Nathaniel Rothman

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci
    Nathaniel Rothman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
    Nat Genet 42:978-84. 2010
  2. pmc Polycyclic aromatic hydrocarbons: determinants of urinary 1-hydroxypyrene glucuronide concentration and risk of colorectal cancer in the Shanghai Women's Health Study
    Jonathan N Hofmann
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA
    BMC Cancer 13:282. 2013
  3. ncbi request reprint Genetic variation in TNF and IL10 and risk of non-Hodgkin lymphoma: a report from the InterLymph Consortium
    Nathaniel Rothman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Lancet Oncol 7:27-38. 2006
  4. ncbi request reprint Commentary: Reflections on G. M. Lower and colleagues' 1979 study associating slow acetylator phenotype with urinary bladder cancer: meta-analysis, historical refinements of the hypothesis, and lessons learned
    Nathaniel Rothman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health DHHS, Bethesda, MD 20892, USA
    Int J Epidemiol 36:23-8. 2007
  5. ncbi request reprint Genetic variation in the nucleotide excision repair pathway and bladder cancer risk
    Montserrat Garcia-Closas
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Room 7076, 6120 Executive Boulevard, MSC 7234, Rockville, MD 20852 7234, USA
    Cancer Epidemiol Biomarkers Prev 15:536-42. 2006
  6. ncbi request reprint One-carbon metabolism gene polymorphisms and risk of non-Hodgkin lymphoma in Australia
    Kyoung Mu Lee
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 6120 Executive Blvd EPS 8118, Bethesda, MD 20892 7240, USA
    Hum Genet 122:525-33. 2007
  7. pmc Lead exposure, polymorphisms in genes related to oxidative stress, and risk of adult brain tumors
    Parveen Bhatti
    Department of Health ad Human Services, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland, USA
    Cancer Epidemiol Biomarkers Prev 18:1841-8. 2009
  8. pmc Risk of non-Hodgkin lymphoma associated with germline variation in genes that regulate the cell cycle, apoptosis, and lymphocyte development
    Lindsay M Morton
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Rockville, MD 20852, USA
    Cancer Epidemiol Biomarkers Prev 18:1259-70. 2009
  9. ncbi request reprint Polymorphisms in folate metabolic genes and lung cancer risk in Xuan Wei, China
    Min Shen
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, MSC 7240, 6120 Executive Blvd, Bethesda, MD 20892 7240, USA
    Lung Cancer 49:299-309. 2005
  10. ncbi request reprint Evidence for an intensity-dependent interaction of NAT2 acetylation genotype and cigarette smoking in the Spanish Bladder Cancer Study
    Jay H Lubin
    Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Rockville, MD 20852, USA
    Int J Epidemiol 36:236-41. 2007

Collaborators

Detail Information

Publications140 found, 100 shown here

  1. pmc A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci
    Nathaniel Rothman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
    Nat Genet 42:978-84. 2010
    ..Our findings on common variants associated with bladder cancer risk should provide new insights into the mechanisms of carcinogenesis...
  2. pmc Polycyclic aromatic hydrocarbons: determinants of urinary 1-hydroxypyrene glucuronide concentration and risk of colorectal cancer in the Shanghai Women's Health Study
    Jonathan N Hofmann
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA
    BMC Cancer 13:282. 2013
    ....
  3. ncbi request reprint Genetic variation in TNF and IL10 and risk of non-Hodgkin lymphoma: a report from the InterLymph Consortium
    Nathaniel Rothman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Lancet Oncol 7:27-38. 2006
    ..We aimed to test this hypothesis using previously unpublished data from eight European, Canadian, and US case-control studies of the International Lymphoma Epidemiology Consortium (InterLymph)...
  4. ncbi request reprint Commentary: Reflections on G. M. Lower and colleagues' 1979 study associating slow acetylator phenotype with urinary bladder cancer: meta-analysis, historical refinements of the hypothesis, and lessons learned
    Nathaniel Rothman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health DHHS, Bethesda, MD 20892, USA
    Int J Epidemiol 36:23-8. 2007
  5. ncbi request reprint Genetic variation in the nucleotide excision repair pathway and bladder cancer risk
    Montserrat Garcia-Closas
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Room 7076, 6120 Executive Boulevard, MSC 7234, Rockville, MD 20852 7234, USA
    Cancer Epidemiol Biomarkers Prev 15:536-42. 2006
    ..A detailed characterization of genetic variation in key NER genes is warranted and might ultimately help identify multiple susceptibility variants that could be responsible for substantial joint increases in risk...
  6. ncbi request reprint One-carbon metabolism gene polymorphisms and risk of non-Hodgkin lymphoma in Australia
    Kyoung Mu Lee
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 6120 Executive Blvd EPS 8118, Bethesda, MD 20892 7240, USA
    Hum Genet 122:525-33. 2007
    ..01). In conclusion, the results of this study suggest that genetic polymorphisms of one-carbon metabolism genes such as MTHFR and TYMS may influence susceptibility to NHL...
  7. pmc Lead exposure, polymorphisms in genes related to oxidative stress, and risk of adult brain tumors
    Parveen Bhatti
    Department of Health ad Human Services, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland, USA
    Cancer Epidemiol Biomarkers Prev 18:1841-8. 2009
    ..Although the results of this study provide some evidence that lead may cause glioblastoma multiforme and meningioma through mechanisms related to oxidative damage, the results must be confirmed in other populations...
