Michael N Sack

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc The role of SIRT3 in mitochondrial homeostasis and cardiac adaptation to hypertrophy and aging
    Michael N Sack
    Center for Molecular Medicine, NHLBI, NIH, Bethesda, MD 20892 1454, USA
    J Mol Cell Cardiol 52:520-5. 2012
  2. pmc The role of sirtuins in modulating redox stressors
    Bradley R Webster
    Center for Molecular Medicine, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Free Radic Biol Med 52:281-90. 2012
  3. doi request reprint Identification of a molecular component of the mitochondrial acetyltransferase programme: a novel role for GCN5L1
    Iain Scott
    Center for Molecular Medicine, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1454, USA
    Biochem J 443:655-61. 2012
  4. pmc Emerging characterization of the role of SIRT3-mediated mitochondrial protein deacetylation in the heart
    Michael N Sack
    Center for Molecular Medicine, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA
    Am J Physiol Heart Circ Physiol 301:H2191-7. 2011
  5. doi request reprint SIRT3-dependent deacetylation exacerbates acetaminophen hepatotoxicity
    Zhongping Lu
    Center for Molecular Medicine, NHLBI, National Institutes of Health, Building 10 CRC, Room 5 3150, 10 Center Drive, Bethesda, Maryland 20892, USA
    EMBO Rep 12:840-6. 2011
  6. pmc SIRT3 is regulated by nutrient excess and modulates hepatic susceptibility to lipotoxicity
    Jianjun Bao
    Translational Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Free Radic Biol Med 49:1230-7. 2010
  7. pmc Protein deacetylation by sirtuins: delineating a post-translational regulatory program responsive to nutrient and redox stressors
    Jianjun Bao
    Translational Medicine Branch, National Heart Lung and Blood Institute, NIH, 10 Center Drive, MSC 1454, Bethesda, MD 20892 1454, USA
    Cell Mol Life Sci 67:3073-87. 2010
  8. pmc Cysteine 203 of cyclophilin D is critical for cyclophilin D activation of the mitochondrial permeability transition pore
    Tiffany T Nguyen
    Systems Biology Center, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 286:40184-92. 2011
  9. doi request reprint Parkin in the regulation of fat uptake and mitochondrial biology: emerging links in the pathophysiology of Parkinson's disease
    Kye Young Kim
    Center for Molecular Medicine, National Heart, Lung, and Blood Institute, Bethesda, Maryland, USA
    Curr Opin Lipidol 23:201-5. 2012
  10. pmc Parkin is a lipid-responsive regulator of fat uptake in mice and mutant human cells
    Kye Young Kim
    Center for Molecular Medicine, NHLBI, 10 Center Drive, Bethesda, Maryland, 20892 1454, USA
    J Clin Invest 121:3701-12. 2011

