Juan M Saavedra

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Blockade of brain angiotensin II AT1 receptors ameliorates stress, anxiety, brain inflammation and ischemia: Therapeutic implications
    Juan M Saavedra
    Section on Pharmacology, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, 10 Center Drive, Building 10, Room 2D 57, Bethesda, MD 20892, USA
    Psychoneuroendocrinology 36:1-18. 2011
  2. pmc Angiotensin II AT(1) receptor blockers as treatments for inflammatory brain disorders
    Juan M Saavedra
    Section on Pharmacology, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
    Clin Sci (Lond) 123:567-90. 2012
  3. pmc Angiotensin II AT(1) receptor blockers ameliorate inflammatory stress: a beneficial effect for the treatment of brain disorders
    Juan M Saavedra
    Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Cell Mol Neurobiol 32:667-81. 2012
  4. ncbi request reprint Mechanisms of the Anti-Ischemic Effect of Angiotensin II AT( 1 ) Receptor Antagonists in the Brain
    Juan M Saavedra
    Section on Pharmacology, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    Cell Mol Neurobiol 26:1099-111. 2006
  5. ncbi request reprint Brain angiotensin II: new developments, unanswered questions and therapeutic opportunities
    Juan M Saavedra
    Section on Pharmacology, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, 10 Center Drive, Room 2D 57, Bethesda, Maryland 20892, USA
    Cell Mol Neurobiol 25:485-512. 2005
  6. ncbi request reprint Angiotensin II: multitasking in the brain
    Juan M Saavedra
    Section on Pharmacology, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    J Hypertens Suppl 24:S131-7. 2006
  7. ncbi request reprint The discovery of a novel macrophage binding site
    Juan M Saavedra
    Section on Pharmacology, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda 20892, USA
    Cell Mol Neurobiol 26:509-26. 2006
  8. ncbi request reprint Anti-stress and anti-anxiety effects of centrally acting angiotensin II AT1 receptor antagonists
    Juan M Saavedra
    Section on Pharmacology, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 1514, USA
    Regul Pept 128:227-38. 2005
  9. ncbi request reprint Brain and peripheral angiotensin II play a major role in stress
    Juan M Saavedra
    Section on Pharmacology, Department of Health and Human Services, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Stress 10:185-93. 2007
  10. ncbi request reprint A centrally acting, anxiolytic angiotensin II AT1 receptor antagonist prevents the isolation stress-induced decrease in cortical CRF1 receptor and benzodiazepine binding
    Juan M Saavedra
    Section on Pharmacology, National Institute of Mental Health, National Institutes of Health, DHHS, Bethesda, MD 20892, USA
    Neuropsychopharmacology 31:1123-34. 2006

Collaborators

Detail Information

Publications56

  1. pmc Blockade of brain angiotensin II AT1 receptors ameliorates stress, anxiety, brain inflammation and ischemia: Therapeutic implications
    Juan M Saavedra
    Section on Pharmacology, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, 10 Center Drive, Building 10, Room 2D 57, Bethesda, MD 20892, USA
    Psychoneuroendocrinology 36:1-18. 2011
    ..Blockade of AT(1) receptors offers a novel and safe therapeutic approach for the treatment of illnesses of increasing prevalence and socioeconomic impact, such as mood disorders and neurodegenerative diseases of the brain...
  2. pmc Angiotensin II AT(1) receptor blockers as treatments for inflammatory brain disorders
    Juan M Saavedra
    Section on Pharmacology, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
    Clin Sci (Lond) 123:567-90. 2012
    ..ARBs should be tested for the prevention and therapy of neurodegenerative disorders, in particular Alzheimer's disease, affective disorders, such as co-morbid cardiovascular disease and depression, and traumatic brain injury...
  3. pmc Angiotensin II AT(1) receptor blockers ameliorate inflammatory stress: a beneficial effect for the treatment of brain disorders
    Juan M Saavedra
    Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Cell Mol Neurobiol 32:667-81. 2012
    ..We propose that including ARBs in a novel integrated approach for the treatment of brain disorders such as depression and Alzheimer's disease may be of immediate translational relevance...
  4. ncbi request reprint Mechanisms of the Anti-Ischemic Effect of Angiotensin II AT( 1 ) Receptor Antagonists in the Brain
    Juan M Saavedra
    Section on Pharmacology, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    Cell Mol Neurobiol 26:1099-111. 2006
    ..8. These results strongly suggest that inhibition of AT(1) receptors should be considered as a preventive therapeutic measure to protect the brain from ischemia, and as a possible novel therapy of inflammatory conditions of the brain...