  8. pmc Risk of non-Hodgkin lymphoma associated with germline variation in genes that regulate the cell cycle, apoptosis, and lymphocyte development
    Lindsay M Morton
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Rockville, MD 20852, USA
    Cancer Epidemiol Biomarkers Prev 18:1259-70. 2009
    ..Replication of our findings and further study to identify functional SNPs are warranted...
  9. ncbi request reprint Polymorphisms in folate metabolic genes and lung cancer risk in Xuan Wei, China
    Min Shen
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, MSC 7240, 6120 Executive Blvd, Bethesda, MD 20892 7240, USA
    Lung Cancer 49:299-309. 2005
    ..002 and P=0.07, respectively). In summary, three genetic variants in folate metabolism genes are associated with an increased risk of lung cancer in Xuan Wei, China...
  10. ncbi request reprint Evidence for an intensity-dependent interaction of NAT2 acetylation genotype and cigarette smoking in the Spanish Bladder Cancer Study
    Jay H Lubin
    Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Rockville, MD 20852, USA
    Int J Epidemiol 36:236-41. 2007
    ..9 in never-smokers and 1.6 in ever-smokers, a 1.8-fold enhancement in smokers. Evidence indicates that acetylation is an exposure-dependent process, and thus the magnitude of the interaction may also depend on exposure level...
  11. ncbi request reprint Common genetic variants in proinflammatory and other immunoregulatory genes and risk for non-Hodgkin lymphoma
    Sophia S Wang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD 20892 7234, USA
    Cancer Res 66:9771-80. 2006
    ..Our results require replication but potentially provide important clues for investigating common genetic variants as susceptibility factors and in disease outcomes, treatment responses, and immunotherapy targets...
  12. ncbi request reprint Genotype frequency and F ST analysis of polymorphisms in immunoregulatory genes in Chinese and Caucasian populations
    Qing Lan
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD, USA
    Immunogenetics 59:839-52. 2007
    ..25). These results suggest that there is substantial genetic diversity in immune genes and exploration of SNP associations with immune-related diseases that vary in incidence across these two populations may be warranted...
  13. pmc Genomic DNA hypomethylation as a biomarker for bladder cancer susceptibility in the Spanish Bladder Cancer Study: a case-control study
    Lee E Moore
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Rockville, MD, USA
    Lancet Oncol 9:359-66. 2008
    ..DNA hypomethylation has been suggested to cause genomic instability and increase cancer risk. We aimed to test the hypothesis that DNA hypomethylation is associated with increased risk of bladder cancer...
  14. ncbi request reprint Polymorphisms in DNA repair genes and risk of non-Hodgkin lymphoma among women in Connecticut
    Min Shen
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD 20892, USA
    Hum Genet 119:659-68. 2006
    ..Further work is needed to extend these findings by carrying out extended haplotype analyses of these and related genes and to replicate the observations in other studies...
  15. pmc Apolipoprotein E/C1 locus variants modify renal cell carcinoma risk
    Lee E Moore
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20852, USA
    Cancer Res 69:8001-8. 2009
    ..In two large case-control studies, our findings further define a functional region of interest at the APOE locus that increases RCC susceptibility...
  16. ncbi request reprint Green tea consumption, genetic susceptibility, PAH-rich smoky coal, and the risk of lung cancer
    Matthew R Bonner
    Division of Cancer Epidemiology and Genetics, Occupational and Environmental Epidemiology Branch, National Cancer Institute, NIH, DHHS, 6120 Executive Blvd, EPS 8121, MSC 7240, Bethesda, MD 20892 7240, USA
    Mutat Res 582:53-60. 2005
    ..The chemopreventive effects of green tea in this population may be restricted to individuals who are particularly susceptible to oxidative stress and oxidative DNA damage...
  17. pmc Organochlorine exposure, immune gene variation, and risk of non-Hodgkin lymphoma
    Joanne S Colt
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 7240, USA
    Blood 113:1899-905. 2009
    ..This shows that the relation between organochlorine exposure and NHL risk may be modified by particular variants in immune genes and provides one of the first examples of a potential gene-environment interaction for NHL...
  18. ncbi request reprint Sun exposure, vitamin D receptor gene polymorphisms and risk of non-Hodgkin lymphoma
    Mark P Purdue
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, EPS 8009, Rockville, MD 20892, USA
    Cancer Causes Control 18:989-99. 2007
    ....
  19. pmc Longer telomere length in peripheral white blood cells is associated with risk of lung cancer and the rs2736100 (CLPTM1L-TERT) polymorphism in a prospective cohort study among women in China
    Qing Lan
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD, USA
    PLoS ONE 8:e59230. 2013
    ..030). Our findings suggest that individuals with longer telomere length in peripheral white blood cells may have an increased risk of lung cancer, but require replication in additional prospective cohorts and populations...
  20. pmc Bladder cancer risk and genetic variation in AKR1C3 and other metabolizing genes
    Jonine D Figueroa
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, MD, USA
    Carcinogenesis 29:1955-62. 2008
    ..These results indicate that genetic variation in carcinogen-metabolizing genes, particularly AKR1C3, could be associated with bladder cancer risk...
  21. ncbi request reprint Polymorphisms in DNA repair genes and risk of non-Hodgkin's lymphoma in New South Wales, Australia
    Min Shen
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20892 7240, USA
    Haematologica 92:1180-5. 2007
    ..We investigated whether putatively functional single-nucleotide polymorphisms (SNP) in DNA repair genes influence susceptibility to NHL in a population-based case-control study conducted in Australia...
