Derek Le Roith

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint The somatomedin hypothesis: 2001
    D Le Roith
    Clinical Endocrinology Branch, National Institutes of Health, Bethesda, Maryland 20892 1758, USA
    Endocr Rev 22:53-74. 2001
  2. ncbi request reprint Non-islet cell hypoglycemia
    D LeRoith
    NIDDK, Bethesda MD 20892, USA
    Ann Endocrinol (Paris) 65:99-103. 2004
  3. pmc The insulin-like growth factor system
    Derek Le Roith
    Diabetes Branch, National Institutes of Health, Bethesda, Maryland 20892 1758, USA
    Exp Diabesity Res 4:205-12. 2003
  4. ncbi request reprint Loss of glucose homoeostasis: implications of basal glycaemia in type 2 diabetes
    Derek LeRoith
    National Institutes of Health, Diabetes Branch, Bethesda, MD 20892, USA
    Diabetes Obes Metab 5:285-94. 2003
  5. ncbi request reprint The new kid on the block(ade) of the IGF-1 receptor
    Derek LeRoith
    Diabetes Branch, NIDDK, Pediatric Oncology Branch, NCI, Bethesda, MD 20892 USA
    Cancer Cell 5:201-2. 2004
  6. ncbi request reprint The insulin-like growth factor system and cancer
    Derek LeRoith
    Diabetes Branch, Room 8D12, Building 10, National Institutes of Health MSC 1758, Bethesda, MD 20892 1758, USA
    Cancer Lett 195:127-37. 2003
  7. pmc Knock your SOCS off!
    Derek LeRoith
    Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases NIDDK, National Cancer Institute, NIH, Bethesda, Maryland 20892 1758, USA
    J Clin Invest 115:233-6. 2005
  8. ncbi request reprint Inactivation of muscle insulin and IGF-I receptors and insulin responsiveness
    Derek Le Roith
    Clinical Endocrinology Branch, National Institutes of Health, Bethesda, Maryland 20892 1758, USA
    Curr Opin Clin Nutr Metab Care 5:371-5. 2002
  9. ncbi request reprint Mouse models created to study the pathophysiology of Type 2 diabetes
    Derek LeRoith
    Diabetes Branch, National Institutes of Health, Room 8D12, Building 10, Bethesda, MD 20892 1758, USA
    Int J Biochem Cell Biol 38:904-12. 2006
  10. ncbi request reprint What is the role of circulating IGF-I?
    D Le Roith
    Clinical Endocrinology Branch, NIDDK, National Institutes of Health, Bethesda, MD 20892 1758, USA
    Trends Endocrinol Metab 12:48-52. 2001

Detail Information

Publications79

  1. ncbi request reprint The somatomedin hypothesis: 2001
    D Le Roith
    Clinical Endocrinology Branch, National Institutes of Health, Bethesda, Maryland 20892 1758, USA
    Endocr Rev 22:53-74. 2001
    ..Thus, the normal postnatal growth and development in these animals may be due to normal free IGF-I levels (from as yet unidentified sources), although the role of autocrine/paracrine IGF-I has yet to be determined...
  2. ncbi request reprint Non-islet cell hypoglycemia
    D LeRoith
    NIDDK, Bethesda MD 20892, USA
    Ann Endocrinol (Paris) 65:99-103. 2004
    ..NICTH has brought together the molecular biologists and endocrinologists in a classic cross cultural coordination to study the disorder from all angles and to further understand the disorder...
  3. pmc The insulin-like growth factor system
    Derek Le Roith
    Diabetes Branch, National Institutes of Health, Bethesda, Maryland 20892 1758, USA
    Exp Diabesity Res 4:205-12. 2003
    ..There are now numerous examples of diseases such as diabetes, cancer, and malnutrition in which the IGF system is a major player and, not surprisingly, there are attempts to affect these disorders by manipulating the system...
