H F Rosenberg

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. doi request reprint Eosinophils: changing perspectives in health and disease
    Helene F Rosenberg
    Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Rev Immunol 13:9-22. 2013
  2. pmc Inflammatory responses to respiratory syncytial virus (RSV) infection and the development of immunomodulatory pharmacotherapeutics
    H F Rosenberg
    Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Curr Med Chem 19:1424-31. 2012
  3. pmc Genetic diversity of human RNase 8
    Calvin C Chan
    Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    BMC Genomics 13:40. 2012
  4. pmc Inflammatory responses to acute pneumovirus infection in neonatal mice
    Cynthia A Bonville
    Department of Pediatrics, SUNY Upstate Medical University, Syracuse, NY, USA
    Virol J 7:320. 2010
  5. pmc Efficient replication of pneumonia virus of mice (PVM) in a mouse macrophage cell line
    Kimberly D Dyer
    Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Virol J 4:48. 2007
  6. pmc Early-life viral infection and allergen exposure interact to induce an asthmatic phenotype in mice
    Jessica S Siegle
    Department of Pathology, University of New South Wales, Sydney, NSW, Australia
    Respir Res 11:14. 2010
  7. pmc Interferon-gamma coordinates CCL3-mediated neutrophil recruitment in vivo
    Cynthia A Bonville
    SUNY Upstate Medical University, Syracuse, New York 13210, USA
    BMC Immunol 10:14. 2009
  8. pmc Eosinophils and their interactions with respiratory virus pathogens
    Helene F Rosenberg
    Eosinophil Biology Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 10, Room 11C215, Bethesda, MD 20892, USA
    Immunol Res 43:128-37. 2009
  9. pmc Respiratory viruses and eosinophils: exploring the connections
    Helene F Rosenberg
    Eosinophil Biology Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Antiviral Res 83:1-9. 2009
  10. pmc HMGB1, a novel biomarker of inflammatory demyelinating disease: an interview with Dr. Robert A. Harris
    Helene F Rosenberg
    Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, USA
    J Leukoc Biol 84:1256-8. 2008

Detail Information

Publications87

  1. doi request reprint Eosinophils: changing perspectives in health and disease
    Helene F Rosenberg
    Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Rev Immunol 13:9-22. 2013
    ....
  2. pmc Inflammatory responses to respiratory syncytial virus (RSV) infection and the development of immunomodulatory pharmacotherapeutics
    H F Rosenberg
    Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Curr Med Chem 19:1424-31. 2012
    ..From this perspective, we consider the case for specific immunomodulatory strategies that may have the potential to alleviate some of the more serious sequelae of this disease...
  3. pmc Genetic diversity of human RNase 8
    Calvin C Chan
    Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    BMC Genomics 13:40. 2012
    ....
  4. pmc Inflammatory responses to acute pneumovirus infection in neonatal mice
    Cynthia A Bonville
    Department of Pediatrics, SUNY Upstate Medical University, Syracuse, NY, USA
    Virol J 7:320. 2010
    ....
  5. pmc Efficient replication of pneumonia virus of mice (PVM) in a mouse macrophage cell line
    Kimberly D Dyer
    Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Virol J 4:48. 2007
    ....
  6. pmc Early-life viral infection and allergen exposure interact to induce an asthmatic phenotype in mice
    Jessica S Siegle
    Department of Pathology, University of New South Wales, Sydney, NSW, Australia
    Respir Res 11:14. 2010
    ..The purpose of this study was to assess whether early-life infection with a species-specific model of RSV and subsequent allergen exposure predisposed to the development of features of asthma...
  7. pmc Interferon-gamma coordinates CCL3-mediated neutrophil recruitment in vivo
    Cynthia A Bonville
    SUNY Upstate Medical University, Syracuse, New York 13210, USA
    BMC Immunol 10:14. 2009
    ....
  8. pmc Eosinophils and their interactions with respiratory virus pathogens
    Helene F Rosenberg
    Eosinophil Biology Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 10, Room 11C215, Bethesda, MD 20892, USA
    Immunol Res 43:128-37. 2009
    ..Interestingly, PVM replicates in eosinophils and promotes cytokine release. The molecular basis of virus infection in eosinophils and its relationship to disease outcome is currently under study...
