Research Topics
Genomes and Genes
| Roberto RomeroSummaryAffiliation: National Institutes of Health Country: USA Publications
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Detail Information
Publications
A longitudinal study of angiogenic (placental growth factor) and anti-angiogenic (soluble endoglin and soluble vascular endothelial growth factor receptor-1) factors in normal pregnancy and patients destined to develop preeclampsia and deliver a small forRoberto Romero
Perinatology Research Branch, National Institute of Child Health and Human Development, NIH DHHS, Bethesda, MD 20892, USA
J Matern Fetal Neonatal Med 21:9-23. 2008....
Timing the delivery of the preterm severely growth-restricted fetus: venous Doppler, cardiotocography or the biophysical profile?R Romero
National Institutes of Child Health and Human Development, NIH, Bethesda, Maryland, USA
Ultrasound Obstet Gynecol 19:118-21. 2002- The use of high-dimensional biology (genomics, transcriptomics, proteomics, and metabolomics) to understand the preterm parturition syndromeR Romero
Perinatology Research Branch, Intramural Division, National Institute of Child Health and Human Development, NIH DHHS, Hutzel Women s Hospital, Bethesda, MD 20892, USA
BJOG 113:118-35. 2006..The complementary nature of discovery science and HDB is emphasised... - The role of inflammation and infection in preterm birthRoberto Romero
Perinatology Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
Semin Reprod Med 25:21-39. 2007..This article reviews the role of inflammation in preterm and term parturition... - Fetal macrophages are not present in the myometrium of women with labor at termChong Jai Kim
Perinatology Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
Am J Obstet Gynecol 195:829-33. 2006..The present study was conducted to determine whether fetal macrophages invade the myometrium of women in labor... - Inflammation in preterm and term labour and deliveryRoberto Romero
Perinatology Research Branch, NICHD, NIH, DHHS, Bethesda, MD, USA
Semin Fetal Neonatal Med 11:317-26. 2006..It is possible that modulation of inflammation using anti-inflammatory cytokines, corticoids, antioxidants and/or other factors may complement antibiotic therapy and limit fetal injury... - Insights into the physiology of childbirth using transcriptomicsRoberto Romero
Perinatology Research Branch, Intramural Division, NICHD/NIH/DHHS, Bethesda, Maryland, USA
PLoS Med 3:e276. 2006 - Over-expression of the thrombin receptor (PAR-1) in the placenta in preeclampsia: a mechanism for the intersection of coagulation and inflammationOffer Erez
Perinatology Research Branch, NICHD, NIH, DHHS, Bethesda, Maryland, USA
J Matern Fetal Neonatal Med 21:345-55. 2008..The aim of this study was to determine whether preterm PE is associated with changes in placental expression of PAR-1... - Can endometrial infection/inflammation explain implantation failure, spontaneous abortion, and preterm birth after in vitro fertilization?Roberto Romero
Perinatology Research Branch, National Institute of Child Health and Development, National Institutes of Health Department of Health and Human Services, Bethesda, Maryland, USA
Fertil Steril 82:799-804. 2004..Microbial products and host-inflammatory mediators such as cytokines and chemokines can cause trophoblast apoptosis and the cascade of events leading to expulsion of the embryo or fetus... - The use of the minimum projection mode in 4-dimensional examination of the fetal heart with spatiotemporal image correlationJimmy Espinoza
Perinatology Research Branch, National Institute of Child Health and Human Development, Department of Obstetrics and Gynecology, Wayne State University Hutzel Hospital, 4707 St Antoine Blvd, Detroit MI 48201 USA
J Ultrasound Med 23:1337-48. 2004..The objective of this study was to compare the information displayed in images obtained with the MPM with their corresponding 2-dimensional ultrasonographic images from fetuses with and without structural heart defects... - Micronutrients and intrauterine infection, preterm birth and the fetal inflammatory response syndromeRoberto Romero
