Vandana Sachdev

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Left atrial volumetric remodeling is predictive of functional capacity in nonobstructive hypertrophic cardiomyopathy
    Vandana Sachdev
    Echocardiography Laboratory, Cardiovascular Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Am Heart J 149:730-6. 2005
  2. pmc Diastolic dysfunction is an independent risk factor for death in patients with sickle cell disease
    Vandana Sachdev
    Cardiovascular Branch, Echocardiography Laboratory, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20892 1454, USA
    J Am Coll Cardiol 49:472-9. 2007
  3. ncbi request reprint Myocardial strain decreases with increasing transmurality of infarction: a Doppler echocardiographic and magnetic resonance correlation study
    Vandana Sachdev
    Echocardiography Laboratory, Cardiovascular Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Am Soc Echocardiogr 19:34-9. 2006
  4. ncbi request reprint Significance of left atrial contractile function in asymptomatic subjects with hereditary hemochromatosis
    Yukitaka Shizukuda
    Cardiovascular Branch, Bethesda, Maryland, USA
    Am J Cardiol 98:954-9. 2006
  5. pmc Hemodynamic and functional assessment of patients with sickle cell disease and pulmonary hypertension
    Anastasia Anthi
    Vascular Medicine Branch, Clinical Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 2089, USA
    Am J Respir Crit Care Med 175:1272-9. 2007
  6. doi request reprint Aortic valve disease in Turner syndrome
    Vandana Sachdev
    National Heart, Lung and Blood Institute, Bethesda, Maryland 20892, USA
    J Am Coll Cardiol 51:1904-9. 2008
  7. pmc Endothelin receptor antagonists for pulmonary hypertension in adult patients with sickle cell disease
    Caterina P Minniti
    Pulmonary and Vascular Medicine Branch, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Br J Haematol 147:737-43. 2009
  8. doi request reprint Changes in left ventricular diastolic function of asymptomatic hereditary hemochromatosis subjects during five years of follow-up
    Yukitaka Shizukuda
    Cardiovascular and Pulmonary Branch, National Heart, Lung, and Blood Institute, Bethesda, Maryland, USA
    Am J Cardiol 108:1796-800. 2011
  9. pmc Severity of pulmonary hypertension during vaso-occlusive pain crisis and exercise in patients with sickle cell disease
    Roberto F Machado
    Vascular Medicine Branch, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1476, USA
    Br J Haematol 136:319-25. 2007
  10. ncbi request reprint Is functional capacity related to left atrial contractile function in nonobstructive hypertrophic cardiomyopathy?
    Yukitaka Shizukuda
    Cardiovascular Branch, National, Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Congest Heart Fail 11:234-40. 2005

Detail Information

Publications50

  1. ncbi request reprint Left atrial volumetric remodeling is predictive of functional capacity in nonobstructive hypertrophic cardiomyopathy
    Vandana Sachdev
    Echocardiography Laboratory, Cardiovascular Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Am Heart J 149:730-6. 2005
    ..We examined the relationship between left atrial volumetric remodeling and objective measures of exercise capacity in patients with nonobstructive hypertrophic cardiomyopathy (HCM)...
  2. pmc Diastolic dysfunction is an independent risk factor for death in patients with sickle cell disease
    Vandana Sachdev
    Cardiovascular Branch, Echocardiography Laboratory, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20892 1454, USA
    J Am Coll Cardiol 49:472-9. 2007
    ..The goal of this study was to characterize left ventricular diastolic function in the sickle cell disease (SCD) population and to relate echocardiographic measures of dysfunction with pulmonary hypertension and mortality...
  3. ncbi request reprint Myocardial strain decreases with increasing transmurality of infarction: a Doppler echocardiographic and magnetic resonance correlation study
    Vandana Sachdev
    Echocardiography Laboratory, Cardiovascular Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Am Soc Echocardiogr 19:34-9. 2006
    ..We studied longitudinal strain measurements in patients with evidence of myocardial infarction by cardiac magnetic resonance imaging to determine whether end-systolic strain could identify the severity of the infarction...
  4. ncbi request reprint Significance of left atrial contractile function in asymptomatic subjects with hereditary hemochromatosis
    Yukitaka Shizukuda
    Cardiovascular Branch, Bethesda, Maryland, USA
    Am J Cardiol 98:954-9. 2006
    ....
  5. pmc Hemodynamic and functional assessment of patients with sickle cell disease and pulmonary hypertension
    Anastasia Anthi
    Vascular Medicine Branch, Clinical Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 2089, USA
    Am J Respir Crit Care Med 175:1272-9. 2007
    ..Although pulmonary hypertension (PH) is a common complication of sickle cell disease (SCD) associated with high mortality, there exist few data characterizing hemodynamics and cardiopulmonary function in this population...