  9. pmc Respiratory viruses and eosinophils: exploring the connections
    Helene F Rosenberg
    Eosinophil Biology Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Antiviral Res 83:1-9. 2009
    ..Lastly, we consider the data that focus on the role of eosinophils in promoting virus clearance and antiviral host defense, and conclude with a recent study that explores the role of eosinophils themselves as targets of virus infection...
  10. pmc HMGB1, a novel biomarker of inflammatory demyelinating disease: an interview with Dr. Robert A. Harris
    Helene F Rosenberg
    Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, USA
    J Leukoc Biol 84:1256-8. 2008
  11. pmc Eosinophil-derived neurotoxin / RNase 2: connecting the past, the present and the future
    H F Rosenberg
    Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Curr Pharm Biotechnol 9:135-40. 2008
    ....
  12. pmc Pneumonia virus of mice: severe respiratory infection in a natural host
    Helene F Rosenberg
    Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA
    Immunol Lett 118:6-12. 2008
    ....
  13. pmc RNase A ribonucleases and host defense: an evolving story
    Helene F Rosenberg
    Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    J Leukoc Biol 83:1079-87. 2008
    ..The properties of individual RNase A ribonucleases, recent experimental findings, and important questions for the near and distant future will be reviewed...
  14. ncbi request reprint Eosinophil trafficking in allergy and asthma
    Helene F Rosenberg
    Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Allergy Clin Immunol 119:1303-10; quiz 1311-2. 2007
    ....
  15. ncbi request reprint The pneumonia virus of mice infection model for severe respiratory syncytial virus infection: identifying novel targets for therapeutic intervention
    Helene F Rosenberg
    Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Pharmacol Ther 105:1-6. 2005
    ..Ongoing exploration into the biology of PVM infection will identify other pathways and targets to be exploited for immunomodulatory control of hRSV and related severe respiratory virus infections...
  16. ncbi request reprint Eosinophils, eosinophil ribonucleases, and their role in host defense against respiratory virus pathogens
    H F Rosenberg
    Eosinophil Biology Unit, Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Leukoc Biol 70:691-8. 2001
    ....
  17. pmc Sequence variation at two eosinophil-associated ribonuclease loci in humans
    J Zhang
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Genetics 156:1949-58. 2000
    ....
  18. ncbi request reprint Rapid evolution of the ribonuclease A superfamily: adaptive expansion of independent gene clusters in rats and mice
    N A Singhania
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 10 Bethesda, MD 20892, USA
    J Mol Evol 49:721-8. 1999
    ....
  19. ncbi request reprint Eosinophils, ribonucleases and host defense: solving the puzzle
    H F Rosenberg
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Immunol Res 20:261-74. 1999
    ..The results of this work have led us to consider the possibility that the EDN/ECP ribonucleases represent a heretofore unrecognized element of innate and specific antiviral host defense...
  20. ncbi request reprint Gene structure and enzymatic activity of mouse eosinophil-associated ribonuclease 2
    A L McDevitt
    Eosinophil Biology Unit, Laboratory of Host Defenses 10 11N104, NIAID National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892 1886, USA
    Gene 267:23-30. 2001
    ..Sequence analysis of the non-coding regions and enzymatic characterization of the gene product provide further evidence indicating that mEAR-2 is a structural and functional ortholog of primate EDNs and ECPs...
  21. ncbi request reprint Characterization of the divergent eosinophil ribonuclease, mEar 6, and its expression in response to Schistosoma mansoni infection in vivo
    T Nitto
    Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 10, Room 11N104, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Genes Immun 5:668-74. 2004
    ..In summary, we have identified mEar 6 as one of only two RNase A superfamily ribonucleases known to be expressed specifically in response to pathophysiologic stress in vivo...
  22. ncbi request reprint Interleukin-5 does not influence differential transcription of transmembrane and soluble isoforms of IL-5R alpha in vivo
    Jonas Bystrom
    Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1883, USA
    Eur J Haematol 77:181-90. 2006
    ..Two variants encoding soluble forms of the alpha subunit (sIL-5R alpha) have been described, although the signals promoting and/or limiting differential transcription remain to be clarified...
  23. pmc Evolution of the rodent eosinophil-associated RNase gene family by rapid gene sorting and positive selection
    J Zhang
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 97:4701-6. 2000
    ..The discovery of a large number of divergent EARs suggests the intriguing possibility that these proteins have been specifically tailored to fight against distinct rodent pathogens...
  24. ncbi request reprint Rapid diversification of RNase A superfamily ribonucleases from the bullfrog, Rana catesbeiana
    H F Rosenberg
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Mol Evol 53:31-8. 2001
    ....
