D L Sacks

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Leishmania priming of human dendritic cells for CD40 ligand-induced interleukin-12p70 secretion is strain and species dependent
    Mary Ann McDowell
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Infect Immun 70:3994-4001. 2002
  2. ncbi request reprint Evasion of innate immunity by parasitic protozoa
    David Sacks
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Nat Immunol 3:1041-7. 2002
  3. ncbi request reprint IL-10 and TGF-beta control the establishment of persistent and transmissible infections produced by Leishmania tropica in C57BL/6 mice
    Charles F Anderson
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 0425, USA
    J Immunol 180:4090-7. 2008
  4. ncbi request reprint The immunology of susceptibility and resistance to Leishmania major in mice
    David Sacks
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Rev Immunol 2:845-58. 2002
  5. ncbi request reprint Re-examination of the immunosuppressive mechanisms mediating non-cure of Leishmania infection in mice
    David Sacks
    Laboratory of Parasitic Diseases, NIAID, Bethesda, MD, USA
    Immunol Rev 201:225-38. 2004
  6. ncbi request reprint Molecular aspects of parasite-vector and vector-host interactions in leishmaniasis
    D Sacks
    Laboratory of Parasitic Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Annu Rev Microbiol 55:453-83. 2001
  7. pmc The role of phosphoglycans in Leishmania-sand fly interactions
    D L Sacks
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 97:406-11. 2000
  8. ncbi request reprint Leishmania-sand fly interactions controlling species-specific vector competence
    D L Sacks
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Cell Microbiol 3:189-96. 2001
  9. pmc Toward a defined anti-Leishmania vaccine targeting vector antigens: characterization of a protective salivary protein
    J G Valenzuela
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 4 Center Dr, Rm. 4/126, Bethesda, MD 20892, USA
    J Exp Med 194:331-42. 2001
  10. pmc The role of antigen and IL-12 in sustaining Th1 memory cells in vivo: IL-12 is required to maintain memory/effector Th1 cells sufficient to mediate protection to an infectious parasite challenge
    L Stobie
    Clinical Immunology Section, Laboratory of Clinical Investigation, Howard Hughes Medical Institute, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 97:8427-32. 2000

