Research Topics
Genomes and Genes
| H F RosenbergSummaryAffiliation: National Institutes of Health Country: USA Publications
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Detail Information
Publications
Eosinophils: changing perspectives in health and diseaseHelene F Rosenberg
Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Nat Rev Immunol 13:9-22. 2013....
Inflammatory responses to respiratory syncytial virus (RSV) infection and the development of immunomodulatory pharmacotherapeuticsH F Rosenberg
Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Curr Med Chem 19:1424-31. 2012..From this perspective, we consider the case for specific immunomodulatory strategies that may have the potential to alleviate some of the more serious sequelae of this disease...- Genetic diversity of human RNase 8Calvin C Chan
Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
BMC Genomics 13:40. 2012.... - Inflammatory responses to acute pneumovirus infection in neonatal miceCynthia A Bonville
Department of Pediatrics, SUNY Upstate Medical University, Syracuse, NY, USA
Virol J 7:320. 2010.... 
Efficient replication of pneumonia virus of mice (PVM) in a mouse macrophage cell lineKimberly D Dyer
Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Virol J 4:48. 2007....- Early-life viral infection and allergen exposure interact to induce an asthmatic phenotype in miceJessica S Siegle
Department of Pathology, University of New South Wales, Sydney, NSW, Australia
Respir Res 11:14. 2010..The purpose of this study was to assess whether early-life infection with a species-specific model of RSV and subsequent allergen exposure predisposed to the development of features of asthma... - Interferon-gamma coordinates CCL3-mediated neutrophil recruitment in vivoCynthia A Bonville
SUNY Upstate Medical University, Syracuse, New York 13210, USA
BMC Immunol 10:14. 2009.... - Eosinophils and their interactions with respiratory virus pathogensHelene F Rosenberg
Eosinophil Biology Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 10, Room 11C215, Bethesda, MD 20892, USA
Immunol Res 43:128-37. 2009..Interestingly, PVM replicates in eosinophils and promotes cytokine release. The molecular basis of virus infection in eosinophils and its relationship to disease outcome is currently under study... - Respiratory viruses and eosinophils: exploring the connectionsHelene F Rosenberg
Eosinophil Biology Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Antiviral Res 83:1-9. 2009..Lastly, we consider the data that focus on the role of eosinophils in promoting virus clearance and antiviral host defense, and conclude with a recent study that explores the role of eosinophils themselves as targets of virus infection... - HMGB1, a novel biomarker of inflammatory demyelinating disease: an interview with Dr. Robert A. HarrisHelene F Rosenberg
Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, USA
J Leukoc Biol 84:1256-8. 2008 - Eosinophil-derived neurotoxin / RNase 2: connecting the past, the present and the futureH F Rosenberg
Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Curr Pharm Biotechnol 9:135-40. 2008.... - Pneumonia virus of mice: severe respiratory infection in a natural hostHelene F Rosenberg
Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA
Immunol Lett 118:6-12. 2008.... - RNase A ribonucleases and host defense: an evolving storyHelene F Rosenberg
Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
J Leukoc Biol 83:1079-87. 2008..The properties of individual RNase A ribonucleases, recent experimental findings, and important questions for the near and distant future will be reviewed... 
