Research Topics
| David R RubinowSummaryAffiliation: National Institutes of Health Country: USA Publications
| Collaborators
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Detail Information
Publications
Gonadal steroid regulation of mood: the lessons of premenstrual syndromeDavid R Rubinow
Behavioral Endocrinology Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 1276, USA
Front Neuroendocrinol 27:210-6. 2006....
Testosterone suppression of CRH-stimulated cortisol in menDavid R Rubinow
Behavioral Endocrinology Branch, National Institute of Mental Health, Building 10 CRC, 10 Center Drive MSC 1276, Bethesda, MD 20892 1276, USA
Neuropsychopharmacology 30:1906-12. 2005..Our results further demonstrate that the enhanced stimulated HPA axis activity previously described in young men compared with young women cannot be ascribed to an activational upregulation of the axis by testosterone...- Dehydroepiandrosterone monotherapy in midlife-onset major and minor depressionPeter J Schmidt
Behavioral Endocrinology Branch, National Institute of Mental Health, Rockville, MD 20892 1276, USA
Arch Gen Psychiatry 62:154-62. 2005..The adrenal androgen and neurosteroid dehydroepiandrosterone (DHEA) is available as over-the-counter hormonal therapy and previously has been reported to have antidepressant-like effects... - Pharmacologically induced hypogonadism and sexual function in healthy young women and menPeter J Schmidt
Behavioral Endocrinology Branch, National Institute of Mental Health, NIH, DHHS, Bethesda, MD 20892 1276, USA
Neuropsychopharmacology 34:565-76. 2009.... - Rapid response to fluoxetine in women with premenstrual dysphoric disorderEmma M Steinberg
Behavioral Endocrinology Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
Depress Anxiety 29:531-40. 2012..Selective serotonin reuptake inhibitors (SRIs) relieve irritability within days in women with premenstrual dysphoric disorder (PMDD); however, the effects on other affective symptoms in PMDD remain to be demonstrated... - Monoamines and neurosteroids in sexual function during induced hypogonadism in healthy menMiki Bloch
Behavioral Endocrinology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
Arch Gen Psychiatry 63:450-6. 2006..CONCLUSION: These data suggest that the neurosteroid androsterone contributes to the regulation of sexual function in men... - Sex-related differences in stimulated hypothalamic-pituitary-adrenal axis during induced gonadal suppressionCatherine A Roca
Office of Special Populations, National Institute of Mental Health, Rockville, Maryland 20857, USA
J Clin Endocrinol Metab 90:4224-31. 2005..e. in the absence of characteristic differences in reproductive steroids)... - Premenstrual symptoms and perimenopausal depressionMisty Richards
Behavioral Endocrinology Branch, NIMH, NIH, U.S. Department of Health and Human Services, Bethesda, MD, USA
Am J Psychiatry 163:133-7. 2006..However, neither menses-related symptom cyclicity nor premenstrual dysphoria was an invariant accompaniment of perimenopausal depression. Additionally, the rate of premenstrual dysphoria was not predicted by initial self-reports... - Facial emotion discrimination across the menstrual cycle in women with premenstrual dysphoric disorder (PMDD) and controlsDavid R Rubinow
Behavioral Endocrinology Branch, National Institute of Mental Health, Bethesda MD 20892 1276, United States
J Affect Disord 104:37-44. 2007..e., state dependent)... - ACTH and cortisol response to Dex/CRH testing in women with and without premenstrual dysphoria during GnRH agonist-induced hypogonadism and ovarian steroid replacementEllen E Lee
Section on Behavioral Endocrinology, National Institute of Mental Health, Bethesda, Maryland 20892 1277, USA
J Clin Endocrinol Metab 97:1887-96. 2012.... - The effects of pharmacologically induced hypogonadism on mood in healthy menPeter J Schmidt
Behavioral Endocrinology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 1276, USA
Arch Gen Psychiatry 61:997-1004. 2004..The effects of declining androgen secretion on mood regulation and the potential psychotropic efficacy of androgen replacement in men are largely undetermined... - Differential menstrual cycle regulation of hypothalamic-pituitary-adrenal axis in women with premenstrual syndrome and controlsCatherine A Roca
Behavioral Endocrinology, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
J Clin Endocrinol Metab 88:3057-63. 2003..These data demonstrate that women with PMS, when symptomatic, appear to have an abnormal response to progesterone and, furthermore, do not display the HPA axis abnormalities characteristic of major depression... - A cross-sectional evaluation of perimenopausal depressionEmma M Steinberg
Behavioral Endocrinology Branch, National Institute of Mental Health, Bethesda, MD 20892 1276, USA
J Clin Psychiatry 69:973-80. 2008.... - Depression in women with spontaneous 46, XX primary ovarian insufficiencyPeter J Schmidt
Behavioral Endocrinology Branch, National Institute of Mental Health, 10 Center Drive MSC 1277, Bethesda, Maryland 20892 1277, USA
J Clin Endocrinol Metab 96:E278-87. 2011..Indeed, studies suggest that depression and/or its pharmacological treatment contribute to the onset of POI... - Sex hormones and mood in the perimenopausePeter J Schmidt
Behavioral Endocrinology Branch, National Institute of Mental Health, Department of Health and Human Services, Bethesda, Maryland, USA
Ann N Y Acad Sci 1179:70-85. 2009..Thus, although depression is not a uniform accompaniment of the menopause transition, in some women, age-related changes in ovarian estrogen production may alter central nervous system function and predispose them to develop depression... 
