Philip S Rosenberg

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Are incidence rates of adult leukemia in the United States significantly associated with birth cohort?
    Philip S Rosenberg
    Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Executive Plaza South, Room 8022, Rockville, MD 20852, USA
    Cancer Epidemiol Biomarkers Prev 21:2159-66. 2012
  2. ncbi request reprint Multiple hypothesis testing strategies for genetic case-control association studies
    Philip S Rosenberg
    Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD 20852 7244, USA
    Stat Med 25:3134-49. 2006
  3. pmc How high are carrier frequencies of rare recessive syndromes? Contemporary estimates for Fanconi Anemia in the United States and Israel
    Philip S Rosenberg
    Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland, USA
    Am J Med Genet A 155:1877-83. 2011
  4. ncbi request reprint Secular trends in outcomes for Fanconi anemia patients who receive transplants: implications for future studies
    Philip S Rosenberg
    Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20852, USA
    Biol Blood Marrow Transplant 11:672-9. 2005
  5. ncbi request reprint Individualized risks of first adverse events in patients with Fanconi anemia
    Philip S Rosenberg
    Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Executive Plaza South, Rm 7006, Rockville, MD 20852 7244, USA
    Blood 104:350-5. 2004
  6. doi request reprint Cancer risks in Fanconi anemia: findings from the German Fanconi Anemia Registry
    Philip S Rosenberg
    Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Executive Plaza South, Room 8022, Rockville 20852 7244 USA
    Haematologica 93:511-7. 2008
  7. ncbi request reprint Risk of head and neck squamous cell cancer and death in patients with Fanconi anemia who did and did not receive transplants
    Philip S Rosenberg
    Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20852 7244, USA
    Blood 105:67-73. 2005
  8. pmc Stable long-term risk of leukaemia in patients with severe congenital neutropenia maintained on G-CSF therapy
    Philip S Rosenberg
    Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852, USA
    Br J Haematol 150:196-9. 2010
  9. pmc Proportional hazards models and age-period-cohort analysis of cancer rates
    Philip S Rosenberg
    Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD 20852 7244, USA
    Stat Med 29:1228-38. 2010
  10. pmc The incidence of leukemia and mortality from sepsis in patients with severe congenital neutropenia receiving long-term G-CSF therapy
    Philip S Rosenberg
    Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20852 7244, USA
    Blood 107:4628-35. 2006

Detail Information

Publications80

  1. pmc Are incidence rates of adult leukemia in the United States significantly associated with birth cohort?
    Philip S Rosenberg
    Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Executive Plaza South, Room 8022, Rockville, MD 20852, USA
    Cancer Epidemiol Biomarkers Prev 21:2159-66. 2012
    ..However, prior studies have not examined leukemia birth cohort effects using contemporary data and methods...
  2. ncbi request reprint Multiple hypothesis testing strategies for genetic case-control association studies
    Philip S Rosenberg
    Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD 20852 7244, USA
    Stat Med 25:3134-49. 2006
    ..Multiple testing balances the desire for statistical power against the implicit costs of false positive results, which up to now appear to be common in the literature...
  3. pmc How high are carrier frequencies of rare recessive syndromes? Contemporary estimates for Fanconi Anemia in the United States and Israel
    Philip S Rosenberg
    Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland, USA
    Am J Med Genet A 155:1877-83. 2011
    ..Assessment of cancer risks in heterozygous carriers merits further study. Clinical trials in FA will require co-ordination and innovative design because the number of living US patients is probably less than 1,000...
  4. ncbi request reprint Secular trends in outcomes for Fanconi anemia patients who receive transplants: implications for future studies
    Philip S Rosenberg
    Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20852, USA
    Biol Blood Marrow Transplant 11:672-9. 2005
    ..To demonstrate further advances in survival, transplant centers may need to coordinate their protocols and engage in multicenter collaborative studies...
  5. ncbi request reprint Individualized risks of first adverse events in patients with Fanconi anemia
    Philip S Rosenberg
    Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Executive Plaza South, Rm 7006, Rockville, MD 20852 7244, USA
    Blood 104:350-5. 2004
    ..6% to 29% in the highest and lowest BMF risk groups, respectively. Abnormal radii are the strongest predictor of early BMF in FA; a congenital abnormality score separates patients with normal radii into distinct prognostic groups...