  22. pmc Common gene variants in the tumor necrosis factor (TNF) and TNF receptor superfamilies and NF-kB transcription factors and non-Hodgkin lymphoma risk
    Sophia S Wang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland, United States of America
    PLoS ONE 4:e5360. 2009
    ..We hypothesized that the TNF and NF-kappaB pathways are important for NHL and that gene variations across the pathways may alter NHL risk...
  23. ncbi request reprint Genetic variation in the base excision repair pathway and bladder cancer risk
    Jonine D Figueroa
    Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, Bethesda, MD, USA
    Hum Genet 121:233-42. 2007
    ..24 (1.02-1.51) and 1.30 (1.04-1.62), respectively. In summary, data from this large case-control study suggested bladder cancer risk associations with selected BER SNPs, which need to be confirmed in other study populations...
  24. pmc Common single nucleotide polymorphisms in immunoregulatory genes and multiple myeloma risk among women in Connecticut
    Kyoung Mu Lee
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
    Am J Hematol 85:560-3. 2010
    ..Additional studies are needed to replicate these findings and, more generally, to explore the manner in which genes and receptors may influence the pathogenesis of this poorly understood malignancy...
  25. pmc Occupation and breast cancer risk among Shanghai women in a population-based cohort study
    Bu Tian Ji
    National Cancer Institute, NIH, DHHS, Bethesda, Maryland 20852, USA
    Am J Ind Med 51:100-10. 2008
    ..A total of 74,942 female subjects were recruited in a population-based cohort study in Shanghai, China between 1997 and 2000. We examined the relationship between occupation and breast cancer risk...
  26. pmc Personal use of hair dye and cancer risk in a prospective cohort of Chinese women
    Julie Bloch Mendelsohn
    Division of Cancer Epidemiology and Genetics, National Cancer Institute NCI, National Institutes of Health, Bethesda, MD, USA
    Cancer Sci 100:1088-91. 2009
    ..We generally found no evidence of an association between personal use of hair dye and cancer risk, although our study is limited by small numbers for certain cancer types...
  27. ncbi request reprint Lead, genetic susceptibility, and risk of adult brain tumors
    Preetha Rajaraman
    Division of Cancer Epidemiology Branch, National Cancer Institute, NIH, Department of Health and Human Services, 6120 Executive Boulevard, EPS Room 7085, Bethesda, MD 20892 7238, USA
    Cancer Epidemiol Biomarkers Prev 15:2514-20. 2006
    ..The ALAD G177C polymorphism affects the toxicokinetics of lead and may confer genetic susceptibility to adverse effects of lead exposure...
  28. pmc A prospective study of telomere length measured by monochrome multiplex quantitative PCR and risk of non-Hodgkin lymphoma
    Qing Lan
    Division of Cancer Epidemiology and Genetics, NCI, NIH, DHHS, Bethesda, Maryland 20892 7240, USA
    Clin Cancer Res 15:7429-33. 2009
    ..We hypothesized that telomere length in peripheral WBC DNA obtained from healthy individuals would be a predictor of future risk of developing non-Hodgkin lymphoma...
  29. pmc DNA repair gene polymorphisms and risk of adult meningioma, glioma, and acoustic neuroma
    Preetha Rajaraman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, Bethesda, MD 20892 7238, USA
    Neuro Oncol 12:37-48. 2010
    ..03). Decreased glioma risk was observed with the XRCC1 rs1799782 variant (P(trend) .04). Our results suggest that common DNA repair variants may affect the risk of adult brain tumors, especially meningioma...
  30. pmc A case-control study of tobacco use and other non-occupational risk factors for lymphoma subtypes defined by t(14; 18) translocations and bcl-2 expression
    Cindy M Chang
    Infections and Immunoepidemiology Branch, National Cancer Institute, Rockville, MD, USA
    Cancer Causes Control 21:1147-54. 2010
    ....
  31. pmc Genetic variation in N-acetyltransferase 1 (NAT1) and 2 (NAT2) and risk of non-Hodgkin lymphoma
    Lindsay M Morton
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland 20852, USA
    Pharmacogenet Genomics 16:537-45. 2006
    ..15-5.20, P = 0.02). Our data provide evidence that NAT1 and NAT2 genotypes are associated with NHL risk and support a contributory role for carcinogenic aromatic and/or heterocyclic amines in the multi-factorial etiology of NHL...
  32. pmc Polymorphisms in DNA repair genes and risk of non-Hodgkin lymphoma in a pooled analysis of three studies
    Min Shen
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD, USA
    Br J Haematol 151:239-44. 2010
    ..These results support the hypothesis that common genetic polymorphisms in human DNA repair genes may modify the risk of NHL...
  33. ncbi request reprint Polymorphisms in one-carbon metabolism and trans-sulfuration pathway genes and susceptibility to bladder cancer
    Lee E Moore
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD, USA
    Int J Cancer 120:2452-8. 2007
    ..Additional work is needed to comprehensively evaluate genomic variation in CTH and related genes in the trans-sulfuration pathway and bladder cancer risk...
  34. ncbi request reprint Urinary mutagenesis and fried red meat intake: influence of cooking temperature, phenotype, and genotype of metabolizing enzymes in a controlled feeding study
    Ulrike Peters
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland 20892 7273, USA
    Environ Mol Mutagen 43:53-74. 2004
    ..The data from this study indicate that urinary mutagenicity correlates with mutagenic exposure from cooked meat and can potentially be used as a marker in etiological studies on cancer...
