Judah L Rosner

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Reduction of cellular stress by TolC-dependent efflux pumps in Escherichia coli indicated by BaeSR and CpxARP activation of spy in efflux mutants
    Judah L Rosner
    Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA
    J Bacteriol 195:1042-50. 2013
  2. pmc An excretory function for the Escherichia coli outer membrane pore TolC: upregulation of marA and soxS transcription and Rob activity due to metabolites accumulated in tolC mutants
    Judah L Rosner
    Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 0560, USA
    J Bacteriol 191:5283-92. 2009
  3. pmc Posttranscriptional activation of the transcriptional activator Rob by dipyridyl in Escherichia coli
    Judah L Rosner
    Laboratory of Molecular Biology, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bldg 5 Rm 333, Bethesda, MD 20892 0560, USA
    J Bacteriol 184:1407-16. 2002
  4. pmc Transcriptional activation by MarA, SoxS and Rob of two tolC promoters using one binding site: a complex promoter configuration for tolC in Escherichia coli
    Aixia Zhang
    Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 0560, USA
    Mol Microbiol 69:1450-5. 2008
  5. ncbi request reprint Genomics of the marA/soxS/rob regulon of Escherichia coli: identification of directly activated promoters by application of molecular genetics and informatics to microarray data
    Robert G Martin
    Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases NIH, Bethesda, MD 20892 0560, USA
    Mol Microbiol 44:1611-24. 2002
  6. pmc Activation of the Escherichia coli marA/soxS/rob regulon in response to transcriptional activator concentration
    Robert G Martin
    Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 0560, USA
    J Mol Biol 380:278-84. 2008
  7. ncbi request reprint Complex formation between activator and RNA polymerase as the basis for transcriptional activation by MarA and SoxS in Escherichia coli
    Robert G Martin
    Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 0560, USA
    Mol Microbiol 43:355-70. 2002
  8. ncbi request reprint Analysis of microarray data for the marA, soxS, and rob regulons of Escherichia coli
    Robert G Martin
    Laboratory of Molecular Biology, NIDDK, National Institutes of Health, Bethesda, Maryland 20892 0560, USA
    Methods Enzymol 370:278-80. 2003
  9. ncbi request reprint Transcriptional and translational regulation of the marRAB multiple antibiotic resistance operon in Escherichia coli
    Robert G Martin
    Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, Bldg 5, Rm 333, National Institutes of Health, Bethesda, MD 20892 0560, USA
    Mol Microbiol 53:183-91. 2004
  10. ncbi request reprint Versatility of the carboxy-terminal domain of the alpha subunit of RNA polymerase in transcriptional activation: use of the DNA contact site as a protein contact site for MarA
    Bindi Dangi
    Laboratory of Chemical Physics, National Institute of Diabetes, Digestive and Kidney Diseases, National Institute of Health, Bethesda, MD 20892, USA
    Mol Microbiol 54:45-59. 2004

