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Genomes and Genes | Vandana SachdevSummaryAffiliation: National Institutes of Health Country: USA Publications
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Publications
Myocardial strain decreases with increasing transmurality of infarction: a Doppler echocardiographic and magnetic resonance correlation studyVandana Sachdev
Echocardiography Laboratory, Cardiovascular Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
J Am Soc Echocardiogr 19:34-9. 2006..We studied longitudinal strain measurements in patients with evidence of myocardial infarction by cardiac magnetic resonance imaging to determine whether end-systolic strain could identify the severity of the infarction...
Diastolic dysfunction is an independent risk factor for death in patients with sickle cell diseaseVandana Sachdev
Cardiovascular Branch, Echocardiography Laboratory, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20892 1454, USA
J Am Coll Cardiol 49:472-9. 2007..The goal of this study was to characterize left ventricular diastolic function in the sickle cell disease (SCD) population and to relate echocardiographic measures of dysfunction with pulmonary hypertension and mortality...- Left atrial volumetric remodeling is predictive of functional capacity in nonobstructive hypertrophic cardiomyopathyVandana Sachdev
Echocardiography Laboratory, Cardiovascular Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
Am Heart J 149:730-6. 2005..We examined the relationship between left atrial volumetric remodeling and objective measures of exercise capacity in patients with nonobstructive hypertrophic cardiomyopathy (HCM)... - Significance of left atrial contractile function in asymptomatic subjects with hereditary hemochromatosisYukitaka Shizukuda
Cardiovascular Branch, Bethesda, Maryland, USA
Am J Cardiol 98:954-9. 2006.... - Hemodynamic and functional assessment of patients with sickle cell disease and pulmonary hypertensionAnastasia Anthi
Vascular Medicine Branch, Clinical Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 2089, USA
Am J Respir Crit Care Med 175:1272-9. 2007..Although pulmonary hypertension (PH) is a common complication of sickle cell disease (SCD) associated with high mortality, there exist few data characterizing hemodynamics and cardiopulmonary function in this population... - Endothelin receptor antagonists for pulmonary hypertension in adult patients with sickle cell diseaseCaterina P Minniti
Pulmonary and Vascular Medicine Branch, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
Br J Haematol 147:737-43. 2009..Therapy was stopped in two patients who were switched then to the other ETR blocker agent. These data suggest preliminary evidence for the benefit of bosentan and ambrisentan in pulmonary hypertension in SCD... 
Aortic valve disease in Turner syndromeVandana Sachdev
National Heart, Lung and Blood Institute, Bethesda, Maryland 20892, USA
J Am Coll Cardiol 51:1904-9. 2008..Our goal was to determine the prevalence and characteristics of aortic valve disease in girls and women with monosomy for the X chromosome, or Turner syndrome (TS)...- Severity of pulmonary hypertension during vaso-occlusive pain crisis and exercise in patients with sickle cell diseaseRoberto F Machado
Vascular Medicine Branch, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1476, USA
Br J Haematol 136:319-25. 2007..001) in all subjects. These data suggest that acute elevations in pulmonary pressures during VOC or exercise may contribute to morbidity and mortality in patients with sickle cell disease... - Is functional capacity related to left atrial contractile function in nonobstructive hypertrophic cardiomyopathy?Yukitaka Shizukuda
Cardiovascular Branch, National, Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
Congest Heart Fail 11:234-40. 2005..These data, obtained at rest, fail to suggest that NHCM-related heart failure symptoms are due to an atrial myopathy... - Changes in left ventricular diastolic function of asymptomatic hereditary hemochromatosis subjects during five years of follow-upYukitaka Shizukuda
Cardiovascular and Pulmonary Branch, National Heart, Lung, and Blood Institute, Bethesda, Maryland, USA
Am J Cardiol 108:1796-800. 2011..In conclusion, LV diastolic function does not significantly deteriorate statistically during a 5-year period in subjects with cardiac asymptomatic HH after conventional phlebotomy treatment, regardless of their treatment history... - Does oxidative stress modulate left ventricular diastolic function in asymptomatic subjects with hereditary hemochromatosis?Yukitaka Shizukuda
