R B Rothman

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Phentermine and fenfluramine. Preclinical studies in animal models of cocaine addiction
    R B Rothman
    Clinical Psychopharmacology Section, National Institute on Drug Abuse NIDA, National Institutes of Health NIH, Baltimore, Maryland 21224, USA
    Ann N Y Acad Sci 844:59-74. 1998
  2. ncbi request reprint Serotonin transporters, serotonin release, and the mechanism of fenfluramine neurotoxicity
    M H Baumann
    Medications Development Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, USA
    Ann N Y Acad Sci 914:172-86. 2000
  3. ncbi request reprint Neurochemical neutralization of methamphetamine with high-affinity nonselective inhibitors of biogenic amine transporters: a pharmacological strategy for treating stimulant abuse
    R B Rothman
    Clinical Psychopharmacology Section, Intramural Research Program, NIDA, NIH, Baltimore, Maryland, USA
    Synapse 35:222-7. 2000
  4. ncbi request reprint Cocaine reward and MPTP toxicity: alteration by regional variant dopamine transporter overexpression
    D M Donovan
    Molecular Neurobiology, Intramural Research Program, National Institute on Drug Abuse, NIH, Baltimore, MD 20857, USA
    Brain Res Mol Brain Res 73:37-49. 1999
  5. ncbi request reprint Aminorex, fenfluramine, and chlorphentermine are serotonin transporter substrates. Implications for primary pulmonary hypertension
    R B Rothman
    Clinical Psychopharmacology Section, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, MD, USA
    Circulation 100:869-75. 1999
  6. ncbi request reprint Inhibition of MAO-A fails to alter cocaine-induced increases in extracellular dopamine and norepinephrine in rat nucleus accumbens
    J P Pepper
    Clinical Psychopharmacology Section, Intramural Research Program, NIDA, NIH, P.O. Box 5180, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Brain Res Mol Brain Res 87:184-9. 2001
  7. ncbi request reprint Discovery of novel peptidic dopamine transporter ligands by screening a positional scanning combinatorial hexapeptide library
    R B Rothman
    Clinical Psychopharmacology Section, DIR, NIDA, NIH, Baltimore, Maryland, USA
    Synapse 33:239-46. 1999
  8. ncbi request reprint Methamphetamine dependence: medication development efforts based on the dual deficit model of stimulant addiction
    R B Rothman
    Clinical Psychopharmacology Section, Intramural Research Program, NIDA, NIH, Baltimore, Maryland 21224, USA
    Ann N Y Acad Sci 914:71-81. 2000
  9. ncbi request reprint 1-(m-chlorophenyl)piperazine (mCPP) dissociates in vivo serotonin release from long-term serotonin depletion in rat brain
    M H Baumann
    Clinical Psychopharmacology Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
    Neuropsychopharmacology 24:492-501. 2001
  10. ncbi request reprint In vivo correlates of central serotonin function after high-dose fenfluramine administration
    M H Baumann
    Clinical Psychopharmacology Section, National Institute on Drug Abuse NIDA, National Institutes of Health NIH, Baltimore, Maryland 21224, USA
    Ann N Y Acad Sci 844:138-52. 1998

Collaborators

Detail Information

Publications29

  1. ncbi request reprint Phentermine and fenfluramine. Preclinical studies in animal models of cocaine addiction
    R B Rothman
    Clinical Psychopharmacology Section, National Institute on Drug Abuse NIDA, National Institutes of Health NIH, Baltimore, Maryland 21224, USA
    Ann N Y Acad Sci 844:59-74. 1998
    ..The preclinical data obtained with PHEN/FEN in various models of drug provide a strong rationale for pursuing controlled clinical trials in humans with agents that act via a similar mechanism of action...
  2. ncbi request reprint Serotonin transporters, serotonin release, and the mechanism of fenfluramine neurotoxicity
    M H Baumann
    Medications Development Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, USA
    Ann N Y Acad Sci 914:172-86. 2000
    ..The relevance of this hypothesis for explaining clinical side effects of FEN and dFEN, such as cardiac valvulopathy and primary pulmonary hypertension, warrants further study...