  5. ncbi request reprint Brain angiotensin II: new developments, unanswered questions and therapeutic opportunities
    Juan M Saavedra
    Section on Pharmacology, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, 10 Center Drive, Room 2D 57, Bethesda, Maryland 20892, USA
    Cell Mol Neurobiol 25:485-512. 2005
    ....
  6. ncbi request reprint Angiotensin II: multitasking in the brain
    Juan M Saavedra
    Section on Pharmacology, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    J Hypertens Suppl 24:S131-7. 2006
    ..Additional preclinical studies and controlled clinical trials are necessary to confirm the efficacy of this novel therapeutic approach...
  7. ncbi request reprint The discovery of a novel macrophage binding site
    Juan M Saavedra
    Section on Pharmacology, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda 20892, USA
    Cell Mol Neurobiol 26:509-26. 2006
    ..10. Our observations indicate that CGP42112 or related molecules could be considered of interest as potential anti-inflammatory compounds...
  8. ncbi request reprint Anti-stress and anti-anxiety effects of centrally acting angiotensin II AT1 receptor antagonists
    Juan M Saavedra
    Section on Pharmacology, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 1514, USA
    Regul Pept 128:227-38. 2005
    ..Blockade of brain angiotensin II AT(1) receptors offers a novel therapeutic opportunity for the treatment of anxiety and other stress-related disorders...
  9. ncbi request reprint Brain and peripheral angiotensin II play a major role in stress
    Juan M Saavedra
    Section on Pharmacology, Department of Health and Human Services, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Stress 10:185-93. 2007
    ..Our observations demonstrate that Ang II is an important stress hormone, and that blockade of AT(1) receptors could be proposed as a potentially useful therapy for stress-induced disorders...
  10. ncbi request reprint A centrally acting, anxiolytic angiotensin II AT1 receptor antagonist prevents the isolation stress-induced decrease in cortical CRF1 receptor and benzodiazepine binding
    Juan M Saavedra
    Section on Pharmacology, National Institute of Mental Health, National Institutes of Health, DHHS, Bethesda, MD 20892, USA
    Neuropsychopharmacology 31:1123-34. 2006
    ..We propose that AT1 receptor antagonists can be considered as compounds with possible therapeutic anti-stress and anti-anxiety properties...
  11. pmc In vivo Angiotensin II AT1 receptor blockade selectively inhibits LPS-induced innate immune response and ACTH release in rat pituitary gland
    Enrique Sanchez-Lemus
    Section on Pharmacology, Division of Intramural Research Programs, Department of Health and Human Services, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Brain Behav Immun 23:945-57. 2009
    ..There is a complementary and complex influence of the PVN and circulating cytokines on the initial pituitary response to LPS. Our findings support the proposal that ARBs may be considered for the treatment of inflammatory conditions...
  12. ncbi request reprint Anti-inflammatory effects of angiotensin II AT1 receptor antagonism prevent stress-induced gastric injury
    Claudia Bregonzio
    Section on Pharmacology, National Institute of Mental Health, National Institute of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Am J Physiol Gastrointest Liver Physiol 285:G414-23. 2003
    ..Angiotensin II has a crucial role, through stimulation of AT1 receptors, in the production and progression of stress-induced gastric injury, and AT1 receptor antagonists could be of therapeutic benefit...
  13. pmc Angiotensin II AT1 blockade reduces the lipopolysaccharide-induced innate immune response in rat spleen
    Enrique Sanchez-Lemus
    Section on Pharmacology, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Am J Physiol Regul Integr Comp Physiol 296:R1376-84. 2009
    ..We postulate that ARBs may have therapeutic effects on inflammatory conditions...
  14. ncbi request reprint Angiotensin II AT1 receptor blockade reverses pathological hypertrophy and inflammation in brain microvessels of spontaneously hypertensive rats
    Hiromichi Ando
    Section on Pharmacology, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Stroke 35:1726-31. 2004
    ..We studied whether AT1 receptor antagonists could exert antiinflammatory effects in the brain vasculature as a mechanism for their protective effects against ischemia...
  15. ncbi request reprint AT1 receptor blockade regulates the local angiotensin II system in cerebral microvessels from spontaneously hypertensive rats
    Jin Zhou
    Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Stroke 37:1271-6. 2006
    ..In this study, we tried to clarify the presence and regulation of the local renin-angiotensin system (RAS) in brain microvessels in hypertension...