Collaborators

Detail Information

Publications36

  1. pmc Leishmania priming of human dendritic cells for CD40 ligand-induced interleukin-12p70 secretion is strain and species dependent
    Mary Ann McDowell
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Infect Immun 70:3994-4001. 2002
    ..The intrinsic differences in the ability of Leishmania species to prime DCs for CD40L-dependent IL-12p70 secretion may account, at least in part, for the evolution of healing and nonhealing forms of leishmanial disease...
  2. ncbi request reprint Evasion of innate immunity by parasitic protozoa
    David Sacks
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Nat Immunol 3:1041-7. 2002
    ..In addition, there is growing evidence that protozoan pathogens modify the antigen-presenting and immunoregulatory functions of dendritic cells, a process that facilitates their evasion of both innate and adaptive immunity...
  3. ncbi request reprint IL-10 and TGF-beta control the establishment of persistent and transmissible infections produced by Leishmania tropica in C57BL/6 mice
    Charles F Anderson
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 0425, USA
    J Immunol 180:4090-7. 2008
    ..Thus, chronic infection with L. tropica appears to be established via multiple suppressive factors, which together maintain the host as a long-term reservoir of infection for vector sand flies...
  4. ncbi request reprint The immunology of susceptibility and resistance to Leishmania major in mice
    David Sacks
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Rev Immunol 2:845-58. 2002
    ..major-resistant mice have revealed complexities in the mechanisms responsible for acquired immunity, which necessitate the redesign of vaccines against Leishmania and other pathogens that require sustained cell-mediated immune responses...
  5. ncbi request reprint Re-examination of the immunosuppressive mechanisms mediating non-cure of Leishmania infection in mice
    David Sacks
    Laboratory of Parasitic Diseases, NIAID, Bethesda, MD, USA
    Immunol Rev 201:225-38. 2004
    ....
  6. ncbi request reprint Molecular aspects of parasite-vector and vector-host interactions in leishmaniasis
    D Sacks
    Laboratory of Parasitic Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Annu Rev Microbiol 55:453-83. 2001
    ..The importance of vector saliva in modulating the host response to transmitted parasites is also reviewed...
  7. pmc The role of phosphoglycans in Leishmania-sand fly interactions
    D L Sacks
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 97:406-11. 2000
    ....
  8. ncbi request reprint Leishmania-sand fly interactions controlling species-specific vector competence
    D L Sacks
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Cell Microbiol 3:189-96. 2001
    ..LPG displays interspecies polymorphisms in their phosphoglycan domains that in most cases can fully account for species-specific vector competence...
  9. pmc Toward a defined anti-Leishmania vaccine targeting vector antigens: characterization of a protective salivary protein
    J G Valenzuela
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 4 Center Dr, Rm. 4/126, Bethesda, MD 20892, USA
    J Exp Med 194:331-42. 2001
    ..These results indicate that DTH response against saliva provides most or all of the protective effects of this vaccine and that salivary gland proteins or their cDNAs are viable vaccine targets against leishmaniasis...
  10. pmc The role of antigen and IL-12 in sustaining Th1 memory cells in vivo: IL-12 is required to maintain memory/effector Th1 cells sufficient to mediate protection to an infectious parasite challenge
    L Stobie
    Clinical Immunology Section, Laboratory of Clinical Investigation, Howard Hughes Medical Institute, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 97:8427-32. 2000
    ..Taken together, these data show that IL-12 is essential to sustain a sufficient number of memory/effector Th1 cells generated in vivo to mediate long-term protection to an intracellular pathogen...
  11. pmc The role of interleukin (IL)-10 in the persistence of Leishmania major in the skin after healing and the therapeutic potential of anti-IL-10 receptor antibody for sterile cure
    Y Belkaid
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bldg 4 Rm 126, Center Dr MSC 0425, Bethesda, MD 20892, USA
    J Exp Med 194:1497-506. 2001
    ....
  12. ncbi request reprint Skin dendritic cells in murine cutaneous leishmaniasis
    M C Udey
    Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-1908, USA
    Immunobiology 204:590-4. 2001
    ....
  13. ncbi request reprint IL-4- and IL-4 receptor-deficient BALB/c mice reveal differences in susceptibility to Leishmania major parasite substrains
    N Noben-Trauth
    Laboratories ofImmunology and Parasitology, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 162:6132-40. 1999
    ..major infection. The results with LV39 infection indicate that yet another unidentified factor is capable of causing susceptibility to L. major in the absence of IL-4 or IL-4 signaling...
  14. ncbi request reprint Leishmania antigens are presented to CD8+ T cells by a transporter associated with antigen processing-independent pathway in vitro and in vivo
    Sylvie Bertholet
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 0425, USA
    J Immunol 177:3525-33. 2006
    ....
  15. ncbi request reprint CD8+ T cells are required for primary immunity in C57BL/6 mice following low-dose, intradermal challenge with Leishmania major
    Yasmine Belkaid
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, and Dermatology Branch, Division of Clinical Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 168:3992-4000. 2002
    ..The low dose, intradermal challenge model reveals that CD8(+) T cells play an essential role in both pathogenesis of and immunity to primary infection with L. major in the skin...
  16. ncbi request reprint Optimization of DNA vaccination against cutaneous leishmaniasis
    Susana Mendez
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Room 126, Building 4, Center Dr MSC 0425, Bethesda, MD 20892 0425, USA
    Vaccine 20:3702-8. 2002
    ..These results establish intradermal vaccination using DNA encoding multiple Leishmania antigens as a way to optimize priming of CD4+ and CD8+ T cells necessary for potent and durable protection against cutaneous leishmaniasis...
  17. ncbi request reprint Splenic cytokine responses in Indian kala-azar before and after treatment
    R T Kenney
    Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD, USA
    J Infect Dis 177:815-8. 1998
    ..With successful treatment and resolution of infection, both components of the immune response appear to involute...
  18. pmc CD4(+)CD25(-)Foxp3(-) Th1 cells are the source of IL-10-mediated immune suppression in chronic cutaneous leishmaniasis
    Charles F Anderson
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 204:285-97. 2007
    ....
  19. pmc IL-27 regulates IL-10 and IL-17 from CD4+ cells in nonhealing Leishmania major infection
    Charles F Anderson
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 183:4619-27. 2009