  4. ncbi request reprint Loss of glucose homoeostasis: implications of basal glycaemia in type 2 diabetes
    Derek LeRoith
    National Institutes of Health, Diabetes Branch, Bethesda, MD 20892, USA
    Diabetes Obes Metab 5:285-94. 2003
  5. ncbi request reprint The new kid on the block(ade) of the IGF-1 receptor
    Derek LeRoith
    Diabetes Branch, NIDDK, Pediatric Oncology Branch, NCI, Bethesda, MD 20892 USA
    Cancer Cell 5:201-2. 2004
    ..Its involvement in cancer cell growth and survival makes the system an excellent target as potential adjunct therapy to standard chemotherapy...
  6. ncbi request reprint The insulin-like growth factor system and cancer
    Derek LeRoith
    Diabetes Branch, Room 8D12, Building 10, National Institutes of Health MSC 1758, Bethesda, MD 20892 1758, USA
    Cancer Lett 195:127-37. 2003
    ..In this review, many aspects of the IGF system and its relationship to cancer will be discussed...
  7. pmc Knock your SOCS off!
    Derek LeRoith
    Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases NIDDK, National Cancer Institute, NIH, Bethesda, Maryland 20892 1758, USA
    J Clin Invest 115:233-6. 2005
    ....
  8. ncbi request reprint Inactivation of muscle insulin and IGF-I receptors and insulin responsiveness
    Derek Le Roith
    Clinical Endocrinology Branch, National Institutes of Health, Bethesda, Maryland 20892 1758, USA
    Curr Opin Clin Nutr Metab Care 5:371-5. 2002
    ..This review will outline the recent advances in the area of insulin-stimulated skeletal muscle glucose uptake and its effect on whole body glucose homeostasis, using gene-deletion and transgenic mouse models...
  9. ncbi request reprint Mouse models created to study the pathophysiology of Type 2 diabetes
    Derek LeRoith
    Diabetes Branch, National Institutes of Health, Room 8D12, Building 10, Bethesda, MD 20892 1758, USA
    Int J Biochem Cell Biol 38:904-12. 2006
    ..This review will summarize many of the more appropriate models that study insulin resistance and Type 2 diabetes...
  10. ncbi request reprint What is the role of circulating IGF-I?
    D Le Roith
    Clinical Endocrinology Branch, NIDDK, National Institutes of Health, Bethesda, MD 20892 1758, USA
    Trends Endocrinol Metab 12:48-52. 2001
    ..Results gleaned from a mouse model created by tissue-specific gene deletion of liver IGF-I has enabled investigators to re-evaluate the original 'somatomedin hypothesis'...
  11. ncbi request reprint Genetic background (C57BL/6J versus FVB/N) strongly influences the severity of diabetes and insulin resistance in ob/ob mice
    Martin Haluzik
    Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Endocrinology 145:3258-64. 2004
    ....
  12. ncbi request reprint Molecular mechanisms by which metabolic control may improve outcomes
    Derek Le Roith
    Diabetes Branch, National Institutes of Health, Bethesda, Maryland, USA
    Endocr Pract 10:57-62. 2004
    ..To summarize available evidence providing potential explanations for metabolic and nonmetabolic abnormalities during conditions of acute stress and possible mechanisms whereby insulin therapy may affect these changes...
  13. ncbi request reprint Leptin improves insulin resistance and hyperglycemia in a mouse model of type 2 diabetes
    Yuka Toyoshima
    Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Room 8D12, Building 10, MSC 1758, National Institutes of Health, Bethesda, Maryland 20892 1758, USA
    Endocrinology 146:4024-35. 2005
    ..Our data suggest that leptin could be a potent antidiabetic drug in cases of type 2 diabetes that are not leptin resistant...
  14. pmc Inhibition of growth hormone action improves insulin sensitivity in liver IGF-1-deficient mice
    Shoshana Yakar
    Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda Maryland 20892 1758, USA
    J Clin Invest 113:96-105. 2004
    ..These results suggest that IGF-1 plays a role in maintaining a fine balance between GH and insulin to promote normal carbohydrate and lipid metabolism...
  15. ncbi request reprint Phloridzin improves hyperglycemia but not hepatic insulin resistance in a transgenic mouse model of type 2 diabetes
    Hong Zhao
    Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 1758, USA
    Diabetes 53:2901-9. 2004
    ..These results suggest that glucotoxicity plays little or no role in the worsening of insulin resistance that occurs in the MKR mouse model of type 2 diabetes...