  16. pmc Peripherally administered angiotensin II AT1 receptor antagonists are anti-stress compounds in vivo
    Jaroslav Pavel
    Section on Pharmacology, National Institute of Mental Health, Bethesda, Maryland 20892, USA
    Ann N Y Acad Sci 1148:360-6. 2008
    ..Our results demonstrate that Angiotensin II, through AT(1) receptor stimulation, is a major stress hormone, and that ARBs, in addition to their antihypertensive effects, may be considered for the treatment of stress-related disorders...
  17. pmc A peripherally administered, centrally acting angiotensin II AT2 antagonist selectively increases brain AT1 receptors and decreases brain tyrosine hydroxylase transcription, pituitary vasopressin and ACTH
    Miroslava Macova
    Section on Pharmacology, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Brain Res 1250:130-40. 2009
    ..Blockade of brain AT(2) receptors is compatible with enhanced hypothalamic-pituitary-adrenal axis and decreased central sympathetic system activity...
  18. ncbi request reprint Oral administration of an AT1 receptor antagonist prevents the central effects of angiotensin II in spontaneously hypertensive rats
    Alicia Seltzer
    Section on Pharmacology, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bldg 10, Rm 2D57, 10 Center Dr, MSC 1514, Bethesda, MD 20892, USA
    Brain Res 1028:9-18. 2004
    ....
  19. pmc Angiotensin II AT1 receptor blockade decreases lipopolysaccharide-induced inflammation in the rat adrenal gland
    Enrique Sanchez-Lemus
    Section on Pharmacology, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, 10 Center Drive, MSC 1514, Building, 10, Room 2D57, Bethesda, Maryland 20892, USA
    Endocrinology 149:5177-88. 2008
    ..We postulate that the ARBs may have therapeutic effects on inflammatory conditions...
  20. pmc Angiotensin II AT1 receptor blockade prevents the hypothalamic corticotropin-releasing factor response to isolation stress
    Ines Armando
    Section on Pharmacology, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Brain Res 1142:92-9. 2007
    ..Inhibition of central AT(1) receptors limits the CRF response to stress and should be considered as a therapeutic tool to preserve homeostasis under chronic stress conditions...
  21. ncbi request reprint Angiotensin II AT1 receptor blockade abolishes brain microvascular inflammation and heat shock protein responses in hypertensive rats
    Jin Zhou
    Section on Pharmacology, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    J Cereb Blood Flow Metab 25:878-86. 2005
    ..These compounds might be considered as potential therapeutic agents against ischemic and inflammatory diseases of the brain...
  22. pmc Estrogen reduces aldosterone, upregulates adrenal angiotensin II AT2 receptors and normalizes adrenomedullary Fra-2 in ovariectomized rats
    Miroslava Macova
    Section on Pharmacology, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
    Neuroendocrinology 88:276-86. 2008
    ..The AT2 receptor upregulation and the decrease in AT1 receptor function and in the production of the fluid-retentive, pro-inflammatory hormone aldosterone partially explain the protective effects of estrogen therapy...
  23. ncbi request reprint Estrogen upregulates renal angiotensin II AT1 and AT2 receptors in the rat
    Gustavo Baiardi
    Section on Pharmacology, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, MSC 1514, Building 10, Room 2D 57, Bethesda, MD 20892, USA
    Regul Pept 124:7-17. 2005
    ..Our results support an important role for AT2 receptors in the regulation of renal function and in the protective effects of estrogen in the kidney...
  24. ncbi request reprint Angiotensin II AT1 receptor blockade decreases brain artery inflammation in a stress-prone rat strain
    Hiromichi Ando
    Section on Pharmacology, DIRP, NIMH, NIH, DHHS, 10 Center Drive, Bldg 10, Room 2D 57, Bethesda, MD 20892, USA
    Ann N Y Acad Sci 1018:345-50. 2004
    ..The anti-inflammatory effects of AT(1) receptor antagonists may be an important mechanism for protection against ischemia and could participate in the anti-stress properties of this class of compounds...
  25. ncbi request reprint Angiotensin II AT(1) and AT(2) receptors contribute to maintain basal adrenomedullary norepinephrine synthesis and tyrosine hydroxylase transcription
    Miroslava Jezova
    Section on Pharmacology, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    Endocrinology 144:2092-101. 2003
    ..Whereas AT(1) and AT(2) receptors involve the Fos-related antigen Fra-2, AT(1) receptor transcriptional effects include pCREB and ERK2, indicating common as well as different regulatory mechanisms for each receptor type...