  6. doi request reprint Cancer risks in Fanconi anemia: findings from the German Fanconi Anemia Registry
    Philip S Rosenberg
    Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Executive Plaza South, Room 8022, Rockville 20852 7244 USA
    Haematologica 93:511-7. 2008
    ..Prior epidemiological studies have quantified the risks of bone marrow failure, acute myeloid leukemia and solid tumors, but these estimates have not been replicated...
  7. ncbi request reprint Risk of head and neck squamous cell cancer and death in patients with Fanconi anemia who did and did not receive transplants
    Philip S Rosenberg
    Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20852 7244, USA
    Blood 105:67-73. 2005
    ..13% per month (1.6% per year) after the first year. Acute and chronic graft-versus-host diseases were significant SCC risk factors. Adverse event rates in these cohorts provide historical control rates to assess emerging therapies for FA...
  8. pmc Stable long-term risk of leukaemia in patients with severe congenital neutropenia maintained on G-CSF therapy
    Philip S Rosenberg
    Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852, USA
    Br J Haematol 150:196-9. 2010
    ..Long-term, the annual risk of MDS/AML attained a plateau (2.3%/year after 10 years). This risk now appears similar to, rather than higher than, the risk of AML in Fanconi anaemia and dyskeratosis congenita...
  9. pmc Proportional hazards models and age-period-cohort analysis of cancer rates
    Philip S Rosenberg
    Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD 20852 7244, USA
    Stat Med 29:1228-38. 2010
    ..The examples illustrate that each type of proportionality may be encountered in practice...
  10. pmc The incidence of leukemia and mortality from sepsis in patients with severe congenital neutropenia receiving long-term G-CSF therapy
    Philip S Rosenberg
    Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20852 7244, USA
    Blood 107:4628-35. 2006
    ..Risk of MDS/AML may be similar in SDS and SCN. In less-responsive SCN patients, early hematopoietic stem cell transplantation may be a rational option...
  11. pmc Apolipoprotein E/C1 locus variants modify renal cell carcinoma risk
    Lee E Moore
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20852, USA
    Cancer Res 69:8001-8. 2009
    ..In two large case-control studies, our findings further define a functional region of interest at the APOE locus that increases RCC susceptibility...
  12. pmc Variants in hormone-related genes and the risk of biliary tract cancers and stones: a population-based study in China
    Sue K Park
    Department of Health and Human Services, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Boulevard, EPS 5024, MSC 7234, Bethesda, MD 20892 7234, USA
    Carcinogenesis 30:606-14. 2009
    ..1-4.9; P-interaction = 0.05) was statistically significant. Our findings suggest that common variants in hormone-related genes contribute to the risk of biliary tract cancers and stones, possibly by modulating hormone metabolism...
  13. pmc Competing risks analysis of correlated failure time data
    Bingshu E Chen
    Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852, USA
    Biometrics 64:172-9. 2008
    ..For women with BRCA1 mutations, we estimate the cumulative incidence of breast cancer in the presence of competing mortality from ovarian cancer, accounting for significant within-family correlation...
  14. pmc Polymorphism of genes related to insulin sensitivity and the risk of biliary tract cancer and biliary stone: a population-based case-control study in Shanghai, China
    Shih Chen Chang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, Bethesda, MD 20892, USA
    Carcinogenesis 29:944-8. 2008
    ..Results from this population-based study suggest that certain genetic variants involved in the regulation of obesity-related insulin sensitivity may increase susceptibility to bile duct cancer and gallstones...
  15. pmc Genetic determinants of serum lipid levels in Chinese subjects: a population-based study in Shanghai, China
    Gabriella Andreotti
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, 6120 Executive Blvd, EPS 8011, MSC 7240, Bethesda, MD, 20892, USA
    Eur J Epidemiol 24:763-74. 2009
    ..These findings provide insight into the role of lipid metabolism genes, as well as the mechanisms by which these genes may be linked with disease...
  16. pmc The association between inflammation-related genes and serum androgen levels in men: the prostate, lung, colorectal, and ovarian study
    Tamra E Meyer
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20852, USA
    Prostate 72:65-71. 2012
    ..Androgens and inflammation have been implicated in the etiology of several cancers, including prostate cancer. Serum androgens have been shown to correlate with markers of inflammation and expression of inflammation-related genes...