  3. ncbi request reprint Neurochemical neutralization of methamphetamine with high-affinity nonselective inhibitors of biogenic amine transporters: a pharmacological strategy for treating stimulant abuse
    R B Rothman
    Clinical Psychopharmacology Section, Intramural Research Program, NIDA, NIH, Baltimore, Maryland, USA
    Synapse 35:222-7. 2000
    ..The major finding reported here is that indatraline blocks the ability of METH and MDMA to release these neurotransmitters. Synapse 35:222-227, 2000. Published 2000 Wiley-Liss, Inc...
  4. ncbi request reprint Cocaine reward and MPTP toxicity: alteration by regional variant dopamine transporter overexpression
    D M Donovan
    Molecular Neurobiology, Intramural Research Program, National Institute on Drug Abuse, NIH, Baltimore, MD 20857, USA
    Brain Res Mol Brain Res 73:37-49. 1999
    ..These results document a model for allelic variation at a gene locus that can exert significant effects in murine models of human substance abuse vulnerability and dopaminergic neurodegeneration...
  5. ncbi request reprint Aminorex, fenfluramine, and chlorphentermine are serotonin transporter substrates. Implications for primary pulmonary hypertension
    R B Rothman
    Clinical Psychopharmacology Section, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, MD, USA
    Circulation 100:869-75. 1999
    ..Development of new medications that produce neurochemical effects like phen/fen without causing unwanted side effects would be a significant therapeutic breakthrough...
  6. ncbi request reprint Inhibition of MAO-A fails to alter cocaine-induced increases in extracellular dopamine and norepinephrine in rat nucleus accumbens
    J P Pepper
    Clinical Psychopharmacology Section, Intramural Research Program, NIDA, NIH, P.O. Box 5180, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Brain Res Mol Brain Res 87:184-9. 2001
    ..Moreover, these findings suggest that adverse consequences related to altered catecholamine transmission would not occur if patients taking phenelzine, a non-selective MAO inhibitor, relapsed and used cocaine...
  7. ncbi request reprint Discovery of novel peptidic dopamine transporter ligands by screening a positional scanning combinatorial hexapeptide library
    R B Rothman
    Clinical Psychopharmacology Section, DIR, NIDA, NIH, Baltimore, Maryland, USA
    Synapse 33:239-46. 1999
    ..These data demonstrate that peptides can function as inhibitors of biogenic amine transport. Future work will focus on developing more potent and selective peptides. Published 1999 Wiley-Liss, Inc...
  8. ncbi request reprint Methamphetamine dependence: medication development efforts based on the dual deficit model of stimulant addiction
    R B Rothman
    Clinical Psychopharmacology Section, Intramural Research Program, NIDA, NIH, Baltimore, Maryland 21224, USA
    Ann N Y Acad Sci 914:71-81. 2000
    ..This paper reviews two approaches, based on the dual deficit model, taken by our laboratory to develop medications to treat stimulant abuse...
  9. ncbi request reprint 1-(m-chlorophenyl)piperazine (mCPP) dissociates in vivo serotonin release from long-term serotonin depletion in rat brain
    M H Baumann
    Clinical Psychopharmacology Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
    Neuropsychopharmacology 24:492-501. 2001
    ..Our data support the notion that 5-HT release per se may not be sufficient to produce the long-term 5-HT deficits associated with d-fenfluramine and other amphetamines...
  10. ncbi request reprint In vivo correlates of central serotonin function after high-dose fenfluramine administration
    M H Baumann
    Clinical Psychopharmacology Section, National Institute on Drug Abuse NIDA, National Institutes of Health NIH, Baltimore, Maryland 21224, USA
    Ann N Y Acad Sci 844:138-52. 1998
    ..Neuroendocrine challenge tests represent a reliable method to test the existence of FEN-induced neurotoxicity in human patients undergoing long-term FEN treatment...