  26. ncbi request reprint Life-long serotonin reuptake deficiency results in complex alterations in adrenomedullary responses to stress
    Olga A Tjurmina
    Laboratory of Clinical Science, NIMH, NIH, Bldg 10, Rm 3D41, 10 Center Dr, Bethesda, MD 20892, USA
    Ann N Y Acad Sci 1018:99-104. 2004
    ..Our results indicate that SERT function not only restrains stress-induced EPI release but also is required for the increase in adrenal catecholamine synthesis and AT(2) receptor expression...
  27. pmc Increased angiotensin II AT1 receptor mRNA and binding in spleen and lung of AT2 receptor gene disrupted mice
    Jaroslav Pavel
    Section on Pharmacology, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, 10 Center Dr MSC 1514 Bethesda, Maryland 20892, USA
    Regul Pept 158:156-66. 2009
    ..AT(1) upregulation explains the increased sensitivity to Angiotensin II characteristic of the AT(2)(-/-) phenotype, consistent with enhanced AT(1) receptor activation in a number of tissues...
  28. pmc Candesartan reduces the innate immune response to lipopolysaccharide in human monocytes
    Ignacio M Larrayoz
    Section on Pharmacology, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    J Hypertens 27:2365-76. 2009
    ..We asked whether AT1 receptor inhibition would reduce the innate inflammatory response induced by bacterial lipopolysaccharide (LPS)...
  29. ncbi request reprint Decreased hypothalamic and adrenal angiotensin II receptor expression and adrenomedullary catecholamines in transgenic mice with impaired glucocorticoid receptor function
    Paul Jain
    Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Neuroendocrinology 80:171-80. 2004
    ..Decreased hypothalamic and adrenal Ang II receptor stimulation as a result of decreased GR expression may explain the decreased hypothalamic CRH and AVP and decreased adrenomedullary and sympathetic activities in this model...
  30. ncbi request reprint Normalization of endothelial and inducible nitric oxide synthase expression in brain microvessels of spontaneously hypertensive rats by angiotensin II AT1 receptor inhibition
    Haruki Yamakawa
    Section on Pharmacology, Division of Intramural Health Programs, National Institute of Mental Health NIH DHHS, 10 Center Drive, Building 10, Room 2D 57 Bethesda, MD 20892, USA
    J Cereb Blood Flow Metab 23:371-80. 2003
    ....
  31. pmc Angiotensin II AT1 receptor blocker candesartan prevents the fast up-regulation of cerebrocortical benzodiazepine-1 receptors induced by acute inflammatory and restraint stress
    Enrique Sanchez-Lemus
    Section on Pharmacology, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, 10 Center Drive, MSC 1514, Building 10, Room 2D 57, Bethesda, MD 20892, USA
    Behav Brain Res 232:84-92. 2012
    ..The results suggest that the anti-anxiety effect of ARBs may be associated with their capacity to regulate stress-induced alterations in cortical BZ(1) receptors...
  32. pmc Minocycline ameliorates LPS-induced inflammation in human monocytes by novel mechanisms including LOX-1, Nur77 and LITAF inhibition
    Tao Pang
    Section on Pharmacology, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Biochim Biophys Acta 1820:503-10. 2012
    ..However, the mechanisms of minocycline anti-inflammatory effects are only partially understood...
  33. pmc Telmisartan ameliorates lipopolysaccharide-induced innate immune response through peroxisome proliferator-activated receptor-γ activation in human monocytes
    Tao Pang
    Section on Pharmacology, Division of Intramural Research Programs, Department of Health and Human Services, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Hypertens 30:87-96. 2012
    ....
  34. ncbi request reprint Angiotensin II AT1 receptor blockade prolongs the lifespan of spontaneously hypertensive rats and reduces stress-induced release of catecholamines, glucocorticoids, and vasopressin
    Gustavo Baiardi
    Section on Pharmacology, DIRP, NIMH, NIH, DHHS, 10 Center Drive, Bldg 10, Room 2D 57, Bethesda, MD 20892, USA
    Ann N Y Acad Sci 1018:131-6. 2004
    ..The long-term protective effects of AT(1) receptor blockade can be important in animals vulnerable to stress and, in conjunction with the normalization of blood pressure, can prolong lifespan through end-organ protection...