  6. doi request reprint Aortic valve disease in Turner syndrome
    Vandana Sachdev
    National Heart, Lung and Blood Institute, Bethesda, Maryland 20892, USA
    J Am Coll Cardiol 51:1904-9. 2008
    ..Our goal was to determine the prevalence and characteristics of aortic valve disease in girls and women with monosomy for the X chromosome, or Turner syndrome (TS)...
  7. pmc Endothelin receptor antagonists for pulmonary hypertension in adult patients with sickle cell disease
    Caterina P Minniti
    Pulmonary and Vascular Medicine Branch, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Br J Haematol 147:737-43. 2009
    ..Therapy was stopped in two patients who were switched then to the other ETR blocker agent. These data suggest preliminary evidence for the benefit of bosentan and ambrisentan in pulmonary hypertension in SCD...
  8. doi request reprint Changes in left ventricular diastolic function of asymptomatic hereditary hemochromatosis subjects during five years of follow-up
    Yukitaka Shizukuda
    Cardiovascular and Pulmonary Branch, National Heart, Lung, and Blood Institute, Bethesda, Maryland, USA
    Am J Cardiol 108:1796-800. 2011
    ..In conclusion, LV diastolic function does not significantly deteriorate statistically during a 5-year period in subjects with cardiac asymptomatic HH after conventional phlebotomy treatment, regardless of their treatment history...
  9. pmc Severity of pulmonary hypertension during vaso-occlusive pain crisis and exercise in patients with sickle cell disease
    Roberto F Machado
    Vascular Medicine Branch, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1476, USA
    Br J Haematol 136:319-25. 2007
    ..001) in all subjects. These data suggest that acute elevations in pulmonary pressures during VOC or exercise may contribute to morbidity and mortality in patients with sickle cell disease...
  10. ncbi request reprint Is functional capacity related to left atrial contractile function in nonobstructive hypertrophic cardiomyopathy?
    Yukitaka Shizukuda
    Cardiovascular Branch, National, Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Congest Heart Fail 11:234-40. 2005
    ..These data, obtained at rest, fail to suggest that NHCM-related heart failure symptoms are due to an atrial myopathy...
  11. pmc Does oxidative stress modulate left ventricular diastolic function in asymptomatic subjects with hereditary hemochromatosis?
    Yukitaka Shizukuda
    Cardiovascular Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA
    Echocardiography 26:1153-8. 2009
    ..However, the increased oxidative stress related to iron overload may be involved in this process, and strain rate (SR), a sensitive echocardiography-derived measure of diastolic function, may detect such changes...
  12. pmc Pulmonary artery pressure in lymphangioleiomyomatosis: an echocardiographic study
    Angelo M Taveira-Dasilva
    Pulmonary Critical Care Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Building 10, Room 6D05, MSC 1590, Bethesda, MD 20892 1590, USA
    Chest 132:1573-8. 2007
    ..The aims of this study were to determine the prevalence of pulmonary hypertension in patients with LAM, to identify physiologic parameters associated with its occurrence, and to evaluate the effect of oxygen on response to exercise...
  13. pmc Echocardiographic markers of elevated pulmonary pressure and left ventricular diastolic dysfunction are associated with exercise intolerance in adults and adolescents with homozygous sickle cell anemia in the United States and United Kingdom
    Vandana Sachdev
    Cardiovascular and Pulmonary Medicine Branch, National Heart, Lung, and Blood Institute, Bethesda, MD, USA
    Circulation 124:1452-60. 2011
    ....
  14. pmc Aortic stenosis and vascular calcifications in alkaptonuria
    Hwaida Hannoush
    Cardiovascular and Pulmonary Branch, National Heart Lung and Blood Institute, NIH, Bethesda, MD, USA
    Mol Genet Metab 105:198-202. 2012
    ..These findings suggest an important role for echocardiographic screening of alkaptonuria patients to detect valvular heart disease and cardiac CT to detect coronary artery calcifications...
  15. pmc Increased pulmonary pressures and myocardial wall stress in children with severe malaria
    Jacqueline J Janka
    Clinical Center Critical Care Medicine Department and Pulmonary and Vascular Medicine and Translational Medicine Branches, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Infect Dis 202:791-800. 2010
    ..To test whether this pathophysiology occurs in malaria, we examined in Mali 53 children who were admitted to the hospital with severe malaria (excluding cerebral malaria) and 31 age-matched controls...
