Research Topics
Genomes and Genes | Tatiana K RostovtsevaSummaryAffiliation: National Institutes of Health Country: USA Publications
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Publications
On the role of VDAC in apoptosis: fact and fictionTatiana K Rostovtseva
Laboratory of Physical and Structural Biology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
J Bioenerg Biomembr 37:129-42. 2005..Closure of VDAC, not VDAC opening, leads to mitochondria outer membrane permeabilization and apoptosis...- Voltage gating of VDAC is regulated by nonlamellar lipids of mitochondrial membranesTatiana K Rostovtseva
Laboratory of Physical and Structural Biology and National Center for Medical Rehabilitation Research, NICHD, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 281:37496-506. 2006..We propose that the specific lipid composition of the mitochondria outer membrane and/or of contact sites might influence MOM permeability by regulating VDAC gating... 
Tubulin binding blocks mitochondrial voltage-dependent anion channel and regulates respirationTatiana K Rostovtseva
Laboratory of Physical and Structural Biology, Program in Physical Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 105:18746-51. 2008..Additionally, tubulins that have lost significant length or anionic character are only found in cells that do not have mitochondria...- VDAC inhibition by tubulin and its physiological implicationsTatiana K Rostovtseva
Laboratory of Physical and Structural Biology, Program in Physical Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institute of Health, Bethesda, MD 20892, USA
Biochim Biophys Acta 1818:1526-35. 2012..This article is part of a Special Issue entitled: VDAC structure, function, and regulation of mitochondrial metabolism... - Membrane lipid composition regulates tubulin interaction with mitochondrial voltage-dependent anion channelTatiana K Rostovtseva
Program in Physical Biology, Eunice Kennedy Shriver NICHD, National Institutes of Health, Bethesda, MD 20892, USA
J Biol Chem 287:29589-98. 2012..More generally, our findings give an example of the lipid-controlled protein-protein interaction where the choice of lipid species is able to change the equilibrium binding constant by orders of magnitude... - VDAC regulation: role of cytosolic proteins and mitochondrial lipidsTatiana K Rostovtseva
Laboratory of Physical and Structural Biology, Program in Physical Biology, NICHD, National Institutes of Health, Rockville Pike, Bethesda, MD 20892, USA
J Bioenerg Biomembr 40:163-70. 2008..Overall, we demonstrate that VDAC gating is not just an observation made under artificial conditions of channel reconstitution but is a major mechanism of MOM permeability control... - Bid, but not Bax, regulates VDAC channelsTatiana K Rostovtseva
Laboratory of Physical and Structural Biology, NICHD, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 279:13575-83. 2004..We speculate that by decreasing the probability of VDAC opening, Bid reduces metabolite exchange between mitochondria and the cytosol, leading to mitochondrial dysfunction... - Tubulin-blocked state of VDAC studied by polymer and ATP partitioningPhilip A Gurnev
Program in Physical Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
FEBS Lett 585:2363-6. 2011..34±0.15, the selectivity reverses from initially anionic to cationic. Directly measuring ATP partitioning we demonstrate that these changes prohibit ATP from entering the channel in its tubulin-blocked state... - Probing tubulin-blocked state of VDAC by varying membrane surface chargePhilip A Gurnev
Program in Physical Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA
Biophys J 102:2070-6. 2012.... - Lipid-dependent effects of halothane on gramicidin channel kinetics: a new role for lipid packing stressMichael Weinrich
National Center for Medical Rehabilitation Research, National Institutes of Health, Bethesda, Maryland 20892, USA
Biochemistry 48:5501-3. 2009.... - Phosphorylation of voltage-dependent anion channel by serine/threonine kinases governs its interaction with tubulinKely L Sheldon
Laboratory of Physical and Structural Biology, Program in Physical Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, United States of America
PLoS ONE 6:e25539. 2011..Our findings suggest a novel functional link between serine/threonine kinase signaling pathways, mitochondrial respiration, and the highly dynamic microtubule network which is characteristic of cancerogenesis and cell proliferation... - Residue ionization and ion transport through OmpF channelsEkaterina M Nestorovich
Laboratory of Physical and Structural Biology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 0924, USA
Biophys J 85:3718-29. 2003..We attribute these effects to the reversible protonation of channel residues whose pH-dependent charge influences transport by direct interactions with ions passing through the channel... - Affixing N-terminal α-helix to the wall of the voltage-dependent anion channel does not prevent its voltage gatingOscar Teijido
Program in Physical Biology, Eunice Kennedy Shriver NICHD, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 287:11437-45. 2012..These results suggest that the N-terminal α-helix is located inside the pore of VDAC in the open state and remains associated with β-strand 11 of the pore wall during voltage gating... - Bax activates endophilin B1 oligomerization and lipid membrane vesiculationTatiana K Rostovtseva
Laboratory of Physical and Structural Biology, Eunice Kennedy Shriver NICHD, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 284:34390-9. 2009..This activity of purified Bax protein to induce cell-free assembly of Endo B1 may reflect its activity in cells that regulates apoptosis and/or mitochondrial fusion... - Partitioning of differently sized poly(ethylene glycol)s into OmpF porinTatiana K Rostovtseva
Laboratory of Physical and Structural Biology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892-0924 USA
Biophys J 82:160-9. 2002..The PEG-induced conductance noise is compatible with the polymer mobility reduced inside the OmpF pore by an order of magnitude relatively to its value in bulk solution... - Dynamics of nucleotides in VDAC channels: structure-specific noise generationTatiana K Rostovtseva
Department of Biology, University of Maryland, College Park, Maryland 20742, USA
Biophys J 82:193-205. 2002..A possible mechanism for this selectivity is two noise-generating processes operating in parallel... - Interfacial polar interactions affect gramicidin channel kineticsTatiana K Rostovtseva
Biophys J 94:L23-5. 2008..Thus we demonstrate that peptide-headgroup interactions may dominate over the effect of hydrophobic mismatch in regulating protein function... - Bax channel inhibitors prevent mitochondrion-mediated apoptosis and protect neurons in a model of global brain ischemiaClaudio Hetz
Serono Pharmaceutical Research Institute, 14 Chemin des Aulx, CH 1228 Plan les Ouates, Geneva, Switzerland
J Biol Chem 280:42960-70. 2005..The protective effect in the animal model correlated with decreased cytochrome c release in the infarcted area. This is the first demonstration that Bax channel activity is required in apoptosis...