Perinatology Research Branch, National Institute of Child Health and Human Development, NIH DHHS, Bethesda, MD 20892, USA
J Nutr 133:1668S-1673S. 2003..A possible role for two micronutrients, vitamins C and E, in the prevention of the preterm prelabor rupture of membranes and the consequences of fetal inflammation is considered. Research needs are listed... - Fetal plasma MMP-9 concentrations are elevated in preterm premature rupture of the membranesRoberto Romero
Perinatology Research Branch, National Institute of Child Health and Human Development, Wayne State University Hutzel Hospital, Department of Ob Gyn, Detroit, MI 48201, USA
Am J Obstet Gynecol 187:1125-30. 2002.... - Identification of novel functional sequence variants in the gene for peptidase inhibitor 3Mahboob A Chowdhury
Center of Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI, USA
BMC Med Genet 7:49. 2006..To elucidate the molecular mechanisms contributing to the decreased expression in amniotic membranes, the PI3 gene was searched for sequence variations and the functional significance of the identified promoter variants was studied... - The change in concentrations of angiogenic and anti-angiogenic factors in maternal plasma between the first and second trimesters in risk assessment for the subsequent development of preeclampsia and small-for-gestational ageOffer Erez
Perinatology Research Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, DHHS, Bethesda, Maryland, USA
J Matern Fetal Neonatal Med 21:279-87. 2008.... 
The maternal plasma soluble vascular endothelial growth factor receptor-1 concentration is elevated in SGA and the magnitude of the increase relates to Doppler abnormalities in the maternal and fetal circulationTinnakorn Chaiworapongsa
Perinatology Research Branch, National Institute of Child Health and Human Development, NIH DHHS, Bethesda, MD 20892, USA
J Matern Fetal Neonatal Med 21:25-40. 2008....- A link between a hemostatic disorder and preterm PROM: a role for tissue factor and tissue factor pathway inhibitorOffer Erez
Perinatology Research Branch, NICHD, NIH, DHHS, Detroit, Michigan, USA
J Matern Fetal Neonatal Med 21:732-44. 2008..A decidual hemostatic disorder may link vaginal bleeding, PPROM and placental abruption. This study was conducted to determine the behaviour of maternal TF and its natural inhibitor, the tissue factor pathway inhibitor (TFPI) in PPROM... - Identification of patients at risk for early onset and/or severe preeclampsia with the use of uterine artery Doppler velocimetry and placental growth factorJimmy Espinoza
Perinatology Research Branch, NICHD NIH DHHS, Bethesda, MD, USA
Am J Obstet Gynecol 196:326.e1-13. 2007.... - Amniotic fluid soluble human leukocyte antigen-G in term and preterm parturition, and intra-amniotic infection/inflammationJuan Pedro Kusanovic
Perinatology Research Branch, NICHD NIH DHHS, Bethesda, Maryland, USA
J Matern Fetal Neonatal Med 22:1151-66. 2009.... - A prospective cohort study of the value of maternal plasma concentrations of angiogenic and anti-angiogenic factors in early pregnancy and midtrimester in the identification of patients destined to develop preeclampsiaJuan Pedro Kusanovic
Perinatology Research Branch, NICHD NIH DHHS, Bethesda, Maryland, USA
J Matern Fetal Neonatal Med 22:1021-38. 2009..This study was conducted to examine the role of maternal plasma PlGF, sEng, and sVEGFR-1 concentrations in early pregnancy and midtrimester in the identification of patients destined to develop preeclampsia... - Gene expression profiling demonstrates a novel role for foetal fibrocytes and the umbilical vessels in human fetoplacental developmentJung Sun Kim
Perinatology Research Branch, NICHD NIH DHHS, Bethesda, MD, USA