  25. ncbi request reprint Inflammatory responses to pneumovirus infection in IFN-alpha beta R gene-deleted mice
    Tara L Garvey
    Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 175:4735-44. 2005
    ....
  26. pmc Pulmonary eosinophils and their role in immunopathologic responses to formalin-inactivated pneumonia virus of mice
    Caroline M Percopo
    Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 183:604-12. 2009
    ..However, levels of both IL-4 and CCL3 (macrophage inflammatory protein-1alpha) in bronchoalveolar lavage fluid were markedly diminished in PVM Ag-vaccinated, PVM-infected eosinophil-deficient mice when compared with wild-type controls...
  27. pmc Diversity among the primate eosinophil-derived neurotoxin genes: a specific C-terminal sequence is necessary for enhanced ribonuclease activity
    H F Rosenberg
    Laboratory of Host Defenses, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Nucleic Acids Res 25:3532-6. 1997
    ....
  28. ncbi request reprint Ribonuclease k6: chromosomal mapping and divergent rates of evolution within the RNase A gene superfamily
    M S Deming
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Genome Res 8:599-607. 1998
    ..The sequence data described in this paper have been submitted to the GenBank data library under accession nos. AF037081-AF037090.]..
  29. ncbi request reprint Diminished expression of an antiviral ribonuclease in response to pneumovirus infection in vivo
    Joanne M Moreau
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 10, Room 11N104, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Antiviral Res 59:181-91. 2003
    ..We propose that this mechanism may represent a novel virus-mediated evasion strategy, with a mechanism that is linked in some fashion to virus-specific pathogenicity...
  30. ncbi request reprint Evolution and function of leukocyte RNase A ribonucleases of the avian species, Gallus gallus
    Takeaki Nitto
    Laboratory of Allergic Diseases and Research Technologies Branch, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 281:25622-34. 2006
    ....
  31. ncbi request reprint The RNase a superfamily: generation of diversity and innate host defense
    Kimberly D Dyer
    Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Divers 10:585-97. 2006
    ..190 words)...
  32. pmc Schistosoma mansoni infection in eosinophil lineage-ablated mice
    Jonathan M Swartz
    Laboratory of Allergic Diseases, NIAID, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892 1883, USA
    Blood 108:2420-7. 2006
    ..However, eosinophils may have unexplored immunomodulatory contributions to this disease process...
  33. pmc Molecular cloning of four novel murine ribonuclease genes: unusual expansion within the ribonuclease A gene family
    D Batten
    The Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Nucleic Acids Res 25:4235-9. 1997
    ..Although the nature of the evolutionary constraints promoting this unusual expansion and diversification remain unclear, the implications with respect to function are intriguing...
  34. ncbi request reprint Suppression of HIV-1 transcription by beta-chemokines RANTES, MIP1-alpha, and MIP-1beta is not mediated by the NFAT-1 enhancer element
    J S Handen
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    FEBS Lett 410:301-2. 1997
    ....
  35. ncbi request reprint Transcriptional regulation of galectin-10 (eosinophil Charcot-Leyden crystal protein): a GC box (-44 to -50) controls butyric acid induction of gene expression
    K D Dyer
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Life Sci 69:201-12. 2001
    ..Additionally, we demonstrate AML3 binding to the consensus AML site and YY1 binding to the Inr sequence, both elements functioning as silencers in the gal-10 promoter...
  36. pmc Localized eosinophil degranulation mediates disease in tropical pulmonary eosinophilia
    Laura O'Bryan
    National Institutes of Health, Bethesda, Maryland, USA
    Infect Immun 71:1337-42. 2003
    ..02). These data suggest it is the eosinophilic granular protein EDN, an RNase capable of damaging the lung epithelium, that plays the most important role in the pathogenesis of TPE...
  37. pmc Molecular cloning and characterization of a novel human ribonuclease (RNase k6): increasing diversity in the enlarging ribonuclease gene family
    H F Rosenberg
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Nucleic Acids Res 24:3507-13. 1996
    ..The identification and characterization of RNase k6 has extended the ribonuclease gene family and suggests the possibility that there are others awaiting discovery...
  38. ncbi request reprint Ribonucleases and host defense: identification, localization and gene expression in adherent monocytes in vitro
    A Egesten
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Biochim Biophys Acta 1358:255-60. 1997
    ..Interestingly, mRNA encoding RNase 4 could not be detected in freshly isolated monocytes, emerging only after 16 h in culture, suggesting the possibility of de novo protein synthesis in association with monocyte differentiation...