Eosinophil trafficking in allergy and asthmaHelene F Rosenberg
Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Allergy Clin Immunol 119:1303-10; quiz 1311-2. 2007....- The pneumonia virus of mice infection model for severe respiratory syncytial virus infection: identifying novel targets for therapeutic interventionHelene F Rosenberg
Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
Pharmacol Ther 105:1-6. 2005..Ongoing exploration into the biology of PVM infection will identify other pathways and targets to be exploited for immunomodulatory control of hRSV and related severe respiratory virus infections... - Eosinophils, eosinophil ribonucleases, and their role in host defense against respiratory virus pathogensH F Rosenberg
Eosinophil Biology Unit, Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
J Leukoc Biol 70:691-8. 2001.... - Sequence variation at two eosinophil-associated ribonuclease loci in humansJ Zhang
Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Genetics 156:1949-58. 2000.... - Rapid evolution of the ribonuclease A superfamily: adaptive expansion of independent gene clusters in rats and miceN A Singhania
Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 10 Bethesda, MD 20892, USA
J Mol Evol 49:721-8. 1999.... - Eosinophils, ribonucleases and host defense: solving the puzzleH F Rosenberg
Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Immunol Res 20:261-74. 1999..The results of this work have led us to consider the possibility that the EDN/ECP ribonucleases represent a heretofore unrecognized element of innate and specific antiviral host defense... - Gene structure and enzymatic activity of mouse eosinophil-associated ribonuclease 2A L McDevitt
Eosinophil Biology Unit, Laboratory of Host Defenses 10 11N104, NIAID National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892 1886, USA
Gene 267:23-30. 2001..Sequence analysis of the non-coding regions and enzymatic characterization of the gene product provide further evidence indicating that mEAR-2 is a structural and functional ortholog of primate EDNs and ECPs... - Characterization of the divergent eosinophil ribonuclease, mEar 6, and its expression in response to Schistosoma mansoni infection in vivoT Nitto
Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 10, Room 11N104, 9000 Rockville Pike, Bethesda, MD 20892, USA
Genes Immun 5:668-74. 2004..In summary, we have identified mEar 6 as one of only two RNase A superfamily ribonucleases known to be expressed specifically in response to pathophysiologic stress in vivo... - Interleukin-5 does not influence differential transcription of transmembrane and soluble isoforms of IL-5R alpha in vivoJonas Bystrom
Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1883, USA
Eur J Haematol 77:181-90. 2006..Two variants encoding soluble forms of the alpha subunit (sIL-5R alpha) have been described, although the signals promoting and/or limiting differential transcription remain to be clarified... - Evolution of the rodent eosinophil-associated RNase gene family by rapid gene sorting and positive selectionJ Zhang
Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 97:4701-6. 2000..The discovery of a large number of divergent EARs suggests the intriguing possibility that these proteins have been specifically tailored to fight against distinct rodent pathogens... - Rapid diversification of RNase A superfamily ribonucleases from the bullfrog, Rana catesbeianaH F Rosenberg
Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
J Mol Evol 53:31-8. 2001.... - Inflammatory responses to pneumovirus infection in IFN-alpha beta R gene-deleted miceTara L Garvey
Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 175:4735-44. 2005.... - Pulmonary eosinophils and their role in immunopathologic responses to formalin-inactivated pneumonia virus of miceCaroline M Percopo
Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 183:604-12. 2009..However, levels of both IL-4 and CCL3 (macrophage inflammatory protein-1alpha) in bronchoalveolar lavage fluid were markedly diminished in PVM Ag-vaccinated, PVM-infected eosinophil-deficient mice when compared with wild-type controls... - Diversity among the primate eosinophil-derived neurotoxin genes: a specific C-terminal sequence is necessary for enhanced ribonuclease activityH F Rosenberg
Laboratory of Host Defenses, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Nucleic Acids Res 25:3532-6. 1997.... - Ribonuclease k6: chromosomal mapping and divergent rates of evolution within the RNase A gene superfamilyM S Deming
Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Genome Res 8:599-607. 1998..The sequence data described in this paper have been submitted to the GenBank data library under accession nos. AF037081-AF037090.].. - Diminished expression of an antiviral ribonuclease in response to pneumovirus infection in vivoJoanne M Moreau
Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 10, Room 11N104, 9000 Rockville Pike, Bethesda, MD 20892, USA
Antiviral Res 59:181-91. 2003..We propose that this mechanism may represent a novel virus-mediated evasion strategy, with a mechanism that is linked in some fashion to virus-specific pathogenicity... - Evolution and function of leukocyte RNase A ribonucleases of the avian species, Gallus gallusTakeaki Nitto
Laboratory of Allergic Diseases and Research Technologies Branch, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 281:25622-34. 2006.... - The RNase a superfamily: generation of diversity and innate host defenseKimberly D Dyer
Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Mol Divers 10:585-97. 2006..190 words)... - Schistosoma mansoni infection in eosinophil lineage-ablated miceJonathan M Swartz
Laboratory of Allergic Diseases, NIAID, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892 1883, USA
Blood 108:2420-7. 2006..However, eosinophils may have unexplored immunomodulatory contributions to this disease process... - Molecular cloning of four novel murine ribonuclease genes: unusual expansion within the ribonuclease A gene familyD Batten
The Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Nucleic Acids Res 25:4235-9. 1997..Although the nature of the evolutionary constraints promoting this unusual expansion and diversification remain unclear, the implications with respect to function are intriguing... - Suppression of HIV-1 transcription by beta-chemokines RANTES, MIP1-alpha, and MIP-1beta is not mediated by the NFAT-1 enhancer elementJ S Handen
Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
FEBS Lett 410:301-2. 1997.... - Transcriptional regulation of galectin-10 (eosinophil Charcot-Leyden crystal protein): a GC box (-44 to -50) controls butyric acid induction of gene expressionK D Dyer
Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Life Sci 69:201-12. 2001..Additionally, we demonstrate AML3 binding to the consensus AML site and YY1 binding to the Inr sequence, both elements functioning as silencers in the gal-10 promoter... - Localized eosinophil degranulation mediates disease in tropical pulmonary eosinophiliaPaula Pinkston
National Institutes of Health, Bethesda, Maryland, USA
Infect Immun 71:1337-42. 2003..02). These data suggest it is the eosinophilic granular protein EDN, an RNase capable of damaging the lung epithelium, that plays the most important role in the pathogenesis of TPE... - Molecular cloning and characterization of a novel human ribonuclease (RNase k6): increasing diversity in the enlarging ribonuclease gene familyH F Rosenberg
Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Nucleic Acids Res 24:3507-13. 1996..The identification and characterization of RNase k6 has extended the ribonuclease gene family and suggests the possibility that there are others awaiting discovery... - Ribonucleases and host defense: identification, localization and gene expression in adherent monocytes in vitroA Egesten
Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Biochim Biophys Acta 1358:255-60. 1997..Interestingly, mRNA encoding RNase 4 could not be detected in freshly isolated monocytes, emerging only after 16 h in culture, suggesting the possibility of de novo protein synthesis in association with monocyte differentiation... - Eosinophil-derived neurotoxin acts as an alarmin to activate the TLR2-MyD88 signal pathway in dendritic cells and enhances Th2 immune responsesDe Yang
Basic Research Program, SAIC Frederick, Inc, MD, USA
J Exp Med 205:79-90. 2008.... - Eosinophil-derived neurotoxin (EDN), an antimicrobial protein with chemotactic activities for dendritic cellsDe Yang
Basic Research Program, SAIC Frederick, Laboratory of Molecular Regulation, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bldg 560, Rm 31 19, Frederick, MD 21702 1201, USA
Blood 102:3396-403. 2003..Thus, EDN and its mouse ortholog, mEAR2, are eosinophil granule-derived antimicrobial RNases that function as chemoattractants for DCs in vitro and in vivo... - The eosinophil ribonucleasesH F Rosenberg
Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Cell Mol Life Sci 54:795-803. 1998..The biochemistry and physiology of EDN, ECP and the recently discovered ribonuclease k6 (RNase 6) will be reviewed in this chapter... - Mouse and human eosinophils degranulate in response to platelet-activating factor (PAF) and lysoPAF via a PAF-receptor-independent mechanism: evidence for a novel receptorKimberly D Dyer
Section of Eosinophil Biology, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1883, USA
J Immunol 184:6327-34. 2010.... - Functionally competent eosinophils differentiated ex vivo in high purity from normal mouse bone marrowKimberly D Dyer