  17. pmc Polymorphisms of estrogen receptors and risk of biliary tract cancers and gallstones: a population-based study in Shanghai, China
    Sue K Park
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institute of Health, EPS MSC 7234, 6120 Executive Boulevard, Bethesda, MD 20892 7234, USA
    Carcinogenesis 31:842-6. 2010
    ..1). No association was found for ESR1 haplotype based on four SNPs. These preliminary results suggest that variants in ESR genes could play a role in the etiology of biliary tract cancers, especially bile duct cancer in men...
  18. pmc Variants in blood pressure genes and the risk of renal cell carcinoma
    Gabriella Andreotti
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20852 4906, USA
    Carcinogenesis 31:614-20. 2010
    ..003). Our findings suggest that common genetic variants of AGT, particularly those in the promoter, increase RCC risk among subjects who are hypertensive or overweight...
  19. pmc Malignancies and survival patterns in the National Cancer Institute inherited bone marrow failure syndromes cohort study
    Blanche P Alter
    Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852 7231, USA
    Br J Haematol 150:179-88. 2010
    ..The findings demonstrate that both FA and DC are major cancer susceptibility syndromes. The IBMFS, historically considered paediatric disorders, have important management implications for physicians treating adult patients...
  20. pmc Variants in inflammation genes and the risk of biliary tract cancers and stones: a population-based study in China
    Ann W Hsing
    Division of Cancer Epidemiology and Genetics and Office of Preventive Oncology, National Cancer Institute, NIH, Bethesda, Maryland 20892 7234, USA
    Cancer Res 68:6442-52. 2008
    ....
  21. ncbi request reprint Selected base excision repair gene polymorphisms and susceptibility to biliary tract cancer and biliary stones: a population-based case-control study in China
    Wen Yi Huang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Carcinogenesis 29:100-5. 2008
    ..This study suggests that genetic variants in XRCC1 and APEX1 may alter susceptibility to biliary tract cancer and stones. Further studies are required to confirm the reported associations...
  22. pmc Cancer in dyskeratosis congenita
    Blanche P Alter
    Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health DHHS, 6120 Executive Blvd, Executive Plaza South, Rockville, MD 20852 7231, USA
    Blood 113:6549-57. 2009
    ....
  23. pmc Neutrophil elastase mutations and risk of leukaemia in severe congenital neutropenia
    Philip S Rosenberg
    Biostatistics Branch, Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Rockville, MD, USA
    Br J Haematol 140:210-3. 2008
    ..96). Patients with either mutant or wild-type ELA2 should be followed closely for leukaemic transformation...
  24. pmc Likelihood ratio test for detecting gene (G)-environment (E) interactions under an additive risk model exploiting G-E independence for case-control data
    Summer S Han
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20852, USA
    Am J Epidemiol 176:1060-7. 2012
    ..5-fold. The authors illustrate their method by applying it to data from a bladder cancer study...
  25. pmc Comprehensive analysis of 5-aminolevulinic acid dehydrogenase (ALAD) variants and renal cell carcinoma risk among individuals exposed to lead
    Dana M Van Bemmel
    Cancer Prevention Fellowship Program, Office of the Director, National Cancer Institute, Bethesda, Maryland, United States of America
    PLoS ONE 6:e20432. 2011
    ..Epidemiologic studies are reporting associations between lead exposure and human cancers. A polymorphism in the 5-aminolevulinic acid dehydratase (ALAD) gene affects lead toxicokinetics and may modify the adverse effects of lead...
  26. pmc Worldwide trends in incidence rates for oral cavity and oropharyngeal cancers
    Anil K Chaturvedi
    Anil K Chaturvedi, William F Anderson, and Philip S Rosenberg, National Cancer Institute, Rockville, MD Maura L Gillison, The Ohio State University, Columbus, OH Joannie Lortet Tieulent, Jacques Ferlay, Silvia Franceschi, and Freddie Bray, International Agency for Research on Cancer and Maria Paula Curado, International Prevention Research Institute, Lyon, France
    J Clin Oncol 31:4550-9. 2013
    ..To investigate whether this represents a global phenomenon, we evaluated incidence trends for OPCs and oral cavity cancers (OCCs) in 23 countries across four continents...
