Michael N Sack

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc ATF-1 is a hypoxia-responsive transcriptional activator of skeletal muscle mitochondrial-uncoupling protein 3
    Zhongping Lu
    Translational Medicine Branch, NHLBI, National Institutes of Health, Bethesda, Maryland 20892 1454, USA
    J Biol Chem 283:23410-8. 2008
  2. ncbi request reprint Mitochondrial depolarization and the role of uncoupling proteins in ischemia tolerance
    Michael N Sack
    Cardiology Branch, NHLBI, National Institutes of Health, Building 10 CRC, Room 5 3150, 10 Center Drive, Bethesda, MD 20892 1454, USA
    Cardiovasc Res 72:210-9. 2006
  3. pmc Emerging characterization of the role of SIRT3-mediated mitochondrial protein deacetylation in the heart
    Michael N Sack
    Center for Molecular Medicine, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA
    Am J Physiol Heart Circ Physiol 301:H2191-7. 2011
  4. pmc Caloric excess or restriction mediated modulation of metabolic enzyme acetylation-proposed effects on cardiac growth and function
    Michael N Sack
    Translational Medicine Branch, NHLBI, NIH, Bld 10 CRC, Room 5 3150, 10 Center Drive, Bethesda, MD, 20892 1454, USA
    Biochim Biophys Acta 1813:1279-85. 2011
  5. pmc Type 2 diabetes, mitochondrial biology and the heart
    Michael N Sack
    Translational Medicine Branch, NHLBI, NIH, Bethesda, MD, USA
    J Mol Cell Cardiol 46:842-9. 2009
  6. pmc Restricted mitochondrial protein acetylation initiates mitochondrial autophagy
    Bradley R Webster
    Center for Molecular Medicine, NHLBI, NIH, Bethesda, MD 20892, USA
    J Cell Sci 126:4843-9. 2013
  7. pmc PGC-1alpha integrates insulin signaling, mitochondrial regulation, and bioenergetic function in skeletal muscle
    Ines Pagel-Langenickel
    Translational Medicine Branch, NHLBI, National Institutes of Health, Bethesda, Maryland 20892 1454, USA
    J Biol Chem 283:22464-72. 2008
  8. pmc The emerging characterization of lysine residue deacetylation on the modulation of mitochondrial function and cardiovascular biology
    Zhongping Lu
    Translational Medicine Branch, National Heart, Lung, and Blood Institute, Bethesda, MD, USA
    Circ Res 105:830-41. 2009
  9. pmc The role of sirtuins in modulating redox stressors
    Bradley R Webster
    Center for Molecular Medicine, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Free Radic Biol Med 52:281-90. 2012
  10. ncbi request reprint Uncoupling proteins 2 and 3 function in concert to augment tolerance to cardiac ischemia
    Christopher J McLeod
    Cardiovascular Branch, Laboratory of Animal Medicine and Surgery, Flow Cytometry Core, NHLBI, National Institutes of Health, Bethesda, Maryland 20892 1454, USA
    J Biol Chem 280:33470-6. 2005

Collaborators

Detail Information

Publications47

  1. pmc ATF-1 is a hypoxia-responsive transcriptional activator of skeletal muscle mitochondrial-uncoupling protein 3
    Zhongping Lu
    Translational Medicine Branch, NHLBI, National Institutes of Health, Bethesda, Maryland 20892 1454, USA
    J Biol Chem 283:23410-8. 2008
    ..These data reinforce the role of ATF-1 as a hypoxia-responsive trans-activator and identifies a novel regulatory program that may modulate cellular responses to oxygen-deficit...
  2. ncbi request reprint Mitochondrial depolarization and the role of uncoupling proteins in ischemia tolerance
    Michael N Sack
    Cardiology Branch, NHLBI, National Institutes of Health, Building 10 CRC, Room 5 3150, 10 Center Drive, Bethesda, MD 20892 1454, USA
    Cardiovasc Res 72:210-9. 2006
    ....
  3. pmc Emerging characterization of the role of SIRT3-mediated mitochondrial protein deacetylation in the heart
    Michael N Sack
    Center for Molecular Medicine, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA
    Am J Physiol Heart Circ Physiol 301:H2191-7. 2011
    ..As therapeutic modulators of other SIRT isoforms have been identified, the longer-term objective of our understanding of this biology would be to identify SIRT3 modulators as putative cardiac therapeutic agents...