Abnormalities of dorsolateral prefrontal function in women with premenstrual dysphoric disorder: a multimodal neuroimaging studyErica B Baller
Section on Integrative Neuroimaging, Clinical Brain Disorders Branch, Gene, Cognition, NIMH Intramural Research Programs, NIH, Bethesda, MD, USA
Am J Psychiatry 170:305-14. 2013....- Estrogen effects on the forced swim test differ in two outbred rat strainsWendy A Koss
National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 1276, USA
Physiol Behav 106:81-6. 2012..These data demonstrate the importance of strain as a variable when interpreting behavioral effects of estrogen... - Reproductive aging, sex steroids, and mood disordersVeronica Harsh
Section on Behavioral Endocrinology, National Institute of Mental Health, Bethesda, MD 20892 1276, USA
Harv Rev Psychiatry 17:87-102. 2009..Finally, we discuss possible causes of affective disturbances during the menopause transition... - Reproductive ageing, sex steroids and depressionPeter J Schmidt
Behavioral Endocrinology Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 1276, USA
J Br Menopause Soc 12:178-85. 2006..Future studies of perimenopausal depression should identify the number of women affected, individual risk factors and the role of hormonal therapies in this condition... - Abnormal luteal phase excitability of the motor cortex in women with premenstrual syndromeMark J Smith
National Institute of Neurological Disorders and Stroke, NIH, Bethesda, Maryland 20892, USA
Biol Psychiatry 54:757-62. 2003..Control subjects showed more inhibition in the luteal phase. Women with PMS showed relative facilitation. CONCLUSIONS: This is the first physiological evidence for an abnormal brain response to progesterone in PMS... - Concordant restoration of ovarian function and mood in perimenopausal depressionRobert C Daly
Behavioral Endocrinology Branch, National Institute of Mental Health, Bethesda, MD 20892-1276, USA
Am J Psychiatry 160:1842-6. 2003..2 IU/liter [SD=36.6] and 51.5 IU/liter [SD=34.2]). CONCLUSIONS: Mood variability in women with perimenopausal depression may reflect episodic alterations in ovarian function that are best detected by longitudinal study designs... - A longitudinal evaluation of the relationship between reproductive status and mood in perimenopausal womenPeter J Schmidt
Behavioral Endocrinology Branch, NIMH, NIH, Department of Health and Human Services, Rm 3N238, Bldg 10, 10 Center Dr, MSC 1276, Bethesda, MD 20892 1276, USA
Am J Psychiatry 161:2238-44. 2004..Mood and reproductive function were prospectively evaluated in asymptomatic premenopausal women to determine whether the onset of depression was temporally linked to the perimenopause... - Magnesium (mg) retention and mood effects after intravenous mg infusion in premenstrual dysphoric disorderKhursheed Khine
Behavioral Endocrinology Branch, National Institute of Mental Health, National Institute of Health, Department of Health and Human Services, Bethesda, Maryland 20892 1277, USA
Biol Psychiatry 59:327-33. 2006..Conflicting data exist regarding the presence of magnesium (Mg) deficiency and the therapeutic efficacy of Mg in premenstrual syndrome or premenstrual dysphoric disorder (PMDD)... - Effects of metergoline on symptoms in women with premenstrual dysphoric disorderCatherine A Roca
National Institute of Mental Health, Bethesda, MD 20892 1277, USA
Am J Psychiatry 159:1876-81. 2002..The authors investigated the role of acute serotonergic modulation in the efficacy of selective serotonin reuptake inhibitors (SSRIs) in women with premenstrual dysphoric disorder... - Risk for premenstrual dysphoric disorder is associated with genetic variation in ESR1, the estrogen receptor alpha geneLiang Huo
Behavioral Endocrinology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA
Biol Psychiatry 62:925-33. 2007..Premenstrual dysphoric disorder (PMDD) is a heritable mood disorder that is triggered by gonadal steroids during the luteal phase in susceptible women... - Cognitive performance in healthy women during induced hypogonadism and ovarian steroid addbackPeter J Schmidt
Section on Behavioral Endocrinology, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bldg 10 CRC, Room 25330, 10 Center Dr MSC 1277, Bethesda, MD, 20892 1277, USA
Arch Womens Ment Health 16:47-58. 2013..Differences in the clinical characteristics of the women receiving GnRH agonists could predict a risk for ovarian steroid-related changes in cognitive performance during induced, and possibly, natural menopause... - Current and lifetime psychiatric illness in women with Turner syndromeGraca Cardoso
Behavioral Endocrinology Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892-1276, USA
Gynecol Endocrinol 19:313-9. 2004..Women with TS reported a higher rate of lifetime depression compared with rates observed in community-based studies but similar to those obtained from gynecologic clinic samples... - National Depressive and Manic-Depressive Association consensus statement on the use of placebo in clinical trials of mood disordersDennis S Charney