J Cell Mol Med 12:1317-30. 2008..This study reports fibrocytes in the human umbilical cord and placenta for the first time, and a novel role for both circulating foetal cells and the umbilical vessels in placental development, which is deranged in IUGR... - Acute pyelonephritis during pregnancy changes the balance of angiogenic and anti-angiogenic factors in maternal plasmaTinnakorn Chaiworapongsa
Perinatology Research Branch, NICHD, NIH, DHHS, Detroit, Michigan, USA
J Matern Fetal Neonatal Med 23:167-78. 2010.... - A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM)Roberto Romero
Perinatology Research Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development National Institutes of Health Department of Health and Human Services, Bethesda, MD, USA
Am J Obstet Gynecol 203:361.e1-361.e30. 2010..We sought to determine whether maternal/fetal single-nucleotide polymorphisms (SNPs) in candidate genes are associated with preterm prelabor rupture of membranes (pPROM)... - Amniotic fluid sTREM-1 in normal pregnancy, spontaneous parturition at term and preterm, and intra-amniotic infection/inflammationJuan Pedro Kusanovic
Perinatology Research Branch, NICHD NIH DHHS, Bethesda, Maryland, USA
J Matern Fetal Neonatal Med 23:34-47. 2010..The aim of this study was to determine the effect of gestational age, parturition (term and preterm) and IAI in the amniotic fluid (AF) concentrations of sTREM-1... - Evidence in support of a role for anti-angiogenic factors in preterm prelabor rupture of membranesZeynep Alpay Savasan
Perinatology Research Branch, NICHD, NIH, DHHS, Detroit, Michigan, USA
J Matern Fetal Neonatal Med 23:828-41. 2010..The purpose of this study was to determine whether the soluble form of VEGFR-1 and -2 concentrations in amniotic fluid (AF) change with preterm PROM, intra-amniotic infection/inflammation (IAI), or parturition... - Surfactant protein-A as an anti-inflammatory component in the amnion: implications for human pregnancyDeug Chan Lee
Perinatology Research Branch, Department of Health and Human Services, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, USA
J Immunol 184:6479-91. 2010..However, AF SP-A and fetal macrophages by themselves do not seem to be exclusive effectors of parturition in humans... - Inhibition of bacterial growth and intramniotic infection in a guinea pig model of chorioamnionitis using PAMAM dendrimersBing Wang
Department of Pediatrics, Children s Hospital of Michigan, Wayne State University, Detroit, MI 48201, United States
Int J Pharm 395:298-308. 2010..coli membrane and the G(3.5)-PAMAM-COOH acts as a polyanion, chelating the divalent ions in outer cell membrane of E. coli. This is the first study which shows that G(4)-PAMAM-OH dendrimer acts as an antibacterial agent... - Fragment Bb in amniotic fluid: evidence for complement activation by the alternative pathway in women with intra-amniotic infection/inflammationEdi Vaisbuch
Perinatology Research Branch, NICHD NIH DHHS, Bethesda, Maryland, USA
J Matern Fetal Neonatal Med 22:905-16. 2009..The aim of this study was to determine whether the amniotic fluid (AF) concentrations of fragment Bb change with gestational age, spontaneous labor (term and preterm) and in the presence of intra-amniotic infection/inflammation (IAI)... - Fetal death: a condition with a dissociation in the concentrations of soluble vascular endothelial growth factor receptor-2 between the maternal and fetal compartmentsTinnakorn Chaiworapongsa
Perinatology Research Branch, NICHD, NIH, DHHS, Bethesda, Maryland, USA
J Matern Fetal Neonatal Med 23:960-72. 2010..The aim of this study was to determine if fetal death was associated with changes in the concentrations of sVEGFR-2 in maternal plasma and amniotic fluid. Study.. - Maternal serum adiponectin multimers in patients with a small-for-gestational-age newbornShali Mazaki-Tovi
Perinatology Research Branch, Intramural Division, NICHD NIH DHHS, Hutzel Women s Hospital, Detroit, MI 48201, USA
J Perinat Med 37:623-35. 2009..Thus, the aim of this study was to determine if third trimester adiponectin concentrations differed between women with normal weight infants and those with an SGA neonate... - A decrease in maternal plasma concentrations of sVEGFR-2 precedes the clinical diagnosis of preeclampsiaTinnakorn Chaiworapongsa
