Sarah M Rothman

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Activity-dependent, stress-responsive BDNF signaling and the quest for optimal brain health and resilience throughout the lifespan
    S M Rothman
    Laboratory of Neurosciences, National Institute on Aging, Intramural Research Program, National Institutes of Health, 251 Bayview Boulevard, Baltimore, MD 21224, USA
    Neuroscience 239:228-40. 2013
  2. pmc Brain-derived neurotrophic factor as a regulator of systemic and brain energy metabolism and cardiovascular health
    Sarah M Rothman
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, Maryland 21224, USA
    Ann N Y Acad Sci 1264:49-63. 2012
  3. doi request reprint Sleep disturbances in Alzheimer's and Parkinson's diseases
    Sarah M Rothman
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD 21224, USA
    Neuromolecular Med 14:194-204. 2012
  4. doi request reprint 3xTgAD mice exhibit altered behavior and elevated Aβ after chronic mild social stress
    Sarah M Rothman
    Laboratory of Neurosciences, National Institute on Aging, Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA
    Neurobiol Aging 33:830.e1-12. 2012
  5. doi request reprint Neuronal expression of familial Parkinson's disease A53T α-synuclein causes early motor impairment, reduced anxiety and potential sleep disturbances in mice
    Sarah M Rothman
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA
    J Parkinsons Dis 3:215-29. 2013
  6. pmc Dietary energy intake modifies brainstem autonomic dysfunction caused by mutant α-synuclein
    Kathleen J Griffioen
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD 21224, USA
    Neurobiol Aging 34:928-35. 2013
  7. doi request reprint Metabolic abnormalities and hypoleptinemia in α-synuclein A53T mutant mice
    Sarah M Rothman
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, MD, USA
    Neurobiol Aging 35:1153-61. 2014
  8. pmc Chronic mild sleep restriction accentuates contextual memory impairments, and accumulations of cortical Aβ and pTau in a mouse model of Alzheimer's disease
    Sarah M Rothman
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, National Institutes of Health, 251 Bayview Blvd Baltimore, MD 21224, USA
    Brain Res 1529:200-8. 2013
  9. pmc Adverse stress, hippocampal networks, and Alzheimer's disease
    Sarah M Rothman
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD 21224, USA
    Neuromolecular Med 12:56-70. 2010
  10. doi request reprint TLR4-dependent metabolic changes are associated with cognitive impairment in an animal model of type 1 diabetes
    Elisa M Kawamoto
    Laboratory of Neurosciences, National Institute on Aging, Intramural Research Program, National Institutes of Health, Baltimore, MD, USA
    Biochem Biophys Res Commun 443:731-7. 2014

Collaborators

Detail Information

Publications11

  1. pmc Activity-dependent, stress-responsive BDNF signaling and the quest for optimal brain health and resilience throughout the lifespan
    S M Rothman
    Laboratory of Neurosciences, National Institute on Aging, Intramural Research Program, National Institutes of Health, 251 Bayview Boulevard, Baltimore, MD 21224, USA
    Neuroscience 239:228-40. 2013
    ..Collectively, the findings described in this article suggest the possibility of developing prescriptions for optimal brain health based on activity-dependent BDNF signaling...
  2. pmc Brain-derived neurotrophic factor as a regulator of systemic and brain energy metabolism and cardiovascular health
    Sarah M Rothman
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, Maryland 21224, USA
    Ann N Y Acad Sci 1264:49-63. 2012
    ..Collectively, findings reviewed in this paper provide a rationale for targeting BDNF signaling for novel therapeutic interventions in a range of metabolic and neurological disorders...
  3. doi request reprint Sleep disturbances in Alzheimer's and Parkinson's diseases
    Sarah M Rothman
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD 21224, USA
    Neuromolecular Med 14:194-204. 2012
    ....
  4. doi request reprint 3xTgAD mice exhibit altered behavior and elevated Aβ after chronic mild social stress
    Sarah M Rothman
    Laboratory of Neurosciences, National Institute on Aging, Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA
    Neurobiol Aging 33:830.e1-12. 2012
    ..Findings suggest 3xTgAD mice are more vulnerable than control mice to chronic psychosocial stress, and that such chronic stress exacerbates Aβ accumulation and impairs neurotrophic signaling...
  5. doi request reprint Neuronal expression of familial Parkinson's disease A53T α-synuclein causes early motor impairment, reduced anxiety and potential sleep disturbances in mice
    Sarah M Rothman
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA
    J Parkinsons Dis 3:215-29. 2013
    ..Mutations in the human α-synuclein gene lead to early-onset Parkinson's disease (PD); however, phenotypes of α-synuclein mutant mice vary depending upon the promoter driving transgene expression...
  6. pmc Dietary energy intake modifies brainstem autonomic dysfunction caused by mutant α-synuclein
    Kathleen J Griffioen
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD 21224, USA
    Neurobiol Aging 34:928-35. 2013
    ....
  7. doi request reprint Metabolic abnormalities and hypoleptinemia in α-synuclein A53T mutant mice
    Sarah M Rothman
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, MD, USA
    Neurobiol Aging 35:1153-61. 2014
    ....
  8. pmc Chronic mild sleep restriction accentuates contextual memory impairments, and accumulations of cortical Aβ and pTau in a mouse model of Alzheimer's disease
    Sarah M Rothman
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, National Institutes of Health, 251 Bayview Blvd Baltimore, MD 21224, USA
    Brain Res 1529:200-8. 2013
    ....
  9. pmc Adverse stress, hippocampal networks, and Alzheimer's disease
    Sarah M Rothman
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD 21224, USA
    Neuromolecular Med 12:56-70. 2010
    ..Finally, we outline potential roles for oxidative stress and neurotrophic factor signaling as the key determinants of the impact of chronic stress on the plasticity of neural networks and AD pathogenesis...
  10. doi request reprint TLR4-dependent metabolic changes are associated with cognitive impairment in an animal model of type 1 diabetes
    Elisa M Kawamoto
    Laboratory of Neurosciences, National Institute on Aging, Intramural Research Program, National Institutes of Health, Baltimore, MD, USA
    Biochem Biophys Res Commun 443:731-7. 2014
    ..Our data show that TLR4 contributes to the negative impact of T1D on anxiety and cognition. ..
  11. pmc Ceruloplasmin deficiency results in an anxiety phenotype involving deficits in hippocampal iron, serotonin, and BDNF
    Sarah J Texel
    Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Neurochem 120:125-34. 2012
    ..Thus, Cp deficiency causes an anxiety phenotype by a mechanism that involves decreased levels of iron, 5HT, NE, and BDNF in the hippocampus...