  16. ncbi request reprint Beta-cell dysfunction and insulin resistance in type 2 diabetes: role of metabolic and genetic abnormalities
    Derek LeRoith
    Clinical Endocrinology Branch of the National Institutes of Health, Bethesda, Maryland, USA
    Am J Med 113:3S-11S. 2002
    ..Therefore, attention to these toxicities may delay the deterioration of beta-cell function and suggest new approaches to the management of type 2 diabetes...
  17. ncbi request reprint Reduced expression of insulin-like growth factor I receptors in MCF-7 breast cancer cells leads to a more metastatic phenotype
    Patricia A Pennisi
    Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland 20892 1758, USA
    Cancer Res 62:6529-37. 2002
    ....
  18. ncbi request reprint Muscle-specific overexpression of CD36 reverses the insulin resistance and diabetes of MKR mice
    Lisa Heron-Milhavet
    Diabetes Branch, NIDDK, Room 8D12, Building 10, National Institutes of Health, Bethesda, Maryland 20892 1758, USA
    Endocrinology 145:4667-76. 2004
    ....
  19. ncbi request reprint Recombinant human insulin-like growth factor-I treatment inhibits gluconeogenesis in a transgenic mouse model of type 2 diabetes mellitus
    Patricia Pennisi
    Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Betheda, MD 20892, USA
    Endocrinology 147:2619-30. 2006
    ..Also, these results suggest that a functional IGF-I receptor in skeletal muscle is required for IGF-I to improve insulin sensitivity in this mouse model of type 2 DM...
  20. ncbi request reprint Insulin resistance in the liver-specific IGF-1 gene-deleted mouse is abrogated by deletion of the acid-labile subunit of the IGF-binding protein-3 complex: relative roles of growth hormone and IGF-1 in insulin resistance
    Martin Haluzik
    Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 1758, USA
    Diabetes 52:2483-9. 2003
    ..The present study suggests that whereas GH plays a major role in inducing insulin resistance, IGF-1 may have a direct modulatory role...
  21. ncbi request reprint Multiple signaling pathways are involved in the regulation of IGF-I receptor inhibition of PTEN-enhanced apoptosis
    Yiping Wu
    Chief Diabetes Branch, Room 8D12, Bldg 10, Bethesda, MD 20892 1758, USA
    Growth Horm IGF Res 14:52-8. 2004
    ..Furthermore, IGF-I receptor abrogation of this apoptotic effect was inhibited by both PI3' kinase and by specific inhibitors of p38 MAP kinase. Thus, we show for the first time that p38 MAP kinase is involved in this process...
  22. ncbi request reprint Hepatic CCAAT/enhancer binding protein alpha mediates induction of lipogenesis and regulation of glucose homeostasis in leptin-deficient mice
    Kimihiko Matsusue
    Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Endocrinol 18:2751-64. 2004
    ..Taken together, these results indicate that hepatic C/EBP alpha plays a critical role in the acceleration of lipogenesis in ob/ob mice and in glucose homeostasis by the indirect regulation of insulin secretion...
  23. ncbi request reprint The role of the growth hormone/insulin-like growth factor axis in tumor growth and progression: Lessons from animal models
    Shoshana Yakar
    Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 1758, USA
    Cytokine Growth Factor Rev 16:407-20. 2005
    ..This review highlights many of the most relevant studies in this exciting area of research, focusing in particular on lessons learned from animal models of cancer...
  24. ncbi request reprint Absence of the full-length breast cancer-associated gene-1 leads to increased expression of insulin-like growth factor signaling axis members
    Vivek Shukla
    Genetics of Development and Disease Branch and Diabetes Branch, National Institute of Diabetes, Digestive and Kidney Diseases, NIH, Bethesda, Maryland 20892, USA
    Cancer Res 66:7151-7. 2006
    ..Those observations provide a molecular insight in understanding both fundamental and therapeutic BRCA1-associated tumorigenesis and aging...
  25. ncbi request reprint 14-3-3sigma mediation of cell cycle progression is p53-independent in response to insulin-like growth factor-I receptor activation
    Yang Zhang
    Section on Molecular and Cellular Physiology, Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases NIH, Bethesda, MD 20892 1758, USA
    J Biol Chem 279:34353-60. 2004
    ..This effect was also associated with a reduction in IGF-I-induced cyclin D1 expression. Taken together, these results suggest that 14-3-3sigma positively mediates IGF-I-induced cell cycle progression...