Cardiovascular Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA
Echocardiography 26:1153-8. 2009..However, the increased oxidative stress related to iron overload may be involved in this process, and strain rate (SR), a sensitive echocardiography-derived measure of diastolic function, may detect such changes... - Echocardiographic markers of elevated pulmonary pressure and left ventricular diastolic dysfunction are associated with exercise intolerance in adults and adolescents with homozygous sickle cell anemia in the United States and United KingdomVandana Sachdev
Cardiovascular and Pulmonary Medicine Branch, National Heart, Lung, and Blood Institute, Bethesda, MD, USA
Circulation 124:1452-60. 2011.... - Pulmonary artery pressure in lymphangioleiomyomatosis: an echocardiographic studyAngelo M Taveira-Dasilva
Pulmonary Critical Care Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Building 10, Room 6D05, MSC 1590, Bethesda, MD 20892 1590, USA
Chest 132:1573-8. 2007..The aims of this study were to determine the prevalence of pulmonary hypertension in patients with LAM, to identify physiologic parameters associated with its occurrence, and to evaluate the effect of oxygen on response to exercise... - Aortic stenosis and vascular calcifications in alkaptonuriaHwaida Hannoush
Cardiovascular and Pulmonary Branch, National Heart Lung and Blood Institute, NIH, Bethesda, MD, USA
Mol Genet Metab 105:198-202. 2012..These findings suggest an important role for echocardiographic screening of alkaptonuria patients to detect valvular heart disease and cardiac CT to detect coronary artery calcifications... - Growth hormone treatment and left ventricular dimensions in Turner syndromeLea Ann Matura
Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
J Pediatr 150:587-91. 2007..To determine whether cardiac dimensions were different in girls with Turner syndrome (TS) who received growth hormone (GH) compared with those who did not receive GH... - Increased pulmonary pressures and myocardial wall stress in children with severe malariaJacqueline J Janka
Clinical Center Critical Care Medicine Department and Pulmonary and Vascular Medicine and Translational Medicine Branches, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
J Infect Dis 202:791-800. 2010..To test whether this pathophysiology occurs in malaria, we examined in Mali 53 children who were admitted to the hospital with severe malaria (excluding cerebral malaria) and 31 age-matched controls... - Left ventricular systolic function during stress echocardiography exercise in subjects with asymptomatic hereditary hemochromatosisYukitaka Shizukuda
Cardiovascular Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA
Am J Cardiol 98:694-8. 2006..In conclusion, LV systolic function during exercise in asymptomatic subjects with HH is preserved, and 6-month induction phlebotomy does not affect stress echocardiographic performance... - Nonsyndromic hearing loss DFNA10 and a novel mutation of EYA4: evidence for correlation of normal cardiac phenotype with truncating mutations of the Eya domainTomoko Makishima
Otolaryngology Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Rockville 20850 3320, Maryland, USA
Am J Med Genet A 143:1592-8. 2007..These results will facilitate the counseling of patients with these phenotypes and EYA4 mutations... - Pulmonary hypertension as a risk factor for death in patients with sickle cell diseaseMark T Gladwin
Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD 20892 1662, USA
N Engl J Med 350:886-95. 2004..The prevalence of pulmonary hypertension in adults with sickle cell disease, the mechanism of its development, and its prospective prognostic significance are unknown... - Mutations and polymorphisms in hemoglobin genes and the risk of pulmonary hypertension and death in sickle cell diseaseJames G Taylor
Vascular Medicine Branch, NHLBI, NIH, Bethesda, Maryland 20892 1476, USA
Am J Hematol 83:6-14. 2008..Despite this protective association, patients with SC who did develop pulmonary hypertension remained at significant risk for death during 49 months of follow-up (Hazard Ratio=8.20, P=0.0057)... - Pleiotropic effect of lovastatin, with and without cholestyramine, in the post coronary artery bypass graft (Post CABG) trialMichael Domanski
Atherothrombosis and Coronary Artery Disease Branch, National Heart, Lung, and Blood Institute, Bethesda, Maryland, USA
Am J Cardiol 102:1023-7. 2008..343 mm, p = 0.042). In conclusion, aggressive versus moderate lovastatin treatment appeared therapeutic in slowing the atherosclerotic process in SVGs from Post CABG patients, independent of its greater LDL cholesterol-lowering effect... - N-terminal pro-brain natriuretic peptide levels and risk of death in sickle cell diseaseRoberto F Machado
