Research Topics
Genomes and Genes
Species | P S RosenbergSummaryAffiliation: National Institutes of Health Country: USA Publications
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Detail Information
Publications
Quantifying epidemiologic risk factors using non-parametric regression: model selection remains the greatest challengePhilip S Rosenberg
National Cancer Institute, Division of Cancer Epidemiology and Genetics, Biostatistics Branch, 6120 Executive Boulevard, EPS 7006, Rockville, MD 20852, USA
Stat Med 22:3369-81. 2003..Nonetheless, the semi-parametric approach appears to be a practical advance...- Trends in HIV incidence among young adults in the United StatesP S Rosenberg
Biostatistics Branch, National Cancer Institute, Bethesda, MD 20892, USA
JAMA 279:1894-9. 1998..Behaviors that result in potential exposure to human immunodeficiency virus (HIV) usually begin in adolescence or young adulthood, but trends in HIV incidence in young people remain unclear... - Zoster incidence in human immunodeficiency virus-infected hemophiliacs and homosexual men, 1984-1997. District of Columbia Gay Cohort Study. Multicenter Hemophilia Cohort StudyE A Engels
Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20822, USA
J Infect Dis 180:1784-9. 1999..During the 14 years of follow-up, zoster incidence declined 9% per year. This trend occurred despite decreasing CD4 cell counts and was unexplained by zidovudine or acyclovir use... - Plasma HIV viral load in patients with hemophilia and late-stage HIV disease: a measure of current immune suppression. Multicenter Hemophilia Cohort StudyE A Engels
Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20822, USA
Ann Intern Med 131:256-64. 1999..For patients infected with HIV, plasma HIV viral load in early disease predicts long-term prognosis. However, the implications of viral load measurements late in HIV disease are uncertain... - Kaposi's sarcoma and non-Hodgkin's lymphoma following the diagnosis of AIDS. Multistate AIDS/Cancer Match Study GroupR J Biggar
Viral Epidemiology, National Cancer Institute, Bethesda, MD, USA
Int J Cancer 68:754-8. 1996..In summary, the risk of KS following another AIDS-defining illness is strikingly high, more in white men than in black men, and the risks of KS and, especially, NHL appear to increase with time from AIDS... - Evidence for concurrent epidemics of human herpesvirus 8 and human immunodeficiency virus type 1 in US homosexual men: rates, risk factors, and relationship to Kaposi's sarcomaT R O'Brien
Viral Epidemiology Branch, National Cancer Institute, EPS 8016, Rockville, MD 20852, USA
J Infect Dis 180:1010-7. 1999..5 months). This study shows an epidemic of HHV-8 among US homosexual men in the early 1980s that was associated with a high risk of developing KS... - Estimating the cumulative incidence of HIV infection among persons with haemophilia in the United States of AmericaP S Rosenberg
National Cancer Institute, Rockville, MD 20852, USA
Stat Med 17:155-68. 1998..The consistency of back-calculation and cohort data in haemophiliacs supports the use of back-calculation to estimate prevalence in other populations... - Virus load and risk of heterosexual transmission of human immunodeficiency virus and hepatitis C virus by men with hemophilia. The Multicenter Hemophilia Cohort StudyM Hisada
Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852, USA
J Infect Dis 181:1475-8. 2000..001). However, much larger studies are needed to clearly show whether HIV/HCV coinfection significantly increases the risk of HCV transmission to female partners... 