Perinatology Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Detroit, MI 48201, USA
Am J Obstet Gynecol 202:550.e1-10. 2010..The aim of this study was to examine if maternal plasma concentrations of soluble vascular endothelial growth factor receptor (sVEGFR)-2 change prior to the diagnosis of preeclampsia... - MicroRNA expression profiling of the human uterine cervix after term labor and deliverySonia S Hassan
Department of Obstetrics and Gynecology, Wayne State University Hutzel Hospital, Detroit, MI, USA
Am J Obstet Gynecol 202:80.e1-8. 2010..MicroRNAs (miRNAs) are noncoding RNAs involved in posttranscriptional regulation of target genes. The objective of this study was to determine the miRNA expression profile of the human uterine cervix after spontaneous term labor (TL)... - Leukocytes of pregnant women with small-for-gestational age neonates have a different phenotypic and metabolic activity from those of women with preeclampsiaGiovanna Ogge
Perinatology Research Branch, NICHD NIH DHHS, Bethesda, Maryland, USA
J Matern Fetal Neonatal Med 23:476-87. 2010..The aim of this study was to determine phenotypic and metabolic changes in granulocytes and monocytes of women who develop preeclampsia and those who deliver an SGA neonate, compared to normal pregnant women... - The transcriptome of cervical ripening in human pregnancy before the onset of labor at term: identification of novel molecular functions involved in this processSonia S Hassan
Department of Obstetrics and Gynecology, Wayne State University Hutzel Women s Hospital, Detroit, MI 48201, USA
J Matern Fetal Neonatal Med 22:1183-93. 2009..The aim of this study was to identify changes in the cervical transcriptome in the human uterine cervix as a function of ripening before the onset of labor... - Proteomic analysis of amniotic fluid to identify women with preterm labor and intra-amniotic inflammation/infection: the use of a novel computational method to analyze mass spectrometric profilingRoberto Romero
Perinatology Research Branch, NICHD NIH DHHS, Bethesda, Maryland, USA
J Matern Fetal Neonatal Med 21:367-88. 2008..The purpose of this study was to combine a novel computational method of pattern discovery with mass spectrometric proteomic profiling of amniotic fluid to discover biomarkers of intra-amniotic infection/inflammation (IAI)... - The anti-inflammatory limb of the immune response in preterm labor, intra-amniotic infection/inflammation, and spontaneous parturition at term: a role for interleukin-10Francesca Gotsch
Perinatology Research Branch, NICHD NIH DHHS, Bethesda, Maryland, USA
J Matern Fetal Neonatal Med 21:529-47. 2008..The objectives of this study were to determine whether there is a relationship between amniotic fluid concentrations of IL-10 and gestational age, parturition (at term and preterm), and intra-amniotic infection/inflammation (IAI)... - Intrauterine administration of endotoxin leads to motor deficits in a rabbit model: a link between prenatal infection and cerebral palsyFadoua Saadani-Makki
Carman and Ann Adams Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI, USA
Am J Obstet Gynecol 199:651.e1-7. 2008..This study was undertaken to determine whether maternal intrauterine endotoxin administration leads to neurobehavioral deficits in newborn rabbits... - Differential expression of microRNAs with progression of gestation and inflammation in the human chorioamniotic membranesDaniel Montenegro
Perinatology Research Branch, National Institute of Child Health and Human Development National Institutes of Health Department of Health and Human Services, Bethesda, MD, USA
Am J Obstet Gynecol 197:289.e1-6. 2007..The aim of this study was to identify differential expression of microRNAs (miRNAs) in chorioamniotic membranes with advancing gestation, labor, and inflammation... - Villitis of unknown etiology is associated with a distinct pattern of chemokine up-regulation in the feto-maternal and placental compartments: implications for conjoint maternal allograft rejection and maternal anti-fetal graft-versus-host diseaseMi Jeong Kim