  16. pmc Growth hormone treatment and left ventricular dimensions in Turner syndrome
    Lea Ann Matura
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    J Pediatr 150:587-91. 2007
    ..To determine whether cardiac dimensions were different in girls with Turner syndrome (TS) who received growth hormone (GH) compared with those who did not receive GH...
  17. ncbi request reprint Left ventricular systolic function during stress echocardiography exercise in subjects with asymptomatic hereditary hemochromatosis
    Yukitaka Shizukuda
    Cardiovascular Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA
    Am J Cardiol 98:694-8. 2006
    ..In conclusion, LV systolic function during exercise in asymptomatic subjects with HH is preserved, and 6-month induction phlebotomy does not affect stress echocardiographic performance...
  18. doi request reprint Spectrum of aortic valve abnormalities associated with aortic dilation across age groups in Turner syndrome
    Laura J Olivieri
    National Institute of Child Health and Human Development and National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD
    Circ Cardiovasc Imaging 6:1018-23. 2013
    ..Our objective was to characterize aortic valve structure in subjects with Turner syndrome and to determine the prevalence of aortic dilation and valve dysfunction associated with different types of aortic valves...
  19. ncbi request reprint Pulmonary hypertension as a risk factor for death in patients with sickle cell disease
    Mark T Gladwin
    Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD 20892 1662, USA
    N Engl J Med 350:886-95. 2004
    ..The prevalence of pulmonary hypertension in adults with sickle cell disease, the mechanism of its development, and its prospective prognostic significance are unknown...
  20. ncbi request reprint Nonsyndromic hearing loss DFNA10 and a novel mutation of EYA4: evidence for correlation of normal cardiac phenotype with truncating mutations of the Eya domain
    Tomoko Makishima
    Otolaryngology Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Rockville 20850 3320, Maryland, USA
    Am J Med Genet A 143:1592-8. 2007
    ..These results will facilitate the counseling of patients with these phenotypes and EYA4 mutations...
  21. pmc Mutations and polymorphisms in hemoglobin genes and the risk of pulmonary hypertension and death in sickle cell disease
    James G Taylor
    Vascular Medicine Branch, NHLBI, NIH, Bethesda, Maryland 20892 1476, USA
    Am J Hematol 83:6-14. 2008
    ..Despite this protective association, patients with SC who did develop pulmonary hypertension remained at significant risk for death during 49 months of follow-up (Hazard Ratio=8.20, P=0.0057)...
  22. doi request reprint Pleiotropic effect of lovastatin, with and without cholestyramine, in the post coronary artery bypass graft (Post CABG) trial
    Michael Domanski
    Atherothrombosis and Coronary Artery Disease Branch, National Heart, Lung, and Blood Institute, Bethesda, Maryland, USA
    Am J Cardiol 102:1023-7. 2008
    ..343 mm, p = 0.042). In conclusion, aggressive versus moderate lovastatin treatment appeared therapeutic in slowing the atherosclerotic process in SVGs from Post CABG patients, independent of its greater LDL cholesterol-lowering effect...
  23. pmc Sildenafil therapy in patients with sickle cell disease and pulmonary hypertension
    Roberto F Machado
    Vascular Therapeutics Section, Cardiovascular Branch, National Heart Lung and Blood Institute, Bethesda, MD, USA
    Br J Haematol 130:445-53. 2005
    ....
  24. ncbi request reprint Prolongation of the cardiac QTc interval in Turner syndrome
    Carolyn A Bondy
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    Medicine (Baltimore) 85:75-81. 2006
    ....
  25. pmc Cardiomyopathy in congenital and acquired generalized lipodystrophy: a clinical assessment
    Beatrice C Lupsa
    Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Medicine (Baltimore) 89:245-50. 2010
    ..The underlying mechanism for cardiomyopathy in lipodystrophy is not clear. Extreme insulin resistance and the possibility of a "lipotoxic cardiomyopathy" should be entertained as possible explanations...
  26. ncbi request reprint N-terminal pro-brain natriuretic peptide levels and risk of death in sickle cell disease
    Roberto F Machado
    Vascular Medicine Branch, Clinical Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1454, USA
    JAMA 296:310-8. 2006
    ..Levels of N-terminal pro-brain natriuretic peptide (NT-proBNP) provide such information in patients with idiopathic pulmonary arterial hypertension...
  27. pmc Hemodynamic predictors of mortality in adults with sickle cell disease
    Alem Mehari
    Cardiovascular and Pulmonary Branch, National Heart, Lung, and Blood Institute, Bethesda, MD, USA
    Am J Respir Crit Care Med 187:840-7. 2013
    ..Pulmonary hypertension (PH) in adults with sickle cell disease (SCD) is associated with early mortality, but no prior studies have evaluated quantitative relationships of mortality to physiological measures of pre- and postcapillary PH...