  26. ncbi request reprint Metabolic effects of IGF-I deficiency: lessons from mouse models
    Shoshana Yakar
    Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Pediatr Endocrinol Rev 3:11-9. 2005
    ..In the present review we will summarize the role of GH and IGF in somatic growth and focus on the metabolic effects of IGF-I deficiency as assessed in various mouse models...
  27. ncbi request reprint Role of growth hormone (GH) in liver regeneration
    Patricia A Pennisi
    Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Room 8D12, Building 10, National Institutes of Health, Bethesda, Maryland 20892 1758, USA
    Endocrinology 145:4748-55. 2004
    ..These results suggest that GH plays a critical role in liver regeneration, although whether it acts directly or indirectly remains to be determined...
  28. ncbi request reprint MKR mice are resistant to the metabolic actions of both insulin and adiponectin: discordance between insulin resistance and adiponectin responsiveness
    Chul Hee Kim
    Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Am J Physiol Endocrinol Metab 291:E298-305. 2006
    ..MKR mice may be a useful model for dissecting relationships between insulin resistance and adiponectin action in regulation of glucose homeostasis...
  29. ncbi request reprint Murine osteosarcoma primary tumour growth and metastatic progression is maintained after marked suppression of serum insulin-like growth factor I
    Sung Hyeok Hong
    Pediatric Oncology Branch, Centre for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Int J Cancer 124:2042-9. 2009
    ..Collectively, these data suggest that marked reduction in serum IGF-I is not sufficient to slow the progression of either primary or metastatic models of osteosarcoma...
  30. pmc Circulating levels of IGF-1 directly regulate bone growth and density
    Shoshana Yakar
    Section on Cellular and Molecular Physiology, Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Health, Bethesda, Maryland 20892, USA
    J Clin Invest 110:771-81. 2002
    ....
  31. ncbi request reprint Reduced circulating insulin-like growth factor I levels delay the onset of chemically and genetically induced mammary tumors
    Yiping Wu
    Section on Cellular and Molecular Physiology, Diabetes Branch, National Institute of Diabetes, Digestive and Kidney Diseases NIH, Building 10, Bethesda, MD 20892, USA
    Cancer Res 63:4384-8. 2003
    ..Our data demonstrate that circulating IGF-I levels play a significant role as a risk factor in the onset and development of mammary tumors in two well-established animal models of breast cancer...
  32. ncbi request reprint Peroxisome proliferator-activated receptor-alpha agonist treatment in a transgenic model of type 2 diabetes reverses the lipotoxic state and improves glucose homeostasis
    Hyunsook Kim
    Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 1758, USA
    Diabetes 52:1770-8. 2003
    ..Taken together, these findings suggest that the reduction in circulating or intracellular lipids by activation of PPAR-alpha improved insulin sensitivity and the diabetic condition of MKR mice...
  33. ncbi request reprint Circulating IGF-1 and its role in cancer: lessons from the IGF-1 gene deletion (LID) mouse
    Shoshana Yakar
    Diabetes Branch, Room 8D12, Building 10, National Institutes of Health, MSC 1758, Bethesda MD 20892 1758, USA
    Novartis Found Symp 262:3-9; discussion 9-18, 265-8. 2004
    ..These mice show a lower risk for the development of colon and breast cancers and metastases when compared with control mice, and lend support to the hypothesis that circulating IGF-1 may be linked to cancer cell growth...
  34. ncbi request reprint The growth hormone-insulin like growth factor axis revisited: lessons from IGF-1 and IGF-1 receptor gene targeting
    Shoshana Yakar
    Diabetes Branch, National Institutes of Health, MSC 1758, Bethesda, MD 20892 1758, USA
    Pediatr Nephrol 20:251-4. 2005
    ..These models are therefore very useful in studying human physiology and disease states...
