Research Topics
Species | M SafaeianSummaryAffiliation: National Institutes of Health Country: USA Publications
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Detail Information
Publications
Direct comparison of HPV16 serological assays used to define HPV-naïve women in HPV vaccine trialsMahboobeh Safaeian
Division of Cancer Epidemiology and Genetics, Infections and Immunoepidemiology Branch, National Cancer Institute, NIH, Bethesda, MD, USA
Cancer Epidemiol Biomarkers Prev 21:1547-54. 2012..Some of the variation in estimated vaccine efficacies may be due to the differences in these assays used to define the HPV-naïve subgroups. To guide the interpretation of published results, we compared these assays...
Single nucleotide polymorphisms in the PRDX3 and RPS19 and risk of HPV persistence and cervical precancer/cancerMahboobeh Safaeian
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, United States of America
PLoS ONE 7:e33619. 2012..Host genetic factors might affect the risk of progression from infection with carcinogenic human papillomavirus (HPV), the etiologic agent for cervical cancer, to persistent HPV infection, and hence to cervical precancer and cancer...- Determinants of seropositivity among HPV-16/18 DNA positive young womenCarolina Porras
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
BMC Infect Dis 10:238. 2010..We evaluated determinants of seropositivity among 646 women infected with HPV-16 and/or HPV-18... - Detection of precancerous cervical lesions is differential by human papillomavirus typeMahboobeh Safaeian
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland, USA
Cancer Res 69:3262-6. 2009..001). These results indicate the underrepresentation of HPV18/45 in precancers, whereas HPV16-associated CIN3+ is diagnosed much earlier. Whether the underrepresentation of 18/45 may be due to occult pathology needs further investigation... - Determinants of incidence and clearance of high-risk human papillomavirus infections in rural Rakai, UgandaMahboobeh Safaeian
Department of Epidemiology, The Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA
Cancer Epidemiol Biomarkers Prev 17:1300-7. 2008..We used self-administered vaginal swabs to assess the incidence and clearance of carcinogenic human papillomavirus (HPV) infections in rural Rakai, Uganda... - Prevalence and risk factors for carcinogenic human papillomavirus infections in rural Rakai, UgandaM Safaeian
Department of Epidemiology, Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD, USA
Sex Transm Infect 84:306-11. 2008..To investigate self-administered vaginal swabs for assessing prevalence and correlates of carcinogenic human papillomavirus (HPV) infection in rural Rakai, Uganda... - Cervical cancer prevention--cervical screening: science in evolutionMahboobeh Safaeian
Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health DHHS, 6120 Executive Blvd, Rockville, MD 20852, USA
Obstet Gynecol Clin North Am 34:739-60, ix. 2007..This article describes the traditional methods of screening for cervical cancer and innovative methods that might help overcome financial and cultural barriers to more widespread screening... - Determinants and correlation of systemic and cervical concentrations of total IgA and IgGMahboobeh Safaeian
Division of Cancer Epidemiology and Genetics, Infections and Immunoepidemiology Branch, National Cancer Institute, 6120 Executive Boulevard, Suite 550, Rockville, MD 20852, USA
Cancer Epidemiol Biomarkers Prev 18:2672-6. 2009..17 and 0.16, respectively). The lack of correlation between systemic and cervical total IgA and IgG suggests that systemic concentrations are not reflective of cervical levels... - Lack of heterogeneity of HPV16 E7 sequence compared with HPV31 and HPV73 may be related to its unique carcinogenic propertiesMahboobeh Safaeian
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, USA
Arch Virol 155:367-70. 2010..The lack of heterogeneity of HPV16 E7 suggests high evolutionary purifying selection that might be related to the unique carcinogenicity of HPV16... - Comparison of the SPF10-LiPA system to the Hybrid Capture 2 Assay for detection of carcinogenic human papillomavirus genotypes among 5,683 young women in Guanacaste, Costa RicaMahboobeh Safaeian
Division of Cancer Epidemiology and Genetics, Hormonal and Reproductive Epidemiology Branch, National Cancer Institute, 6120 Executive Boulevard, Suite 550, Rockville, MD 20852, USA
J Clin Microbiol 45:1447-54. 2007..The crude agreement between the two assays was 88%, with a kappa value of 0.75 (95% confidence limits, 0.73 to 0.76). We observed very good agreement between HC2 and SPF(10)-LiPA for carcinogenic HPV type detection... 