  11. ncbi request reprint Opioid peptide receptor studies. 15. Relative efficacy of 4-[(N-allyl-3-methyl-4-piperidinyl)phenylamino]-N,N-diethylbenzamide and related compounds at the cloned human delta-opioid receptor
    H Xu
    CPS, NIDA, IRP, NIDA, NIH, Baltimore, Maryland 21224, USA
    Synapse 40:269-74. 2001
    ....
  12. ncbi request reprint Noribogaine (12-hydroxyibogamine): a biologically active metabolite of the antiaddictive drug ibogaine
    M H Baumann
    Clinical Psychopharmacology Section, Intramural Research Program, NIDA, NIH, Baltimore, Maryland 21224, USA
    Ann N Y Acad Sci 914:354-68. 2000
    ..Most importantly, NORIBO appears less likely to produce the adverse effects associated with IBO (i.e., tremors and stress-axis activation), suggesting that the metabolite may be a safer alternative for medication development...
  13. ncbi request reprint Amphetamine-type central nervous system stimulants release norepinephrine more potently than they release dopamine and serotonin
    R B Rothman
    Clinical Psychopharmacology Section, Intramural Research Program, NIDA, NIH, Baltimore, Maryland 21224, USA
    Synapse 39:32-41. 2001
    ..These results suggest that NE may contribute to the amphetamine-type subjective effects of stimulants in humans...
  14. pmc Tolerance to 3,4-methylenedioxymethamphetamine in rats exposed to single high-dose binges
    M H Baumann
    Clinical Psychopharmacology Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, DHHS, 333 Cassell Drive, Suite 4500, Baltimore, MD 21224, USA
    Neuroscience 152:773-84. 2008
    ..Our results suggest that MDMA tolerance in humans may reflect 5-HT deficits which could contribute to further dose escalation...
  15. ncbi request reprint Functional consequences of central serotonin depletion produced by repeated fenfluramine administration in rats
    M H Baumann
    Clinical Psychopharmacology Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, USA
    J Neurosci 18:9069-77. 1998
    ..FEN should remain an important pharmacological tool for determining the role of 5-HT neurons in mediating diverse physiological and behavioral processes...
  16. ncbi request reprint Neurochemical and neuroendocrine effects of ibogaine in rats: comparison to MK-801
    M H Baumann
    Clinical Psychopharmacology Section, National Institute on Drug Abuse NIDA, National Institutes of Health NIH Baltimore, Maryland 21224, USA
    Ann N Y Acad Sci 844:252-64. 1998
    ..Thus, the in vivo mechanism of IBO action cannot be explained simply on the basis of antagonism at NMDA receptors...
  17. ncbi request reprint In vivo neurobiological effects of ibogaine and its O-desmethyl metabolite, 12-hydroxyibogamine (noribogaine), in rats
    M H Baumann
    Clinical Psychopharmacology Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, USA
    J Pharmacol Exp Ther 297:531-9. 2001
    ..More importantly, noribogaine appears less apt to produce the adverse effects associated with ibogaine, indicating the metabolite may be a safer alternative for medication development...
  18. ncbi request reprint Comparative neurobiological effects of ibogaine and MK-801 in rats
    M H Baumann
    Medications Discovery Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, PO Box 5180, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Drug Alcohol Depend 59:143-51. 2000
    ..Thus, the wide spectrum of in vivo actions of ibogaine can probably not be explained simply on the basis of antagonism at NMDA receptors...
  19. ncbi request reprint Restoration of 3,4-methylenedioxymethamphetamine-induced 5-HT depletion by the administration of L-5-hydroxytryptophan
    X Wang
    Clinical Psychopharmacology Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, P O Box 5180, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Neuroscience 148:212-20. 2007
    ..Next, we treated rats with the 5-HT precursor, l-5-hydroxytryptophan (5-HTP), in an attempt to restore MDMA-induced depletions of 5-HT...
  20. ncbi request reprint Evidence for alterations in alpha2-adrenergic receptor sensitivity in rats exposed to repeated cocaine administration
    M H Baumann
    Clinical Psychopharmacology Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, PO Box 5180, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Neuroscience 125:683-90. 2004
    ..Since human patients with depression often exhibit blunted GH responses to clonidine, our findings provide evidence that cocaine withdrawal might produce depressive-like symptoms via dysregulation of NE mechanisms...
