, 550 First Avenue, New York, NY 11016, USA
    Environ Health Perspect 110:831-4. 2002
  8. pmc Enhanced overexpression of an HIF-1/hypoxia-related protein in cancer cells
    Hakan Cangul
    Department of Environmental Medicine, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Environ Health Perspect 110:783-8. 2002
  9. ncbi request reprint The involvement of hypoxia-inducible transcription factor-1-dependent pathway in nickel carcinogenesis
    Konstantin Salnikow
    The Nelson Institute of Environmental Medicine, National Institute of Environmental Health Sciences Center, National Institutes of Health and The New York University Cancer Institute, School of Medicine, New York, NY 10016, USA
    Cancer Res 63:3524-30. 2003
  10. ncbi request reprint Microarray analysis of altered gene expression in murine fibroblasts transformed by nickel(II) to nickel(II)-resistant malignant phenotype
    Renata Kowara
    Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, MD 21702, USA
    Toxicol Appl Pharmacol 205:1-10. 2005

Collaborators

Detail Information

Publications33

  1. pmc Ascorbate depletion: a critical step in nickel carcinogenesis?
    Konstantin Salnikow
    Laboratory of Comparative Carcinogenesis, Building 538, Room 205 E, National Cancer Institute at Frederick NIH, Frederick, MD 21702, USA
    Environ Health Perspect 113:577-84. 2005
    ..Key words: ascorbate, carcinogenesis, collagens, extracellular matrix, hypoxia-inducible transcription factor, metals, nickel, protein hydroxylation...
  2. ncbi request reprint Depletion of intracellular ascorbate by the carcinogenic metals nickel and cobalt results in the induction of hypoxic stress
    Konstantin Salnikow
    NCI Frederick, National Institutes of Health, Frederick, Maryland 21702, USA
    J Biol Chem 279:40337-44. 2004
    ....
  3. pmc Regulation of hypoxia-inducible genes by ETS1 transcription factor
    Konstantin Salnikow
    Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, Frederick, MD 21702, USA
    Carcinogenesis 29:1493-9. 2008
    ..Collectively, our data indicate the involvement of ETS1 along with HIF-1 in regulating hypoxia-inducible genes...
  4. ncbi request reprint Effect of nickel and iron co-exposure on human lung cells
    Konstantin Salnikow
    Nelson Institute of Environmental Medicine, EPA PM Health Effects Research Center and NIEHS Environmental Health Sciences Center, New York University School of Medicine, New York, NY 10016, USA
    Toxicol Appl Pharmacol 196:258-65. 2004
    ..The obtained data indicate that nickel can induce different signaling pathways with or without interference with iron metabolism. Our observations suggest that in some cases the excess of iron in PM can cancel the effects of nickel...
  5. ncbi request reprint Ascorbate depletion mediates up-regulation of hypoxia-associated proteins by cell density and nickel
    Aldona Karaczyn
    Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, Frederick, Maryland 21702, USA
    J Cell Biochem 97:1025-35. 2006
    ..We suggest, that, in addition to low oxygenation, insufficient supply of ascorbate or its excessive oxidation in tumors, can contribute to the induction of hypoxia-associated proteins via both HIF-dependent and independent mechanisms...
  6. pmc Metal ions-stimulated iron oxidation in hydroxylases facilitates stabilization of HIF-1 alpha protein
    Monika Kaczmarek
    Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, Frederick, Maryland 21702, USA
    Toxicol Sci 107:394-403. 2009
    ....
  7. pmc The role of hypoxia-inducible signaling pathway in nickel carcinogenesis
    Konstantin Salnikow
    Nelson Institute of Environmental Medicine, NIEHS Center and Kaplan Comprehensive Cancer Center, New York University School of Medicine, 550 First Avenue, New York, NY 11016, USA
    Environ Health Perspect 110:831-4. 2002
    ....
  8. pmc Enhanced overexpression of an HIF-1/hypoxia-related protein in cancer cells
    Hakan Cangul
    Department of Environmental Medicine, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Environ Health Perspect 110:783-8. 2002
    ..We hypothesize that the mechanism of Cap43 overexpression in cancer cells involves a state of hypoxia characteristic of cancer cells where the Cap43 protein becomes a signature for this hypoxic state...
  9. ncbi request reprint The involvement of hypoxia-inducible transcription factor-1-dependent pathway in nickel carcinogenesis
    Konstantin Salnikow
    The Nelson Institute of Environmental Medicine, National Institute of Environmental Health Sciences Center, National Institutes of Health and The New York University Cancer Institute, School of Medicine, New York, NY 10016, USA
    Cancer Res 63:3524-30. 2003
    ..We hypothesize that the induction of HIF-1 transcription factor by nickel may be important during the nickel-induced carcinogenic process...
  10. ncbi request reprint Microarray analysis of altered gene expression in murine fibroblasts transformed by nickel(II) to nickel(II)-resistant malignant phenotype
    Renata Kowara
    Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, MD 21702, USA
    Toxicol Appl Pharmacol 205:1-10. 2005
    ....
