Research Topics
Genomes and Genes
| Michael N SackSummaryAffiliation: National Institutes of Health Country: USA Publications
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Detail Information
Publications
ATF-1 is a hypoxia-responsive transcriptional activator of skeletal muscle mitochondrial-uncoupling protein 3Zhongping Lu
Translational Medicine Branch, NHLBI, National Institutes of Health, Bethesda, Maryland 20892 1454, USA
J Biol Chem 283:23410-8. 2008..These data reinforce the role of ATF-1 as a hypoxia-responsive trans-activator and identifies a novel regulatory program that may modulate cellular responses to oxygen-deficit...
Mitochondrial depolarization and the role of uncoupling proteins in ischemia toleranceMichael N Sack
Cardiology Branch, NHLBI, National Institutes of Health, Building 10 CRC, Room 5 3150, 10 Center Drive, Bethesda, MD 20892 1454, USA
Cardiovasc Res 72:210-9. 2006....- Type 2 diabetes, mitochondrial biology and the heartMichael N Sack
Translational Medicine Branch, NHLBI, NIH, Bethesda, MD, USA
J Mol Cell Cardiol 46:842-9. 2009.... - Caloric excess or restriction mediated modulation of metabolic enzyme acetylation-proposed effects on cardiac growth and functionMichael N Sack
Translational Medicine Branch, NHLBI, NIH, Bld 10 CRC, Room 5 3150, 10 Center Drive, Bethesda, MD, 20892 1454, USA
Biochim Biophys Acta 1813:1279-85. 2011..Areas of investigation that need to be explored are highlighted. This article is part of a Special Issue entitled: Mitochondria and Cardioprotection... - Emerging characterization of the role of SIRT3-mediated mitochondrial protein deacetylation in the heartMichael N Sack
Center for Molecular Medicine, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA
Am J Physiol Heart Circ Physiol 301:H2191-7. 2011..As therapeutic modulators of other SIRT isoforms have been identified, the longer-term objective of our understanding of this biology would be to identify SIRT3 modulators as putative cardiac therapeutic agents... - PGC-1alpha integrates insulin signaling, mitochondrial regulation, and bioenergetic function in skeletal muscleInes Pagel-Langenickel
Translational Medicine Branch, NHLBI, National Institutes of Health, Bethesda, Maryland 20892 1454, USA
J Biol Chem 283:22464-72. 2008..Pioglitazone functions in part via the induction of PGC-1alpha. Moreover, PGC-1alpha is identified as a bidirectional regulatory link integrating insulin-signaling and mitochondrial homeostasis in skeletal muscle... - The emerging characterization of lysine residue deacetylation on the modulation of mitochondrial function and cardiovascular biologyZhongping Lu
Translational Medicine Branch, National Heart, Lung, and Blood Institute, Bethesda, MD, USA
Circ Res 105:830-41. 2009..This review will introduce the role of nonhistone protein lysine residue acetyl modifications, discuss their regulation and biochemistry and present the direct and indirect data implicating their involvement in the heart and vasculature... - The role of sirtuins in modulating redox stressorsBradley R Webster
Center for Molecular Medicine, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
Free Radic Biol Med 52:281-90. 2012..Here we investigate the links between sirtuins and their oxidative/redox environment and review the control mechanisms that are regulated by the activity of sirtuin deacetylase proteins... - Uncoupling proteins 2 and 3 function in concert to augment tolerance to cardiac ischemiaChristopher J McLeod
Cardiovascular Branch, Laboratory of Animal Medicine and Surgery, Flow Cytometry Core, NHLBI, National Institutes of Health, Bethesda, Maryland 20892 1454, USA
J Biol Chem 280:33470-6. 2005..In the cytoprotective hierarchy, uncoupling protein-2 appears to play a greater role than uncoupling protein-3 in modulating ischemia/anoxia tolerance in heart-derived cells... - SIRT3 is regulated by nutrient excess and modulates hepatic susceptibility to lipotoxicityJianjun Bao
Translational Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
Free Radic Biol Med 49:1230-7. 2010..This SIRT3-dependent lipotoxic susceptibility is possibly modulated, in part, by SIRT3-mediated control of electron transfer chain flux... 