Vascular Medicine Branch, Clinical Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1454, USA
JAMA 296:310-8. 2006..Levels of N-terminal pro-brain natriuretic peptide (NT-proBNP) provide such information in patients with idiopathic pulmonary arterial hypertension... - Sildenafil therapy in patients with sickle cell disease and pulmonary hypertensionRoberto F Machado
Vascular Therapeutics Section, Cardiovascular Branch, National Heart Lung and Blood Institute, Bethesda, MD, USA
Br J Haematol 130:445-53. 2005.... - Cardiomyopathy in congenital and acquired generalized lipodystrophy: a clinical assessmentBeatrice C Lupsa
Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA
Medicine (Baltimore) 89:245-50. 2010..The underlying mechanism for cardiomyopathy in lipodystrophy is not clear. Extreme insulin resistance and the possibility of a "lipotoxic cardiomyopathy" should be entertained as possible explanations... - Prolongation of the cardiac QTc interval in Turner syndromeCarolyn A Bondy
Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
Medicine (Baltimore) 85:75-81. 2006.... - Direct injection of autologous mesenchymal stromal cells improves myocardial functionYifu Zhou
Cellular Biology Section, Cardiothoracic Surgery Research Program, NHLBI, National Institutes of Health, 10 Center Drive, MSC 1550, Building 10, Room 2N246, Bethesda, MD 20892 1550, USA
Biochem Biophys Res Commun 390:902-7. 2009..This suggests that the angiogenesis engendered by cell treatment may be physiologically meaningful by improving the contractility of ischemic myocardium... - FOS expression in blood as a LDL-independent marker of statin treatmentJu Gyeong Kang
Translational Medicine Branch, Cardiology Section National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
Atherosclerosis 212:567-70. 2010..In this pilot study, we hypothesized that blood FOS mRNA levels will be sensitive to statin treatment independent of LDL cholesterol levels... - Does laser type impact myocardial function following transmyocardial laser revascularization?Soren K Estvold
National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA
Lasers Surg Med 42:746-51. 2010.... - Prevalence and risk factors for pulmonary artery systolic hypertension among sickle cell disease patients in NigeriaZakari Y Aliyu
Department of Medicine and Center for Sickle Cell Disease, Howard University, Washington, District of Columbia 20060, USA
Am J Hematol 83:485-90. 2008..The inclusion of African sites in sickle cell pulmonary hypertension clinical trials should be encouraged... - The ClinSeq Project: piloting large-scale genome sequencing for research in genomic medicineLeslie G Biesecker
National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Genome Res 19:1665-74. 2009..The early experiences with ClinSeq illustrate how large-scale medical sequencing can be a practical, productive, and critical component of research in genomic medicine... - Pulmonary nontuberculous mycobacterial disease: prospective study of a distinct preexisting syndromeRichard D Kim
Immunopathogenesis Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892 1684, USA
Am J Respir Crit Care Med 178:1066-74. 2008..Pulmonary nontuberculous mycobacterial (PNTM) disease is increasing, but predisposing features have been elusive... - Effect of statin therapy on survival in patients with nonischemic dilated cardiomyopathy (from the Beta-blocker Evaluation of Survival Trial [BEST])Michael Domanski
Atherothrombosis and Coronary Artery Disease Branch, Division of Cardiovascular Disease, National Heart, Lung, and Blood Institute NIH, Bethesda, MD 20892, USA
Am J Cardiol 99:1448-50. 2007..18 to 0.95, p = 0.037). In conclusion, in patients with moderate or severe HF due to non-IDC entered into BEST, statin therapy at entry was independently associated with a decrease in all-cause and cardiovascular mortality... - Postprandial endothelial function does not differ in women by race: an insulin resistance paradox?Ranganath Muniyappa
Diabetes, Endocrinology, and Obesity Branch, Intramural Program, National Institute of Diabetes and Digestive and Kidney Diseases NIH, 10 Center Drive, Bethesda, MD 20892 0920, USA
Am J Physiol Endocrinol Metab 302:E218-25. 2012..These results imply that insulin sensitivity may not be an important determinant of racial differences in endothelial function... - Echocardiographic findings in the PANDAS subgroupLisa A Snider