Division of Intramural Research Programs, National Institute of Mental Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
Arch Gen Psychiatry 59:262-70. 2002..Research is needed on the ethical conduct of studies to limit risks of medication-free intervals and facilitate poststudy treatment. Patients must fully understand the risks and lack of individualized treatment involved in research... - Sex-related differences in neuronal cell survival and signaling in ratsLei Zhang
Behavioral Endocrinology Branch, National Institute of Mental Health, NIH, Building 10, Room 3N238, 10 Center Dr MSC 1276, Bethesda, MD 20892 1276, USA
Neurosci Lett 337:65-8. 2003..Further, the appearance of sex-related differences at cellular and signaling levels in cortical neuronal cultures demonstrates that the effects of gender are not limited to parts of the brain mediating reproduction... - Dehydroepiandrosterone (DHEA) and its sulfated derivative (DHEAS) regulate apoptosis during neurogenesis by triggering the Akt signaling pathway in opposing waysLei Zhang
Behavioral Endocrinology Branch, National Institute of Mental Health, Building 36, Room 2C02, Bethesda, MD 20892, USA
Brain Res Mol Brain Res 98:58-66. 2002..These findings suggest that during neurogenesis in the developing cortex, DHEA and DHEAS regulate the survival of neural precursors and progeny through the Akt signaling pathway... - Operationalizing DSM-IV criteria for PMDD: selecting symptomatic and asymptomatic cycles for researchMark J Smith
Behavioral Endocrinology Branch, National Institute of Mental Health, National Institutes of Health, Bldg. 10, Room 3N238, 10 Center Dr MSC 1276, Bethesda MD 20892-1276, USA
J Psychiatr Res 37:75-83. 2003..At the very least, the method for operationalizing DSM-IV criteria should be described in studies of PMDD... - Why study reproductive neuroscience? A clinical perspectivePeter J Schmidt
Behavioral Endocrinology Branch, National Institute of Mental Health, Bethesda, Maryland, USA
J Clin Psychiatry 69:972. 2008 - Sex-related differences in MAPKs activation in rat astrocytes: effects of estrogen on cell deathLei Zhang
Behavioral Endocrinology Branch, National Institute of Mental Health, NIH Bldg. 10, Room 3N238, 10 Center Drive MSC 1276, Bethesda, MD 20892-1276, USA
Brain Res Mol Brain Res 103:1-11. 2002.... - Alteration in estrogen receptor alpha mRNA levels in frontal cortex and hippocampus of patients with major mental illnessWilliam R Perlman
Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, U.S. Department of Health and Human Services, MD 20892-1385, USA
Biol Psychiatry 58:812-24. 2005..CONCLUSIONS: Our results suggest that alterations in ERalpha mRNA levels exist in distinct telencephalic regions in male and female MDD patients, and in both genders in schizophrenia... - The menopause transition: the next neuroendocrine frontierVeronica Harsh
National Institutes of Health, Behavioral Endocrinology Branch, National Institute of Mental Health, Department of Health and Human Services, Bldg 10-CRC, Room 65340, 10 Center Drive MSC 1276, Bethesda, MD 20892-1276, USA
Expert Rev Neurother 7:S7-10. 2007 - Effects of ovarian hormones on human cortical excitabilityMark J Smith
Brain Stimulation Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892-1430, USA
Ann Neurol 51:599-603. 2002..These findings demonstrate an excitatory neuronal effect associated with estradiol and confirm our earlier finding of inhibition associated with progesterone... - Differentiation of women with premenstrual dysphoric disorder, recurrent brief depression, and healthy controls by daily mood rating dynamicsSteven M Pincus
J Psychiatr Res 42:337-47. 2008..The statistical methodologies have broad and direct applicability to behavioral studies for many psychiatric disorders, and indeed to similar analyses of associated biological signals across multiple axes... - Cortisol response to ovine corticotropin-releasing hormone in a model of pregnancy and parturition in euthymic women with and without a history of postpartum depressionMiki Bloch
Department of Psychiatry, Tel-Aviv Sourasky Medical Center, Israel 64239
J Clin Endocrinol Metab 90:695-9. 2005.... - Low CSF somatostatin associated with response to nimodipine in patents with affective illnessMark A Frye
UCLA Neuropsychiatric Institute, Los Angeles, California, USA
Biol Psychiatry 53:180-3. 2003..6 pg/mL; t(19) = 1.98, p =.03, one-tailed].CONCLUSIONS: Low baseline CSF somatostatin in depression may be associated with response to nimodipine, which in turn may be related to the ability of nimodipine to increase CSF somatostatin... - Treatment strategies after SSRI failure--good news and bad newsDavid R Rubinow
N Engl J Med 354:1305-7. 2006 - Endocrine factors in the etiology of postpartum depressionMiki Bloch
Psychiatric Division, Rambam Medical Center, Haifa, Israel
Compr Psychiatry 44:234-46. 2003..The mechanisms underlying such differential sensitivities remain undetermined. Future directions for research are explored...