  27. pmc Association between genetic variants in the 8q24 cancer risk regions and circulating levels of androgens and sex hormone-binding globulin
    Lisa W Chu
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA
    Cancer Epidemiol Biomarkers Prev 19:1848-54. 2010
    ..Genome-wide association studies have identified multiple independent regions on chromosome 8q24 that are associated with cancers of the prostate, breast, colon, and bladder...
  28. pmc Underlying causes of the black-white racial disparity in breast cancer mortality: a population-based analysis
    Idan Menashe
    Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD 20852 7244, USA
    J Natl Cancer Inst 101:993-1000. 2009
    ..In the United States, a black-to-white disparity in age-standardized breast cancer mortality rates emerged in the 1980s and has widened since then...
  29. pmc Male breast cancer: a population-based comparison with female breast cancer
    William F Anderson
    Biostatistics Branch BB, DHHS NIH NCI Division of Cancer Epidemiology and Genetics DCEG, EPS, Room 8036, 6120 Executive Blvd, Bethesda, MD 20892 7244, USA
    J Clin Oncol 28:232-9. 2010
    ..Because of its rarity, male breast cancer is often compared with female breast cancer...
  30. ncbi request reprint Cancer incidence in persons with Fanconi anemia
    Philip S Rosenberg
    Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    Blood 101:822-6. 2003
    ..The risk of a solid tumor may become even higher as death from aplastic anemia is reduced and as patients survive longer after BMT...
  31. ncbi request reprint Resampling-based multiple hypothesis testing procedures for genetic case-control association studies
    Bingshu E Chen
    Biostatistics Branch, Department of Health and Human Services, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, Maryland 20852 7244, USA
    Genet Epidemiol 30:495-507. 2006
    ....
  32. pmc Pathway analysis by adaptive combination of P-values
    Kai Yu
    Division of Cancer Epidemiology and Genetics, NCI, Rockville, Maryland 20892, USA
    Genet Epidemiol 33:700-9. 2009
    ..We also illustrate the advantage of the proposed methods using a study of the association between the nicotinic receptor pathway and cigarette smoking behaviors...
  33. pmc Age-related crossover in breast cancer incidence rates between black and white ethnic groups
    William F Anderson
    Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, United States Department of Health and Human Services, Bethesda, MD 20892 7244, USA
    J Natl Cancer Inst 100:1804-14. 2008
    ..This crossover in incidence rates between black and white ethnic groups has been well described, has not been completely understood, and has been viewed as an artifact...
  34. ncbi request reprint Reconstruction of the hepatitis C virus epidemic in the US hemophilia population, 1940-1990
    James J Goedert
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20852, USA
    Am J Epidemiol 165:1443-53. 2007
    ....
  35. pmc Analysis of SNPs and haplotypes in vitamin D pathway genes and renal cancer risk
    Sara Karami
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health NIH, Department of Health and Human Services DHHS, Bethesda, Maryland, USA
    PLoS ONE 4:e7013. 2009
    ..This study comprehensively evaluated genetic variation across eight vitamin D pathway genes in relation to RCC risk. We found increased risk associated with VDR and RXRA. Replication studies are warranted to confirm these findings...
  36. pmc Variants in or near KITLG, BAK1, DMRT1, and TERT-CLPTM1L predispose to familial testicular germ cell tumour
    Christian P Kratz
    Division of CancerEpidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, Maryland 20852, USA
    J Med Genet 48:473-6. 2011
    ..Familial testicular germ cell tumours (TGCTs) and bilateral TGCTs comprise 1-2% and 5% of all TGCTs, respectively, but their genetic basis remains largely unknown...
  37. pmc Divergent trends for gastric cancer incidence by anatomical subsite in US adults
    M Constanza Camargo
    Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852, USA
    Gut 60:1644-9. 2011
    ..To investigate this heterogeneity further, incidence trends were evaluated by anatomical subsite...