Human epidermal growth factor receptor-2 and estrogen receptor expression, a demonstration project using the residual tissue repository of the Surveillance, Epidemiology, and End Results (SEER) programW F Anderson
NIH NCI DCEG, EPS Room 8036, 6120 Executive Blvd, Bethesda, MD 20852, USA
Breast Cancer Res Treat 113:189-96. 2009..To validate the utility of the RTR for supplementing SEER's central database, we assessed human epidermal growth factor receptor-2 (HER2) and estrogen receptor expression (ER) in a demonstration project...- Analysis of exposure-time-response relationships using a spline weight functionM Hauptmann
GSF National Research Center for Environment and Health, Institute of Epidemiology, Ingolstadter Landstrasse 1, 85764 Neuherberg, Germany
Biometrics 56:1105-8. 2000..The method is evaluated in a simulation study and is applied to data on smoking histories and lung cancer from a recent case-control study in Germany... - Cancers associated with Kaposi's sarcoma (KS) in AIDS: a link between KS herpesvirus and immunoblastic lymphomaE A Engels
Viral Epidemiology Branch and Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Rockville, MD, USA
Br J Cancer 85:1298-303. 2001..Our findings, and the previously demonstrated presence of KSHV in the histologically related primary effusion lymphoma, suggest that KSHV is involved in the pathogenesis of some immunoblastic lymphomas... - A case-control study reveals immunoregulatory gene haplotypes that influence inhibitor risk in severe haemophilia AJ N Lozier
Department of Laboratory Medicine, National Institutes of Health Clinical Center, Bethesda, MD, USA
Haemophilia 17:641-9. 2011..8, P = 0.004). We replicate previous findings for IL10; identify new associations with IL1, IL2 and IL12; and identify a rare FVIII haplotype in caucasians that is associated with increased inhibitor risk... - Estrogen replacement therapy and breast cancer survival in a large screening studyC Schairer
Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7374, USA
J Natl Cancer Inst 91:264-70. 1999..We examined breast cancer mortality among women who were diagnosed with axillary lymph node-negative and node-positive breast cancer according to the currency of estrogen use at diagnosis... - Trends in human immunodeficiency virus type 1 (HIV-1) load among HIV-1-infected children with hemophiliaE A Engels
Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20852, USA
J Infect Dis 184:364-8. 2001..In conclusion, those subjects had virus load trends similar to those in adults. Early virus loads were lower than those in vertically infected infants, which suggests that factors changing soon after birth affect viral replication... - Cancer in human immunodeficiency virus-infected children: a case series from the Children's Cancer Group and the National Cancer InstituteM O Granovsky
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
J Clin Oncol 16:1729-35. 1998..To describe the spectrum of malignancies in human immunodeficiency virus (HIV)-infected children and the clinical outcome of patients with these tumors... - Granulocyte colony-stimulating factor and severe aplastic anemiaBlanche P Alter
Blood 109:4589; author reply 4589-90. 2007 - Breast cancer mortality trends in the United States according to estrogen receptor status and age at diagnosisIsmail Jatoi
Department of Surgery, National Naval Medical Center and Uniformed Services, University of the Health Sciences, Bethesda, MD 20814, USA
J Clin Oncol 25:1683-90. 2007..However, the efficacy of these modalities may depend on estrogen receptor (ER) expression and age. We therefore examined breast cancer mortality trends in the United States according to ER status and age... - Reconstruction of the hepatitis C virus epidemic in the US hemophilia population, 1940-1990James J Goedert
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20852, USA
Am J Epidemiol 165:1443-53. 2007.... - Dietary fat and postmenopausal invasive breast cancer in the National Institutes of Health-AARP Diet and Health Study cohortAnne C M Thiebaut
Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Executive Plaza South Rm 3033, Bethesda, MD 20892, USA
J Natl Cancer Inst 99:451-62. 2007..Although ecologic association and animal studies support a direct effect of dietary fat on the development of breast cancer, results of epidemiologic studies have been inconclusive... - Estimating age-specific breast cancer risks: a descriptive tool to identify age interactionsWilliam F Anderson
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institute of Health, Executive Plaza South 8070, 6120 Executive Plaza Blvd, Rockville, MD 20892 7242, USA
Cancer Causes Control 18:439-47. 2007..Clarifying age-specific female breast cancer risks and interactions may provide important etiologic clues... - Lineage-specific hematopoietic growth factorsDavid C Dale
N Engl J Med 355:526-7; author reply 527. 2006 - Competing risks analysis of correlated failure time dataBingshu E Chen
Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852, USA
Biometrics 64:172-9. 2008..For women with BRCA1 mutations, we estimate the cumulative incidence of breast cancer in the presence of competing mortality from ovarian cancer, accounting for significant within-family correlation... - Selected base excision repair gene polymorphisms and susceptibility to biliary tract cancer and biliary stones: a population-based case-control study in ChinaWen Yi Huang
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
Carcinogenesis 29:100-5. 2008..This study suggests that genetic variants in XRCC1 and APEX1 may alter susceptibility to biliary tract cancer and stones. Further studies are required to confirm the reported associations... - Neutrophil elastase mutations and risk of leukaemia in severe congenital neutropeniaPhilip S Rosenberg
Biostatistics Branch, Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Rockville, MD, USA
Br J Haematol 140:210-3. 2008..96). Patients with either mutant or wild-type ELA2 should be followed closely for leukaemic transformation... - Constitutional cytogenetic analysis in men with hereditary testicular germ cell tumor: no evidence of disease-related abnormalitiesChristine M Mueller
Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, 6120 Executive Boulevard, EPS 7101, Rockville, MD 20852-7231, USA
Cancer Epidemiol Biomarkers Prev 16:2791-4. 2007 - Correlates of spontaneous clearance of hepatitis C virus among people with hemophiliaMingdong Zhang
Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852, USA
Blood 107:892-7. 2006..These data highlight and clarify the importance of nongenetic determinants in spontaneous recovery from HCV infection... 