  35. ncbi request reprint Immune mechanisms in non-Hodgkin lymphoma: joint effects of the TNF G308A and IL10 T3575A polymorphisms with non-Hodgkin lymphoma risk factors
    Sophia S Wang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland 20892 7234, USA
    Cancer Res 67:5042-54. 2007
    ....
  36. pmc A prospective study of telomere length measured by monochrome multiplex quantitative PCR and risk of lung cancer
    Min Shen
    Division of Cancer Epidemiology and Genetics, NCI, NIH, DHHS, Bethesda, MD 20892, United States
    Lung Cancer 73:133-7. 2011
    ..Telomere length plays an important role in chromosomal stability and tumorigenesis, and its measurement in peripheral white blood cell DNA may be a predictor of the development of lung cancer...
  37. pmc Renal cancer risk and occupational exposure to polycyclic aromatic hydrocarbons and plastics
    Sara Karami
    National Cancer Institute, Division of Cancer Epidemiology and Genetics, Occupational and Environmental Epidemiology Branch, 6120 Executive Blvd, EPS 8121, Rockville, MD 20852, USA
    J Occup Environ Med 53:218-23. 2011
    ..To investigate whether occupational exposure to polycyclic aromatic hydrocarbons and certain plastic monomers increased renal cell carcinoma (RCC) risk...
  38. ncbi request reprint Evaluation of genetic variation in the double-strand break repair pathway and bladder cancer risk
    Jonine D Figueroa
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, MD, USA
    Carcinogenesis 28:1788-93. 2007
    ..17 (1.00-1.36). Results from this study provide evidence for associations between variants in genes in the DSBR pathway and bladder cancers risk that warrant replication in other study populations...
  39. ncbi request reprint Polymorphisms in apoptosis and cell cycle control genes and risk of brain tumors in adults
    Preetha Rajaraman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, EPS Room 7085, 6120 Executive Boulevard, Bethesda, MD 20892 7238, USA
    Cancer Epidemiol Biomarkers Prev 16:1655-61. 2007
    ..Our results suggest that common variants in the CASP8, CCND1, CCNH, and MDM2 genes may influence brain tumor risk. Future research in this area should include more detailed coverage of genes in the apoptosis/cell cycle control pathways...
  40. pmc Hair dye use, genetic variation in N-acetyltransferase 1 (NAT1) and 2 (NAT2), and risk of non-Hodgkin lymphoma
    Lindsay M Morton
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Rockville, MD 20852, USA
    Carcinogenesis 28:1759-64. 2007
    ..Several previous studies have found non-Hodgkin lymphoma (NHL) risk to be associated with hair dye use, particularly use of permanent, dark colors and use before 1980, when hair dye formulations changed...
  41. pmc NAT2 slow acetylation, GSTM1 null genotype, and risk of bladder cancer: results from the Spanish Bladder Cancer Study and meta-analyses
    Montserrat Garcia-Closas
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, MD 20852 7234, USA
    Lancet 366:649-59. 2005
    ..Associations between polymorphisms in other NAT and GST genes and bladder-cancer risk have been inconsistent...
  42. pmc Occupational trichloroethylene exposure and renal carcinoma risk: evidence of genetic susceptibility by reductive metabolism gene variants
    Lee E Moore
    Division of Cancer Epidemiology and Genetics, NIH, National Cancer Institute, NIH, Bethesda, Maryland 20852, USA
    Cancer Res 70:6527-36. 2010
    ....
  43. pmc Gene-nutrient interactions among determinants of folate and one-carbon metabolism on the risk of non-Hodgkin lymphoma: NCI-SEER case-control study
    Unhee Lim
    Division of Cancer Epidemiology and Genetics, National Cancer Institute NCI, National Institutes of Health NIH, Department of Health and Human Services DHHS, Rockville, MD 20852, USA
    Blood 109:3050-9. 2007
    ..04-0.39), and MTRR Ex5+136T>CTT (OR = 0.67; 95% CI = 0.47-0.97) genotypes. Warranting replication, our finding of gene-nutrient interactions in one-carbon metabolism supports their etiologic involvement in lymphomagenesis...
  44. ncbi request reprint Leukocyte polycyclic aromatic hydrocarbon-DNA adduct formation and colorectal adenoma
    Marc J Gunter
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Division of Health and Human Services, Bethesda, MD 20852, USA
    Carcinogenesis 28:1426-9. 2007
    ..8 (95% CI, 1.2-6.5; P(trend) = 0.048) for risk of colorectal adenoma. These data support a link between PAH exposure and colorectal adenoma...
  45. ncbi request reprint Inflammation-related gene polymorphisms and colorectal adenoma
    Marc J Gunter
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland, USA
    Cancer Epidemiol Biomarkers Prev 15:1126-31. 2006
    ..7; 95% CI, 0.3-1.5; P(interaction) = 0.01). These exploratory data provide evidence that polymorphic variation in genes that regulate inflammation could alter risk for colorectal adenoma...
  46. pmc Occupation and bladder cancer in a population-based case-control study in Northern New England
    Joanne S Colt
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 7240, USA
    Occup Environ Med 68:239-49. 2011
    ..We used data from a large, population-based case-control study in Maine, New Hampshire, and Vermont to examine relationships between occupation, industry and bladder cancer risk...