  35. pmc Induction of intrahepatic cholangiocellular carcinoma by liver-specific disruption of Smad4 and Pten in mice
    Xiaoling Xu
    Genetics of Development and Disease Branch, NIDDK, NIH, Bethesda, Maryland 20892, USA
    J Clin Invest 116:1843-52. 2006
    ..These findings elucidate the relationship between SMAD4 and PTEN and extend our understanding of CC formation...
  36. ncbi request reprint Effect of adipocyte beta3-adrenergic receptor activation on the type 2 diabetic MKR mice
    Hyunsook Kim
    Diabetes Branch, National Institute of Diabetes, Digestive and Kidney Diseases, NIH, Bethesda, MD, USA
    Am J Physiol Endocrinol Metab 290:E1227-36. 2006
    ....
  37. pmc Muscle-specific inactivation of the IGF-I receptor induces compensatory hyperplasia in skeletal muscle
    Ana M Fernandez
    Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Invest 109:347-55. 2002
    ..These findings suggest that regulation of these cellular elements by IGF-I may play a role in the development and differentiation of skeletal muscle in vivo...
  38. pmc PTEN overexpression suppresses proliferation and differentiation and enhances apoptosis of the mouse mammary epithelium
    Joelle Dupont
    Section on Molecular and Cellular Physiology, Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland 20892, USA
    J Clin Invest 110:815-25. 2002
    ..MK-PTEN mice also exhibited a 50% decrease in the phosphorylation state of Akt. Taken together, these results suggest that PTEN controls mammary gland development and, consequently, lactation...
  39. ncbi request reprint Intact insulin and insulin-like growth factor-I receptor signaling is required for growth hormone effects on skeletal muscle growth and function in vivo
    Hyunsook Kim
    Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 9000 Rockville Pike, Building 10, Room 8D12, Bethesda, Maryland 20892 1758, USA
    Endocrinology 146:1772-9. 2005
    ..Taken together, these data suggest that the in vivo effects of GH on muscle mass and strength are primarily mediated by activation of the IGF-I receptor...
  40. ncbi request reprint TDAG51 mediates the effects of insulin-like growth factor I (IGF-I) on cell survival
    Yuka Toyoshima
    Section on Molecular and Cellular Physiology, Diabetes Branch, NIDDK, National Institutes of Health, Bethesda, Maryland 20892 1758, USA
    J Biol Chem 279:25898-904. 2004
    ..Furthermore, TDAG51 siRNA expression abolished the ability of IGF-I to rescue cells from serum starvation-induced apoptosis. These findings suggest that TDAG51 plays an important role in the anti-apoptotic effects of IGF-I...
  41. ncbi request reprint Clinical relevance of systemic and local IGF-I
    Shoshana Yakar
    Diabetes Branch, NIDDK, NIH MSC, Bethesda, MD 20892 1758, USA
    Endocr Dev 9:11-6. 2005
    ..In addition, low levels of circulating IGF-I retard the progression and metastatic potential of a number of cancers...
  42. ncbi request reprint Circulating insulin-like growth factor-I levels regulate colon cancer growth and metastasis
    Yiping Wu
    Section of Cellular and Molecular Physiology, Cellular Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland 20892 1758, USA
    Cancer Res 62:1030-5. 2002
    ..This study supports the hypothesis that circulating IGF-I levels play an important role in tumor development and metastasis...
  43. ncbi request reprint Characterization of gsp-mediated growth hormone excess in the context of McCune-Albright syndrome
    Sunday O Akintoye
    Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research NIH, Building 30, MSC 4320, Bethesda, MD 20892 4320, USA
    J Clin Endocrinol Metab 87:5104-12. 2002
    ....
  44. ncbi request reprint PTEN inhibits cell proliferation and induces apoptosis by downregulating cell surface IGF-IR expression in prostate cancer cells
    Hong Zhao
    Diabetes Branch, NIDDK, National Institute of Health, Room 8D12, Bldg 10, Bethesda, MD 20892 1758, USA
    Oncogene 23:786-94. 2004
    ..These results have important implications for understanding the roles of PTEN and the IGF-IR in prostate cancer cell tumorigenesis...