Cancer risks in Fanconi anemia: findings from the German Fanconi Anemia RegistryPhilip S Rosenberg
Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Executive Plaza South, Room 8022, Rockville 20852 7244 USA
Haematologica 93:511-7. 2008..Prior epidemiological studies have quantified the risks of bone marrow failure, acute myeloid leukemia and solid tumors, but these estimates have not been replicated...- Polymorphism of genes related to insulin sensitivity and the risk of biliary tract cancer and biliary stone: a population-based case-control study in Shanghai, ChinaShih Chen Chang
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, Bethesda, MD 20892, USA
Carcinogenesis 29:944-8. 2008..Results from this population-based study suggest that certain genetic variants involved in the regulation of obesity-related insulin sensitivity may increase susceptibility to bile duct cancer and gallstones... - PGA: power calculator for case-control genetic association analysesIdan Menashe
Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institute of Health, Department of Health and Human Services, Rockville, MD, USA
BMC Genet 9:36. 2008..Statistical power calculations inform the design and interpretation of genetic association studies, but few programs are tailored to case-control studies of single nucleotide polymorphisms (SNPs) in unrelated subjects... - Variants in inflammation genes and the risk of biliary tract cancers and stones: a population-based study in ChinaAnn W Hsing
Division of Cancer Epidemiology and Genetics and Office of Preventive Oncology, National Cancer Institute, NIH, Bethesda, Maryland 20892 7234, USA
Cancer Res 68:6442-52. 2008.... - Clinical and molecular features associated with biallelic mutations in FANCD1/BRCA2Blanche P Alter
Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Executive Plaza South, Room 7020, Rockville, MD 20852 7231, USA
J Med Genet 44:1-9. 2007..Several of the alleles were not associated with cancer in presumed carriers, and thus counselling presents more uncertainties than usual... - Resampling-based multiple hypothesis testing procedures for genetic case-control association studiesBingshu E Chen
Biostatistics Branch, Department of Health and Human Services, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, Maryland 20852 7244, USA
Genet Epidemiol 30:495-507. 2006.... - Effects of estrogen receptor expression and histopathology on annual hazard rates of death from breast cancerWilliam F Anderson
DHHS NIH NCI Division of Cancer Epidemiology and Genetics, Biostatistics Branch, EPS, Room 8036, 6120 Executive Blvd, Rockville, MD 20852 7244, USA
Breast Cancer Res Treat 100:121-6. 2006..We hypothesized that annual mortality rates from breast cancer after initial diagnosis (hazard rates) might also vary by ER and histopathology... - End-stage liver disease in persons with hemophilia and transfusion-associated infectionsJames J Goedert
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA
Blood 100:1584-9. 2002..04-fold (95% CI, 1.03-1.06) per year of age. Thus, HIV is associated with a markedly increased risk of HCV-related ESLD for persons with hemophilia, particularly with HBV infection, low CD4(+) lymphocytes, or older age... - Cancer incidence in persons with Fanconi anemiaPhilip S Rosenberg
Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
Blood 101:822-6. 2003..The risk of a solid tumor may become even higher as death from aplastic anemia is reduced and as patients survive longer after BMT... - Trends in U.S. pleural mesothelioma incidence rates following simian virus 40 contamination of early poliovirus vaccinesHoward D Strickler
Department of Epidemiology and Social Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
J Natl Cancer Inst 95:38-45. 2003..We examined the relationship between SV40-contaminated poliovirus vaccine exposure and subsequent rates of pleural mesothelioma in the United States... - Effects of CCR5-Delta32 and CCR2-64I alleles on HIV-1 disease progression: the protection varies with duration of infectionStephanie A Mulherin
Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH DHHS, 6120 Executive Boulevard, Rockville, MD 20852, USA
AIDS 17:377-87. 2003..To examine temporal variation in the effects of CCR5-Delta32 and CCR2-64I chemokine receptor gene polymorphisms on HIV-1 disease progression... - Cancer in Fanconi anemiaBlanche P Alter
Blood 101:2072. 2003 - Cancer incidence in Denmark following exposure to poliovirus vaccine contaminated with simian virus 40Eric A Engels
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD 20892, USA
J Natl Cancer Inst 95:532-9. 2003..To clarify whether SV40 infection increases risk of these cancers or of cancers arising in children, we examined cancer incidence in three Danish birth cohorts... - Effects of CCR5-delta32 and CCR2-64I alleles on disease progression of perinatally HIV-1-infected children: an international meta-analysisJohn P A Ioannidis
Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
AIDS 17:1631-8. 2003..Among perinatally infected children, the effects of certain alleles of the CCR5 and CCR2 genes on the rate of disease progression remain unclear. We addressed the effects of CCR5-delta32 and CCR2-64I in an international meta-analysis... - Individualized risks of first adverse events in patients with Fanconi anemiaPhilip S Rosenberg
Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Executive Plaza South, Rm 7006, Rockville, MD 20852 7244, USA
Blood 104:350-5. 2004..6% to 29% in the highest and lowest BMF risk groups, respectively. Abnormal radii are the strongest predictor of early BMF in FA; a congenital abnormality score separates patients with normal radii into distinct prognostic groups... - Risk of head and neck squamous cell cancer and death in patients with Fanconi anemia who did and did not receive transplantsPhilip S Rosenberg
Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20852 7244, USA
Blood 105:67-73. 2005..13% per month (1.6% per year) after the first year. Acute and chronic graft-versus-host diseases were significant SCC risk factors. Adverse event rates in these cohorts provide historical control rates to assess emerging therapies for FA... - Secular trends in outcomes for Fanconi anemia patients who receive transplants: implications for future studiesPhilip S Rosenberg
Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20852, USA
Biol Blood Marrow Transplant 11:672-9. 2005..To demonstrate further advances in survival, transplant centers may need to coordinate their protocols and engage in multicenter collaborative studies... - Assessing uncertainty in reference intervals via tolerance intervals: application to a mixed model describing HIV infectionHormuzd A Katki
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS 6120 Executive Blvd, Rockville, MD 20852 4910, USA
Stat Med 24:3185-98. 2005..The Bayesian formulation naturally overcomes some important limitations of the likelihood model... - Multiple hypothesis testing strategies for genetic case-control association studiesPhilip S Rosenberg
Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD 20852 7244, USA
Stat Med 25:3134-49. 2006..Multiple testing balances the desire for statistical power against the implicit costs of false positive results, which up to now appear to be common in the literature... - Prophylactic oophorectomy reduces breast cancer penetrance during prospective, long-term follow-up of BRCA1 mutation carriersJoan L Kramer
Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Blvd, Room 7016, MSC 7231, Rockville, MD 20852, USA
J Clin Oncol 23:8629-35. 2005..Because prophylactic oophorectomy reduces breast cancer risk by approximately 50%, we hypothesized that population differences in oophorectomy prevalence might significantly influence breast cancer penetrance estimates... - Prostaglandin-endoperoxide synthase 2 (PTGS2) gene polymorphisms and risk of biliary tract cancer and gallstones: a population-based study in Shanghai, ChinaLori C Sakoda
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 7234, USA
Carcinogenesis 27:1251-6. 2006..Further investigation is needed to confirm and extend our findings in studies of biliary tract cancer that more comprehensively examine PTGS2 and other inflammation-related genes... - The incidence of leukemia and mortality from sepsis in patients with severe congenital neutropenia receiving long-term G-CSF therapyPhilip S Rosenberg
Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20852 7244, USA
Blood 107:4628-35. 2006..Risk of MDS/AML may be similar in SDS and SCN. In less-responsive SCN patients, early hematopoietic stem cell transplantation may be a rational option... - Qualitative age-interactions in breast cancer: a tale of two diseases?Ismail Jatoi
Department of Surgery, National Naval Medical Center and The Uniformed Services University, Bethesda, MD 20889, USA
Am J Clin Oncol 31:504-6. 2008..Taken together, these qualitative age-interactions may indicate that early and late-onset breast cancers are different diseases, derived from different pathways... - Commentary: meta-analysis of individual participants' data in genetic epidemiologyJohn P A Ioannidis
Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, and Ioannina Biomedical Research Institute, Foundation for Research and Technology-Hellas, Ioannina, Greece
Am J Epidemiol 156:204-10. 2002..For questions that justify the required intensive effort, the MIPD method is a useful tool to help clarify the role of candidate genes in complex human diseases...