  38. ncbi request reprint Estimating age-specific breast cancer risks: a descriptive tool to identify age interactions
    William F Anderson
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institute of Health, Executive Plaza South 8070, 6120 Executive Plaza Blvd, Rockville, MD 20892 7242, USA
    Cancer Causes Control 18:439-47. 2007
    ..Clarifying age-specific female breast cancer risks and interactions may provide important etiologic clues...
  39. pmc The chromosome 2p21 region harbors a complex genetic architecture for association with risk for renal cell carcinoma
    Summer S Han
    Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 7231, USA
    Hum Mol Genet 21:1190-200. 2012
    ..72 × 10(-9), per-allele OR = 1.28, 95% CI: 1.18-1.39) In conclusion, we report that chromosome 2p21 harbors a complex genetic architecture for common RCC risk variants...
  40. pmc Genetic regulation of fetal haemoglobin in inherited bone marrow failure syndromes
    Blanche P Alter
    Clinical Genetics Branch, Division of Clinical Epidemiology and Genetics, National Cancer Institute, National Institutes of Health DCEG CGB Branch, 9609 Medical Center Dr, Rm 6E452, Bethesda, MD 20892, USA
    Br J Haematol 162:542-6. 2013
    ..Thus Hb F is regulated in IBMFS by Xmn1-HBG2, as it is in the haemoglobinopathies. ..
  41. pmc Pediatric, elderly, and emerging adult-onset peaks in Burkitt's lymphoma incidence diagnosed in four continents, excluding Africa
    Sam M Mbulaiteye
    Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health DHHS, Rockville, MD 20892, USA
    Am J Hematol 87:573-8. 2012
    ..Our findings, based on the international BL cases, support our hypothesis that BL is multimodal and that BL peaks at different ages may be clues to differences in the etiology and/or biology of BL at those ages...
  42. pmc Pathway analysis of breast cancer genome-wide association study highlights three pathways and one canonical signaling cascade
    Idan Menashe
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, MD20852 7244, USA
    Cancer Res 70:4453-9. 2010
    ..0051, FDR = 0.07). These results suggest that genetic alterations associated with these three pathways and one canonical signaling cascade may contribute to breast cancer susceptibility...
  43. pmc Regional variations in esophageal cancer rates by census region in the United States, 1999-2008
    Jennifer Drahos
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, United States of America
    PLoS ONE 8:e67913. 2013
    ..Leveraging the unique resource of National Program of Cancer Registries (NPCR)-SEER, we assessed whether regional rates and trends of esophageal cancer significantly deviated from national estimates...
  44. ncbi request reprint Effects of estrogen receptor expression and histopathology on annual hazard rates of death from breast cancer
    William F Anderson
    DHHS NIH NCI Division of Cancer Epidemiology and Genetics, Biostatistics Branch, EPS, Room 8036, 6120 Executive Blvd, Rockville, MD 20852 7244, USA
    Breast Cancer Res Treat 100:121-6. 2006
    ..We hypothesized that annual mortality rates from breast cancer after initial diagnosis (hazard rates) might also vary by ER and histopathology...
  45. doi request reprint Associations between genes in the one-carbon metabolism pathway and advanced colorectal adenoma risk in individuals with low folate intake
    Summer S Han
    1Epidemiology and Biostatistics Program, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    Cancer Epidemiol Biomarkers Prev 21:417-27. 2012
    ..Low dietary and circulating folate and polymorphic variation in this pathway are associated with increased risk of colorectal adenoma and cancer...
  46. pmc Telomere length is associated with disease severity and declines with age in dyskeratosis congenita
    Blanche P Alter
    Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD 20852 7231, USA
    Haematologica 97:353-9. 2012
    ..Dyskeratosis congenita is a cancer-prone bone marrow failure syndrome caused by aberrations in telomere biology...
  47. ncbi request reprint Prophylactic oophorectomy reduces breast cancer penetrance during prospective, long-term follow-up of BRCA1 mutation carriers
    Joan L Kramer
    Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Blvd, Room 7016, MSC 7231, Rockville, MD 20852, USA
    J Clin Oncol 23:8629-35. 2005
    ..Because prophylactic oophorectomy reduces breast cancer risk by approximately 50%, we hypothesized that population differences in oophorectomy prevalence might significantly influence breast cancer penetrance estimates...