  45. ncbi request reprint The cyclin-dependent kinase inhibitor p21CIP/WAF is a positive regulator of insulin-like growth factor I-induced cell proliferation in MCF-7 human breast cancer cells
    Joelle Dupont
    Section on Molecular and Cellular Physiology, Diabetes Branch, NIDDK, National Institutes of Health, Bethesda, Maryland 20892 1758, USA
    J Biol Chem 278:37256-64. 2003
    ..Taken together, these results define p21CIP/WAF as a positive regulator in the cell proliferation induced by IGF-1 in MCF-7 cells...
  46. ncbi request reprint The ternary IGF complex influences postnatal bone acquisition and the skeletal response to intermittent parathyroid hormone
    Shoshana Yakar
    National Institute of Diabetes, Digestive and Kidney Diseases, Bethesda, Maryland, USA
    J Endocrinol 189:289-99. 2006
    ..We postulate that the ternary complex itself, rather than IGF-I alone, influences bone acquisition in a compartment-specific manner (i.e. cortical vs trabecular bone)...
  47. ncbi request reprint Insulin-like growth factor I induces MDM2-dependent degradation of p53 via the p38 MAPK pathway in response to DNA damage
    Lisa Heron-Milhavet
    Section on Cellular and Molecular Physiology, Clinical Endocrinology Branch, NIDDK, National Institutes of Health, Bethesda, Maryland 20892 1758, USA
    J Biol Chem 277:15600-6. 2002
    ..In conclusion, we describe a novel role for IGF-I in the regulation of the MDM2/p53/p21 signaling pathway during DNA damage...
  48. ncbi request reprint Increased tumor growth in mice with diet-induced obesity: impact of ovarian hormones
    Shoshana Yakar
    Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Endocrinology 147:5826-34. 2006
    ..Overall, these data point to more rapid tumor growth in obese mice and suggest that endogenous sex steroids, together with diet, affect adiposity, insulin sensitivity, and tumor growth in female mice...
  49. ncbi request reprint Hodgkin lymphoma in temporal association with growth hormone replacement
    Renee J Freedman
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, Bethesda, MD 20892, USA
    Endocr J 52:571-5. 2005
    ....
  50. ncbi request reprint Protection against hypoxic-ischemic injury in transgenic mice overexpressing Kir6.2 channel pore in forebrain
    Lisa Heron-Milhavet
    National Institutes of Health, Diabetes Branch, NIDDK, Bethesda, MD 20892 1758, USA
    Mol Cell Neurosci 25:585-93. 2004
    ..Taken together, these results indicate that the transgenic overexpression of Kir6.2 in forebrain significantly protects mice from hypoxic-ischemic injury and neuronal damage seen in stroke...
  51. ncbi request reprint Local adeno-associated virus-mediated interleukin 10 gene transfer has disease-modifying effects in a murine model of Sjögren's syndrome
    Marc R Kok
    Gene Therapy and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    Hum Gene Ther 14:1605-18. 2003
    ....
  52. ncbi request reprint Metabolic memory in diabetes--focus on insulin
    Derek LeRoith
    Georgetown University School of Medicine, USA
    Diabetes Metab Res Rev 21:85-90. 2005
    ..Thus, our overall goal is to understand in more detail the molecular mechanisms involved in these changes, thereby affording us opportunities to reduce the long-term effects of diabetes...
  53. ncbi request reprint Effects of organ-specific loss of insulin-like growth factor-I production on murine hematopoiesis
    Lisbeth A Welniak
    Department of Microbiology and Immunology, University of Nevada School of Medicine, Reno 89557, USA
    Biol Blood Marrow Transplant 10:32-9. 2004
    ..Liver production of IGF-I and, therefore, normal serum levels of this hormone, although not necessary for general organ growth and development, seems necessary for survival or transition of myeloid progenitors into the spleen...
  54. ncbi request reprint Epithelial-specific and stage-specific functions of insulin-like growth factor-I during postnatal mammary development
    Aimee V Loladze
    Department of Neural and Behavioral Sciences, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Endocrinology 147:5412-23. 2006
    ..Taken together, our results support distinct roles for IGF-I expressed in epithelial and stromal compartments in mediating growth of the postnatal mammary gland...
  55. ncbi request reprint The role of the IGF system in cancer growth and metastasis: overview and recent insights
    Amir Abbas Samani
    Department of Medicine, McGill University Health Center, Royal Victoria Hospital, Room H6 25687, Pine Avenue West, Montreal, Quebec, Canada H3A 1A1
    Endocr Rev 28:20-47. 2007
    ....