  39. pmc Eosinophil-derived neurotoxin acts as an alarmin to activate the TLR2-MyD88 signal pathway in dendritic cells and enhances Th2 immune responses
    De Yang
    Basic Research Program, SAIC Frederick, Inc, MD, USA
    J Exp Med 205:79-90. 2008
    ....
  40. ncbi request reprint Eosinophil-derived neurotoxin (EDN), an antimicrobial protein with chemotactic activities for dendritic cells
    De Yang
    Basic Research Program, SAIC Frederick, Laboratory of Molecular Regulation, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bldg 560, Rm 31 19, Frederick, MD 21702 1201, USA
    Blood 102:3396-403. 2003
    ..Thus, EDN and its mouse ortholog, mEAR2, are eosinophil granule-derived antimicrobial RNases that function as chemoattractants for DCs in vitro and in vivo...
  41. ncbi request reprint The eosinophil ribonucleases
    H F Rosenberg
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Cell Mol Life Sci 54:795-803. 1998
    ..The biochemistry and physiology of EDN, ECP and the recently discovered ribonuclease k6 (RNase 6) will be reviewed in this chapter...
  42. pmc Mouse and human eosinophils degranulate in response to platelet-activating factor (PAF) and lysoPAF via a PAF-receptor-independent mechanism: evidence for a novel receptor
    Kimberly D Dyer
    Section of Eosinophil Biology, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1883, USA
    J Immunol 184:6327-34. 2010
    ....
  43. pmc Functionally competent eosinophils differentiated ex vivo in high purity from normal mouse bone marrow
    Kimberly D Dyer
    Eosinophil Biology Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 181:4004-9. 2008
    ..Finally, differentiating bmEos are readily transfected with lentiviral vectors, suggesting a means for rapid production of genetically manipulated cells...
  44. pmc Multisystemic eosinophilia resembling hypereosinophilic syndrome in a colony-bred owl monkey (Aotus vociferans)
    Alfonso S Gozalo
    Comparative Medicine Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    J Am Assoc Lab Anim Sci 48:303-6. 2009
    ..To our knowledge, this report is the first description of presumptive hypereosinophilic syndrome in a nonhuman primate...
  45. pmc Pneumoviruses infect eosinophils and elicit MyD88-dependent release of chemoattractant cytokines and interleukin-6
    Kimberly D Dyer
    Eosinophil Biology Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health NIH, Bethesda, MD, USA
    Blood 114:2649-56. 2009
    ..Taken together, our findings suggest that eosinophils are targets of virus infection and may have varied and complex contributions to the pathogenesis and resolution of pneumovirus disease...
  46. ncbi request reprint Eosinophils from lineage-ablated Delta dblGATA bone marrow progenitors: the dblGATA enhancer in the promoter of GATA-1 is not essential for differentiation ex vivo
    Kimberly D Dyer
    Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases National Institutes of Health NIAID NIH, Bethesda, MD 20892, USA
    J Immunol 179:1693-9. 2007
    ....
  47. pmc Complementary advantageous substitutions in the evolution of an antiviral RNase of higher primates
    Jianzhi Zhang
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 99:5486-91. 2002
    ..Overall, our study illustrates the power of the "paleomolecular biochemistry" approach in delineating the complex interplays of amino acid substitutions in evolution and in identifying the molecular basis of biological innovation...
  48. ncbi request reprint Identification of a purine-rich intronic enhancer element in the mouse eosinophil-associated ribonuclease 2 (mEar 2) gene
    Kimberly D Dyer
    Eosinophil Pathophysiology Section, LHD, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mamm Genome 15:126-34. 2004
    ..Similar intronic enhancers have been described as regulating transcription of the human EDN gene, suggesting an overall conservation of an important regulatory strategy...
  49. ncbi request reprint Gene microarray analysis reveals interleukin-5-dependent transcriptional targets in mouse bone marrow
    Jonas Bystrom
    NIAID, NIH, Bldg 10, Rm 11N104, 9000 Rockville Pike, Bethesda, MD, 20892, USA
    Blood 103:868-77. 2004
    ....
