Antonina Roll-Mecak

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Tubulin tyrosine ligase structure reveals adaptation of an ancient fold to bind and modify tubulin
    Agnieszka Szyk
    Cell Biology and Biophysics Unit, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland, USA
    Nat Struct Mol Biol 18:1250-8. 2011
  2. pmc Microtubule-severing enzymes
    Antonina Roll-Mecak
    Cell Biology and Biophysics Unit, NINDS Porter Neuroscience Research Center, Building 35, Room 3B 203, 35 Convent Drive, MSC 3701, Bethesda, MD 20892 3701, United States
    Curr Opin Cell Biol 22:96-103. 2010
  3. doi request reprint Tubulin tyrosine ligase and stathmin compete for tubulin binding in vitro
    Agnieszka Szyk
    Cell Biology and Biophysics Unit, National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892, USA
    J Mol Biol 425:2412-4. 2013
  4. ncbi request reprint Molecular basis for age-dependent microtubule acetylation by tubulin acetyltransferase
    Agnieszka Szyk
    Cell Biology and Biophysics Unit, Porter Neuroscience Research Center, National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892, USA
    Cell 157:1405-15. 2014
  5. pmc Crystal structures of tubulin acetyltransferase reveal a conserved catalytic core and the plasticity of the essential N terminus
    Vasilisa Kormendi
    Cell Biology and Biophysics Unit, NINDS, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 287:41569-75. 2012
  6. pmc The chemical complexity of cellular microtubules: tubulin post-translational modification enzymes and their roles in tuning microtubule functions
    Christopher P Garnham
    Cell Biology and Biophysics Unit, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland, USA
    Cytoskeleton (Hoboken) 69:442-63. 2012
  7. doi request reprint In vitro microtubule severing assays
    Natasza E Ziółkowska
    Cell Biology and Biophysics Unit, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA
    Methods Mol Biol 1046:323-34. 2013
  8. doi request reprint Generation of differentially modified microtubules using in vitro enzymatic approaches
    Annapurna Vemu
    Cell Biology and Biophysics Unit, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland, USA
    Methods Enzymol 540:149-66. 2014

Collaborators

Detail Information

Publications8

  1. pmc Tubulin tyrosine ligase structure reveals adaptation of an ancient fold to bind and modify tubulin
    Agnieszka Szyk
    Cell Biology and Biophysics Unit, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland, USA
    Nat Struct Mol Biol 18:1250-8. 2011
    ....
  2. pmc Microtubule-severing enzymes
    Antonina Roll-Mecak
    Cell Biology and Biophysics Unit, NINDS Porter Neuroscience Research Center, Building 35, Room 3B 203, 35 Convent Drive, MSC 3701, Bethesda, MD 20892 3701, United States
    Curr Opin Cell Biol 22:96-103. 2010
    ..Here we review the diverse in vivo functions of these proteins and the recent significant advances in deciphering the biophysical mechanism of microtubule severing...
  3. doi request reprint Tubulin tyrosine ligase and stathmin compete for tubulin binding in vitro
    Agnieszka Szyk
    Cell Biology and Biophysics Unit, National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892, USA
    J Mol Biol 425:2412-4. 2013
    ..These results suggest either that TTL and stathmin have a partially overlapping footprint on the tubulin dimer or that stathmin induces a tubulin conformation incompatible with stable TTL binding. ..
  4. ncbi request reprint Molecular basis for age-dependent microtubule acetylation by tubulin acetyltransferase
    Agnieszka Szyk
    Cell Biology and Biophysics Unit, Porter Neuroscience Research Center, National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892, USA
    Cell 157:1405-15. 2014
    ..Thus, because of its preference for microtubules over free tubulin and its modest catalytic rate, TAT can function as a slow clock for microtubule lifetimes. ..
  5. pmc Crystal structures of tubulin acetyltransferase reveal a conserved catalytic core and the plasticity of the essential N terminus
    Vasilisa Kormendi
    Cell Biology and Biophysics Unit, NINDS, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 287:41569-75. 2012
    ..Our structures provide a rational platform for the mechanistic dissection of TAT activity and the design of TAT inhibitors with therapeutic potential in neuronal regeneration...
  6. pmc The chemical complexity of cellular microtubules: tubulin post-translational modification enzymes and their roles in tuning microtubule functions
    Christopher P Garnham
    Cell Biology and Biophysics Unit, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland, USA
    Cytoskeleton (Hoboken) 69:442-63. 2012
    ....
  7. doi request reprint In vitro microtubule severing assays
    Natasza E Ziółkowska
    Cell Biology and Biophysics Unit, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA
    Methods Mol Biol 1046:323-34. 2013
    ..We present a detailed protocol for a light microscopy based in vitro microtubule severing assay that was instrumental in the identification and characterization of these enzymes. ..
  8. doi request reprint Generation of differentially modified microtubules using in vitro enzymatic approaches
    Annapurna Vemu
    Cell Biology and Biophysics Unit, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland, USA
    Methods Enzymol 540:149-66. 2014
    ....