  47. pmc Comprehensive analysis of 5-aminolevulinic acid dehydrogenase (ALAD) variants and renal cell carcinoma risk among individuals exposed to lead
    Dana M Van Bemmel
    Cancer Prevention Fellowship Program, Office of the Director, National Cancer Institute, Bethesda, Maryland, United States of America
    PLoS ONE 6:e20432. 2011
    ..Epidemiologic studies are reporting associations between lead exposure and human cancers. A polymorphism in the 5-aminolevulinic acid dehydratase (ALAD) gene affects lead toxicokinetics and may modify the adverse effects of lead...
  48. ncbi request reprint Polymorphisms in the DNA nucleotide excision repair genes and lung cancer risk in Xuan Wei, China
    Min Shen
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 7240, USA
    Int J Cancer 116:768-73. 2005
    ..However, due to the small sample size, additional studies are needed to evaluate these associations within Xuan Wei and in other populations with substantial environmental exposure to PAHs...
  49. ncbi request reprint Polymorphisms in genes involved in DNA double-strand break repair pathway and susceptibility to benzene-induced hematotoxicity
    Min Shen
    Division of Cancer Epidemiology and Genetics, NCI, NIH, DHHS, Bethesda, MD 20892, USA
    Carcinogenesis 27:2083-9. 2006
    ..The effect of BRCA2 Ex11 +1487 A > G polymorphism was limited to granulocytes. These results suggest that genetic polymorphisms in WRN, TP53 and BRCA2 that maintain genomic stability impact benzene-induced hematotoxicity...
  50. ncbi request reprint Smoking and bladder cancer in Spain: effects of tobacco type, timing, environmental tobacco smoke, and gender
    Claudine Samanic
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, MD 20892, USA
    Cancer Epidemiol Biomarkers Prev 15:1348-54. 2006
    ..2 to 1.7, suggesting that nearly the entire male excess of bladder cancer observed in Spain is explained by cigarette smoking rather than occupational/environmental exposures to other bladder carcinogens...
  51. ncbi request reprint Assessment of dermal exposure to benzene and toluene in shoe manufacturing by activated carbon cloth patches
    Roel Vermeulen
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Rockville, MD 20892, USA
    J Environ Monit 8:1143-8. 2006
    ..The aim of this investigation was to use activated carbon cloth (ACC) patches to study the probability and extent of dermal exposure to benzene and toluene in a shoe factory...
  52. doi request reprint Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia
    Qing Lan
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    Nat Genet 44:1330-5. 2012
    ..3. We observed no evidence of association for lung cancer at 15q25 in never-smoking women in Asia, providing strong evidence that this locus is not associated with lung cancer independent of smoking...
  53. pmc A pooled investigation of Toll-like receptor gene variants and risk of non-Hodgkin lymphoma
    Mark P Purdue
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD 20892, USA
    Carcinogenesis 30:275-81. 2009
    ..No associations with TLR4 variants were observed. This pooled analysis provides strong evidence that variation in the TLR10-TLR1-TLR6 region is associated with NHL risk and suggests that TLR2 variants may influence susceptibility to MZL...
  54. ncbi request reprint Lymphocyte toxicity and T cell receptor excision circles in workers exposed to benzene
    Qing Lan
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 6120 Executive Blvd, EPS 8109, Bethesda, MD 20892 7240, USA
    Chem Biol Interact 153:111-5. 2005
    ..Although our study does not rule out counterbalancing alterations of TREC levels in specific T cell subsets, benzene's lymphotoxicity does not appear to be mediated through diminished thymus function...
  55. pmc Oxidative response gene polymorphisms and risk of adult brain tumors
    Preetha Rajaraman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 7238, USA
    Neuro Oncol 10:709-15. 2008
    ..6; 95% CI, 0.3-1.0). These relationships persisted when major groups of disease controls were excluded from the analysis. Our results suggest that common variants in the SOD2, SOD3, and CAT genes may influence brain tumor risk...
  56. pmc Genetic variation in metabolic genes, occupational solvent exposure, and risk of non-hodgkin lymphoma
    Kathryn Hughes Barry
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    Am J Epidemiol 173:404-13. 2011
    ..77, 95% CI: 1.06, 2.97; P(interaction) = 0.06). In contrast, no effect was observed among AG/GG women. Additional studies with larger sample size are needed to replicate these findings...
  57. ncbi request reprint Polymorphisms in cytokine and cellular adhesion molecule genes and susceptibility to hematotoxicity among workers exposed to benzene
    Qing Lan
    Division of Cancer Epidemiology, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, MD 20892 7240, USA
    Cancer Res 65:9574-81. 2005
    ..041) and increased (P = 0.076) CFU-GEMM progenitor cell colony formation in 29 benzene-exposed workers. This is the first report to provide evidence that SNPs in genes that regulate hematopoiesis influence benzene-induced hematotoxicity...
  58. pmc Common variation in genes related to innate immunity and risk of adult glioma
    Preetha Rajaraman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852, USA
    Cancer Epidemiol Biomarkers Prev 18:1651-8. 2009
    ..We have identified a promising set of innate immunity-related genetic regions for further investigation...
  59. pmc Occupation and chronic bronchitis among Chinese women
    Srmena Krstev
    Occupational and Environmental Epidemiology Branch, National Cancer Institute, National Institutes of Health DHHS, 6120 Executive Boulevard, Bethesda, MD 20892, USA
    J Occup Environ Med 50:64-71. 2008
    ..To examine the association between occupation and chronic bronchitis among a cross section of Chinese women who participated in the Shanghai Women's Health Study...