  56. ncbi request reprint Insulin-like growth factor-I stimulates both cell growth and lipogenesis during differentiation of human mesenchymal stem cells into adipocytes
    Louis M Scavo
    Division of Neonatology, Children s National Medical Center, George Washington University School of Medicine, Washington, DC 20010, USA
    J Clin Endocrinol Metab 89:3543-53. 2004
    ..Taken together, these findings suggest that IGF-I plays a critical role in adipocyte differentiation and lipid accumulation...
  57. ncbi request reprint Mechanisms of disease: metabolic effects of growth hormone and insulin-like growth factor 1
    Derek LeRoith
    Division of Endocrinology, Diabetes and Bone Diseases, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    Nat Clin Pract Endocrinol Metab 3:302-10. 2007
    ..For example, excess growth hormone causes insulin resistance and hyperglycemia, whereas IGF1 has insulin-like effects that reduce blood glucose levels and has been used experimentally to treat both type 1 and type 2 diabetes...
  58. ncbi request reprint Insulin resistance as the underlying cause for the metabolic syndrome
    Danielle Lann
    Division of Endocrinology, Diabetes, and Bone Diseases, Department of Medicine, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1055, New York, NY 10029 6574, USA
    Med Clin North Am 91:1063-77, viii. 2007
    ..This article outlines how abnormal insulin signaling and secretion, impaired glucose disposal, lipotoxicity, and proinflammatory cytokines exacerbate insulin resistance and result in the perturbations of the metabolic syndrome...
  59. ncbi request reprint Peroxisome proliferator-activated receptor-alpha deficiency does not alter insulin sensitivity in mice maintained on regular or high-fat diet: hyperinsulinemic-euglycemic clamp studies
    Martin Haluzik
    Third Department of Medicine, First Faculty of Medicine, Charles University, Prague, Czech Republic
    Endocrinology 145:1662-7. 2004
    ....
  60. pmc Mechanisms of disease: using genetically altered mice to study concepts of type 2 diabetes
    Derek LeRoith
    Department of Medicine, Mount Sinai School of Medicine, 1 Gustave L Levy Place, Atran AB4 36, Box 1055, New York, NY 10029 6574, USA
    Nat Clin Pract Endocrinol Metab 4:164-72. 2008
    ....
  61. ncbi request reprint Clinical relevance of systemic and local IGF-I: lessons from animal models
    Derek LeRoith
    Mount Sinai School of Medicine, One Gustave L Levy Place, Levy Place Box 1055, New York, NY 10029, USA
    Pediatr Endocrinol Rev 5:739-43. 2008
    ..Despite the advances in knowledge made through these animal models, our understanding of the IGF-I system is still incomplete...
  62. ncbi request reprint Treatment of diabetes: a clinical update on insulin trials
    Derek LeRoith
    Division of Endocrinology, Diabetes and Bone Disease, Department of Medicine, Mount Sinai School of Medicine, New York, New York 10024, USA
    Clin Cornerstone 8:21-9; discussion 30-2. 2007
    ..The newer insulin analogues in combination with oral antidiabetic agents provide a viable option for improving glycemic control and preventing or delaying the occurrence of complications...
  63. pmc Targeted deletion of hepatic Igf1 in TRAMP mice leads to dramatic alterations in the circulating insulin-like growth factor axis but does not reduce tumor progression
    Makoto Anzo
    David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Cancer Res 68:3342-9. 2008
    ....
  64. ncbi request reprint Dyslipidemia and glucose dysregulation in overweight and obese patients
    Derek LeRoith
    Division of Endocrinology, Diabetes and Bone Disease Department, Medicine Mount Sinai School of Medicine, New York, New York 10024, USA
    Clin Cornerstone 8:38-52. 2007
    ..The endocannabinoid system plays an important role in regulating metabolism through its effects on food intake at the level of the hypothalamus and on body composition through peripheral effects on adipose tissue...