Collaborators

Detail Information

Publications13

  1. pmc Reduction of cellular stress by TolC-dependent efflux pumps in Escherichia coli indicated by BaeSR and CpxARP activation of spy in efflux mutants
    Judah L Rosner
    Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA
    J Bacteriol 195:1042-50. 2013
    ..We propose that, unless TolC-dependent pumps excrete certain metabolites, the metabolites accumulate and activate at least five different stress response systems...
  2. pmc An excretory function for the Escherichia coli outer membrane pore TolC: upregulation of marA and soxS transcription and Rob activity due to metabolites accumulated in tolC mutants
    Judah L Rosner
    Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 0560, USA
    J Bacteriol 191:5283-92. 2009
    ..As these metabolites accumulate during growth, they trigger the upregulation of MarA, SoxS, and Rob, which in turn upregulate tolC and help rid the bacteria of these metabolites, thereby restoring homeostasis...
  3. pmc Posttranscriptional activation of the transcriptional activator Rob by dipyridyl in Escherichia coli
    Judah L Rosner
    Laboratory of Molecular Biology, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bldg 5 Rm 333, Bethesda, MD 20892 0560, USA
    J Bacteriol 184:1407-16. 2002
    ..Thus, it appears that Rob can be converted from a low activity state to a high-activity state by a CTD-mediated mechanism in vivo or by purification in vitro...
  4. pmc Transcriptional activation by MarA, SoxS and Rob of two tolC promoters using one binding site: a complex promoter configuration for tolC in Escherichia coli
    Aixia Zhang
    Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 0560, USA
    Mol Microbiol 69:1450-5. 2008
    ..The multiple tolC promoters may allow the cell to respond to diverse environments by co-ordinating tolC transcription with other appropriate functions...
  5. ncbi request reprint Genomics of the marA/soxS/rob regulon of Escherichia coli: identification of directly activated promoters by application of molecular genetics and informatics to microarray data
    Robert G Martin
    Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases NIH, Bethesda, MD 20892 0560, USA
    Mol Microbiol 44:1611-24. 2002
    ..We estimate that the total number of directly activated promoters in the regulon is less than 40...
  6. pmc Activation of the Escherichia coli marA/soxS/rob regulon in response to transcriptional activator concentration
    Robert G Martin
    Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 0560, USA
    J Mol Biol 380:278-84. 2008
    ..Thus, the concentration and nature of activator determine which regulon promoters are activated, as well as the extent of their activation...
  7. ncbi request reprint Complex formation between activator and RNA polymerase as the basis for transcriptional activation by MarA and SoxS in Escherichia coli
    Robert G Martin
    Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 0560, USA
    Mol Microbiol 43:355-70. 2002
    ..We suggest that activator-RNP complexes scan the chromosome and bind promoters of the regulon more efficiently than either RNP or the activators alone...
  8. ncbi request reprint Analysis of microarray data for the marA, soxS, and rob regulons of Escherichia coli
    Robert G Martin
    Laboratory of Molecular Biology, NIDDK, National Institutes of Health, Bethesda, Maryland 20892 0560, USA
    Methods Enzymol 370:278-80. 2003
  9. ncbi request reprint Transcriptional and translational regulation of the marRAB multiple antibiotic resistance operon in Escherichia coli
    Robert G Martin
    Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, Bldg 5, Rm 333, National Institutes of Health, Bethesda, MD 20892 0560, USA
    Mol Microbiol 53:183-91. 2004
    ..Increasing the 5 bp spacing between the SD sequence and the GTG codon by one to four bases reduced the translational efficiency by 50-75%. Inefficient translation of marR may help to sensitize the cell to environmental signals...
  10. ncbi request reprint Versatility of the carboxy-terminal domain of the alpha subunit of RNA polymerase in transcriptional activation: use of the DNA contact site as a protein contact site for MarA
    Bindi Dangi
    Laboratory of Chemical Physics, National Institute of Diabetes, Digestive and Kidney Diseases, National Institute of Health, Bethesda, MD 20892, USA
    Mol Microbiol 54:45-59. 2004
    ..These results reveal a new versatility for alpha-CTD in transcriptional activation...
  11. pmc Promoter discrimination at class I MarA regulon promoters mediated by glutamic acid 89 of the MarA transcriptional activator of Escherichia coli
    Robert G Martin
    Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD 20892 0560, USA
    J Bacteriol 193:506-15. 2011
    ..We present a model which attributes the differences in binding and activation to the interference between the β- and γ-carbons of the amino acid at position 89 and the phosphate group between positions 12 and 13...
  12. pmc Detection of low-level promoter activity within open reading frame sequences of Escherichia coli
    Mitsuoki Kawano
    Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, Building 18T, Room 101, Bethesda, MD 20892 5430, USA
    Nucleic Acids Res 33:6268-76. 2005
    ..coli chromosome carries numerous -35 and -10 sequences with weak promoter activity but that most are not productively expressed because other features needed to enhance promoter activity and transcript stability are absent...
  13. pmc Identification of the Escherichia coli K-12 ybhE gene as pgl, encoding 6-phosphogluconolactonase
    Lynn C Thomason
    Gene Regulation and Chromosome Biology Laboratory, Building 539, Room 243, National Cancer Institute Frederick, Frederick, MD 21702, USA
    J Bacteriol 186:8248-53. 2004
    ..This is likely due to poor growth of Bgl+ pgl strains on salicin due to the accumulation of 6-phosphogluconolactone...