  60. pmc Genetic variation in Th1/Th2 pathway genes and risk of non-Hodgkin lymphoma: a pooled analysis of three population-based case-control studies
    Qing Lan
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Rockville, MD, USA
    Br J Haematol 153:341-50. 2011
    ..This SNP was also associated specifically with risk of follicular lymphoma (allele risk OR= 1·26; P(trend)= 0·0012). These findings suggest that genetic variation in Th1/Th2 cytokine genes may contribute to lymphomagenesis...
  61. pmc Mitochondrial DNA copy number and lung cancer risk in a prospective cohort study
    H Dean Hosgood
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, EPS 8118, MCS 7240, Bethesda, MD 20892 7240, USA
    Carcinogenesis 31:847-9. 2010
    ....
  62. pmc Genetic variation in N-acetyltransferases 1 and 2, cigarette smoking, and risk of non-Hodgkin lymphoma
    Briseis A Kilfoy
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD, USA
    Cancer Causes Control 21:127-33. 2010
    ..We conclude that these findings require replication in larger studies and ultimately in pooled analyses...
  63. pmc Variants in blood pressure genes and the risk of renal cell carcinoma
    Gabriella Andreotti
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20852 4906, USA
    Carcinogenesis 31:614-20. 2010
    ..003). Our findings suggest that common genetic variants of AGT, particularly those in the promoter, increase RCC risk among subjects who are hypertensive or overweight...
  64. pmc Risk of meningioma and common variation in genes related to innate immunity
    Preetha Rajaraman
    Division of Cancer Epidemiology and Genetics, Neuro Oncology Branch, National Cancer Institute, NIH, Department of Health and Human Services, 6120 Executive Boulevard, EPS Room 7058, Bethesda, MD 20892 7238, USA
    Cancer Epidemiol Biomarkers Prev 19:1356-61. 2010
    ..The etiology of meningioma, the second most common type of adult brain tumor in the United States, is largely unknown. Prior studies indicate that history of immune-related conditions may affect the risk of meningioma...
  65. ncbi request reprint Genetic variants in caspase genes and susceptibility to non-Hodgkin lymphoma
    Qing Lan
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute NIH, DHHS, Bethesda, MD 20892 7240, USA
    Carcinogenesis 28:823-7. 2007
    ..The striking protective associations observed for polymorphisms in all four genes for NHL and/or one or more subtypes suggest that genetic variation in CASP genes may play an important role in the etiology of NHL...
  66. ncbi request reprint Polymorphisms in oxidative stress genes and risk for non-Hodgkin lymphoma
    Sophia S Wang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA
    Carcinogenesis 27:1828-34. 2006
    ....
  67. pmc Urinary prostaglandin E2 metabolite and gastric cancer risk in the Shanghai women's health study
    Linda M Dong
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA
    Cancer Epidemiol Biomarkers Prev 18:3075-8. 2009
    ..pylori status, and for cases diagnosed within 46 months after study enrollment. Our findings suggest that higher levels of urinary PGE-M, a marker of inflammation, may be associated with gastric cancer risk...
  68. pmc Hematotoxicity in workers exposed to low levels of benzene
    Qing Lan
    Division of Cancer Epidemiology and Genetics, National Cancer Institute NCI, National Institutes of Health NIH, Department of Health and Human Services DHHS, Bethesda, MD 20892, USA
    Science 306:1774-6. 2004
    ..Thus, hematotoxicity from exposure to benzene occurred at air levels of 1 ppm or less and may be particularly evident among genetically susceptible subpopulations...
  69. ncbi request reprint Common variants in genes that mediate immunity and risk of multiple myeloma
    Elizabeth E Brown
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD, USA
    Int J Cancer 120:2715-22. 2007
    ..Our findings provide preliminary evidence that common genetic variants in specific immune-mediated pathways could influence the risk of MM...
  70. ncbi request reprint Occupation and adult-onset asthma among Chinese women in a population-based cohort
    Srmena Krstev
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, Maryland 20892, USA
    Am J Ind Med 50:265-73. 2007
    ..We examined the associations between occupation and asthma among women in a case-control study nested in the population-based Shanghai Women's Health Study cohort in China...
  71. pmc Circulating 25-hydroxyvitamin D and risk of non-hodgkin lymphoma: Cohort Consortium Vitamin D Pooling Project of Rarer Cancers
    Mark P Purdue
    National Cancer Institute, Bethesda, Maryland, USA
    Am J Epidemiol 172:58-69. 2010
    ..Future research investigating the biologic basis for the sunlight-NHL association should consider alternative mechanisms, such as immunologic effects...
  72. pmc Relationship between interferon regulatory factor 4 genetic polymorphisms, measures of sun sensitivity and risk for non-Hodgkin lymphoma
    Allison H Gathany
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 6120 Executive Blvd, Rockville, MD 20852, USA
    Cancer Causes Control 20:1291-302. 2009
    ..We evaluated the independent roles of these IRF4 polymorphisms and sun sensitivity in mediating NHL risk and explored whether they are confounded or modified by each other...
  73. ncbi request reprint A quantitative approach for estimating exposure to pesticides in the Agricultural Health Study
    Mustafa Dosemeci
    National Cancer Institute, NIH, Bethesda, MD, USA
    Ann Occup Hyg 46:245-60. 2002
    ....