  50. ncbi request reprint Isolation, characterization, and evolutionary divergence of mouse RNase 6: evidence for unusual evolution in rodents
    Kimberly D Dyer
    Eosinophil Biology Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Mol Evol 59:657-65. 2004
    ..66. These data suggest that the ancestral rodent RNase 6 was subject to accelerated evolution, resulting in the conserved modern gene, which most likely plays an important role in mouse physiology...
  51. pmc The mouse RNase 4 and RNase 5/ang 1 locus utilizes dual promoters for tissue-specific expression
    Kimberly D Dyer
    Laboratory of Allergic Diseases NIAID, NIH, Bethesda, MD 20892, USA
    Nucleic Acids Res 33:1077-86. 2005
    ....
  52. ncbi request reprint Characterization of a ribonuclease gene and encoded protein from the reptile, Iguana iguana
    Takeaki Nitto
    Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, United States
    Gene 352:36-44. 2005
    ..Further analysis of ribonucleases from non-mammalian vertebrate species is needed in order to define relationships and lineages within the larger RNase A gene superfamily...
  53. ncbi request reprint Adaptive evolution of a duplicated pancreatic ribonuclease gene in a leaf-eating monkey
    Jianzhi Zhang
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Nat Genet 30:411-5. 2002
    ..Our findings demonstrate the contribution of gene duplication to organismal adaptation and show the power of combining sequence analysis and functional assays in delineating the molecular basis of adaptive evolution...
  54. ncbi request reprint The gene for familial Mediterranean fever, MEFV, is expressed in early leukocyte development and is regulated in response to inflammatory mediators
    M Centola
    Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Instiutes of Health, Bethesda, MD 20892 1820, USA
    Blood 95:3223-31. 2000
    ..These results refine understanding of MEFV by placing the gene in the myelomonocytic-specific proinflammatory pathway and identifying it as an IFN-gamma immediate early gene...
  55. pmc Human ribonuclease 4 (RNase 4): coding sequence, chromosomal localization and identification of two distinct transcripts in human somatic tissues
    H F Rosenberg
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Nucleic Acids Res 23:4290-5. 1995
    ....
  56. pmc GATA transcription factors regulate the expression of the human eosinophil-derived neurotoxin (RNase 2) gene
    Zhijun Qiu
    Laboratory of Allergic Diseases, NIAID, NIH, Bethesda, MD 20892, USA
    J Biol Chem 284:13099-109. 2009
    ..Taken together, our data suggest that GATA-2 functions directly via interactions with the EDN promoter and also indirectly, via its ability to regulate the expression of GATA-1 in differentiating eosinophils and eosinophil cell lines...
  57. pmc RNase 1 genes from the family Sciuridae define a novel rodent ribonuclease cluster
    Steven J Siegel
    Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA
    Mamm Genome 20:749-57. 2009
    ..The full significance of these findings awaits a more complete understanding of biological role of mammalian RNase 1s...
  58. pmc Interleukin-5 (IL-5) augments the progression of liver fibrosis by regulating IL-13 activity
    Rachael M Reiman
    Immunopathogenesis, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 8003, USA
    Infect Immun 74:1471-9. 2006
    ..Thus, inhibiting the activity of IL-5 or eosinophils may prove effective for a variety of chronic fibrotic diseases...
  59. ncbi request reprint Rapid evolution of a unique family of primate ribonuclease genes
    H F Rosenberg
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Genet 10:219-23. 1995
    ..These results suggest that both EDN and ECP may be responding to unusual evolutionary constraints, which has prompted a reexamination of their physiologic function...
  60. ncbi request reprint The genomic structure of the human Charcot-Leyden crystal protein gene is analogous to those of the galectin genes
    K D Dyer
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Genomics 40:217-21. 1997
    ..The most likely interpretation of these results suggest the occurrence of one or more exon duplication and insertion events, resulting in the distribution of this lectin domain to CLC as well as to the multiple galectin genes...
  61. ncbi request reprint De novo CIAS1 mutations, cytokine activation, and evidence for genetic heterogeneity in patients with neonatal-onset multisystem inflammatory disease (NOMID): a new member of the expanding family of pyrin-associated autoinflammatory diseases
    Ivona Aksentijevich
    National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland 20892, USA
    Arthritis Rheum 46:3340-8. 2002
    ....
  62. ncbi request reprint Chemokine regulation of inflammation during acute viral infection
    William G Glass
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Curr Opin Allergy Clin Immunol 3:467-73. 2003
    ..This article will discuss scientific papers published primarily since June 2002 that have introduced new concepts in how chemokines regulate the inflammatory response to specific viruses...