Eosinophil Biology Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 181:4004-9. 2008..Finally, differentiating bmEos are readily transfected with lentiviral vectors, suggesting a means for rapid production of genetically manipulated cells... - Multisystemic eosinophilia resembling hypereosinophilic syndrome in a colony-bred owl monkey (Aotus vociferans)Alfonso S Gozalo
Comparative Medicine Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
J Am Assoc Lab Anim Sci 48:303-6. 2009..To our knowledge, this report is the first description of presumptive hypereosinophilic syndrome in a nonhuman primate... - Pneumoviruses infect eosinophils and elicit MyD88-dependent release of chemoattractant cytokines and interleukin-6Kimberly D Dyer
Eosinophil Biology Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health NIH, Bethesda, MD, USA
Blood 114:2649-56. 2009..Taken together, our findings suggest that eosinophils are targets of virus infection and may have varied and complex contributions to the pathogenesis and resolution of pneumovirus disease... - Eosinophils from lineage-ablated Delta dblGATA bone marrow progenitors: the dblGATA enhancer in the promoter of GATA-1 is not essential for differentiation ex vivoKimberly D Dyer
Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases National Institutes of Health NIAID NIH, Bethesda, MD 20892, USA
J Immunol 179:1693-9. 2007.... - Complementary advantageous substitutions in the evolution of an antiviral RNase of higher primatesJianzhi Zhang
Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 99:5486-91. 2002.... - Identification of a purine-rich intronic enhancer element in the mouse eosinophil-associated ribonuclease 2 (mEar 2) geneKimberly D Dyer
Eosinophil Pathophysiology Section, LHD, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA
Mamm Genome 15:126-34. 2004..Similar intronic enhancers have been described as regulating transcription of the human EDN gene, suggesting an overall conservation of an important regulatory strategy... - Gene microarray analysis reveals interleukin-5-dependent transcriptional targets in mouse bone marrowJonas Bystrom
NIAID, NIH, Bldg 10, Rm 11N104, 9000 Rockville Pike, Bethesda, MD, 20892, USA
Blood 103:868-77. 2004.... - Isolation, characterization, and evolutionary divergence of mouse RNase 6: evidence for unusual evolution in rodentsKimberly D Dyer
Eosinophil Biology Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Mol Evol 59:657-65. 2004..66. These data suggest that the ancestral rodent RNase 6 was subject to accelerated evolution, resulting in the conserved modern gene, which most likely plays an important role in mouse physiology... - The mouse RNase 4 and RNase 5/ang 1 locus utilizes dual promoters for tissue-specific expressionKimberly D Dyer
Laboratory of Allergic Diseases NIAID, NIH, Bethesda, MD 20892, USA
Nucleic Acids Res 33:1077-86. 2005.... - Characterization of a ribonuclease gene and encoded protein from the reptile, Iguana iguanaTakeaki Nitto
Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, United States
Gene 352:36-44. 2005..Further analysis of ribonucleases from non-mammalian vertebrate species is needed in order to define relationships and lineages within the larger RNase A gene superfamily... - Adaptive evolution of a duplicated pancreatic ribonuclease gene in a leaf-eating monkeyJianzhi Zhang
Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
Nat Genet 30:411-5. 2002..Our findings demonstrate the contribution of gene duplication to organismal adaptation and show the power of combining sequence analysis and functional assays in delineating the molecular basis of adaptive evolution... - The gene for familial Mediterranean fever, MEFV, is expressed in early leukocyte development and is regulated in response to inflammatory mediatorsM Centola
Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Instiutes of Health, Bethesda, MD 20892 1820, USA
Blood 95:3223-31. 2000..These results refine understanding of MEFV by placing the gene in the myelomonocytic-specific proinflammatory pathway and identifying it as an IFN-gamma immediate early gene... - Human ribonuclease 4 (RNase 4): coding sequence, chromosomal localization and identification of two distinct transcripts in human somatic tissuesH F Rosenberg
Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Nucleic Acids Res 23:4290-5. 1995.... - GATA transcription factors regulate the expression of the human eosinophil-derived neurotoxin (RNase 2) geneZhijun Qiu
Laboratory of Allergic Diseases, NIAID, NIH, Bethesda, MD 20892, USA
J Biol Chem 284:13099-109. 2009..Taken together, our data suggest that GATA-2 functions directly via interactions with the EDN promoter and also indirectly, via its ability to regulate the expression of GATA-1 in differentiating eosinophils and eosinophil cell lines... - RNase 1 genes from the family Sciuridae define a novel rodent ribonuclease clusterSteven J Siegel
Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA
Mamm Genome 20:749-57. 2009..The full significance of these findings awaits a more complete understanding of biological role of mammalian RNase 1s... - Interleukin-5 (IL-5) augments the progression of liver fibrosis by regulating IL-13 activityRachael M Reiman
Immunopathogenesis, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 8003, USA
Infect Immun 74:1471-9. 2006..Thus, inhibiting the activity of IL-5 or eosinophils may prove effective for a variety of chronic fibrotic diseases... - Rapid evolution of a unique family of primate ribonuclease genesH F Rosenberg
Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Nat Genet 10:219-23. 1995..These results suggest that both EDN and ECP may be responding to unusual evolutionary constraints, which has prompted a reexamination of their physiologic function... - The genomic structure of the human Charcot-Leyden crystal protein gene is analogous to those of the galectin genesK D Dyer
Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Genomics 40:217-21. 1997..The most likely interpretation of these results suggest the occurrence of one or more exon duplication and insertion events, resulting in the distribution of this lectin domain to CLC as well as to the multiple galectin genes... - De novo CIAS1 mutations, cytokine activation, and evidence for genetic heterogeneity in patients with neonatal-onset multisystem inflammatory disease (NOMID): a new member of the expanding family of pyrin-associated autoinflammatory diseasesIvona Aksentijevich
National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland 20892, USA
Arthritis Rheum 46:3340-8. 2002.... - Chemokine regulation of inflammation during acute viral infectionWilliam G Glass
Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Curr Opin Allergy Clin Immunol 3:467-73. 2003..Identifying master chemokines to target or exploit in human viral infection is a major opportunity and challenge for clinical immunologists... - Plasminogen activator inhibitor-2 (PAI-2) in eosinophilic leukocytesJonathan M Swartz
Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Leukoc Biol 76:812-9. 2004.... - RNase 8, a novel RNase A superfamily ribonuclease expressed uniquely in placentaJianzhi Zhang
Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Nucleic Acids Res 30:1169-75. 2002..The rapid evolution, species-limited deactivation and tissue-specific expression of RNase 8 suggest a unique physiological function and reiterates the evolutionary plasticity of the RNase A superfamily... - Diversifying selection of the tumor-growth promoter angiogenin in primate evolutionJianzhi Zhang
Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 10, Rm 11 N 104, 9000 Rockville Pike, Bethesda, MD 20892, USA
Mol Biol Evol 19:438-45. 2002.... - Functional antagonism of chemokine receptor CCR1 reduces mortality in acute pneumovirus infection in vivoCynthia A Bonville
Department of Pediatrics, SUNY Upstate Medical University, Syracuse, NY 13210, USA
J Virol 78:7984-9. 2004.... - Ribavirin and cysteinyl leukotriene-1 receptor blockade as treatment for severe bronchiolitisCynthia A Bonville
Department of Pediatrics, State University of New York Upstate Medical University, 750 East Adams Street, Syracuse, New York 13210, USA
Antiviral Res 69:53-9. 2006..01). These findings define further the independent contributions made by virus replication and by the ensuing inflammatory response to the detrimental sequelae of pneumovirus infection in vivo... - Pulmonary eosinophilia in mice devoid of interleukin-5Joseph B Domachowske
Department of Pediatrics, SUNY Upstate Medical University, Syracuse, New York, USA
J Leukoc Biol 71:966-72. 2002..Furthermore, the presence of functional eosinophils in IL-5 -/- mice suggests the possibility of developmentally distinct subsets of what has been presumed to be a homogeneous leukocyte population... - Differential expression of proinflammatory cytokine genes in vivo in response to pathogenic and nonpathogenic pneumovirus infectionsJoseph B Domachowske
Department of Pediatrics, State University of New York Upstate Medical University, Syracuse, NY 13210, USA
J Infect Dis 186:8-14. 2002.... - Respiratory dysfunction and proinflammatory chemokines in the pneumonia virus of mice (PVM) model of viral bronchiolitisCynthia A Bonville
SUNY Upstate Medical University, Syracuse, NY 13210 2375, USA
Virology 349:87-95. 2006.... - Mucosal inoculation with an attenuated mouse pneumovirus strain protects against virulent challenge in wild type and interferon-gamma receptor deficient miceJohn A Ellis
Western Veterinary Medical College, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