Identification of a molecular component of the mitochondrial acetyltransferase programme: a novel role for GCN5L1Iain Scott
Center for Molecular Medicine, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1454, USA
Biochem J 443:655-61. 2012..The results of the present study identify GCN5L1 as a critical prokaryote-derived component of the mitochondrial acetyltransferase programme...- Characterization of the murine SIRT3 mitochondrial localization sequence and comparison of mitochondrial enrichment and deacetylase activity of long and short SIRT3 isoformsJianjun Bao
Translational Medicine Branch, NHLBI, NIH, Bethesda, Maryland, USA
J Cell Biochem 110:238-47. 2010..This overexpression effect, may partially account for previously observed divergent phenotypes attributed to SIRT3... - SIRT3-dependent deacetylation exacerbates acetaminophen hepatotoxicityZhongping Lu
Center for Molecular Medicine, NHLBI, National Institutes of Health, Building 10 CRC, Room 5 3150, 10 Center Drive, Bethesda, Maryland 20892, USA
EMBO Rep 12:840-6. 2011..Thus, protein deacetylation enhances xenobiotic liver injury by modulating the binding of a toxic metabolite to mitochondrial proteins... - SIRT2 is a negative regulator of anoxia-reoxygenation tolerance via regulation of 14-3-3 zeta and BAD in H9c2 cellsEdward G Lynn
Translational Medicine Branch, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1454, USA
FEBS Lett 582:2857-62. 2008..SIRT2 functions to moderate cellular stress-tolerance, in part, by modulating the levels of 14-3-3 zeta with the concordant control of BAD subcellular localization... - Cysteine 203 of cyclophilin D is critical for cyclophilin D activation of the mitochondrial permeability transition poreTiffany T Nguyen
Systems Biology Center, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 286:40184-92. 2011..Our results indicate that the Cys-203 residue of CypD is necessary for redox stress-induced activation of mPTP... - The role of SIRT3 in mitochondrial homeostasis and cardiac adaptation to hypertrophy and agingMichael N Sack
Center for Molecular Medicine, NHLBI, NIH, Bethesda, MD 20892 1454, USA
J Mol Cell Cardiol 52:520-5. 2012..This article is part of a Special Section entitled "Post-translational Modification.".. - Parkin is a lipid-responsive regulator of fat uptake in mice and mutant human cellsKye Young Kim
Center for Molecular Medicine, NHLBI, 10 Center Drive, Bethesda, Maryland, 20892 1454, USA
J Clin Invest 121:3701-12. 2011..Whether this metabolic regulation contributes to premature Parkinsonism warrants investigation... - Transient upregulation of PGC-1alpha diminishes cardiac ischemia tolerance via upregulation of ANT1Edward G Lynn
Translational Medicine Branch, NHLBI, NIH, Bethesda, MD 20892 1454, USA
J Mol Cell Cardiol 49:693-8. 2010..These adverse phenotypes appear to be mediated, in part, by PGC-1alpha induced upregulation of ANT1... - The role of mitochondria in the pathophysiology of skeletal muscle insulin resistanceInes Pagel-Langenickel
Translational Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, 10 Center Drive, Bethesda, Maryland 20892 1454, USA
Endocr Rev 31:25-51. 2010.... - Protein deacetylation by sirtuins: delineating a post-translational regulatory program responsive to nutrient and redox stressorsJianjun Bao
Translational Medicine Branch, National Heart Lung and Blood Institute, NIH, 10 Center Drive, MSC 1454, Bethesda, MD 20892 1454, USA
Cell Mol Life Sci 67:3073-87. 2010..We review the sirtuin family proteins, discuss their functional effects on target proteins, and postulate on potential biological programs and disease processes that may be modified by sirtuin-mediated deacetylation of target proteins... - Targeting the mitochondria to augment myocardial protectionDaniel R Schwartz
Translational Medicine Branch, NHLBI, National Institutes of Health, Bethesda, MD 20892 1454, United States