  63. ncbi request reprint Plasminogen activator inhibitor-2 (PAI-2) in eosinophilic leukocytes
    Jonathan M Swartz
    Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Leukoc Biol 76:812-9. 2004
    ....
  64. pmc RNase 8, a novel RNase A superfamily ribonuclease expressed uniquely in placenta
    Jianzhi Zhang
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Nucleic Acids Res 30:1169-75. 2002
    ..The rapid evolution, species-limited deactivation and tissue-specific expression of RNase 8 suggest a unique physiological function and reiterates the evolutionary plasticity of the RNase A superfamily...
  65. ncbi request reprint Diversifying selection of the tumor-growth promoter angiogenin in primate evolution
    Jianzhi Zhang
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 10, Rm 11 N 104, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Mol Biol Evol 19:438-45. 2002
    ....
  66. pmc Functional antagonism of chemokine receptor CCR1 reduces mortality in acute pneumovirus infection in vivo
    Cynthia A Bonville
    Department of Pediatrics, SUNY Upstate Medical University, Syracuse, NY 13210, USA
    J Virol 78:7984-9. 2004
    ....
  67. ncbi request reprint Ribavirin and cysteinyl leukotriene-1 receptor blockade as treatment for severe bronchiolitis
    Cynthia A Bonville
    Department of Pediatrics, State University of New York Upstate Medical University, 750 East Adams Street, Syracuse, New York 13210, USA
    Antiviral Res 69:53-9. 2006
    ..01). These findings define further the independent contributions made by virus replication and by the ensuing inflammatory response to the detrimental sequelae of pneumovirus infection in vivo...
  68. ncbi request reprint Pulmonary eosinophilia in mice devoid of interleukin-5
    Joseph B Domachowske
    Department of Pediatrics, SUNY Upstate Medical University, Syracuse, New York, USA
    J Leukoc Biol 71:966-72. 2002
    ..Furthermore, the presence of functional eosinophils in IL-5 -/- mice suggests the possibility of developmentally distinct subsets of what has been presumed to be a homogeneous leukocyte population...
  69. ncbi request reprint Differential expression of proinflammatory cytokine genes in vivo in response to pathogenic and nonpathogenic pneumovirus infections
    Joseph B Domachowske
    Department of Pediatrics, State University of New York Upstate Medical University, Syracuse, NY 13210, USA
    J Infect Dis 186:8-14. 2002
    ....
  70. ncbi request reprint Respiratory dysfunction and proinflammatory chemokines in the pneumonia virus of mice (PVM) model of viral bronchiolitis
    Cynthia A Bonville
    SUNY Upstate Medical University, Syracuse, NY 13210 2375, USA
    Virology 349:87-95. 2006
    ....
  71. pmc Mucosal inoculation with an attenuated mouse pneumovirus strain protects against virulent challenge in wild type and interferon-gamma receptor deficient mice
    John A Ellis
    Western Veterinary Medical College, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
    Vaccine 25:1085-95. 2007
    ....
  72. ncbi request reprint Animal models for studying respiratory syncytial virus infection and its long term effects on lung function
    Joseph B Domachowske
    Department of Pediatrics, State University of New York Upstate Medical University, Syracuse, NY, USA
    Pediatr Infect Dis J 23:S228-34. 2004
    ..Human studies on the pathogenesis of RSV infection are invaluable, but animal models permit advances with the use of experimental strategies that would be inappropriate in human studies...
  73. ncbi request reprint Eosinophils contribute to innate antiviral immunity and promote clearance of respiratory syncytial virus
    Simon Phipps
    Centre for Asthma and Respiratory Diseases CARD, School of Biomedical Sciences, University of Newcastle, Newcastle, Australia
    Blood 110:1578-86. 2007
    ..Collectively, our results demonstrate that eosinophils can protect against RSV in vivo, as they promote virus clearance and may thus limit virus-induced lung dysfunction...
  74. pmc Altered pathogenesis of severe pneumovirus infection in response to combined antiviral and specific immunomodulatory agents
    Cynthia A Bonville
    Department of Pediatrics, SUNY Upstate Medical University, Syracuse, New York 13210, USA
    J Virol 77:1237-44. 2003
    ....
  75. pmc Human RNase 7: a new cationic ribonuclease of the RNase A superfamily
    Jianzhi Zhang
    Department of Ecology and Evolutionary Biology, University of Michigan, 3003 Natural Science Building, 830 North University Avenue, Ann Arbor, MI 48109, USA
    Nucleic Acids Res 31:602-7. 2003
    ....