  28. pmc Direct injection of autologous mesenchymal stromal cells improves myocardial function
    Yifu Zhou
    Cellular Biology Section, Cardiothoracic Surgery Research Program, NHLBI, National Institutes of Health, 10 Center Drive, MSC 1550, Building 10, Room 2N246, Bethesda, MD 20892 1550, USA
    Biochem Biophys Res Commun 390:902-7. 2009
    ..This suggests that the angiogenesis engendered by cell treatment may be physiologically meaningful by improving the contractility of ischemic myocardium...
  29. pmc Does laser type impact myocardial function following transmyocardial laser revascularization?
    Soren K Estvold
    National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA
    Lasers Surg Med 42:746-51. 2010
    ....
  30. pmc FOS expression in blood as a LDL-independent marker of statin treatment
    Ju Gyeong Kang
    Translational Medicine Branch, Cardiology Section National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Atherosclerosis 212:567-70. 2010
    ..In this pilot study, we hypothesized that blood FOS mRNA levels will be sensitive to statin treatment independent of LDL cholesterol levels...
  31. pmc Prevalence and risk factors for pulmonary artery systolic hypertension among sickle cell disease patients in Nigeria
    Zakari Y Aliyu
    Department of Medicine and Center for Sickle Cell Disease, Howard University, Washington, District of Columbia 20060, USA
    Am J Hematol 83:485-90. 2008
    ..The inclusion of African sites in sickle cell pulmonary hypertension clinical trials should be encouraged...
  32. pmc Pulmonary nontuberculous mycobacterial disease: prospective study of a distinct preexisting syndrome
    Richard D Kim
    Immunopathogenesis Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892 1684, USA
    Am J Respir Crit Care Med 178:1066-74. 2008
    ..Pulmonary nontuberculous mycobacterial (PNTM) disease is increasing, but predisposing features have been elusive...
  33. pmc The ClinSeq Project: piloting large-scale genome sequencing for research in genomic medicine
    Leslie G Biesecker
    National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Genome Res 19:1665-74. 2009
    ..The early experiences with ClinSeq illustrate how large-scale medical sequencing can be a practical, productive, and critical component of research in genomic medicine...
  34. ncbi request reprint Effect of statin therapy on survival in patients with nonischemic dilated cardiomyopathy (from the Beta-blocker Evaluation of Survival Trial [BEST])
    Michael Domanski
    Atherothrombosis and Coronary Artery Disease Branch, Division of Cardiovascular Disease, National Heart, Lung, and Blood Institute NIH, Bethesda, MD 20892, USA
    Am J Cardiol 99:1448-50. 2007
    ..18 to 0.95, p = 0.037). In conclusion, in patients with moderate or severe HF due to non-IDC entered into BEST, statin therapy at entry was independently associated with a decrease in all-cause and cardiovascular mortality...
  35. doi request reprint Effect of extended-release niacin on serum lipids and on endothelial function in adults with sickle cell anemia and low high-density lipoprotein cholesterol levels
    Heather M Scoffone
    Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Bethesda, Maryland Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland
    Am J Cardiol 112:1499-504. 2013
    ..Thus, the relatively small changes in HDL-C levels achieved by the dose of niacin-ER used in our study are not associated with improved vascular function in patients with SCD with initially low levels of apoA-I or HDL-C...
  36. pmc Tenascin-X haploinsufficiency associated with Ehlers-Danlos syndrome in patients with congenital adrenal hyperplasia
    Deborah P Merke
    National Institutes of Health Clinical Center, Building 10, CRC, Room 1 2740, 10 Center Drive, MSC 1932, Bethesda, Maryland 20892 1932, USA
    J Clin Endocrinol Metab 98:E379-87. 2013
    ..A contiguous deletion of CYP21A2 and TNXB has been described...
  37. pmc Postprandial endothelial function does not differ in women by race: an insulin resistance paradox?
    Ranganath Muniyappa
    Diabetes, Endocrinology, and Obesity Branch, Intramural Program, National Institute of Diabetes and Digestive and Kidney Diseases NIH, 10 Center Drive, Bethesda, MD 20892 0920, USA
    Am J Physiol Endocrinol Metab 302:E218-25. 2012
    ..These results imply that insulin sensitivity may not be an important determinant of racial differences in endothelial function...
  38. pmc Technology preview: X-ray fused with magnetic resonance during invasive cardiovascular procedures
    Luis F Gutierrez
    Laboratory of Cardiac Energetics, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland
    Catheter Cardiovasc Interv 70:773-82. 2007
    ..We report our initial clinical experience applying XFM, using external fiducial markers, electrocardiogram (ECG)- gating, and automated real-time correction for gantry and table movement...