  11. ncbi request reprint Molecular mechanisms of nickel carcinogenesis: gene silencing by nickel delivery to the nucleus and gene activation/inactivation by nickel-induced cell signaling
    Max Costa
    Department of Environmental Medicine, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    J Environ Monit 5:222-3. 2003
    ....
  12. pmc The role of ascorbate in the modulation of HIF-1alpha protein and HIF-dependent transcription by chromium(VI) and nickel(II)
    Monika Kaczmarek
    National Cancer Institute at Frederick, Building 538, Room 205 E, Frederick, MD 21701, USA
    Free Radic Biol Med 42:1246-57. 2007
    ..Thus, the obtained data emphasize the important role of ascorbate in regulation of HIF-1 transcriptional activity in metal-exposed human lung cells...
  13. ncbi request reprint GeneChip analysis of signaling pathways effected by nickel
    Konstantin Salnikow
    Nelson Institute of Environmental Medicine, NYU NIEHS Center of Excellence, The NYU Cancer Institute, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    J Environ Monit 5:206-9. 2003
    ..The activation of the same signaling pathways by soluble and insoluble nickel compounds suggested that both nickel compounds have similar carcinogenic potential in vitro...
  14. ncbi request reprint The role of oxidative stress in nickel and chromate genotoxicity
    Max Costa
    Department of Environmental Medicine, New York University School of Medicine, Tuxedo 10987, USA
    Mol Cell Biochem 234:265-75. 2002
    ..In addition to nickel, the role of oxidative stress in chromate-induced genotoxicity will also be discussed with particular attention directed to the effects of vitamin E on mutations and chromosomal aberrations inducedby chromate...
  15. pmc Genetic and epigenetic mechanisms in metal carcinogenesis and cocarcinogenesis: nickel, arsenic, and chromium
    Konstantin Salnikow
    National Cancer Institute, Frederick, MD 21702, USA
    Chem Res Toxicol 21:28-44. 2008
    ..Overall, metal carcinogenesis appears to require the formation of specific metal complexes, chromosomal damage, and activation of signal transduction pathways promoting survival and expansion of genetically/epigenetically altered cells...
  16. ncbi request reprint Nickel-induced down-regulation of serpin by hypoxic signaling
    Jianhua Zhao
    Department of Environmental Medicine, New York University School of Medicine, Tuxedo, NY 10987, USA
    Toxicol Appl Pharmacol 194:60-8. 2004
    ..Serpina3g gene expression returned to basal levels following Ni removal, suggesting that the observed silencing was a dynamic and reversible process...
  17. ncbi request reprint Nickel carcinogenesis
    Kazimierz S Kasprzak
    Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, Frederick, MD 21702 1201, USA
    Mutat Res 533:67-97. 2003
    ....
  18. ncbi request reprint Hypoxia inducible factor-1 alpha-independent suppression of aryl hydrocarbon receptor-regulated genes by nickel
    Todd Davidson
    Nelson Institute of Environmental Medicine, New York University School of Medicine, NewYork, USA
    Mol Pharmacol 64:1485-93. 2003
    ..Our data suggest that an Fe(II)-, oxoglutarate-, and oxygen-dependent enzyme may directly or indirectly be involved in the regulation of AhR-dependent transcriptional activity by nickel and other hypoxia-mimicking agents...
  19. pmc Two novel VHL targets, TGFBI (BIGH3) and its transactivator KLF10, are up-regulated in renal clear cell carcinoma and other tumors
    Sergey V Ivanov
    Basic Research Program, SAIC Frederick, Inc, 462 First Avenue, Bellevue Hospital, Room 15N20, NY 10016, USA
    Biochem Biophys Res Commun 370:536-40. 2008
    ..These data provide the molecular basis for the observed VHL effect on TGFBI and stimulate further research into the KLF10 and TGFBI roles in cancer...
  20. ncbi request reprint Quantum chemical modeling of reaction mechanism for 2-oxoglutarate dependent enzymes: effect of substitution of iron by nickel and cobalt
    Igor A Topol
    Advanced Biomedical Computing Center, SAIC Frederick, National Cancer Institute at Frederick, Frederick, Maryland 21702, USA
    J Phys Chem A 110:4223-8. 2006
    ..Thus, we would postulate that if the iron ion in the active site were substitutable by nickel and/or cobalt ions enzyme activity would be considerably altered due to high activation barriers...
  21. ncbi request reprint Downregulation of major histocompatibility complex antigens in invading glioma cells: stealth invasion of the brain
    David Zagzag
    Microvascular and Molecular Neuro Oncology Laboratory, New York University School of Medicine, New York, NY, USA
    Lab Invest 85:328-41. 2005
    ..These results suggest that the very process of tumor invasion is associated with decreased expression of MHC antigens allowing glioma cells to invade the surrounding brain in a 'stealth'-like manner...