  74. pmc Non-Hodgkin lymphoma (NHL) subtypes defined by common translocations: utility of fluorescence in situ hybridization (FISH) in a case-control study
    Cindy M Chang
    Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Blvd, EPS 7074, Rockville, MD 20892, USA
    Leuk Res 34:190-5. 2010
    ..FISH assays detected twice as many t(14;18)-positive follicular lymphomas as PCR assays. Overall, study findings support the use of FISH assays to detect t(14;18) in archival tumor samples for epidemiologic studies of NHL subtypes...
  75. pmc Analysis of SNPs and haplotypes in vitamin D pathway genes and renal cancer risk
    Sara Karami
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health NIH, Department of Health and Human Services DHHS, Bethesda, Maryland, USA
    PLoS ONE 4:e7013. 2009
    ..This study comprehensively evaluated genetic variation across eight vitamin D pathway genes in relation to RCC risk. We found increased risk associated with VDR and RXRA. Replication studies are warranted to confirm these findings...
  76. pmc Prediagnostic serum concentrations of organochlorine compounds and risk of testicular germ cell tumors
    Mark P Purdue
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    Environ Health Perspect 117:1514-9. 2009
    ..Recent findings suggest that exposure to organochlorine (OC) compounds, chlordanes and p,p'-dichlorodiphenyldichloroethylene (p,p'-DDE) in particular, may increase the risk of developing testicular germ cell tumors (TGCTs)...
  77. pmc Bladder cancer and reproductive factors among women in Spain
    An Tsun Huang
    Department of Health and Human Services, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    Cancer Causes Control 20:1907-13. 2009
    ..Women have a lower risk of bladder cancer than men, and hormonal factors related to childbearing may play a role...
  78. pmc A prospective study of mitochondrial DNA copy number and risk of non-Hodgkin lymphoma
    Qing Lan
    Division of Cancer Epidemiology and Genetics, National Cancer Institute NCI, National Institutes of Health NIH, Department of Health and Human Services DHHS, Bethesda, MD, USA
    Blood 112:4247-9. 2008
    ..0; 3.2 [0.7-15.7]; 14.1 [1.9-103.2]; P(trend) = .009). These results suggest that mtDNA copy number could be associated with the risk of NHL, particularly CLL/SLL...
  79. ncbi request reprint Pooled analysis and meta-analysis of glutathione S-transferase M1 and bladder cancer: a HuGE review
    Lawrence S Engel
    Occupational Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 7240, USA
    Am J Epidemiol 156:95-109. 2002
    ..45, 95% CI: -0.03, 0.93). These results indicate that, among populations studied to date, GSTM1 null status is associated with a modest increase in the risk of bladder cancer...
  80. pmc Predictors of 2,4-dichlorophenoxyacetic acid exposure among herbicide applicators
    Parveen Bhatti
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20892 7238, USA
    J Expo Sci Environ Epidemiol 20:160-8. 2010
    ..As a large proportion of the variance remained unexplained, further studies should be conducted to try to systematically assess other exposure determinants...
  81. pmc Polymorphisms in GSTT1, GSTZ1, and CYP2E1, disinfection by-products, and risk of bladder cancer in Spain
    Kenneth P Cantor
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892 7240, USA
    Environ Health Perspect 118:1545-50. 2010
    ..Bladder cancer has been linked with long-term exposure to disinfection by-products (DBPs) in drinking water...
  82. ncbi request reprint Urothelial cell DNA adducts in rubber workers
    Roel Vermeulen
    Environmental and Occupational Health Group, Institute of Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands
    Environ Mol Mutagen 39:306-13. 2002
    ..Larger studies among rubber workers should be conducted to study in more detail the potential carcinogenicity of exposures encountered in these work areas...
  83. pmc Variation in innate immunity genes and risk of multiple myeloma
    Mark P Purdue
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH DHHS, Bethesda, MD, USA
    Hematol Oncol 29:42-6. 2011
    ..0 × 10(-5) , P(permutation)  = 0.07). Our findings suggest that genetic variants in SERPINE1 and HGF, and possibly CCR7, are associated with MM risk, and warrant further investigation in other studies...
  84. pmc Household coal use and lung cancer: systematic review and meta-analysis of case-control studies, with an emphasis on geographic variation
    H Dean Hosgood
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    Int J Epidemiol 40:719-28. 2011
    ..Although coal emissions are a known human carcinogen, there is still uncertainty about the level of risk for lung and other cancers...
  85. pmc Family cancer history affecting risk of colorectal cancer in a prospective cohort of Chinese women
    Gwen Murphy
    Cancer Prevention Fellowship Program, Office of Preventive Oncology, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD, USA
    Cancer Causes Control 20:1517-21. 2009
    ..Our cohort results suggest that consistent with findings from Western populations, having a family history of colorectal cancer may influence colorectal cancer risk to a similar extent in a low-risk population...
  86. pmc Intra-individual variability over time in serum cytokine levels among participants in the prostate, lung, colorectal, and ovarian cancer screening Trial
    Jonathan N Hofmann
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7240, United States
    Cytokine 56:145-8. 2011
    ..We assessed the reproducibility of serum cytokine measurements over a five-year period among participants in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO)...
  87. pmc Large-scale evaluation of candidate genes identifies associations between VEGF polymorphisms and bladder cancer risk
    Montserrat Garcia-Closas
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, Maryland, United States of America
    PLoS Genet 3:e29. 2007
    ..In conclusion, this large-scale evaluation of candidate cancer genes has identified common genetic variants in the regulatory regions of VEGF that could be associated with bladder cancer risk...