Perinatology Research Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 and Detroit, MI 48201, USA
J Immunol 182:3919-27. 2009..We propose that VUE be a unique state combining maternal allograft rejection and maternal antifetal graft-vs-host disease mechanisms... - Emergence of hormonal and redox regulation of galectin-1 in placental mammals: implication in maternal-fetal immune toleranceNandor Gabor Than
Perinatology Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, and Department of Health and Human Services, Detroit, MI 48201, USA
Proc Natl Acad Sci U S A 105:15819-24. 2008.... - Magnitude of [(11)C]PK11195 binding is related to severity of motor deficits in a rabbit model of cerebral palsy induced by intrauterine endotoxin exposureSujatha Kannan
Department of Pediatrics, Wayne State University, Detroit, MI, USA
Dev Neurosci 33:231-40. 2011..Molecular imaging of ongoing neuroinflammation in the neonatal period may be helpful as a screening biomarker for detecting patients at risk of developing cerebral palsy due to a perinatal insult... - Toll-like receptor 4: a potential link between "danger signals," the innate immune system, and preeclampsia?Yeon Mee Kim
Perinatology Research Branch, NICHD NIH DHHS, Bethesda, MD, USA
Am J Obstet Gynecol 193:921-7. 2005..quot; This study was conducted to determine whether changes in TLR-4 and TLR-2 expressions can be detected in the trophoblasts at the placental bed of women with and without preeclampsia... - Toll-like receptor-2 and -4 in the chorioamniotic membranes in spontaneous labor at term and in preterm parturition that are associated with chorioamnionitisYeon Mee Kim
Perinatology Research Branch, National Institute of Child Health and Human Development/NIH/DHHS, Bethesda, MD, USA
Am J Obstet Gynecol 191:1346-55. 2004..These observations have implications for understanding the biologic nature of innate immunity... - Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranesRoberto Romero
Perinatology Research Branch, NICHD NIH DHHS, Bethesda, MD, USA
Am J Obstet Gynecol 202:431.e1-34. 2010..The purpose of this study was to determine whether maternal/fetal single nucleotide polymorphisms (SNPs) in candidate genes are associated with spontaneous preterm labor/delivery... - Widespread microbial invasion of the chorioamniotic membranes is a consequence and not a cause of intra-amniotic infectionMi Jeong Kim
Perinatology Research Branch, NICHD NIH DHHS, Bethesda, MD, USA
Lab Invest 89:924-36. 2009..This study emphasizes the importance of assessing the intra-amniotic compartment for diagnosis and treatment of preterm birth... - Chronic chorioamnionitis displays distinct alterations of the amniotic fluid proteomeGiovanna Ogge
Perinatology Research Branch, NICHD NIH DHHS, Bethesda, MD, USA
J Pathol 223:553-65. 2011.... - The frequency and clinical significance of intra-amniotic infection and/or inflammation in women with placenta previa and vaginal bleeding: an unexpected observationIchchha Madan
Perinatology Research Branch, NICHD NIH DHHS, Bethesda, Maryland and Detroit, MI 48201, USA
J Perinat Med 38:275-9. 2010..The aim of this study was to determine the frequency and clinical significance of IAI in women with placenta previa and vaginal bleeding in the absence of preterm labor... - A role for CXCL13 (BCA-1) in pregnancy and intra-amniotic infection/inflammationChia Ling Nhan-Chang
Perinatology Research Branch, Intramural Division, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NICHD NIH DHHS, Hutzel Women s Hospital, Detroit, MI 48201, USA
J Matern Fetal Neonatal Med 21:763-75. 2008.... - Preeclampsia and pregnancies with small-for-gestational age neonates have different profiles of complement split productsEleazar Soto