    ..The results demonstrate the pleiotropic effects that IL-27 has on L. major-driven Th1, Th2, and Th17 development, and reinforce its function as a key regulatory cytokine that controls the balance between immunity and pathology...
  20. ncbi request reprint Protective immunity using recombinant human IL-12 and alum as adjuvants in a primate model of cutaneous leishmaniasis
    R T Kenney
    Laboratory of Parasitic Biology, Division of Veterinary Medicine, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20852, USA
    J Immunol 163:4481-8. 1999
    ..This study extends the murine data to primates, and provides a basis for further human trials...
  21. pmc Quantification of the infectious dose of Leishmania major transmitted to the skin by single sand flies
    Nicola Kimblin
    Laboratories of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 105:10125-30. 2008
    ..The low dose resulted in only minor pathology but a higher parasite titer in the chronic phase, and it established the host as an efficient long-term reservoir of infection back to vector sand flies...
  22. pmc Role for CD4(+) CD25(+) regulatory T cells in reactivation of persistent leishmaniasis and control of concomitant immunity
    Susana Mendez
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 200:201-10. 2004
    ....
  23. ncbi request reprint Inhibition of host cell signal transduction by Leishmania: observations relevant to the selective impairment of IL-12 responses
    M A McDowell
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Disease, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Curr Opin Microbiol 2:438-43. 1999
    ....
  24. pmc In vivo imaging reveals an essential role for neutrophils in leishmaniasis transmitted by sand flies
    Nathan C Peters
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    Science 321:970-4. 2008
    ..Thus, L.m. appears to have evolved to both evade and exploit the innate host response to sand fly bite in order to establish and promote disease...
  25. ncbi request reprint Animal models for the analysis of immune responses to leishmaniasis
    D L Sacks
    National Institute of Allergy and Infectious, Diseases, Bethesda, Maryland, USA
    Curr Protoc Immunol . 2001
    ....
  26. ncbi request reprint Characterization of a blood activated chitinolytic system in the midgut of the sand fly vectors Lutzomyia longipalpis and Phlebotomus papatasi
    J M Ramalho-Ortigão
    Intracellular Parasite Biology Section, Laboratory of Parasitic Diseases, National Institute for Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20852 8132, USA
    Insect Mol Biol 14:703-12. 2005
    ..Additionally, the rPpChit1 and the native chitinase displayed similar retention times in a HPLC size fractionation column. When added to rPpChit1 or to midgut lysates, PpChit1 sera reduced chitinolytic activity by 65-70%...
  27. ncbi request reprint Unique gene expression profiles of human macrophages and dendritic cells to phylogenetically distinct parasites
    Damien Chaussabel
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 102:672-81. 2003
    ..The association of characteristic functional clusters with each infectious agent is consistent with the concept that antigen-presenting cells have prewired signaling patterns for use in the response to different pathogens...
  28. pmc Splenic accumulation of IL-10 mRNA in T cells distinct from CD4+CD25+ (Foxp3) regulatory T cells in human visceral leishmaniasis
    Susanne Nylen
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 204:805-17. 2007
    ..The elevated levels of IL-10 in VL plasma significantly enhanced the growth of L. donovani amastigotes in human macrophages. The data implicate IL-10-producing CD25(-)Foxp3(-) T cells in the pathogenesis of human VL...
  29. pmc Proteophosphoglycan confers resistance of Leishmania major to midgut digestive enzymes induced by blood feeding in vector sand flies
    Nagila Secundino
    Laboratory of Parasitic Diseases, NIAID, NIH, Bethesda, MD 20892, USA
    Cell Microbiol 12:906-18. 2010
    ....
  30. ncbi request reprint Interleukin-10 and the pathogenesis of human visceral leishmaniasis
    Susanne Nylen
    Laboratory of Parasitic Diseases, Bldg 4 RmB1 12, National Institute of Allergy and Infectious Diseases, 4 Center Drive MSC0425, Bethesda, MD 20892 0425, USA
    Trends Immunol 28:378-84. 2007
    ..Here, we review the studies with relevance to immune responses in human VL and highlight the central role that IL-10 might have in the pathogenesis of VL and as a target for immune-based therapy...
  31. ncbi request reprint Immune privilege in sites of chronic infection: Leishmania and regulatory T cells
    Nathan Peters
    Laboratory of Parasitic Diseases, NIAID, Bethesda, MD 20892 0425, USA
    Immunol Rev 213:159-79. 2006
    ..Finally, following resolution of infection in healed mice, CD25+Foxp3+ Tregs function in an IL-10-dependent manner to prevent sterile cure and establish a long-term state of functional immune privilege in the skin...
  32. doi request reprint Intracellular replication-deficient Leishmania donovani induces long lasting protective immunity against visceral leishmaniasis
    Angamuthu Selvapandiyan
    Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA
    J Immunol 183:1813-20. 2009
    ..braziliensis that causes mucocutaneous leishmaniasis. Results indicate that LdCen1(-/-) can be a safe and effective vaccine candidate against VL as well as mucocutaneous leishmaniasis causing parasites...
  33. pmc Vaccination with the Leishmania infantum acidic ribosomal P0 protein plus CpG oligodeoxynucleotides induces protection against cutaneous leishmaniasis in C57BL/6 mice but does not prevent progressive disease in BALB/c mice
    Salvador Iborra
    Centro de Biologia Molecular Severo Ochoa, Universidad Autonoma de Madrid, 28049 Madrid, Spain
    Infect Immun 73:5842-52. 2005
    ....
  34. ncbi request reprint Phagosomes are competent organelles for antigen cross-presentation
    Mathieu Houde
    Departement de pathologie et biologie cellulaire, Universite de Montreal, C P 6128, Succ Centre Ville, Montreal, Quebec, H3C 3J7, Canada
    Nature 425:402-6. 2003
    ..Here we show that phagosomes display the elements and properties needed to be self-sufficient for the cross-presentation of exogenous antigens, a newly ascribed function linked to phagocytosis mediated by the endoplasmic reticulum...
  35. pmc Leishmania disease development depends on the presence of apoptotic promastigotes in the virulent inoculum
    Ger van Zandbergen
    Institute for Medical Microbiology and Hygiene, University of Lubeck, D 23538 Lubeck, Germany
    Proc Natl Acad Sci U S A 103:13837-42. 2006
    ..The data demonstrate that apoptotic promastigotes, in an altruistic way, enable the intracellular survival of the viable parasites...
  36. pmc Genetic characterization of glucose transporter function in Leishmania mexicana
    Richard J S Burchmore
    Institute of Biomedical and Life Sciences, Division of Infection and Immunity, Joseph Black Building, University of Glasgow, Glasgow G12 8QQ, United Kingdom
    Proc Natl Acad Sci U S A 100:3901-6. 2003
    ..These results establish that each glucose transporter isoform has distinct biological functions in the parasite...