M Safaeian

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Durable antibody responses following one dose of the bivalent human papillomavirus L1 virus-like particle vaccine in the Costa Rica Vaccine Trial
    Mahboobeh Safaeian
    Division of Cancer Epidemiology and Genetics, Infections and Immunoepidemiology Branch, National Cancer Institute, 9609 Medical Center Drive, Rm 6 E224, MSC 9767, Bethesda, MD 20892
    Cancer Prev Res (Phila) 6:1242-50. 2013
  2. ncbi request reprint Joint effects between five identified risk variants, allergy, and autoimmune conditions on glioma risk
    Mahboobeh Safaeian
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    Cancer Causes Control 24:1885-91. 2013
  3. doi request reprint Direct comparison of HPV16 serological assays used to define HPV-naïve women in HPV vaccine trials
    Mahboobeh Safaeian
    Division of Cancer Epidemiology and Genetics, Infections and Immunoepidemiology Branch, National Cancer Institute, NIH, Bethesda, MD, USA
    Cancer Epidemiol Biomarkers Prev 21:1547-54. 2012
  4. pmc Single nucleotide polymorphisms in the PRDX3 and RPS19 and risk of HPV persistence and cervical precancer/cancer
    Mahboobeh Safaeian
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, United States of America
    PLoS ONE 7:e33619. 2012
  5. pmc Determinants of seropositivity among HPV-16/18 DNA positive young women
    Carolina Porras
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    BMC Infect Dis 10:238. 2010
  6. doi request reprint Factors associated with fluctuations in IgA and IgG levels at the cervix during the menstrual cycle
    Mahboobeh Safaeian
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    J Infect Dis 199:455-63. 2009
  7. pmc Lack of heterogeneity of HPV16 E7 sequence compared with HPV31 and HPV73 may be related to its unique carcinogenic properties
    Mahboobeh Safaeian
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, USA
    Arch Virol 155:367-70. 2010
  8. pmc Determinants of incidence and clearance of high-risk human papillomavirus infections in rural Rakai, Uganda
    Mahboobeh Safaeian
    Department of Epidemiology, The Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA
    Cancer Epidemiol Biomarkers Prev 17:1300-7. 2008
  9. doi request reprint Prevalence and risk factors for carcinogenic human papillomavirus infections in rural Rakai, Uganda
    M Safaeian
    Department of Epidemiology, Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD, USA
    Sex Transm Infect 84:306-11. 2008
  10. pmc Determinants and correlation of systemic and cervical concentrations of total IgA and IgG
    Mahboobeh Safaeian
    Division of Cancer Epidemiology and Genetics, Infections and Immunoepidemiology Branch, National Cancer Institute, 6120 Executive Boulevard, Suite 550, Rockville, MD 20852, USA
    Cancer Epidemiol Biomarkers Prev 18:2672-6. 2009

Detail Information

Publications29

  1. ncbi request reprint Durable antibody responses following one dose of the bivalent human papillomavirus L1 virus-like particle vaccine in the Costa Rica Vaccine Trial
    Mahboobeh Safaeian
    Division of Cancer Epidemiology and Genetics, Infections and Immunoepidemiology Branch, National Cancer Institute, 9609 Medical Center Drive, Rm 6 E224, MSC 9767, Bethesda, MD 20892
    Cancer Prev Res (Phila) 6:1242-50. 2013
    ..Antibody levels following one-dose remained stable from month 6 through month 48. Results raise the possibility that even a single dose of HPV VLPs will induce long-term protection...
  2. ncbi request reprint Joint effects between five identified risk variants, allergy, and autoimmune conditions on glioma risk
    Mahboobeh Safaeian
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    Cancer Causes Control 24:1885-91. 2013
    ..Our results do not provide evidence that allergies or AIC modulate the association between the four GWAS-identified SNPs examined and risk of glioma...
  3. doi request reprint Direct comparison of HPV16 serological assays used to define HPV-naïve women in HPV vaccine trials
    Mahboobeh Safaeian
    Division of Cancer Epidemiology and Genetics, Infections and Immunoepidemiology Branch, National Cancer Institute, NIH, Bethesda, MD, USA
    Cancer Epidemiol Biomarkers Prev 21:1547-54. 2012
    ..Some of the variation in estimated vaccine efficacies may be due to the differences in these assays used to define the HPV-naïve subgroups. To guide the interpretation of published results, we compared these assays...
  4. pmc Single nucleotide polymorphisms in the PRDX3 and RPS19 and risk of HPV persistence and cervical precancer/cancer
    Mahboobeh Safaeian
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, United States of America
    PLoS ONE 7:e33619. 2012
    ..Host genetic factors might affect the risk of progression from infection with carcinogenic human papillomavirus (HPV), the etiologic agent for cervical cancer, to persistent HPV infection, and hence to cervical precancer and cancer...
  5. pmc Determinants of seropositivity among HPV-16/18 DNA positive young women
    Carolina Porras
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    BMC Infect Dis 10:238. 2010
    ..We evaluated determinants of seropositivity among 646 women infected with HPV-16 and/or HPV-18...