  4. pmc Caloric excess or restriction mediated modulation of metabolic enzyme acetylation-proposed effects on cardiac growth and function
    Michael N Sack
    Translational Medicine Branch, NHLBI, NIH, Bld 10 CRC, Room 5 3150, 10 Center Drive, Bethesda, MD, 20892 1454, USA
    Biochim Biophys Acta 1813:1279-85. 2011
    ..Areas of investigation that need to be explored are highlighted. This article is part of a Special Issue entitled: Mitochondria and Cardioprotection...
  5. pmc Type 2 diabetes, mitochondrial biology and the heart
    Michael N Sack
    Translational Medicine Branch, NHLBI, NIH, Bethesda, MD, USA
    J Mol Cell Cardiol 46:842-9. 2009
    ....
  6. pmc Restricted mitochondrial protein acetylation initiates mitochondrial autophagy
    Bradley R Webster
    Center for Molecular Medicine, NHLBI, NIH, Bethesda, MD 20892, USA
    J Cell Sci 126:4843-9. 2013
    ....
  7. pmc PGC-1alpha integrates insulin signaling, mitochondrial regulation, and bioenergetic function in skeletal muscle
    Ines Pagel-Langenickel
    Translational Medicine Branch, NHLBI, National Institutes of Health, Bethesda, Maryland 20892 1454, USA
    J Biol Chem 283:22464-72. 2008
    ..Pioglitazone functions in part via the induction of PGC-1alpha. Moreover, PGC-1alpha is identified as a bidirectional regulatory link integrating insulin-signaling and mitochondrial homeostasis in skeletal muscle...
  8. pmc The emerging characterization of lysine residue deacetylation on the modulation of mitochondrial function and cardiovascular biology
    Zhongping Lu
    Translational Medicine Branch, National Heart, Lung, and Blood Institute, Bethesda, MD, USA
    Circ Res 105:830-41. 2009
    ..This review will introduce the role of nonhistone protein lysine residue acetyl modifications, discuss their regulation and biochemistry and present the direct and indirect data implicating their involvement in the heart and vasculature...
  9. pmc The role of sirtuins in modulating redox stressors
    Bradley R Webster
    Center for Molecular Medicine, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Free Radic Biol Med 52:281-90. 2012
    ..Here we investigate the links between sirtuins and their oxidative/redox environment and review the control mechanisms that are regulated by the activity of sirtuin deacetylase proteins...
  10. ncbi request reprint Uncoupling proteins 2 and 3 function in concert to augment tolerance to cardiac ischemia
    Christopher J McLeod
    Cardiovascular Branch, Laboratory of Animal Medicine and Surgery, Flow Cytometry Core, NHLBI, National Institutes of Health, Bethesda, Maryland 20892 1454, USA
    J Biol Chem 280:33470-6. 2005
    ..In the cytoprotective hierarchy, uncoupling protein-2 appears to play a greater role than uncoupling protein-3 in modulating ischemia/anoxia tolerance in heart-derived cells...
  11. pmc GCN5-like protein 1 (GCN5L1) controls mitochondrial content through coordinated regulation of mitochondrial biogenesis and mitophagy
    Iain Scott
    From the Laboratory of Mitochondrial Biology and Metabolism, NHLBI, National Institutes of Health, Bethesda, Maryland 20892
    J Biol Chem 289:2864-72. 2014
    ....
  12. doi request reprint Cyclophilin D modulates mitochondrial acetylome
    Tiffany Tuyen M Nguyen
    From the Systems Biology Center T T M N, S M, J S, E M, Division of Cardiovascular Sciences R W, Proteomics Core Facility Y C, G W, M G, and Center for Molecular Medicine M N S, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD and Department of Pathology, Johns Hopkins Medical Center, Baltimore, MD C S
    Circ Res 113:1308-19. 2013
    ..As acetylation has been shown to regulate metabolism, we tested whether changes in protein acetylation might play a role in these metabolic changes in CypD(-/-) hearts...
  13. pmc SIRT3 is regulated by nutrient excess and modulates hepatic susceptibility to lipotoxicity
    Jianjun Bao
    Translational Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Free Radic Biol Med 49:1230-7. 2010
    ..This SIRT3-dependent lipotoxic susceptibility is possibly modulated, in part, by SIRT3-mediated control of electron transfer chain flux...
  14. doi request reprint Identification of a molecular component of the mitochondrial acetyltransferase programme: a novel role for GCN5L1
    Iain Scott
    Center for Molecular Medicine, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1454, USA
    Biochem J 443:655-61. 2012
    ..The results of the present study identify GCN5L1 as a critical prokaryote-derived component of the mitochondrial acetyltransferase programme...