Collaborators

Detail Information

Publications17

  1. pmc The role of SIRT3 in mitochondrial homeostasis and cardiac adaptation to hypertrophy and aging
    Michael N Sack
    Center for Molecular Medicine, NHLBI, NIH, Bethesda, MD 20892 1454, USA
    J Mol Cell Cardiol 52:520-5. 2012
    ..This article is part of a Special Section entitled "Post-translational Modification."..
  2. pmc The role of sirtuins in modulating redox stressors
    Bradley R Webster
    Center for Molecular Medicine, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Free Radic Biol Med 52:281-90. 2012
    ..Here we investigate the links between sirtuins and their oxidative/redox environment and review the control mechanisms that are regulated by the activity of sirtuin deacetylase proteins...
  3. doi request reprint Identification of a molecular component of the mitochondrial acetyltransferase programme: a novel role for GCN5L1
    Iain Scott
    Center for Molecular Medicine, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1454, USA
    Biochem J 443:655-61. 2012
    ..The results of the present study identify GCN5L1 as a critical prokaryote-derived component of the mitochondrial acetyltransferase programme...
  4. pmc Emerging characterization of the role of SIRT3-mediated mitochondrial protein deacetylation in the heart
    Michael N Sack
    Center for Molecular Medicine, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA
    Am J Physiol Heart Circ Physiol 301:H2191-7. 2011
    ..As therapeutic modulators of other SIRT isoforms have been identified, the longer-term objective of our understanding of this biology would be to identify SIRT3 modulators as putative cardiac therapeutic agents...
  5. doi request reprint SIRT3-dependent deacetylation exacerbates acetaminophen hepatotoxicity
    Zhongping Lu
    Center for Molecular Medicine, NHLBI, National Institutes of Health, Building 10 CRC, Room 5 3150, 10 Center Drive, Bethesda, Maryland 20892, USA
    EMBO Rep 12:840-6. 2011
    ..Thus, protein deacetylation enhances xenobiotic liver injury by modulating the binding of a toxic metabolite to mitochondrial proteins...
  6. pmc SIRT3 is regulated by nutrient excess and modulates hepatic susceptibility to lipotoxicity
    Jianjun Bao
    Translational Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Free Radic Biol Med 49:1230-7. 2010
    ..This SIRT3-dependent lipotoxic susceptibility is possibly modulated, in part, by SIRT3-mediated control of electron transfer chain flux...
  7. pmc Protein deacetylation by sirtuins: delineating a post-translational regulatory program responsive to nutrient and redox stressors
    Jianjun Bao
    Translational Medicine Branch, National Heart Lung and Blood Institute, NIH, 10 Center Drive, MSC 1454, Bethesda, MD 20892 1454, USA
    Cell Mol Life Sci 67:3073-87. 2010
    ..We review the sirtuin family proteins, discuss their functional effects on target proteins, and postulate on potential biological programs and disease processes that may be modified by sirtuin-mediated deacetylation of target proteins...
  8. pmc Cysteine 203 of cyclophilin D is critical for cyclophilin D activation of the mitochondrial permeability transition pore
    Tiffany T Nguyen
    Systems Biology Center, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 286:40184-92. 2011
    ..Our results indicate that the Cys-203 residue of CypD is necessary for redox stress-induced activation of mPTP...
  9. doi request reprint Parkin in the regulation of fat uptake and mitochondrial biology: emerging links in the pathophysiology of Parkinson's disease
    Kye Young Kim
    Center for Molecular Medicine, National Heart, Lung, and Blood Institute, Bethesda, Maryland, USA
    Curr Opin Lipidol 23:201-5. 2012
    ....
  10. pmc Parkin is a lipid-responsive regulator of fat uptake in mice and mutant human cells
    Kye Young Kim
    Center for Molecular Medicine, NHLBI, 10 Center Drive, Bethesda, Maryland, 20892 1454, USA
    J Clin Invest 121:3701-12. 2011
    ..Whether this metabolic regulation contributes to premature Parkinsonism warrants investigation...
  11. pmc Caloric excess or restriction mediated modulation of metabolic enzyme acetylation-proposed effects on cardiac growth and function
    Michael N Sack
    Translational Medicine Branch, NHLBI, NIH, Bld 10 CRC, Room 5 3150, 10 Center Drive, Bethesda, MD, 20892 1454, USA
    Biochim Biophys Acta 1813:1279-85. 2011
    ..Areas of investigation that need to be explored are highlighted. This article is part of a Special Issue entitled: Mitochondria and Cardioprotection...
  12. pmc Wnt signaling regulates hepatic metabolism
    Hongjun Liu
    Center for Molecular Medicine, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Sci Signal 4:ra6. 2011
    ..These observations implicate Wnt signaling in the modulation of hepatic metabolism and raise the possibility that Wnt signaling may play a similar role in the metabolic regulation of other tissues...
  13. pmc The role of comorbidities in cardioprotection
    Michael N Sack
    Center for Molecular Medicine, NHLBI, NIH, Bethesda, MD, USA
    J Cardiovasc Pharmacol Ther 16:267-72. 2011
    ..It is important to understand at a mechanistic level the reasons for these differences. The effects of sex and diseases need to be considered in design of cardioprotective interventions in animal studies and clinical trials...
  14. pmc Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS)
    Ariel C Bulua
    Immunoregulation Section, Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutesof Health, Bethesda, MD 20892, USA
    J Exp Med 208:519-33. 2011
    ..These findings suggest that mitochondrial ROS may be a novel therapeutic target for TRAPS and other inflammatory diseases...
  15. pmc Characterization of the murine SIRT3 mitochondrial localization sequence and comparison of mitochondrial enrichment and deacetylase activity of long and short SIRT3 isoforms
    Jianjun Bao
    Translational Medicine Branch, NHLBI, NIH, Bethesda, Maryland, USA
    J Cell Biochem 110:238-47. 2010
    ..This overexpression effect, may partially account for previously observed divergent phenotypes attributed to SIRT3...
  16. pmc The emerging characterization of lysine residue deacetylation on the modulation of mitochondrial function and cardiovascular biology
    Zhongping Lu
    Translational Medicine Branch, National Heart, Lung, and Blood Institute, Bethesda, MD, USA
    Circ Res 105:830-41. 2009
    ..This review will introduce the role of nonhistone protein lysine residue acetyl modifications, discuss their regulation and biochemistry and present the direct and indirect data implicating their involvement in the heart and vasculature...
  17. pmc Transient upregulation of PGC-1alpha diminishes cardiac ischemia tolerance via upregulation of ANT1
    Edward G Lynn
    Translational Medicine Branch, NHLBI, NIH, Bethesda, MD 20892 1454, USA
    J Mol Cell Cardiol 49:693-8. 2010
    ..These adverse phenotypes appear to be mediated, in part, by PGC-1alpha induced upregulation of ANT1...