  6. doi request reprint Factors associated with fluctuations in IgA and IgG levels at the cervix during the menstrual cycle
    Mahboobeh Safaeian
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    J Infect Dis 199:455-63. 2009
    ..The objective of this analysis was to describe patterns and determinants of cervical immunoglobulin A (IgA) and G (IgG) levels during the menstrual cycle...
  7. pmc Lack of heterogeneity of HPV16 E7 sequence compared with HPV31 and HPV73 may be related to its unique carcinogenic properties
    Mahboobeh Safaeian
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, USA
    Arch Virol 155:367-70. 2010
    ..The lack of heterogeneity of HPV16 E7 suggests high evolutionary purifying selection that might be related to the unique carcinogenicity of HPV16...
  8. pmc Determinants of incidence and clearance of high-risk human papillomavirus infections in rural Rakai, Uganda
    Mahboobeh Safaeian
    Department of Epidemiology, The Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA
    Cancer Epidemiol Biomarkers Prev 17:1300-7. 2008
    ..We used self-administered vaginal swabs to assess the incidence and clearance of carcinogenic human papillomavirus (HPV) infections in rural Rakai, Uganda...
  9. doi request reprint Prevalence and risk factors for carcinogenic human papillomavirus infections in rural Rakai, Uganda
    M Safaeian
    Department of Epidemiology, Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD, USA
    Sex Transm Infect 84:306-11. 2008
    ..To investigate self-administered vaginal swabs for assessing prevalence and correlates of carcinogenic human papillomavirus (HPV) infection in rural Rakai, Uganda...
  10. pmc Determinants and correlation of systemic and cervical concentrations of total IgA and IgG
    Mahboobeh Safaeian
    Division of Cancer Epidemiology and Genetics, Infections and Immunoepidemiology Branch, National Cancer Institute, 6120 Executive Boulevard, Suite 550, Rockville, MD 20852, USA
    Cancer Epidemiol Biomarkers Prev 18:2672-6. 2009
    ..17 and 0.16, respectively). The lack of correlation between systemic and cervical total IgA and IgG suggests that systemic concentrations are not reflective of cervical levels...
  11. pmc Cervical cancer prevention--cervical screening: science in evolution
    Mahboobeh Safaeian
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health DHHS, 6120 Executive Blvd, Rockville, MD 20852, USA
    Obstet Gynecol Clin North Am 34:739-60, ix. 2007
    ..This article describes the traditional methods of screening for cervical cancer and innovative methods that might help overcome financial and cultural barriers to more widespread screening...
  12. pmc Epidemiological study of anti-HPV16/18 seropositivity and subsequent risk of HPV16 and -18 infections
    Mahboobeh Safaeian
    Division of Cancer Epidemiology and Genetics, Infections and Immunoepidemiology Branch, National Cancer Institute, National Institutes of Health, 6120 Executive Blvd, Ste 550, Rockville, MD 20852, USA
    J Natl Cancer Inst 102:1653-62. 2010
    ..Infection with human papillomavirus (HPV) 16 or HPV18 elicits an antibody response, but whether the elicited antibodies protect women against subsequent infection by a homologous HPV type compared with seronegative women is unknown...
  13. pmc Comparison of the SPF10-LiPA system to the Hybrid Capture 2 Assay for detection of carcinogenic human papillomavirus genotypes among 5,683 young women in Guanacaste, Costa Rica
    Mahboobeh Safaeian
    Division of Cancer Epidemiology and Genetics, Hormonal and Reproductive Epidemiology Branch, National Cancer Institute, 6120 Executive Boulevard, Suite 550, Rockville, MD 20852, USA
    J Clin Microbiol 45:1447-54. 2007
    ..The crude agreement between the two assays was 88%, with a kappa value of 0.75 (95% confidence limits, 0.73 to 0.76). We observed very good agreement between HC2 and SPF(10)-LiPA for carcinogenic HPV type detection...
  14. ncbi request reprint Comparability of self-collected vaginal swabs and physician-collected cervical swabs for detection of human papillomavirus infections in Rakai, Uganda
    Mahboobeh Safaeian
    Department of Epidemiology, The Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 20852, USA
    Sex Transm Dis 34:429-36. 2007
    ..The objective of this study was to compare human papillomavirus (HPV) DNA testing between self-administered vaginal swabs and physician-administered cervical swabs in women from rural Rakai District, Uganda...
  15. pmc Chlamydia trachomatis and risk of prevalent and incident cervical premalignancy in a population-based cohort
    Mahboobeh Safaeian
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20852, USA
    J Natl Cancer Inst 102:1794-804. 2010
    ..In a large prospective cohort, we assessed the role of C trachomatis in cervical premalignancy and addressed confounding by HPV...
  16. pmc Chronic typhoid infection and the risk of biliary tract cancer and stones in Shanghai, China
    Mahboobeh Safaeian
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
    Infect Agent Cancer 6:6. 2011
    ..The low seroprevalence of S. Typhi in Shanghai is unlikely to explain the high incidence of biliary cancers in this population...