Curr Opin Pharmacol 8:160-5. 2008..The objective of this manuscript is to briefly review these regulatory programs and to postulate novel therapeutic approaches with the primary goal of modulating mitochondria to enhance tolerance to cardiac ischemic stress... - Wnt signaling regulates hepatic metabolismHongjun Liu
Center for Molecular Medicine, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
Sci Signal 4:ra6. 2011..These observations implicate Wnt signaling in the modulation of hepatic metabolism and raise the possibility that Wnt signaling may play a similar role in the metabolic regulation of other tissues... - Parkin in the regulation of fat uptake and mitochondrial biology: emerging links in the pathophysiology of Parkinson's diseaseKye Young Kim
Center for Molecular Medicine, National Heart, Lung, and Blood Institute, Bethesda, Maryland, USA
Curr Opin Lipidol 23:201-5. 2012.... - Heme oxygenase-1 deficiency accelerates formation of arterial thrombosis through oxidative damage to the endothelium, which is rescued by inhaled carbon monoxideAndrea L True
National Heart, Lung and Blood Institute, NIH, Bethesda, MD 20892, USA
Circ Res 101:893-901. 2007..Induction of HO-1 may be beneficial in the prevention of thrombosis associated with vascular oxidant stress and inflammation... - Nitrite augments tolerance to ischemia/reperfusion injury via the modulation of mitochondrial electron transferSruti Shiva
Vascular Medicine Branch, National Heart Lung Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
J Exp Med 204:2089-102. 2007..These data suggest that nitrite dynamically modulates mitochondrial resilience to reperfusion injury and may represent an effector of the cell-survival program of ischemic preconditioning and the Mediterranean diet... - The role of comorbidities in cardioprotectionMichael N Sack
Center for Molecular Medicine, NHLBI, NIH, Bethesda, MD, USA
J Cardiovasc Pharmacol Ther 16:267-72. 2011..It is important to understand at a mechanistic level the reasons for these differences. The effects of sex and diseases need to be considered in design of cardioprotective interventions in animal studies and clinical trials... - Delayed ischemic preconditioning activates nuclear-encoded electron-transfer-chain gene expression in parallel with enhanced postanoxic mitochondrial respiratory recoveryChristopher J McLeod
Cardiovascular Branch, NHLBI, National Institutes of Health, Bethesda, MD 20892-1650, USA
Circulation 110:534-9. 2004..This program appears to be mediated by reactive oxygen species signaling... - The mitochondrial biogenesis regulatory program in cardiac adaptation to ischemia--a putative target for therapeutic interventionChristopher J McLeod
Cardiovascular Branch, NHLBI, National Institutes of Health, Bethesda, MD 20892-1454, USA
Trends Cardiovasc Med 15:118-23. 2005.... - The regulation, control, and consequences of mitochondrial oxygen utilization and disposition in the heart and skeletal muscle during hypoxiaEdward G Lynn
Cardiology Branch, NHLBI, National Institutes of Health, Bethesda, Maryland 20892 1454, USA
Antioxid Redox Signal 9:1353-61. 2007..Moreover, data supporting the role of mitochondria as oxygen-sensing organelles, integrated into global cellular signal transduction are discussed... - Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS)Ariel C Bulua
Immunoregulation Section, Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutesof Health, Bethesda, MD 20892, USA
J Exp Med 208:519-33. 2011..These findings suggest that mitochondrial ROS may be a novel therapeutic target for TRAPS and other inflammatory diseases... - Ambient oxygen promotes tumorigenesisHo Joong Sung
Center for Molecular Medicine, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, United States of America
PLoS ONE 6:e19785. 2011.... - A discordance in rosiglitazone mediated insulin sensitization and skeletal muscle mitochondrial content/activity in Type 2 diabetes mellitusInes Pagel Langenickel
Cardiology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1454, USA