  48. pmc Correlates of spontaneous clearance of hepatitis C virus among people with hemophilia
    Mingdong Zhang
    Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852, USA
    Blood 107:892-7. 2006
    ..These data highlight and clarify the importance of nongenetic determinants in spontaneous recovery from HCV infection...
  49. pmc Gender is an age-specific effect modifier for papillary cancers of the thyroid gland
    Briseis A Kilfoy
    National Cancer Institute, National Institutes of Health, Bethesda, MD 20852 7244, USA
    Cancer Epidemiol Biomarkers Prev 18:1092-100. 2009
    ..There are few known thyroid cancer risk factors except female gender, and the reasons for the increasing incidence and gender differences are unknown...
  50. pmc Divergent cancer pathways for early-onset and late-onset cutaneous malignant melanoma
    William F Anderson
    Biostatistics Branch, Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Institutes of Health, National Cancer Institute, Bethesda, Maryland 20892 7244, USA
    Cancer 115:4176-85. 2009
    ..However, numerous questions remain regarding the timing and/or age of exposure...
  51. pmc Incidence of breast cancer in the United States: current and future trends
    William F Anderson
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Biostatistics Branch, Executive Plaza South, Rm 8036, 6120 Executive Blvd, Bethesda, MD, USA
    J Natl Cancer Inst 103:1397-402. 2011
    ..Time trends provide important clues for cancer etiology and prevention; however, the observed trends of ER-positive and ER-negative breast cancers can be biased by missing ER data...
  52. pmc Trimodal age-specific incidence patterns for Burkitt lymphoma in the United States, 1973-2005
    Sam M Mbulaiteye
    Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics DCEG, National Cancer Institute, Bethesda, MD 20852, USA
    Int J Cancer 126:1732-9. 2010
    ..To our knowledge, tri/bimodal incidence patterns have not previously been reported for BL. Trimodal/bimodal BL suggests heterogeneity in etiology or biology of BL diagnosed at different ages in males and females...
  53. pmc Age-specific trends in incidence of noncardia gastric cancer in US adults
    William F Anderson
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20852, USA
    JAMA 303:1723-8. 2010
    ..For the last 50 years, overall age-standardized incidence rates for noncardia gastric cancer have steadily declined in most populations. However, overall rates are summary measures that may obscure important age-specific trends...
  54. pmc Ovarian cancer incidence trends in relation to changing patterns of menopausal hormone therapy use in the United States
    Hannah P Yang
    National Cancer Institute, Bethesda, MD, MD 20852, USA
    J Clin Oncol 31:2146-51. 2013
    ..Given that MHT use is also associated with increased ovarian cancer risk, we tested whether ovarian cancer incidence rates changed after 2002...
  55. pmc An analysis of growth, differentiation and apoptosis genes with risk of renal cancer
    Linda M Dong
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, United States of America
    PLoS ONE 4:e4895. 2009
    ..In conclusion, our evaluation has identified common genetic variants in CASP1, CASP5, EGFR, and IGFBP3 that could be associated with renal cancer risk...
  56. pmc Comprehensive evaluation of one-carbon metabolism pathway gene variants and renal cell cancer risk
    Todd M Gibson
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, United States of America
    PLoS ONE 6:e26165. 2011
    ..Variation in one-carbon metabolism genes, particularly MTHFR, has been associated with risk of a number of cancers in epidemiologic studies, but little is known regarding renal cancer...
  57. ncbi request reprint Prostaglandin-endoperoxide synthase 2 (PTGS2) gene polymorphisms and risk of biliary tract cancer and gallstones: a population-based study in Shanghai, China
    Lori C Sakoda
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 7234, USA
    Carcinogenesis 27:1251-6. 2006
    ..Further investigation is needed to confirm and extend our findings in studies of biliary tract cancer that more comprehensively examine PTGS2 and other inflammation-related genes...
  58. ncbi request reprint Cancer incidence in Denmark following exposure to poliovirus vaccine contaminated with simian virus 40
    Eric A Engels
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD 20892, USA
    J Natl Cancer Inst 95:532-9. 2003
    ..To clarify whether SV40 infection increases risk of these cancers or of cancers arising in children, we examined cancer incidence in three Danish birth cohorts...