  17. pmc Detection of precancerous cervical lesions is differential by human papillomavirus type
    Mahboobeh Safaeian
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland, USA
    Cancer Res 69:3262-6. 2009
    ..001). These results indicate the underrepresentation of HPV18/45 in precancers, whereas HPV16-associated CIN3+ is diagnosed much earlier. Whether the underrepresentation of 18/45 may be due to occult pathology needs further investigation...
  18. ncbi request reprint Prevalence, incidence, and type-specific persistence of human papillomavirus in human immunodeficiency virus (HIV)-positive and HIV-negative women
    L Ahdieh
    Department of Epidemiology, Johns Hopkins University School of Hygiene and Public Health, Baltimore, Maryland 21205, USA
    J Infect Dis 184:682-90. 2001
    ..9 (95% CI, 1.5-2.3) times greater if the subject had a CD4 cell count <200 cells/microL (vs. >500 cells/microL). Thus, HIV infection and immunosuppression play an important role in modulating the natural history of HPV infection...
  19. ncbi request reprint Risk of precancer and follow-up management strategies for women with human papillomavirus-negative atypical squamous cells of undetermined significance
    Mahboobeh Safaeian
    Division of Cancer Epidemiology and Genetics and Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20852, USA
    Obstet Gynecol 109:1325-31. 2007
    ....
  20. pmc Human papillomavirus cofactors by disease progression and human papillomavirus types in the study to understand cervical cancer early endpoints and determinants
    Sophia S Wang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Room 5104, Rockville, MD 20854 7234, USA
    Cancer Epidemiol Biomarkers Prev 18:113-20. 2009
    ..Investigations on the molecular distinctions along the disease continuum of cervical pathogenesis by HPV type are needed...
  21. doi request reprint Seroprevalence and correlates of human papillomavirus 16/18 seropositivity among young women in Costa Rica
    Sarah Coseo
    Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 6120 Executive Blvd, EPS, Room 7079, Rockville, MD 20852, USA
    Sex Transm Dis 37:706-14. 2010
    ..We investigated HPV16 and 18 seroepidemiology among young, unvaccinated women aged between 18 and 25...
  22. pmc A population-based prospective study of carcinogenic human papillomavirus variant lineages, viral persistence, and cervical neoplasia
    Mark Schiffman
    Divisions of Cancer Epidemiology and Genetics and Cancer Prevention, National Cancer Institute, Bethesda, Maryland 20852, USA
    Cancer Res 70:3159-69. 2010
    ..Larger viral genomic studies are warranted, especially to identify the genetic basis for HPV16's unique carcinogenicity...
  23. ncbi request reprint Longitudinal patterns of drug injection behavior in the ALIVE Study cohort,1988-2000: description and determinants
    N Galai
    Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
    Am J Epidemiol 158:695-704. 2003
    ..This view emphasizes the need for prolonged efforts to sustain cessation and to prevent adverse health and social outcomes among injection drug users...
  24. ncbi request reprint Temporal trends in the incidence of human immunodeficiency virus infection and risk behavior among injection drug users in Baltimore, Maryland, 1988-1998
    Kenrad E Nelson
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Am J Epidemiol 156:641-53. 2002
    ..These data suggest that high-risk behavior and HIV incidence among IDUs have decreased recently in Baltimore. Nevertheless, additional prevention strategies are needed in these populations...
  25. ncbi request reprint Validity of self-reported needle exchange attendance among injection drug users: implications for program evaluation
    Mahboobeh Safaeian
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Am J Epidemiol 155:169-75. 2002
    ..These findings have important implications for evaluations of NEPs...
  26. ncbi request reprint Changes in willingness to participate in HIV vaccine trials among HIV-negative injection drug users
    Elizabeth T Golub
    Department of Epidemiology, Johns Hopkins School of Public Health, Baltimore, Maryland 21205, USA
    AIDS Behav 9:301-9. 2005
    ..In this cohort, WTP remained strong and modestly increased over the study period. These results should be considered in the planning of sampling and retention strategies for future vaccine trials...
  27. pmc Evaluation of a novel PCR-based assay for detection and identification of Chlamydia trachomatis serovars in cervical specimens
    Koen Quint
    DDL Diagnostic Laboratory, Voorburg, The Netherlands
    J Clin Microbiol 45:3986-91. 2007
    ..In conclusion, the novel Ct-DT assay permits reliable detection and identification of C. trachomatis serovars...
  28. pmc Impact of 6-month frozen storage of cervical specimens in alkaline buffer conditions on human papillomavirus genotyping
    Brandon J LaMere
    Regional Laboratory, Kaiser Permanente Northern California, Berkley, CA, USA
    J Virol Methods 151:298-300. 2008
    ..Six-month frozen storage of cervical specimens at alkaline pH had little impact on testing for HPV genotypes among hc2-positive women using this HPV genotyping method...
  29. ncbi request reprint Sexual risk behavior among injection drug users before widespread availability of highly active antiretroviral therapy
    Melanie L Rusch
    Department of Health Care and Epidemiology, University of British Columbia, Vancouver, BC, Canada
    AIDS Behav 9:289-99. 2005
    ..No significant change in the odds of inconsistent condom use was observed with continued study exposure. Condom use remained low, indicating a need for interventions to reduce sexual risks and HIV transmission in this population...