Am J Physiol Heart Circ Physiol 293:H2659-66. 2007..It remains to be determined whether longer-term insulin sensitization therapy with rosiglitazone will augment skeletal muscle mitochondrial bioenergetics in those diabetic subjects with relatively preserved basal aerobic capacity... - Exploring mitochondria in the intact ischemic heart: advancing technologies to image intracellular functionMichael N Sack
Circulation 114:1452-4. 2006 - Metabolic plasticity and the promotion of cardiac protection in ischemia and ischemic preconditioningLionel H Opie
Hatter Institute for Cardiology Research and Medical Research Council Inter University Cape Heart Group, Cape Heart Centre, University of Cape Town Medical School, South Africa
J Mol Cell Cardiol 34:1077-89. 2002..In this review we discuss studies that demonstrate how metabolic plasticity can promote cardioprotection against ischemia and reperfusion injury and highlight areas that require further characterization... - Innate immunity and cardiac preconditioning: a putative intrinsic cardioprotective programRobert M Smith
Hatter Institute for Cardiology Research, MRC Inter-University Cape Heart Group, University of Cape Town Medical School, South Africa
Cardiovasc Res 55:474-82. 2002.... - Classic ischemic but not pharmacologic preconditioning is abrogated following genetic ablation of the TNFalpha geneRobert M Smith
Hatter Institute for Cardiology Research, MRC Inter University Cape Heart Group, University of Cape Town Medical School, Observatory 7925, South Africa
Cardiovasc Res 55:553-60. 2002..Moreover, whether TNFalpha is required to induce the ischemic preconditioning phenotype has not been determined... - Mitochondrial plasticity in classical ischemic preconditioning-moving beyond the mitochondrial KATP channelJan Minners
Hatter Institute for Cardiology Research and MRC Inter-University Cape Heart Group, University of Cape Town Medical School, Cape Town, South Africa
Cardiovasc Res 59:1-6. 2003.... - Insulin therapy as an adjunct to reperfusion after acute coronary ischemia: a proposed direct myocardial cell survival effect independent of metabolic modulationMichael N Sack
The Hatter Institute for Cardiology Research, MRC Inter-University Cape Heart Group, University of Cape Town Medical School, South Africa
J Am Coll Cardiol 41:1404-7. 2003.... - Identification of a novel role for sphingolipid signaling in TNF alpha and ischemic preconditioning mediated cardioprotectionSandrine Lecour
Hatter Institute for Cardiology Research, MRC Inter-University Cape Heart Group, University of Cape Town Medical School, South Africa
J Mol Cell Cardiol 34:509-18. 2002..In conclusion, TNF alpha activates preconditioning-like tolerance against infarction and contractile dysfunction. This cardioprotection is mediated, in part, via activation of novel sphingolipid signaling intermediates... - p70s6 kinase is a functional target of insulin activated Akt cell-survival signalingAnne K Jonassen
Department of Medical Physiology, Institute of Medical Biology, University of Troms, Norway
Biochem Biophys Res Commun 315:160-5. 2004..Collectively, these data demonstrate that p70s6 kinase activation is a functional target of Akt following insulin-activated cytoprotection during ischemia-reoxygenation-induced injury... - PKCepsilon activation augments cardiac mitochondrial respiratory post-anoxic reserve--a putative mechanism in PKCepsilon cardioprotectionJoy McCarthy
Hatter Institute for Cardiology Research, University of Cape Town Medical School, Cape Town, South Africa
J Mol Cell Cardiol 38:697-700. 2005.... - Genetic depletion of cardiac myocyte STAT-3 abolishes classical preconditioningRobert M Smith
Hatter Institute for Cardiology Research, Faculty of Health Sciences, University of Cape Town Observatory, Cape Heart Centre, Chris Barnard Building, Cape Town 7925, South Africa
Cardiovasc Res 63:611-6. 2004..To evaluate the functional requirement of signal transducer and activator of transcription-3 (STAT-3) in cardiac myocyte tolerance to ischemia (I) and in classical preconditioning...