Comparability of self-collected vaginal swabs and physician-collected cervical swabs for detection of human papillomavirus infections in Rakai, UgandaMahboobeh Safaeian
Department of Epidemiology, The Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 20852, USA
Sex Transm Dis 34:429-36. 2007..The objective of this study was to compare human papillomavirus (HPV) DNA testing between self-administered vaginal swabs and physician-administered cervical swabs in women from rural Rakai District, Uganda...- Epidemiological study of anti-HPV16/18 seropositivity and subsequent risk of HPV16 and -18 infectionsMahboobeh Safaeian
Division of Cancer Epidemiology and Genetics, Infections and Immunoepidemiology Branch, National Cancer Institute, National Institutes of Health, 6120 Executive Blvd, Ste 550, Rockville, MD 20852, USA
J Natl Cancer Inst 102:1653-62. 2010..Infection with human papillomavirus (HPV) 16 or HPV18 elicits an antibody response, but whether the elicited antibodies protect women against subsequent infection by a homologous HPV type compared with seronegative women is unknown... - Chlamydia trachomatis and risk of prevalent and incident cervical premalignancy in a population-based cohortMahboobeh Safaeian
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20852, USA
J Natl Cancer Inst 102:1794-804. 2010..In a large prospective cohort, we assessed the role of C trachomatis in cervical premalignancy and addressed confounding by HPV... - Chronic typhoid infection and the risk of biliary tract cancer and stones in Shanghai, ChinaMahboobeh Safaeian
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
Infect Agent Cancer 6:6. 2011..The low seroprevalence of S. Typhi in Shanghai is unlikely to explain the high incidence of biliary cancers in this population... - Factors associated with fluctuations in IgA and IgG levels at the cervix during the menstrual cycleMahboobeh Safaeian
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
J Infect Dis 199:455-63. 2009..The objective of this analysis was to describe patterns and determinants of cervical immunoglobulin A (IgA) and G (IgG) levels during the menstrual cycle... - Prevalence, incidence, and type-specific persistence of human papillomavirus in human immunodeficiency virus (HIV)-positive and HIV-negative womenL Ahdieh
Department of Epidemiology, Johns Hopkins University School of Hygiene and Public Health, Baltimore, Maryland 21205, USA
J Infect Dis 184:682-90. 2001..9 (95% CI, 1.5-2.3) times greater if the subject had a CD4 cell count <200 cells/microL (vs. >500 cells/microL). Thus, HIV infection and immunosuppression play an important role in modulating the natural history of HPV infection... - Risk of precancer and follow-up management strategies for women with human papillomavirus-negative atypical squamous cells of undetermined significanceMahboobeh Safaeian
Division of Cancer Epidemiology and Genetics and Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20852, USA
Obstet Gynecol 109:1325-31. 2007.... - Human papillomavirus cofactors by disease progression and human papillomavirus types in the study to understand cervical cancer early endpoints and determinantsSophia S Wang
Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Room 5104, Rockville, MD 20854 7234, USA
Cancer Epidemiol Biomarkers Prev 18:113-20. 2009..Investigations on the molecular distinctions along the disease continuum of cervical pathogenesis by HPV type are needed... - A population-based prospective study of carcinogenic human papillomavirus variant lineages, viral persistence, and cervical neoplasiaMark Schiffman
Divisions of Cancer Epidemiology and Genetics and Cancer Prevention, National Cancer Institute, Bethesda, Maryland 20852, USA
Cancer Res 70:3159-69. 2010..Larger viral genomic studies are warranted, especially to identify the genetic basis for HPV16's unique carcinogenicity... - Seroprevalence and correlates of human papillomavirus 16/18 seropositivity among young women in Costa RicaSarah Coseo
Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 6120 Executive Blvd, EPS, Room 7079, Rockville, MD 20852, USA
Sex Transm Dis 37:706-14. 2010..We investigated HPV16 and 18 seroepidemiology among young, unvaccinated women aged between 18 and 25... - Longitudinal patterns of drug injection behavior in the ALIVE Study cohort,1988-2000: description and determinantsN Galai
Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
Am J Epidemiol 158:695-704. 2003..This view emphasizes the need for prolonged efforts to sustain cessation and to prevent adverse health and social outcomes among injection drug users... - Validity of self-reported needle exchange attendance among injection drug users: implications for program evaluationMahboobeh Safaeian
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
Am J Epidemiol 155:169-75. 2002..These findings have important implications for evaluations of NEPs... - Temporal trends in the incidence of human immunodeficiency virus infection and risk behavior among injection drug users in Baltimore, Maryland, 1988-1998Kenrad E Nelson
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
Am J Epidemiol 156:641-53. 2002..These data suggest that high-risk behavior and HIV incidence among IDUs have decreased recently in Baltimore. Nevertheless, additional prevention strategies are needed in these populations... - Changes in willingness to participate in HIV vaccine trials among HIV-negative injection drug usersElizabeth T Golub
Department of Epidemiology, Johns Hopkins School of Public Health, Baltimore, Maryland 21205, USA
AIDS Behav 9:301-9. 2005..In this cohort, WTP remained strong and modestly increased over the study period. These results should be considered in the planning of sampling and retention strategies for future vaccine trials... - Impact of 6-month frozen storage of cervical specimens in alkaline buffer conditions on human papillomavirus genotypingBrandon J LaMere
Regional Laboratory, Kaiser Permanente Northern California, Berkley, CA, USA
J Virol Methods 151:298-300. 2008..Six-month frozen storage of cervical specimens at alkaline pH had little impact on testing for HPV genotypes among hc2-positive women using this HPV genotyping method... - Evaluation of a novel PCR-based assay for detection and identification of Chlamydia trachomatis serovars in cervical specimensKoen Quint
DDL Diagnostic Laboratory, Voorburg, The Netherlands
J Clin Microbiol 45:3986-91. 2007..In conclusion, the novel Ct-DT assay permits reliable detection and identification of C. trachomatis serovars... - Sexual risk behavior among injection drug users before widespread availability of highly active antiretroviral therapyMelanie L Rusch
Department of Health Care and Epidemiology, University of British Columbia, Vancouver, BC, Canada
AIDS Behav 9:289-99. 2005..No significant change in the odds of inconsistent condom use was observed with continued study exposure. Condom use remained low, indicating a need for interventions to reduce sexual risks and HIV transmission in this population...