  88. pmc Genetic susceptibility for chronic lymphocytic leukemia among Chinese in Hong Kong
    Qing Lan
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7240, USA
    Eur J Haematol 85:492-5. 2010
    ..5%) lower in the Chinese population compared with Caucasians. These results suggest that variants in three loci may contribute to risk of CLL among Chinese...
  89. ncbi request reprint Polymorphisms in immune function genes and risk of non-Hodgkin lymphoma: findings from the New South Wales non-Hodgkin Lymphoma Study
    Mark P Purdue
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20892 7240, USA
    Carcinogenesis 28:704-12. 2007
    ..06, 95% CI=0.88-4.83; trend test, P=0.02). Our findings offer further evidence that variation in the IL10 and TNF loci influences NHL risk. Additional studies are needed to clarify the genetic and biologic basis for these relationships...
  90. pmc Decreased levels of CXC-chemokines in serum of benzene-exposed workers identified by array-based proteomics
    Roel Vermeulen
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, 6120 Executive Boulevard, Rockville, MD 20852, USA
    Proc Natl Acad Sci U S A 102:17041-6. 2005
    ....
  91. pmc Cytokine polymorphisms in the Th1/Th2 pathway and susceptibility to non-Hodgkin lymphoma
    Qing Lan
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH DHHS, MSC 7240, 6120 Executive Blvd, EPS 8109, Bethesda, MD 20892 7240, USA
    Blood 107:4101-8. 2006
    ..84; 95% CI = 1.79-8.22; P < .001). Further, the IL10 and IL4 SNP associations remained significant after adjusting for multiple comparisons. These results suggest that SNPs in Th2 cytokine genes may be associated with risk of NHL...
  92. pmc Risk of non-Hodgkin's lymphoma and prediagnostic serum organochlorines: beta-hexachlorocyclohexane, chlordane/heptachlor-related compounds, dieldrin, and hexachlorobenzene
    Kenneth P Cantor
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892 7240, USA
    Environ Health Perspect 111:179-83. 2003
    ..These findings do not support the hypothesis that the organochlorine compounds included in this study are strongly linked to the development of NHL. The possibility of a weak association cannot be excluded by these data...
  93. ncbi request reprint Dietary benzo[a]pyrene intake and risk of colorectal adenoma
    Rashmi Sinha
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD, USA
    Cancer Epidemiol Biomarkers Prev 14:2030-4. 2005
    ..21 (1.79-9.91) for the third quintile, 2.45 (0.98-6.12) for the fourth quintile, and 5.60 (2.20-14.20) for the fifth quintile (Ptrend=0.002). This study provides evidence that dietary BaP plays a role in colorectal adenoma etiology...
  94. ncbi request reprint Genetic variation and willingness to participate in epidemiologic research: data from three studies
    Parveen Bhatti
    Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, 6120 Executive Boulevard, EPS 7091, MSC 7238, Bethesda, MD 20892 7238, USA
    Cancer Epidemiol Biomarkers Prev 14:2449-53. 2005
    ..To the extent possible, investigators should evaluate their own genetic data for bias in response categories...
  95. pmc Delta-aminolevulinic acid dehydratase polymorphism and risk of brain tumors in adults
    Preetha Rajaraman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Environ Health Perspect 113:1209-11. 2005
    ..2; 95% CI, 0.7-2.2). No increased risk associated with the ALAD2 variant was observed for glioma or acoustic neuroma. These findings suggest that the ALAD2 allele may increase genetic susceptibility to meningioma...
  96. pmc Large-scale evaluation of candidate genes identifies associations between DNA repair and genomic maintenance and development of benzene hematotoxicity
    Qing Lan
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Carcinogenesis 30:50-8. 2009
    ..Our findings suggest that SNPs involved in DNA repair and genomic maintenance, with particular clustering in the homologous DNA recombination pathway, play an important role in benzene-induced hematotoxicity...
  97. ncbi request reprint Assessing the probability that a positive report is false: an approach for molecular epidemiology studies
    Sholom Wacholder
    Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 7244, USA
    J Natl Cancer Inst 96:434-42. 2004
    ..An FPRP-based criterion for deciding whether to call a finding noteworthy formalizes the process already used informally by investigators--that is, tempering enthusiasm for remarkable study findings with considerations of plausibility...
  98. pmc A case-control study of occupational exposure to trichloroethylene and non-Hodgkin lymphoma
    Mark P Purdue
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20892, USA
    Environ Health Perspect 119:232-8. 2011
    ..Previous epidemiologic findings suggest an association between exposure to trichloroethylene (TCE), a chlorinated solvent primarily used for vapor degreasing of metal parts, and non-Hodgkin lymphoma (NHL)...
  99. pmc A prospective study of serum soluble CD30 concentration and risk of non-Hodgkin lymphoma
    Mark P Purdue
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD 20892, USA
    Blood 114:2730-2. 2009
    ....
  100. ncbi request reprint Cancer survivorship--genetic susceptibility and second primary cancers: research strategies and recommendations
    Lois B Travis
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    J Natl Cancer Inst 98:15-25. 2006
    ..These research areas warrant high priority to promote NCI's goal of eliminating pain and suffering related to cancer...
  101. ncbi request reprint Genetic polymorphisms in heterocyclic amine metabolism and risk of colorectal adenomas
    Naoko Ishibe
    Genetic Epidemioly Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, Maryland 20892, USA
    Pharmacogenetics 12:145-50. 2002
    ..Further study of larger populations is needed to confirm and extend these observations...