  35. ncbi request reprint Intracisternal administration of Angiotensin II AT1 receptor antisense oligodeoxynucleotides protects against cerebral ischemia in spontaneously hypertensive rats
    Haruki Yamakawa
    Section on Pharmacology, IRP, NIMH, NIH, DHHS, 10 Center Drive, Bldg 10, Room 2D 57, Bethesda, MD 20892, USA
    Regul Pept 111:117-22. 2003
    ....
  36. pmc Expression and transport of Angiotensin II AT1 receptors in spinal cord, dorsal root ganglia and sciatic nerve of the rat
    Jaroslav Pavel
    Section on Pharmacology, National Institute of Mental Health, Bethesda, MD 20892, USA
    Brain Res 1246:111-22. 2008
    ..We found inconsistent levels of AT(2) receptor binding and mRNA. Our results suggest multiple roles of Angiotensin II AT(1) receptors in the regulation of sensory and motor functions...
  37. ncbi request reprint Estrogen upregulates renal angiotensin II AT(2) receptors
    Ines Armando
    Section on Pharmacology, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    Am J Physiol Renal Physiol 283:F934-43. 2002
    ..We propose that the protective effects of estrogen may be partially mediated through enhancement of AT(2) receptor stimulation...
  38. pmc Telmisartan directly ameliorates the neuronal inflammatory response to IL-1β partly through the JNK/c-Jun and NADPH oxidase pathways
    Tao Pang
    Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Section on Pharmacology, NIMH, NIH, DHHS, 10 Center Drive, Bldg, 10, Room 2D 57, Bethesda, MD, 20892, USA
    J Neuroinflammation 9:102. 2012
    ..The aim of this study was to determine whether, in addition, AT1 receptor blockade directly attenuates IL-1β-induced inflammatory responses in neuronal cultures...
  39. pmc Angiotensin II AT1 receptor blockade ameliorates brain inflammation
    Julius Benicky
    Section on Pharmacology, Division of Intramural Research Programs, Department of Health and Human Services, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Neuropsychopharmacology 36:857-70. 2011
    ..Our results indicate that these compounds may offer a novel and safe therapeutic approach for the treatment of brain disorders...
  40. pmc Anti-inflammatory effects of angiotensin receptor blockers in the brain and the periphery
    Julius Benicky
    Department of Health and Human Services, Division of Intramural Research Programs, Section on Pharmacology, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Cell Mol Neurobiol 29:781-92. 2009
    ..ARBs, due to their immune response-limiting properties, may be considered as therapeutically useful in a number of inflammatory diseases of the peripheral organs and the brain...
  41. ncbi request reprint Protection against ischemia and improvement of cerebral blood flow in genetically hypertensive rats by chronic pretreatment with an angiotensin II AT1 antagonist
    Takeshi Ito
    Section on Pharmacology, Intramural Research Program, National Institute of Mental Health, Bethesda, MD 20892, USA
    Stroke 33:2297-303. 2002
    ..Pretreatment with angiotensin II AT(1) receptor antagonists protects against cerebral ischemia. We studied whether modulation of cerebral blood flow (CBF) and morphometric changes in brain arteries participated in this protective mechanism...
  42. pmc Candesartan, an angiotensin II AT₁-receptor blocker and PPAR-γ agonist, reduces lesion volume and improves motor and memory function after traumatic brain injury in mice
    Sonia Villapol
    Center for Neuroscience and Regenerative Medicine, Bethesda, MD, USA
    Neuropsychopharmacology 37:2817-29. 2012
    ..Overall, our data suggest that ARBs with dual AT₁R-blocking and PPARγ activation properties may have therapeutic value in treating TBI...
  43. pmc Matrix metalloproteinase-2 cleavage of adrenomedullin produces a vasoconstrictor out of a vasodilator
    Alfredo Martinez
    Cell and Cancer Biology Branch and Vascular Biology Faculty, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Biochem J 383:413-8. 2004
    ..The present study defines a new mechanism through which MMP-2 may regulate blood pressure by simultaneously eliminating a vasodilator and generating a vasoconstrictor...
  44. ncbi request reprint Increased angiotensin II AT(1) receptor expression in paraventricular nucleus and hypothalamic-pituitary-adrenal axis stimulation in AT(2) receptor gene disrupted mice
    Ines Armando
    Section on Pharmacology, National Institute of Mental Health, Bethesda, MD 20892, USA
    Neuroendocrinology 76:137-47. 2002
    ..Our results provide an explanation for the increased sensitivity to stress in this model...