  15. pmc Characterization of the murine SIRT3 mitochondrial localization sequence and comparison of mitochondrial enrichment and deacetylase activity of long and short SIRT3 isoforms
    Jianjun Bao
    Translational Medicine Branch, NHLBI, NIH, Bethesda, Maryland, USA
    J Cell Biochem 110:238-47. 2010
    ..This overexpression effect, may partially account for previously observed divergent phenotypes attributed to SIRT3...
  16. pmc Regulation of autophagy and mitophagy by nutrient availability and acetylation
    Bradley R Webster
    Center for Molecular Medicine, NHLBI, NIH, Bethesda, MD, USA
    Biochim Biophys Acta 1841:525-34. 2014
    ..In particular, we focus on how acetylation may control the degradation and turnover of mitochondria, the major source of fuel-derived acetyl-CoA. ..
  17. pmc Transient upregulation of PGC-1alpha diminishes cardiac ischemia tolerance via upregulation of ANT1
    Edward G Lynn
    Translational Medicine Branch, NHLBI, NIH, Bethesda, MD 20892 1454, USA
    J Mol Cell Cardiol 49:693-8. 2010
    ..These adverse phenotypes appear to be mediated, in part, by PGC-1alpha induced upregulation of ANT1...
  18. pmc SIRT2 is a negative regulator of anoxia-reoxygenation tolerance via regulation of 14-3-3 zeta and BAD in H9c2 cells
    Edward G Lynn
    Translational Medicine Branch, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1454, USA
    FEBS Lett 582:2857-62. 2008
    ..SIRT2 functions to moderate cellular stress-tolerance, in part, by modulating the levels of 14-3-3 zeta with the concordant control of BAD subcellular localization...
  19. pmc SIRT3-dependent deacetylation exacerbates acetaminophen hepatotoxicity
    Zhongping Lu
    Center for Molecular Medicine, NHLBI, National Institutes of Health, Building 10 CRC, Room 5 3150, 10 Center Drive, Bethesda, Maryland 20892, USA
    EMBO Rep 12:840-6. 2011
    ..Thus, protein deacetylation enhances xenobiotic liver injury by modulating the binding of a toxic metabolite to mitochondrial proteins...
  20. pmc Cysteine 203 of cyclophilin D is critical for cyclophilin D activation of the mitochondrial permeability transition pore
    Tiffany T Nguyen
    Systems Biology Center, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 286:40184-92. 2011
    ..Our results indicate that the Cys-203 residue of CypD is necessary for redox stress-induced activation of mPTP...
  21. pmc The role of SIRT3 in mitochondrial homeostasis and cardiac adaptation to hypertrophy and aging
    Michael N Sack
    Center for Molecular Medicine, NHLBI, NIH, Bethesda, MD 20892 1454, USA
    J Mol Cell Cardiol 52:520-5. 2012
    ..This article is part of a Special Section entitled "Post-translational Modification."..
  22. pmc Protein deacetylation by sirtuins: delineating a post-translational regulatory program responsive to nutrient and redox stressors
    Jianjun Bao
    Translational Medicine Branch, National Heart Lung and Blood Institute, NIH, 10 Center Drive, MSC 1454, Bethesda, MD 20892 1454, USA
    Cell Mol Life Sci 67:3073-87. 2010
    ..We review the sirtuin family proteins, discuss their functional effects on target proteins, and postulate on potential biological programs and disease processes that may be modified by sirtuin-mediated deacetylation of target proteins...
  23. pmc Parkin is a lipid-responsive regulator of fat uptake in mice and mutant human cells
    Kye Young Kim
    Center for Molecular Medicine, NHLBI, 10 Center Drive, Bethesda, Maryland, 20892 1454, USA
    J Clin Invest 121:3701-12. 2011
    ..Whether this metabolic regulation contributes to premature Parkinsonism warrants investigation...
  24. pmc The role of mitochondria in the pathophysiology of skeletal muscle insulin resistance
    Ines Pagel-Langenickel
    Translational Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, 10 Center Drive, Bethesda, Maryland 20892 1454, USA
    Endocr Rev 31:25-51. 2010
    ....
  25. pmc Targeting the mitochondria to augment myocardial protection
    Daniel R Schwartz
    Translational Medicine Branch, NHLBI, National Institutes of Health, Bethesda, MD 20892 1454, United States
    Curr Opin Pharmacol 8:160-5. 2008
    ..The objective of this manuscript is to briefly review these regulatory programs and to postulate novel therapeutic approaches with the primary goal of modulating mitochondria to enhance tolerance to cardiac ischemic stress...