  21. ncbi request reprint An electrophilic affinity ligand based on (+)-MK801 distinguishes PCP site 1 from PCP site 2
    H C Akunne
    Clinical Psychopharmacology Section, NIDA NIH Addiction Research Center, Baltimore, MD 21224
    Neurochem Res 19:385-9. 1994
    ....
  22. ncbi request reprint The effect of FMRFamide analogs on [35S]GTP-gamma-S stimulation in squid optic lobes
    S O Heyliger
    Clinical Psychopharmacology Section, Division of Intramural Research, NIDA, NIH, Baltimore, MD 21224, USA
    Peptides 19:739-47. 1998
    ..These results agree with published receptor radioligand studies and indicate that the [35S]GTP-gamma-S assay may be useful in classifying novel FMRFamide-selective ligands...
  23. ncbi request reprint Evidence for possible involvement of 5-HT(2B) receptors in the cardiac valvulopathy associated with fenfluramine and other serotonergic medications
    R B Rothman
    Clinical Psychopharmacology Section, Division of Intramural Research, National Institute on Drug Abuse, NIH, Baltimore, MD 21224, USA
    Circulation 102:2836-41. 2000
    ..We hypothesized that fenfluramine or its metabolite norfenfluramine and other medications known to produce VHD have preferentially high affinities for a particular serotonin receptor subtype capable of stimulating mitogenesis...
  24. ncbi request reprint An open-label study of a functional opioid kappa antagonist in the treatment of opioid dependence
    R B Rothman
    National Institute on Drug Abuse, National Institutes of Health, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    J Subst Abuse Treat 18:277-81. 2000
    ..The positive response to treatment exceeds that expected from naltrexone alone (90% dropout). These promising results suggest that controlled studies of this medication combination should be conducted...
  25. ncbi request reprint SoRI 9409, a non-peptide opioid mu receptor agonist/delta receptor antagonist, fails to stimulate [35S]-GTP-gamma-S binding at cloned opioid receptors
    H Xu
    Clinical Psychopharmacology Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
    Brain Res Bull 55:507-11. 2001
    ..Viewed collectively, the in vitro data reported here predict that SoRI 9409 should be a mu antagonist in vivo, which is not observed. Resolving these discrepant findings will require additional research...
  26. ncbi request reprint Monoamine releasers with varying selectivity for dopamine/norepinephrine versus serotonin release as candidate "agonist" medications for cocaine dependence: studies in assays of cocaine discrimination and cocaine self-administration in rhesus mo
    S S Negus
    Alcohol and Drug Abuse Research Center, McLean Hospital, Harvard Medical School, Belmont, MA 02478 9106, USA
    J Pharmacol Exp Ther 320:627-36. 2007
    ....
  27. ncbi request reprint Synthesis and biological evaluation of tropane-like 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine (GBR 12909) analogues
    Y Zhang
    Laboratory of Medicinal Chemistry, Building 8, Room B1-22, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-0815, USA
    J Med Chem 44:3937-45. 2001
    ..The 3 alpha-substituted tropanes had lower affinity and less selectivity than the comparable unsaturated ligands...
  28. ncbi request reprint Relationship between the serotonergic activity and reinforcing effects of a series of amphetamine analogs
    S Wee
    Department of Psychiatry, University of Mississippi Medical Center, Jackson, 39216 4505, USA
    J Pharmacol Exp Ther 313:848-54. 2005
    ..The results suggest that the mechanism for this effect involves a decrease in reinforcing potency and efficacy among monoamine releasing agents when 5-HT releasing potency is increased relative to DA...
  29. ncbi request reprint An opioid agonist that does not induce mu-opioid receptor--arrestin interactions or receptor internalization
    C E Groer
    Department of Pharmacology, The Ohio State University College of Medicine, 333 W 10th Avenue, 5184A Graves Hall, Columbus, OH 43210, USA
    Mol Pharmacol 71:549-57. 2007
    ....