Tatiana K Rostovtseva

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint On the role of VDAC in apoptosis: fact and fiction
    Tatiana K Rostovtseva
    Laboratory of Physical and Structural Biology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    J Bioenerg Biomembr 37:129-42. 2005
  2. ncbi request reprint Voltage gating of VDAC is regulated by nonlamellar lipids of mitochondrial membranes
    Tatiana K Rostovtseva
    Laboratory of Physical and Structural Biology and National Center for Medical Rehabilitation Research, NICHD, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 281:37496-506. 2006
  3. pmc Tubulin binding blocks mitochondrial voltage-dependent anion channel and regulates respiration
    Tatiana K Rostovtseva
    Laboratory of Physical and Structural Biology, Program in Physical Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 105:18746-51. 2008
  4. pmc VDAC inhibition by tubulin and its physiological implications
    Tatiana K Rostovtseva
    Laboratory of Physical and Structural Biology, Program in Physical Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institute of Health, Bethesda, MD 20892, USA
    Biochim Biophys Acta 1818:1526-35. 2012
  5. pmc Membrane lipid composition regulates tubulin interaction with mitochondrial voltage-dependent anion channel
    Tatiana K Rostovtseva
    Program in Physical Biology, Eunice Kennedy Shriver NICHD, National Institutes of Health, Bethesda, MD 20892, USA
    J Biol Chem 287:29589-98. 2012
  6. pmc VDAC regulation: role of cytosolic proteins and mitochondrial lipids
    Tatiana K Rostovtseva
    Laboratory of Physical and Structural Biology, Program in Physical Biology, NICHD, National Institutes of Health, Rockville Pike, Bethesda, MD 20892, USA
    J Bioenerg Biomembr 40:163-70. 2008
  7. ncbi request reprint Bid, but not Bax, regulates VDAC channels
    Tatiana K Rostovtseva
    Laboratory of Physical and Structural Biology, NICHD, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 279:13575-83. 2004
  8. pmc Tubulin-blocked state of VDAC studied by polymer and ATP partitioning
    Philip A Gurnev
    Program in Physical Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    FEBS Lett 585:2363-6. 2011
  9. pmc Probing tubulin-blocked state of VDAC by varying membrane surface charge
    Philip A Gurnev
    Program in Physical Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA
    Biophys J 102:2070-6. 2012
  10. pmc Lipid-dependent effects of halothane on gramicidin channel kinetics: a new role for lipid packing stress
    Michael Weinrich
    National Center for Medical Rehabilitation Research, National Institutes of Health, Bethesda, Maryland 20892, USA
    Biochemistry 48:5501-3. 2009