  22. pmc Effects of ascorbic acid on carcinogenicity and acute toxicity of nickel subsulfide, and on tumor transplants growth in gulonolactone oxidase knock-out mice and wild-type C57BL mice
    Kazimierz S Kasprzak
    Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, Frederick, MD 21702, USA
    Toxicol Appl Pharmacol 257:32-7. 2011
    ..Dietary ascorbate tends to attenuate acute toxicity of Ni₃S₂ and to extend the latency of transplanted tumors. The latter effects may be of practical importance to humans and thus deserve further studies...
  23. ncbi request reprint Extracellular matrix and HIF-1 signaling: the role of prolidase
    Arkadiusz Surazynski
    Metabolism and Cancer Susceptibility Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, Frederick, MD 21702, USA
    Int J Cancer 122:1435-40. 2008
    ..These findings show that metabolism of imidodipeptides by prolidase plays a previously unrecognized role in angiogenic signaling...
  24. pmc The regulation of hypoxic genes by calcium involves c-Jun/AP-1, which cooperates with hypoxia-inducible factor 1 in response to hypoxia
    Konstantin Salnikow
    Department of Environmental Medicine, NIEHS and Kaplan Comprehensive Cancer Center, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Mol Cell Biol 22:1734-41. 2002
    ..Cooperation between the HIF-1 and AP-1 pathways allows fine regulation of gene expression during hypoxia...
  25. ncbi request reprint Effects of select PM-associated metals on alveolar macrophage phosphorylated ERK1 and -2 and iNOS expression during ongoing alteration in iron homeostasis
    Colette Prophete
    NYU EPA Particulate Matter Health Research Center, Nelson Institute of Environmental Medicine, New York University School of Medicine, Tuxedo, New York 10987, USA
    J Toxicol Environ Health A 69:935-51. 2006
    ..These results confirmed our hypothesis that certain metals associated with PM(2.5) might alter the pulmonary immunocompetence of exposed hosts by affecting the Fe status of AM, a major class of deep lung defense cells...
  26. ncbi request reprint Altered N-myc downstream-regulated gene 1 protein expression in African-American compared with caucasian prostate cancer patients
    Robert P Caruso
    Department of Urology, New York University Cancer Institute, Kaplan Comprehensive Cancer Center, New York, USA
    Clin Cancer Res 10:222-7. 2004
    ..We hypothesized that NDRG1 expression patterns might reveal a biological basis for the disparity of clinical outcome of prostate cancer patients with different ethnic backgrounds...
  27. ncbi request reprint Reduced Fhit protein expression in nickel-transformed mouse cells and in nickel-induced murine sarcomas
    Renata Kowara
    Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, Frederick, MD 21702 1201, USA
    Mol Cell Biochem 255:195-202. 2004
    ..Overall, the decline of Fhit in cells or tissues malignantly transformed by nickel may indicate possible involvement of this effect in the mechanisms of nickel carcinogenesis...
  28. ncbi request reprint Comparison of the cytotoxicity, cellular uptake, and DNA-protein crosslinks induced by potassium chromate in lymphoblast cell lines derived from three different individuals
    Qunwei Zhang
    Department of Environmental Medicine, New York University School of Medicine, Tuxedo 10987, USA
    Biol Trace Elem Res 86:11-22. 2002
    ..This lower uptake of chromate combined with interindividual differences in extracellular Cr(VI) reducing capacity are probably the two most important determinants of genetic susceptibility to chromate toxicity...
  29. ncbi request reprint A new intrinsic hypoxia marker in esophageal cancer
    Ivan Ding
    University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Adv Exp Med Biol 540:227-33. 2003
  30. ncbi request reprint HIF-1: an oxygen and metal responsive transcription factor
    Patrick Maxwell
    Imperial College, London, UK
    Cancer Biol Ther 3:29-35. 2004
    ..Here we review the implications of the metal sensitivity of the HIF-1 system, and examine the hypothesis that HIF-1 activation may play an important role in metal induced carcinogenesis...
  31. ncbi request reprint Inhibition and reversal of nickel-induced transformation by the histone deacetylase inhibitor trichostatin A
    Qunwei Zhang
    Department of Environmental Medicine, NYU School of Medicine, 57 Old Forge Road, Tuxedo, NY 10987, USA
    Toxicol Appl Pharmacol 192:201-11. 2003
    ..In contrast, treatment with TSA was not able to revert established cancer cell lines as readily as the nickel-transformed cells. These data indicated that modulation of gene expression is important for nickel-induced transformation...
  32. pmc Molecular mechanisms in nickel carcinogenesis: modeling Ni(II) binding site in histone H4
    Maria Antonietta Zoroddu
    Department of Chemistry, University of Sassari, Via Vienna 2, 07100 Sassari, Italy
    Environ Health Perspect 110:719-23. 2002
    ..The results allowed us to propose that the binding of Ni(II) is able to promote a secondary structure with organized side-chain orientation on the N-terminal tail of histone H4...
  33. ncbi request reprint Backing into cancer: effects of arsenic on cell differentiation
    Konstantin Salnikow
    Department of Environmental Medicine, New York University Medical Center, 57 Old Forge Road, Tuxedo, New York 10987, USA
    Toxicol Sci 65:161-3. 2002