  76. ncbi request reprint Both aromatic and cationic residues contribute to the membrane-lytic and bactericidal activity of eosinophil cationic protein
    Esther Carreras
    Departament de Bioquimica i Biologia Molecular, Facultat de Ciencies, Universitat Autonoma de Barcelona, 08193 Bellaterra, Spain
    Biochemistry 42:6636-44. 2003
    ....
  77. pmc Human ribonuclease A superfamily members, eosinophil-derived neurotoxin and pancreatic ribonuclease, induce dendritic cell maturation and activation
    De Yang
    Basic Research Program, Science Applications International Corporation SAIC Frederick, MD 21702, USA
    J Immunol 173:6134-42. 2004
    ..We therefore propose these mediators be considered as endogenous multifunctional immune alarmins...
  78. ncbi request reprint Diminished inflammatory responses to natural pneumovirus infection among older mice
    Cynthia A Bonville
    Department of Pediatrics, SUNY Upstate Medical University, Syracuse, NY 13210, USA
    Virology 368:182-90. 2007
    ....
  79. pmc Animal pneumoviruses: molecular genetics and pathogenesis
    Andrew J Easton
    University of Warwick, Coventry, United Kingdom
    Clin Microbiol Rev 17:390-412. 2004
    ....
  80. doi request reprint Eosinophils: biological properties and role in health and disease
    Simon P Hogan
    Clin Exp Allergy 38:709-50. 2008
    ..Finally, strategies for targeted therapeutic intervention in eosinophil-mediated mucosal diseases are conceptualized...
  81. ncbi request reprint Replication of respiratory syncytial virus is inhibited in target cells generating nitric oxide in situ
    Dania Ali-Ahmad
    Department of Pediatrics, Division of Infectious Diseases, State University of New York Upstate Medical University, Syracuse, New York 13210, USA
    Front Biosci 8:a48-53. 2003
    ....
  82. pmc Targeting eosinophils in asthma
    Paul S Foster
    Discipline of Immunology and Microbiology, Faculty of Health, University of Newcastle, Newcastle NSW, Australia
    Curr Mol Med 8:585-90. 2008
    ..This may predispose to the development of acute exacerbations of asthma, an outcome that would have significant clinical implications...
  83. doi request reprint Cytokines and fibrocyte differentiation -- altering the balance: an interview with Dr. Darrell Pilling. Interview by Helene F. Rosenberg
    Helene F Rosenberg
    J Leukoc Biol 83:1334-5. 2008
  84. ncbi request reprint The 2007 Dolph Adams Award and the state of the Journal of Leukocyte Biology
    Helene F Rosenberg
    J Leukoc Biol 83:227-8. 2008
  85. ncbi request reprint Advances in the treatment and prevention of severe viral bronchiolitis
    Joseph B Domachowske
    Department of Pediatrics, SUNY Upstate Medical University, Syracuse, NY 13210, USA
    Pediatr Ann 34:35-41. 2005
    ..Supportive therapy is the mainstay for the treatment of established infection while new antiviral and anti-inflammatory strategies are being explored in preclinical trials...
  86. ncbi request reprint Proteomic-based discovery and characterization of glycosylated eosinophil-derived neurotoxin and COOH-terminal osteopontin fragments for ovarian cancer in urine
    Bin Ye
    Laboratory of Gynecologic Oncology, Department of Obstetrics and Gynecology and Reproductive Biology, Brigham and Women s Hospital, Harvard Medical School, Dana Farber Cancer Center, 221 Longwood Avenue, LMRC 601B, Boston, MA 02115, USA
    Clin Cancer Res 12:432-41. 2006
    ..The objective was to identify and characterize low molecular weight proteins/peptides in urine and their posttranslational modifications that might be used as a screening tool for ovarian cancer...
  87. ncbi request reprint Surface-exposed amino acids of eosinophil cationic protein play a critical role in the inhibition of mammalian cell proliferation
    Esther Carreras
    Departament de Bioquimica i Biologia Molecular, Facultat de Ciencies, Universitat Autonoma de Barcelona, 08193 Bellaterra, Spain
    Mol Cell Biochem 272:1-7. 2005
    ..This may be related to the ability of the protein to bind carbohydrates such as those found on the surface of mammalian cells...