  26. pmc Wnt signaling regulates hepatic metabolism
    Hongjun Liu
    Center for Molecular Medicine, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Sci Signal 4:ra6. 2011
    ..These observations implicate Wnt signaling in the modulation of hepatic metabolism and raise the possibility that Wnt signaling may play a similar role in the metabolic regulation of other tissues...
  27. doi request reprint The NAD-dependent deacetylase SIRT2 is required for programmed necrosis
    Nisha Narayan
    Center for Molecular Medicine, National Heart, Lung and Blood Institute, NIH, Bethesda, Maryland 20892, USA
    Nature 492:199-204. 2012
    ....
  28. doi request reprint Parkin in the regulation of fat uptake and mitochondrial biology: emerging links in the pathophysiology of Parkinson's disease
    Kye Young Kim
    Center for Molecular Medicine, National Heart, Lung, and Blood Institute, Bethesda, Maryland, USA
    Curr Opin Lipidol 23:201-5. 2012
    ....
  29. pmc Nitrite augments tolerance to ischemia/reperfusion injury via the modulation of mitochondrial electron transfer
    Sruti Shiva
    Vascular Medicine Branch, National Heart Lung Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 204:2089-102. 2007
    ..These data suggest that nitrite dynamically modulates mitochondrial resilience to reperfusion injury and may represent an effector of the cell-survival program of ischemic preconditioning and the Mediterranean diet...
  30. ncbi request reprint Heme oxygenase-1 deficiency accelerates formation of arterial thrombosis through oxidative damage to the endothelium, which is rescued by inhaled carbon monoxide
    Andrea L True
    National Heart, Lung and Blood Institute, NIH, Bethesda, MD 20892, USA
    Circ Res 101:893-901. 2007
    ..Induction of HO-1 may be beneficial in the prevention of thrombosis associated with vascular oxidant stress and inflammation...
  31. pmc The role of comorbidities in cardioprotection
    Michael N Sack
    Center for Molecular Medicine, NHLBI, NIH, Bethesda, MD, USA
    J Cardiovasc Pharmacol Ther 16:267-72. 2011
    ..It is important to understand at a mechanistic level the reasons for these differences. The effects of sex and diseases need to be considered in design of cardioprotective interventions in animal studies and clinical trials...
  32. ncbi request reprint Delayed ischemic preconditioning activates nuclear-encoded electron-transfer-chain gene expression in parallel with enhanced postanoxic mitochondrial respiratory recovery
    Christopher J McLeod
    Cardiovascular Branch, NHLBI, National Institutes of Health, Bethesda, MD 20892 1650, USA
    Circulation 110:534-9. 2004
    ..Delayed ischemic preconditioning promotes cardioprotection via genomic reprogramming. We hypothesize that molecular regulation of mitochondrial energetics is integral to this cardioprotective program...
  33. ncbi request reprint The mitochondrial biogenesis regulatory program in cardiac adaptation to ischemia--a putative target for therapeutic intervention
    Christopher J McLeod
    Cardiovascular Branch, NHLBI, National Institutes of Health, Bethesda, MD 20892 1454, USA
    Trends Cardiovasc Med 15:118-23. 2005
    ....
  34. ncbi request reprint A discordance in rosiglitazone mediated insulin sensitization and skeletal muscle mitochondrial content/activity in Type 2 diabetes mellitus
    Ines Pagel-Langenickel
    Cardiology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1454, USA
    Am J Physiol Heart Circ Physiol 293:H2659-66. 2007
    ..It remains to be determined whether longer-term insulin sensitization therapy with rosiglitazone will augment skeletal muscle mitochondrial bioenergetics in those diabetic subjects with relatively preserved basal aerobic capacity...
  35. ncbi request reprint The regulation, control, and consequences of mitochondrial oxygen utilization and disposition in the heart and skeletal muscle during hypoxia
    Edward G Lynn
    Cardiology Branch, NHLBI, National Institutes of Health, Bethesda, Maryland 20892 1454, USA
    Antioxid Redox Signal 9:1353-61. 2007
    ..Moreover, data supporting the role of mitochondria as oxygen-sensing organelles, integrated into global cellular signal transduction are discussed...