  39. ncbi request reprint Echocardiographic findings in the PANDAS subgroup
    Lisa A Snider
    Pediatric Developmental and Neuropsychiatry Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, 10 Center Dr, Room 4N208, MSC 1255, Bethesda, MD 20892 1255, USA
    Pediatrics 114:e748-51. 2004
    ....
  40. ncbi request reprint Pediatric Fabry disease
    Markus Ries
    Developmental and Metabolic Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Building 10, Room 3D03, Bethesda, MD 20892 1260, USA
    Pediatrics 115:e344-55. 2005
    ..Fabry disease is an underdiagnosed, treatable, X-linked, multisystem disorder...
  41. pmc Metabolic effects of liothyronine therapy in hypothyroidism: a randomized, double-blind, crossover trial of liothyronine versus levothyroxine
    Francesco S Celi
    Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Building 10, CRC, room 6 3940, 10 Center Drive, MSC 1613, Bethesda, Maryland 20892 1613, USA
    J Clin Endocrinol Metab 96:3466-74. 2011
    ..Previous combination L-T(4)/liothyronine (L-T(3)) therapy trials focused on quality-of-life endpoints, and limited information is available on the effects on other measures of thyroid hormone action...
  42. ncbi request reprint Cardiac studies in patients treated with depsipeptide, FK228, in a phase II trial for T-cell lymphoma
    Richard L Piekarz
    Center for Cancer Research and Cancer Therapeutics Evaluation Program, National Cancer Institute and National Heart Lung and Blood Institute, NIH, Bethesda, Maryland 20892 1903, USA
    Clin Cancer Res 12:3762-73. 2006
    ....
  43. pmc Phenotype and course of Hutchinson-Gilford progeria syndrome
    Melissa A Merideth
    National Human Genome Research Institute, Intramural Office of Rare Disease, National Institutes of Health, Bethesda, MD 20892 1851, USA
    N Engl J Med 358:592-604. 2008
    ....
  44. doi request reprint Analysis of cardiac anomalies in VACTERL association
    Bridget K Cunningham
    Department of Pediatrics, Walter Reed National Military Medical Center Bethesda, Maryland Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland
    Birth Defects Res A Clin Mol Teratol 97:792-7. 2013
    ..Controversy still remains regarding the definition of VATER association and its expansion to VACTERL, the appropriate diagnostic criteria and the overall incidence...
  45. pmc A 3-year randomized therapeutic trial of nitisinone in alkaptonuria
    Wendy J Introne
    Office of the Clinical Director, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Genet Metab 103:307-14. 2011
    ..Side effects were infrequent. This trial illustrates the remarkable tolerability of nitisinone, its biochemical efficacy, and the need to investigate its use in younger individuals prior to development of debilitating arthritis...
  46. ncbi request reprint Familial eosinophilia: a benign disorder?
    Amy D Klion
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 103:4050-5. 2004
    ..These data suggest that, despite prolonged marked eosinophilia, FE can be distinguished from HES by a more benign clinical course that may be related to a relative lack of eosinophil activation...
  47. ncbi request reprint Effect of a histone deacetylase inhibitor on human cardiac mass
    Yukitaka Shizukuda
    Cardiovasc Drugs Ther 19:89-90. 2005
  48. pmc Dysregulated arginine metabolism, hemolysis-associated pulmonary hypertension, and mortality in sickle cell disease
    Claudia R Morris
    Department of Emergency Medicine, Children s Hospital and Research Center at Oakland, CA 94609, USA
    JAMA 294:81-90. 2005
    ..We hypothesized that increased arginase activity and dysregulated arginine metabolism contribute to endothelial dysfunction, pulmonary hypertension, and patient outcomes...
  49. pmc Relative systemic hypertension in patients with sickle cell disease is associated with risk of pulmonary hypertension and renal insufficiency
    Victor R Gordeuk
    Center for Sickle Cell Disease, Howard University, Washington, District of Columbia 20060, USA
    Am J Hematol 83:15-8. 2008
    ..Whether antihypertensive and/or nitric oxide donor therapy in sickle cell disease patients with relative hypertension prevents these and other complications should be determined by clinical trials...
  50. pmc Cerebellar ataxia, seizures, premature death, and cardiac abnormalities in mice with targeted disruption of the Cacna2d2 gene
    Sergey V Ivanov
    Basic Research Program, Science Applications International Corporation Frederick, Inc, National Cancer Institute at Frederick, Frederick, Maryland, USA
    Am J Pathol 165:1007-18. 2004
    ....