Perinatology Research Branch, National Institute of Child Health and Human Development, NIH DHHS, Bethesda, MD 20892, USA
J Matern Fetal Neonatal Med 23:646-57. 2010..The objective of this study was to determine whether preeclampsia and small-for-gestational age (SGA) are associated with changes in the maternal plasma concentrations of anaphylatoxins C3a, C4a and C5a... - Evidence of changes in the immunophenotype and metabolic characteristics (intracellular reactive oxygen radicals) of fetal, but not maternal, monocytes and granulocytes in the fetal inflammatory response syndromeSun Kwon Kim
Perinatology Research Branch, NICHD, NIH, DHHS, Wayne State University Hutzel Women s Hospital, Detroit, MI 48201, USA
J Perinat Med 37:543-52. 2009..The aim of this study was to determine whether fetal and maternal granulocytes and monocytes have the phenotypic and metabolic characteristics of activation in cases with FIRS... - Amniotic fluid angiopoietin-2 in term and preterm parturition, and intra-amniotic infection/inflammationPercy Pacora
Perinatology Research Branch, NICHD NIH DHHS, Wayne State University Hutzel Women s Hospital, Detroit, MI 48201, USA
J Perinat Med 37:503-11. 2009.... - Maternal anti-protein Z antibodies in pregnancies complicated by pre-eclampsia, SGA and fetal deathOffer Erez
Perinatology Research Branch, NICHD NIH DHHS, Bethesda, Maryland, USA
J Matern Fetal Neonatal Med 22:662-71. 2009..The objective of this study was to determine the maternal plasma concentration of APZ-AB in women with a normal pregnancy, and patients with PE, an SGA neonate or a FD... - Dysregulation of maternal serum adiponectin in preterm laborShali Mazaki-Tovi
Perinatology Research Branch, Intramural Division, NICHD NIH DHHS, HutzelWomen s Hospital, Bethesda, Maryland, USA
J Matern Fetal Neonatal Med 22:887-904. 2009..The aim of this study was to determine whether spontaneous preterm labor (PTL) with intact membranes and intra-amniotic infection/inflammation (IAI) is associated with changes in maternal serum circulating adiponectin multimers... - Late-onset preeclampsia is associated with an imbalance of angiogenic and anti-angiogenic factors in patients with and without placental lesions consistent with maternal underperfusionEleazar Soto
Perinatology Research Branch, NICHD NIH DHHS, Detroit, MI, USA
J Matern Fetal Neonatal Med 25:498-507. 2012.... - Unexplained fetal death has a biological signature of maternal anti-fetal rejection: chronic chorioamnionitis and alloimmune anti-human leucocyte antigen antibodiesJoonho Lee
Perinatology Research Branch, NICHD NIH DHHS, USA
Histopathology 59:928-38. 2011..The aim of this study was to assess whether there is evidence of cellular and antibody-mediated rejection in fetal death... - Maternal plasma visfatin in preterm laborShali Mazaki-Tovi
Intramural Division, Perinatology Research Branch, NICHD NIH DHHS, Hutzel Women s Hospital, Bethesda, Maryland, USA
J Matern Fetal Neonatal Med 22:693-704. 2009..The aim of this study was to determine whether spontaneous PTL with intact membranes and intra-amniotic infection/inflammation (IAI) is associated with changes in maternal plasma circulating visfatin concentrations... - Should bilateral uterine artery notching be used in the risk assessment for preeclampsia, small-for-gestational-age, and gestational hypertension?Jimmy Espinoza
Perinatology Research Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland, USA
J Ultrasound Med 29:1103-15. 2010..The purpose of this study was to determine the value of bilateral uterine artery notching in the second trimester in the risk assessment for preeclampsia, gestational hypertension, and small-for-gestational-age (SGA) without preeclampsia... - A signature of maternal anti-fetal rejection in spontaneous preterm birth: chronic chorioamnionitis, anti-human leukocyte antigen antibodies, and C4dJoonho Lee
Perinatology Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