  36. pmc Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS)
    Ariel C Bulua
    Immunoregulation Section, Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutesof Health, Bethesda, MD 20892, USA
    J Exp Med 208:519-33. 2011
    ..These findings suggest that mitochondrial ROS may be a novel therapeutic target for TRAPS and other inflammatory diseases...
  37. pmc Ambient oxygen promotes tumorigenesis
    Ho Joong Sung
    Center for Molecular Medicine, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 6:e19785. 2011
    ....
  38. ncbi request reprint Metabolic plasticity and the promotion of cardiac protection in ischemia and ischemic preconditioning
    Lionel H Opie
    Hatter Institute for Cardiology Research and Medical Research Council Inter University Cape Heart Group, Cape Heart Centre, University of Cape Town Medical School, South Africa
    J Mol Cell Cardiol 34:1077-89. 2002
    ..In this review we discuss studies that demonstrate how metabolic plasticity can promote cardioprotection against ischemia and reperfusion injury and highlight areas that require further characterization...
  39. ncbi request reprint Exploring mitochondria in the intact ischemic heart: advancing technologies to image intracellular function
    Michael N Sack
    Circulation 114:1452-4. 2006
  40. ncbi request reprint Identification of a novel role for sphingolipid signaling in TNF alpha and ischemic preconditioning mediated cardioprotection
    Sandrine Lecour
    Hatter Institute for Cardiology Research, MRC Inter University Cape Heart Group, University of Cape Town Medical School, South Africa
    J Mol Cell Cardiol 34:509-18. 2002
    ..In conclusion, TNF alpha activates preconditioning-like tolerance against infarction and contractile dysfunction. This cardioprotection is mediated, in part, via activation of novel sphingolipid signaling intermediates...
  41. ncbi request reprint Innate immunity and cardiac preconditioning: a putative intrinsic cardioprotective program
    Robert M Smith
    Hatter Institute for Cardiology Research, MRC Inter University Cape Heart Group, University of Cape Town Medical School, South Africa
    Cardiovasc Res 55:474-82. 2002
    ....
  42. ncbi request reprint Classic ischemic but not pharmacologic preconditioning is abrogated following genetic ablation of the TNFalpha gene
    Robert M Smith
    Hatter Institute for Cardiology Research, MRC Inter University Cape Heart Group, University of Cape Town Medical School, Observatory 7925, South Africa
    Cardiovasc Res 55:553-60. 2002
    ..Moreover, whether TNFalpha is required to induce the ischemic preconditioning phenotype has not been determined...
  43. ncbi request reprint Mitochondrial plasticity in classical ischemic preconditioning-moving beyond the mitochondrial KATP channel
    Jan Minners
    Hatter Institute for Cardiology Research and MRC Inter University Cape Heart Group, University of Cape Town Medical School, Cape Town, South Africa
    Cardiovasc Res 59:1-6. 2003
    ....
  44. ncbi request reprint Insulin therapy as an adjunct to reperfusion after acute coronary ischemia: a proposed direct myocardial cell survival effect independent of metabolic modulation
    Michael N Sack
    The Hatter Institute for Cardiology Research, MRC Inter University Cape Heart Group, University of Cape Town Medical School, South Africa
    J Am Coll Cardiol 41:1404-7. 2003
    ....
  45. ncbi request reprint p70s6 kinase is a functional target of insulin activated Akt cell-survival signaling
    Anne K Jonassen
    Department of Medical Physiology, Institute of Medical Biology, University of Tromsø, Norway
    Biochem Biophys Res Commun 315:160-5. 2004
    ..Collectively, these data demonstrate that p70s6 kinase activation is a functional target of Akt following insulin-activated cytoprotection during ischemia-reoxygenation-induced injury...
  46. ncbi request reprint Genetic depletion of cardiac myocyte STAT-3 abolishes classical preconditioning
    Robert M Smith
    Hatter Institute for Cardiology Research, Faculty of Health Sciences, University of Cape Town Observatory, Cape Heart Centre, Chris Barnard Building, Cape Town 7925, South Africa
    Cardiovasc Res 63:611-6. 2004
    ..To evaluate the functional requirement of signal transducer and activator of transcription-3 (STAT-3) in cardiac myocyte tolerance to ischemia (I) and in classical preconditioning...
  47. ncbi request reprint PKCepsilon activation augments cardiac mitochondrial respiratory post-anoxic reserve--a putative mechanism in PKCepsilon cardioprotection
    Joy McCarthy
    Hatter Institute for Cardiology Research, University of Cape Town Medical School, Cape Town, South Africa
    J Mol Cell Cardiol 38:697-700. 2005
    ....