Collaborators

Detail Information

Publications18

  1. ncbi request reprint On the role of VDAC in apoptosis: fact and fiction
    Tatiana K Rostovtseva
    Laboratory of Physical and Structural Biology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    J Bioenerg Biomembr 37:129-42. 2005
    ..Closure of VDAC, not VDAC opening, leads to mitochondria outer membrane permeabilization and apoptosis...
  2. ncbi request reprint Voltage gating of VDAC is regulated by nonlamellar lipids of mitochondrial membranes
    Tatiana K Rostovtseva
    Laboratory of Physical and Structural Biology and National Center for Medical Rehabilitation Research, NICHD, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 281:37496-506. 2006
    ..We propose that the specific lipid composition of the mitochondria outer membrane and/or of contact sites might influence MOM permeability by regulating VDAC gating...
  3. pmc Tubulin binding blocks mitochondrial voltage-dependent anion channel and regulates respiration
    Tatiana K Rostovtseva
    Laboratory of Physical and Structural Biology, Program in Physical Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 105:18746-51. 2008
    ..Additionally, tubulins that have lost significant length or anionic character are only found in cells that do not have mitochondria...
  4. pmc VDAC inhibition by tubulin and its physiological implications
    Tatiana K Rostovtseva
    Laboratory of Physical and Structural Biology, Program in Physical Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institute of Health, Bethesda, MD 20892, USA
    Biochim Biophys Acta 1818:1526-35. 2012
    ..This article is part of a Special Issue entitled: VDAC structure, function, and regulation of mitochondrial metabolism...
  5. pmc Membrane lipid composition regulates tubulin interaction with mitochondrial voltage-dependent anion channel
    Tatiana K Rostovtseva
    Program in Physical Biology, Eunice Kennedy Shriver NICHD, National Institutes of Health, Bethesda, MD 20892, USA
    J Biol Chem 287:29589-98. 2012
    ..More generally, our findings give an example of the lipid-controlled protein-protein interaction where the choice of lipid species is able to change the equilibrium binding constant by orders of magnitude...
  6. pmc VDAC regulation: role of cytosolic proteins and mitochondrial lipids
    Tatiana K Rostovtseva
    Laboratory of Physical and Structural Biology, Program in Physical Biology, NICHD, National Institutes of Health, Rockville Pike, Bethesda, MD 20892, USA
    J Bioenerg Biomembr 40:163-70. 2008
    ..Overall, we demonstrate that VDAC gating is not just an observation made under artificial conditions of channel reconstitution but is a major mechanism of MOM permeability control...
  7. ncbi request reprint Bid, but not Bax, regulates VDAC channels
    Tatiana K Rostovtseva
    Laboratory of Physical and Structural Biology, NICHD, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 279:13575-83. 2004
    ..We speculate that by decreasing the probability of VDAC opening, Bid reduces metabolite exchange between mitochondria and the cytosol, leading to mitochondrial dysfunction...
  8. pmc Tubulin-blocked state of VDAC studied by polymer and ATP partitioning
    Philip A Gurnev
    Program in Physical Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    FEBS Lett 585:2363-6. 2011
    ..34±0.15, the selectivity reverses from initially anionic to cationic. Directly measuring ATP partitioning we demonstrate that these changes prohibit ATP from entering the channel in its tubulin-blocked state...
  9. pmc Probing tubulin-blocked state of VDAC by varying membrane surface charge
    Philip A Gurnev
    Program in Physical Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA
    Biophys J 102:2070-6. 2012
    ....
  10. pmc Lipid-dependent effects of halothane on gramicidin channel kinetics: a new role for lipid packing stress
    Michael Weinrich
    National Center for Medical Rehabilitation Research, National Institutes of Health, Bethesda, Maryland 20892, USA
    Biochemistry 48:5501-3. 2009
    ....
  11. pmc Phosphorylation of voltage-dependent anion channel by serine/threonine kinases governs its interaction with tubulin
    Kely L Sheldon
    Laboratory of Physical and Structural Biology, Program in Physical Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 6:e25539. 2011
    ..Our findings suggest a novel functional link between serine/threonine kinase signaling pathways, mitochondrial respiration, and the highly dynamic microtubule network which is characteristic of cancerogenesis and cell proliferation...
  12. pmc Residue ionization and ion transport through OmpF channels
    Ekaterina M Nestorovich
    Laboratory of Physical and Structural Biology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 0924, USA
    Biophys J 85:3718-29. 2003
    ..We attribute these effects to the reversible protonation of channel residues whose pH-dependent charge influences transport by direct interactions with ions passing through the channel...
  13. pmc Affixing N-terminal α-helix to the wall of the voltage-dependent anion channel does not prevent its voltage gating
    Oscar Teijido
    Program in Physical Biology, Eunice Kennedy Shriver NICHD, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 287:11437-45. 2012
    ..These results suggest that the N-terminal α-helix is located inside the pore of VDAC in the open state and remains associated with β-strand 11 of the pore wall during voltage gating...
  14. pmc Bax activates endophilin B1 oligomerization and lipid membrane vesiculation
    Tatiana K Rostovtseva
    Laboratory of Physical and Structural Biology, Eunice Kennedy Shriver NICHD, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 284:34390-9. 2009
    ..This activity of purified Bax protein to induce cell-free assembly of Endo B1 may reflect its activity in cells that regulates apoptosis and/or mitochondrial fusion...
  15. pmc Partitioning of differently sized poly(ethylene glycol)s into OmpF porin
    Tatiana K Rostovtseva
    Laboratory of Physical and Structural Biology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 0924 USA
    Biophys J 82:160-9. 2002
    ..The PEG-induced conductance noise is compatible with the polymer mobility reduced inside the OmpF pore by an order of magnitude relatively to its value in bulk solution...
  16. pmc Dynamics of nucleotides in VDAC channels: structure-specific noise generation
    Tatiana K Rostovtseva
    Department of Biology, University of Maryland, College Park, Maryland 20742, USA
    Biophys J 82:193-205. 2002
    ..A possible mechanism for this selectivity is two noise-generating processes operating in parallel...
  17. pmc Interfacial polar interactions affect gramicidin channel kinetics
    Tatiana K Rostovtseva
    Biophys J 94:L23-5. 2008
    ..Thus we demonstrate that peptide-headgroup interactions may dominate over the effect of hydrophobic mismatch in regulating protein function...
  18. ncbi request reprint Bax channel inhibitors prevent mitochondrion-mediated apoptosis and protect neurons in a model of global brain ischemia
    Claudio Hetz
    Serono Pharmaceutical Research Institute, 14 Chemin des Aulx, CH 1228 Plan les Ouates, Geneva, Switzerland
    J Biol Chem 280:42960-70. 2005
    ..The protective effect in the animal model correlated with decreased cytochrome c release in the infarcted area. This is the first demonstration that Bax channel activity is required in apoptosis...