  45. ncbi request reprint Exaggerated adrenomedullary response to immobilization in mice with targeted disruption of the serotonin transporter gene
    Olga A Tjurmina
    Laboratory of Clinical Science, National Institute of Mental Health, and Clinical Neurocardiology Section, National Institutes of Health, Bethesda, Maryland 20892, USA
    Endocrinology 143:4520-6. 2002
    ..Exaggerated adrenomedullary responses seem to be an autonomic correlate of the anxiety-like behaviors in 5-HTT knockout mice...
  46. ncbi request reprint Molecular cloning, characterization, and distribution of the gerbil angiotensin II AT2 receptor
    Kwang Lae Hoe
    Section on Pharmacology, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 1514, USA
    Am J Physiol Regul Integr Comp Physiol 285:R1373-83. 2003
    ....
  47. ncbi request reprint Stress and angiotensin II: novel therapeutic opportunities
    Ines Armando
    Section on Pharmacology, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 1514, USA
    Curr Drug Targets CNS Neurol Disord 2:413-9. 2003
    ..A novel role emerges for the use of peripheral and centrally acting AT1 receptor antagonists as therapeutically advantageous for the treatment of stress-related disorders...
  48. ncbi request reprint Site-directed mutagenesis of the gerbil and human angiotensin II AT(1) receptors identifies amino acid residues attributable to the binding affinity for the nonpeptidic antagonist losartan
    Kwang Lae Hoe
    Section on Pharmacology, Intramural Research Program, National Institute of Mental Health, Bethesda, Maryland 20892, USA
    Mol Pharmacol 61:1404-15. 2002
    ..The study of gerbil natural mutants allowed us to advance our understanding of amino acids selectively involved in the determination of antagonist affinity for gerbil and, most importantly, for human angiotensin II AT(1) receptors...
  49. pmc Six commercially available angiotensin II AT1 receptor antibodies are non-specific
    Julius Benicky
    Section on Pharmacology, DIRP, NIMH, NIH, 10 Center Drive, Bldg, 10, Room 2D 57, Bethesda, MD 20892, USA
    Cell Mol Neurobiol 32:1353-65. 2012
    ....
  50. pmc Regulation of angiotensin II type 2 receptor gene expression in the adrenal medulla by acute and repeated immobilization stress
    Regina Nostramo
    Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, New York 10595, USA
    J Endocrinol 215:291-301. 2012
    ..Overall, the effects of stress on adrenomedullary AT(1A) and AT(2) receptor expression may contribute to allostatic changes, such as regulation of catecholamine biosynthesis...
  51. pmc Commercially available angiotensin II At₂ receptor antibodies are nonspecific
    Roman Hafko
    Section on Pharmacology, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 8:e69234. 2013
    ..In the absence of full antibody characterization, competitive radioligand binding and determination of mRNA expression remain the only reliable approaches to study At₂ receptor expression...
  52. pmc Targeting brain angiotensin and corticotrophin-releasing hormone systems interaction for the treatment of mood and alcohol use disorders
    Wolfgang H Sommer
    Laboratory of Clinical and Translational Studies, National Institute of Alcohol Abuse and Alcoholism, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892 1108, USA
    J Mol Med (Berl) 86:723-8. 2008
    ....
  53. ncbi request reprint Increased expression of cardiac angiotensin II type 1 (AT(1)) receptors decreases myocardial microvessel density after experimental myocardial infarction
    Rudolf A de Boer
    Thoraxcenter, Department of Cardiology, Hanzeplein 1, 9713 GZ, PO Box 30 001, 9700 RB, University Hospital, Groningen, The Netherlands
    Cardiovasc Res 57:434-42. 2003
    ..To study the effects of increased levels of myocardial angiotensin II type 1 (AT(1)) receptor on microvascular growth following myocardial infarction (MI)...
  54. pmc Long-term angiotensin II AT1 receptor inhibition produces adipose tissue hypotrophy accompanied by increased expression of adiponectin and PPARgamma
    Stefan Zorad
    Institute of Experimental Endocrinology, Slovak Academy of Sciences, Bratislava, Slovakia
    Eur J Pharmacol 552:112-22. 2006
    ..The decrease in the pro-inflammatory cytokine TNFalpha and the increase in the anti-inflammatory adipokine adiponectin indicate that Candesartan cilexetil may exert significant anti-inflammatory properties...
  55. ncbi request reprint Studies on genes and hypertension: a daunting task
    Juan M Saavedra
    J Hypertens 23:929-32. 2005
  56. ncbi request reprint The challenge of genetic studies in hypertension
    Juan M Saavedra
    Circ Res 100:1389-93. 2007