  59. doi request reprint Estimation of the prevalence of Fanconi anemia among patients with de novo acute myelogenous leukemia who have poor recovery from chemotherapy
    Andrzej Rochowski
    Center for Cancer and Blood Disorders, Children s National Medical Center, Washington, DC, USA
    Leuk Res 36:29-31. 2012
    ..18%, and around 0.83% in the subset who had poor marrow recovery. We suggest that FA or other inherited bone marrow failure syndromes be considered prior to treatment, or certainly among those with poor recovery...
  60. pmc PGA: power calculator for case-control genetic association analyses
    Idan Menashe
    Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institute of Health, Department of Health and Human Services, Rockville, MD, USA
    BMC Genet 9:36. 2008
    ..Statistical power calculations inform the design and interpretation of genetic association studies, but few programs are tailored to case-control studies of single nucleotide polymorphisms (SNPs) in unrelated subjects...
  61. pmc Clinical and molecular features associated with biallelic mutations in FANCD1/BRCA2
    Blanche P Alter
    Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Executive Plaza South, Room 7020, Rockville, MD 20852 7231, USA
    J Med Genet 44:1-9. 2007
    ..Several of the alleles were not associated with cancer in presumed carriers, and thus counselling presents more uncertainties than usual...
  62. ncbi request reprint Assessing uncertainty in reference intervals via tolerance intervals: application to a mixed model describing HIV infection
    Hormuzd A Katki
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS 6120 Executive Blvd, Rockville, MD 20852 4910, USA
    Stat Med 24:3185-98. 2005
    ..The Bayesian formulation naturally overcomes some important limitations of the likelihood model...
  63. doi request reprint Hairy cell leukaemia: a heterogeneous disease?
    Graca M Dores
    Department of Veterans Affairs Medical Center, Oklahoma City, OK 73104, USA
    Br J Haematol 142:45-51. 2008
    ..Distinct early- and late-onset HCL populations may reflect different age-related causal pathways, risk factor profiles, and/or stem cells of origin...
  64. pmc Declining incidence of contralateral breast cancer in the United States from 1975 to 2006
    Hazel B Nichols
    Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    J Clin Oncol 29:1564-9. 2011
    ..Contralateral breast cancer (CBC) is the most frequent new malignancy among women diagnosed with a first breast cancer. Although temporal trends for first breast cancers have been well studied, trends for CBC are not so well established...
  65. ncbi request reprint Quantifying epidemiologic risk factors using non-parametric regression: model selection remains the greatest challenge
    Philip S Rosenberg
    National Cancer Institute, Division of Cancer Epidemiology and Genetics, Biostatistics Branch, 6120 Executive Boulevard, EPS 7006, Rockville, MD 20852, USA
    Stat Med 22:3369-81. 2003
    ..Nonetheless, the semi-parametric approach appears to be a practical advance...
  66. ncbi request reprint Effects of CCR5-Delta32 and CCR2-64I alleles on HIV-1 disease progression: the protection varies with duration of infection
    Stephanie A Mulherin
    Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH DHHS, 6120 Executive Boulevard, Rockville, MD 20852, USA
    AIDS 17:377-87. 2003
    ..To examine temporal variation in the effects of CCR5-Delta32 and CCR2-64I chemokine receptor gene polymorphisms on HIV-1 disease progression...
  67. pmc Constitutional cytogenetic analysis in men with hereditary testicular germ cell tumor: no evidence of disease-related abnormalities
    Christine M Mueller
    Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, 6120 Executive Boulevard, EPS 7101, Rockville, MD 20852 7231, USA
    Cancer Epidemiol Biomarkers Prev 16:2791-4. 2007
  68. pmc Human papillomavirus and rising oropharyngeal cancer incidence in the United States
    Anil K Chaturvedi
    National Cancer Institute, National Institutes of Health, 6120 Executive Blvd, EPS 7072, Rockville, MD 20852, USA
    J Clin Oncol 29:4294-301. 2011
    ..Recent increases in incidence and survival of oropharyngeal cancers in the United States have been attributed to human papillomavirus (HPV) infection, but empirical evidence is lacking...