Pediatric Developmental and Neuropsychiatry Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, 10 Center Dr, Room 4N208, MSC 1255, Bethesda, MD 20892 1255, USA
Pediatrics 114:e748-51. 2004.... - Phenotype and course of Hutchinson-Gilford progeria syndromeMelissa A Merideth
National Human Genome Research Institute, Intramural Office of Rare Disease, National Institutes of Health, Bethesda, MD 20892 1851, USA
N Engl J Med 358:592-604. 2008.... - Metabolic effects of liothyronine therapy in hypothyroidism: a randomized, double-blind, crossover trial of liothyronine versus levothyroxineFrancesco S Celi
Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Building 10, CRC, room 6 3940, 10 Center Drive, MSC 1613, Bethesda, Maryland 20892 1613, USA
J Clin Endocrinol Metab 96:3466-74. 2011..Previous combination L-T(4)/liothyronine (L-T(3)) therapy trials focused on quality-of-life endpoints, and limited information is available on the effects on other measures of thyroid hormone action... - Technology preview: X-ray fused with magnetic resonance during invasive cardiovascular proceduresLuis F Gutierrez
Laboratory of Cardiac Energetics, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland
Catheter Cardiovasc Interv 70:773-82. 2007..We report our initial clinical experience applying XFM, using external fiducial markers, electrocardiogram (ECG)- gating, and automated real-time correction for gantry and table movement... - Cardiac studies in patients treated with depsipeptide, FK228, in a phase II trial for T-cell lymphomaRichard L Piekarz
Center for Cancer Research and Cancer Therapeutics Evaluation Program, National Cancer Institute and National Heart Lung and Blood Institute, NIH, Bethesda, Maryland 20892 1903, USA
Clin Cancer Res 12:3762-73. 2006.... - Pediatric Fabry diseaseMarkus Ries
Developmental and Metabolic Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Building 10, Room 3D03, Bethesda, MD 20892 1260, USA
Pediatrics 115:e344-55. 2005..Fabry disease is an underdiagnosed, treatable, X-linked, multisystem disorder... - Tenascin-x haploinsufficiency associated with ehlers-danlos syndrome in patients with congenital adrenal hyperplasiaDeborah P Merke
MD, MS, National Institutes of Health Clinical Center, Building 10, CRC, Room 1 2740, 10 Center Drive, MSC 1932, Bethesda, Maryland 20892 1932
J Clin Endocrinol Metab 98:E379-87. 2013..A subset of parents had clinical findings. Conclusions: Clinical evaluation for connective tissue dysplasia should be routinely performed in CAH patients, especially those harboring a CYP21A2 deletion... - A 3-year randomized therapeutic trial of nitisinone in alkaptonuriaWendy J Introne
Office of the Clinical Director, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
Mol Genet Metab 103:307-14. 2011..Side effects were infrequent. This trial illustrates the remarkable tolerability of nitisinone, its biochemical efficacy, and the need to investigate its use in younger individuals prior to development of debilitating arthritis... - Familial eosinophilia: a benign disorder?Amy D Klion
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Blood 103:4050-5. 2004..These data suggest that, despite prolonged marked eosinophilia, FE can be distinguished from HES by a more benign clinical course that may be related to a relative lack of eosinophil activation... - Effect of a histone deacetylase inhibitor on human cardiac massYukitaka Shizukuda
Cardiovasc Drugs Ther 19:89-90. 2005 - Dysregulated arginine metabolism, hemolysis-associated pulmonary hypertension, and mortality in sickle cell diseaseClaudia R Morris
Department of Emergency Medicine, Children s Hospital and Research Center at Oakland, CA 94609, USA
JAMA 294:81-90. 2005..We hypothesized that increased arginase activity and dysregulated arginine metabolism contribute to endothelial dysfunction, pulmonary hypertension, and patient outcomes... - Cerebellar ataxia, seizures, premature death, and cardiac abnormalities in mice with targeted disruption of the Cacna2d2 geneSergey V Ivanov
Basic Research Program, Science Applications International Corporation Frederick, Inc, National Cancer Institute at Frederick, Frederick, Maryland, USA
Am J Pathol 165:1007-18. 2004.... - Relative systemic hypertension in patients with sickle cell disease is associated with risk of pulmonary hypertension and renal insufficiencyVictor R Gordeuk
Center for Sickle Cell Disease, Howard University, Washington, District of Columbia 20060, USA
Am J Hematol 83:15-8. 2008..Whether antihypertensive and/or nitric oxide donor therapy in sickle cell disease patients with relative hypertension prevents these and other complications should be determined by clinical trials...