PLoS ONE 6:e16806. 2011..Antibody-mediated rejection is another type of transplantation rejection. We investigated whether there was evidence for antibody-mediated rejection against the fetus in spontaneous preterm birth... - Discordant placental echogenicity: a novel sign of impaired placental perfusion in twin-twin transfusion syndrome?Juan Pedro Kusanovic
Perinatology Research Branch, NICHD NIH DHHS, Bethesda, Maryland, USA
J Matern Fetal Neonatal Med 23:103-6. 2010.... - Maternal serum soluble CD30 is increased in normal pregnancy, but decreased in preeclampsia and small for gestational age pregnanciesJuan Pedro Kusanovic
Perinatology Research Branch, NICHD NIH DHHS, Bethesda, Maryland, USA
J Matern Fetal Neonatal Med 20:867-78. 2007..The objective of this study was to determine whether the maternal serum concentration of sCD30 changes with normal pregnancy, as well as in mothers with preeclampsia and those who deliver SGA neonates... - The frequency, clinical significance, and pathological features of chronic chorioamnionitis: a lesion associated with spontaneous preterm birthChong Jai Kim
Perinatology Research Branch, NICHD NIH DHHS, Bethesda, MD, USA
Mod Pathol 23:1000-11. 2010..Its association with villitis of unknown etiology and the chemokine profile in amniotic fluid suggests an immunological origin, akin to transplantation rejection and graft-versus-host disease in the chorioamniotic membranes... - Twin-to-twin transfusion syndrome: an antiangiogenic state?Juan Pedro Kusanovic
Perinatology Research Branch, NICHD NIH DHHS, Bethesda, MD, USA
Am J Obstet Gynecol 198:382.e1-8. 2008..This study was conducted to determine maternal plasma concentrations of placental growth factor (PlGF), soluble VEGFR-1, and soluble endoglin (s-Eng) in monochorionic-diamniotic pregnancies with and without TTTS... - Unexplained fetal death is associated with increased concentrations of anti-angiogenic factors in amniotic fluidTinnakorn Chaiworapongsa
Perinatology Research Branch, NICHD, NIH, DHHS, Detroit, MI 48201, USA
J Matern Fetal Neonatal Med 23:794-805. 2010..These observations indicate that an excess of anti-angiogenic factors in the amniotic cavity is associated with unexplained fetal death especially in preterm gestations... - First-trimester maternal serum PP13 in the risk assessment for preeclampsiaRoberto Romero
Department of Health and Human Services, Perinatology Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA
Am J Obstet Gynecol 199:122.e1-122.e11. 2008..The objective of the study was to determine whether first-trimester maternal serum placental protein 13 (PP13) concentrations can be used in the risk assessment for preeclampsia... - Serum and plasma determination of angiogenic and anti-angiogenic factors yield different results: the need for standardization in clinical practiceGiovanna Ogge
Perinatology Research Branch, NICHD NIH DHHS, Detroit, Michigan, USA
J Matern Fetal Neonatal Med 23:820-7. 2010..The purpose of this study was to determine if there are differences in the concentrations of these analytes between plasma and serum in normal pregnancy and in preeclampsia... - Visfatin/Pre-B cell colony-enhancing factor in amniotic fluid in normal pregnancy, spontaneous labor at term, preterm labor and prelabor rupture of membranes: an association with subclinical intrauterine infection in preterm parturitionShali Mazaki-Tovi
Perinatology Research Branch, Intramural Division, NICHD NIH DHHS, Hutzel Women s Hospital, Bethesda, MD, USA
J Perinat Med 36:485-96. 2008.... - Could alterations in maternal plasma visfatin concentration participate in the phenotype definition of preeclampsia and SGA?Shali Mazaki-Tovi
Perinatology Research Branch, Intramural Division, NICHD NIH DHHS, Hutzel Women s Hospital, Bethesda, MD, and Detroit, MI 48201, USA
J Matern Fetal Neonatal Med 23:857-68. 2010..Visfatin is a novel adipocytokine with metabolic and immunomodulating properties. The objective of this study was to determine whether preeclampsia and SGA are associated with alterations in maternal circulating visfatin concentrations...