  69. pmc Cancer in Noonan, Costello, cardiofaciocutaneous and LEOPARD syndromes
    Christian P Kratz
    Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, 6120 Executive Boulevard, EPS 7018, Rockville, MD 20892, USA
    Am J Med Genet C Semin Med Genet 157:83-9. 2011
    ..The cancers described in CFCS and NSML overlapped with those reported in NS and CS. Future epidemiologic studies will be required to confirm the described cancer spectrum and to estimate precise cancer risks...
  70. ncbi request reprint End-stage liver disease in persons with hemophilia and transfusion-associated infections
    James J Goedert
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA
    Blood 100:1584-9. 2002
    ..04-fold (95% CI, 1.03-1.06) per year of age. Thus, HIV is associated with a markedly increased risk of HCV-related ESLD for persons with hemophilia, particularly with HBV infection, low CD4(+) lymphocytes, or older age...
  71. ncbi request reprint Dietary fat and postmenopausal invasive breast cancer in the National Institutes of Health-AARP Diet and Health Study cohort
    Anne C M Thiebaut
    Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Executive Plaza South Rm 3033, Bethesda, MD 20892, USA
    J Natl Cancer Inst 99:451-62. 2007
    ..Although ecologic association and animal studies support a direct effect of dietary fat on the development of breast cancer, results of epidemiologic studies have been inconclusive...
  72. pmc Age-period-cohort models in cancer surveillance research: ready for prime time?
    Philip S Rosenberg
    Cancer Epidemiol Biomarkers Prev 20:1263-8. 2011
    ..We illustrate these principles by using invasive female breast cancer incidence in the United States, but these concepts apply equally well to other cancer sites for incidence or mortality...
  73. ncbi request reprint Granulocyte colony-stimulating factor and severe aplastic anemia
    Blanche P Alter
    Blood 109:4589; author reply 4589-90. 2007
  74. ncbi request reprint Effects of CCR5-delta32 and CCR2-64I alleles on disease progression of perinatally HIV-1-infected children: an international meta-analysis
    John P A Ioannidis
    Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    AIDS 17:1631-8. 2003
    ..Among perinatally infected children, the effects of certain alleles of the CCR5 and CCR2 genes on the rate of disease progression remain unclear. We addressed the effects of CCR5-delta32 and CCR2-64I in an international meta-analysis...
  75. ncbi request reprint Breast cancer mortality trends in the United States according to estrogen receptor status and age at diagnosis
    Ismail Jatoi
    Department of Surgery, National Naval Medical Center and Uniformed Services, University of the Health Sciences, Bethesda, MD 20814, USA
    J Clin Oncol 25:1683-90. 2007
    ..However, the efficacy of these modalities may depend on estrogen receptor (ER) expression and age. We therefore examined breast cancer mortality trends in the United States according to ER status and age...
  76. ncbi request reprint Cancer in Fanconi anemia
    Blanche P Alter
    Blood 101:2072. 2003
  77. ncbi request reprint Trends in U.S. pleural mesothelioma incidence rates following simian virus 40 contamination of early poliovirus vaccines
    Howard D Strickler
    Department of Epidemiology and Social Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Natl Cancer Inst 95:38-45. 2003
    ..We examined the relationship between SV40-contaminated poliovirus vaccine exposure and subsequent rates of pleural mesothelioma in the United States...
  78. ncbi request reprint Lineage-specific hematopoietic growth factors
    David C Dale
    N Engl J Med 355:526-7; author reply 527. 2006
  79. doi request reprint Qualitative age-interactions in breast cancer: a tale of two diseases?
    Ismail Jatoi
    Department of Surgery, National Naval Medical Center and The Uniformed Services University, Bethesda, MD 20889, USA
    Am J Clin Oncol 31:504-6. 2008
    ..Taken together, these qualitative age-interactions may indicate that early and late-onset breast cancers are different diseases, derived from different pathways...
  80. ncbi request reprint Commentary: meta-analysis of individual participants' data in genetic epidemiology
    John P A Ioannidis
    Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, and Ioannina Biomedical Research Institute, Foundation for Research and Technology Hellas, Ioannina, Greece
    Am J Epidemiol 156:204-10. 2002
    ..For questions that justify the required intensive effort, the MIPD method is a useful tool to help clarify the role of candidate genes in complex human diseases...