Vaccine 25:1085-95. 2007.... - Animal models for studying respiratory syncytial virus infection and its long term effects on lung functionJoseph B Domachowske
Department of Pediatrics, State University of New York Upstate Medical University, Syracuse, NY, USA
Pediatr Infect Dis J 23:S228-34. 2004.... - Eosinophils contribute to innate antiviral immunity and promote clearance of respiratory syncytial virusSimon Phipps
Centre for Asthma and Respiratory Diseases CARD, School of Biomedical Sciences, University of Newcastle, Newcastle, Australia
Blood 110:1578-86. 2007..Collectively, our results demonstrate that eosinophils can protect against RSV in vivo, as they promote virus clearance and may thus limit virus-induced lung dysfunction... - Altered pathogenesis of severe pneumovirus infection in response to combined antiviral and specific immunomodulatory agentsCynthia A Bonville
Department of Pediatrics, SUNY Upstate Medical University, Syracuse, New York 13210, USA
J Virol 77:1237-44. 2003.... - Human RNase 7: a new cationic ribonuclease of the RNase A superfamilyJianzhi Zhang
Department of Ecology and Evolutionary Biology, University of Michigan, 3003 Natural Science Building, 830 North University Avenue, Ann Arbor, MI 48109, USA
Nucleic Acids Res 31:602-7. 2003.... - Both aromatic and cationic residues contribute to the membrane-lytic and bactericidal activity of eosinophil cationic proteinEsther Carreras
, , , 08193-Bellaterra, Spain
Biochemistry 42:6636-44. 2003.... - Human ribonuclease A superfamily members, eosinophil-derived neurotoxin and pancreatic ribonuclease, induce dendritic cell maturation and activationDe Yang
Basic Research Program, Science Applications International Corporation SAIC Frederick, MD 21702, USA
J Immunol 173:6134-42. 2004..We therefore propose these mediators be considered as endogenous multifunctional immune alarmins... - Diminished inflammatory responses to natural pneumovirus infection among older miceCynthia A Bonville
Department of Pediatrics, SUNY Upstate Medical University, Syracuse, NY 13210, USA
Virology 368:182-90. 2007.... - Animal pneumoviruses: molecular genetics and pathogenesisAndrew J Easton
University of Warwick, Coventry, United Kingdom
Clin Microbiol Rev 17:390-412. 2004.... - Eosinophils: biological properties and role in health and diseaseSimon P Hogan
Clin Exp Allergy 38:709-50. 2008..Finally, strategies for targeted therapeutic intervention in eosinophil-mediated mucosal diseases are conceptualized... - Replication of respiratory syncytial virus is inhibited in target cells generating nitric oxide in situDania Ali-Ahmad
Department of Pediatrics, Division of Infectious Diseases, State University of New York Upstate Medical University, Syracuse, New York 13210, USA
Front Biosci 8:a48-53. 2003.... - Targeting eosinophils in asthmaPaul S Foster
Discipline of Immunology and Microbiology, Faculty of Health, University of Newcastle, Newcastle NSW, Australia
Curr Mol Med 8:585-90. 2008..This may predispose to the development of acute exacerbations of asthma, an outcome that would have significant clinical implications... - Cytokines and fibrocyte differentiation -- altering the balance: an interview with Dr. Darrell Pilling. Interview by Helene F. RosenbergHelene F Rosenberg
J Leukoc Biol 83:1334-5. 2008 - The 2007 Dolph Adams Award and the state of the Journal of Leukocyte BiologyHelene F Rosenberg
J Leukoc Biol 83:227-8. 2008 - Advances in the treatment and prevention of severe viral bronchiolitisJoseph B Domachowske
Department of Pediatrics, SUNY Upstate Medical University, Syracuse, NY 13210, USA
Pediatr Ann 34:35-41. 2005..Supportive therapy is the mainstay for the treatment of established infection while new antiviral and anti-inflammatory strategies are being explored in preclinical trials... - Proteomic-based discovery and characterization of glycosylated eosinophil-derived neurotoxin and COOH-terminal osteopontin fragments for ovarian cancer in urineBin Ye
Laboratory of Gynecologic Oncology, Department of Obstetrics and Gynecology and Reproductive Biology, Brigham and Women s Hospital, Harvard Medical School, Dana Farber Cancer Center, 221 Longwood Avenue, LMRC 601B, Boston, MA 02115, USA
Clin Cancer Res 12:432-41. 2006..The objective was to identify and characterize low molecular weight proteins/peptides in urine and their posttranslational modifications that might be used as a screening tool for ovarian cancer... - Surface-exposed amino acids of eosinophil cationic protein play a critical role in the inhibition of mammalian cell proliferationEsther Carreras
Departament de Bioquimica i Biologia Molecular, Facultat de Ciencies, Universitat Autonoma de Barcelona, 08193 Bellaterra, Spain
Mol Cell Biochem 272:1-7. 2005..This may be related to the ability of the protein to bind carbohydrates such as those found on the surface of mammalian cells...