  65. ncbi request reprint Role of STAT-3 in regulation of hepatic gluconeogenic genes and carbohydrate metabolism in vivo
    Hiroshi Inoue
    Department of Clinical Molecular Medicine, Division of Diabetes and Digestive and Kidney Diseases, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    Nat Med 10:168-74. 2004
    ..Hepatic STAT-3 signaling is thus essential for normal glucose homeostasis and may provide new therapeutic targets for diabetes mellitus...
  66. ncbi request reprint Intensive insulin therapy in the medical ICU
    Ronald Tamler
    N Engl J Med 354:2069-71; author reply 2069-71. 2006
  67. ncbi request reprint Pancreatic-specific inactivation of IGF-I gene causes enlarged pancreatic islets and significant resistance to diabetes
    Yarong Lu
    Department of Medicine, McGill University Health Centre, Montreal, Quebec, Canada
    Diabetes 53:3131-41. 2004
    ..Our results suggest that locally produced IGF-I within the pancreas inhibits islet cell growth; its deficiency provides a protective environment to the beta-cells and potential in combating diabetes...
  68. ncbi request reprint Microarray analysis and identification of novel molecules involved in insulin-like growth factor-1 receptor signaling and gene expression
    Joelle Dupont
    Physiologie de la Reproduction et des Comportements, Unite Mixte de Recherches 6073, Institut National de la Recherche Agronomique Centre National de la Recherche Scientifique, Université F Rabelais, Tours 37380 Nouzilly, France
    Recent Prog Horm Res 58:325-42. 2003
    ..These results strongly suggest that this technology may be extremely useful in identifying groups of genes that are specifically regulated by different ligands and their activated receptors...
  69. pmc Serine phosphorylation proximal to its phosphotyrosine binding domain inhibits insulin receptor substrate 1 function and promotes insulin resistance
    Yan Fang Liu
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Mol Cell Biol 24:9668-81. 2004
    ....
  70. ncbi request reprint The luteinizing hormone-releasing hormone inhibits the anti-apoptotic activity of insulin-like growth factor-1 in pituitary alphaT3 cells by protein kinase Calpha-mediated negative regulation of Akt
    Annabel Rose
    Unite de Physiologie de la Reproduction et des Comportements, Institut National de la Recherche Agronomique, 37380 Nouzilly, France
    J Biol Chem 279:52500-16. 2004
    ..Our results demonstrate for the first time that several interactions take place between IGF-1 and LHRH receptors in gonadotrope cells...
  71. ncbi request reprint Liver-specific IGF-I gene deficient mice exhibit accelerated diabetes in response to streptozotocin, associated with early onset of insulin resistance
    Rong Yu
    Fraser Laboratories, M3 15, Department of Medicine, McGill University Health Center, 687 Pine Avenue West, Montreal, Quebec, Canada H3A 1A1
    Mol Cell Endocrinol 204:31-42. 2003
    ..The pancreatic islet hyperplasia observed in these mice seems to represent a compensatory response to insulin resistance, therefore, offers no protection against beta-cell damage...
  72. ncbi request reprint Protein calorie restriction affects nonhepatic IGF-I production and the lymphoid system: studies using the liver-specific IGF-I gene-deleted mouse model
    Wilson Mejia Naranjo
    Department of Chemistry, National University of Columbia, Bogota, Cundinamarca
    Endocrinology 143:2233-41. 2002
    ..These results support the hypothesis that the splenic GH/IGF-I axis responds to the nutritional stress caused by a low protein intake, to maintain the tissue homeostasis...
  73. ncbi request reprint Increased P85alpha is a potent negative regulator of skeletal muscle insulin signaling and induces in vivo insulin resistance associated with growth hormone excess
    Linda A Barbour
    Department of Medicine, University Colorado Health Sciences Center, Denver, 80262, USA
    J Biol Chem 280:37489-94. 2005
    ....
  74. ncbi request reprint Editorial: A blast from the past--insulin does it again!
    Derek LeRoith
    J Clin Endocrinol Metab 89:3103-4. 2004
  75. ncbi request reprint Insulin-like growth factor-I: compartmentalization within the somatotropic axis?
    Andrew A Butler
    The Vollum Institute, Oregon Health Sciences University, Portland, Oregon 97201, USA
    News Physiol Sci 17:82-5. 2002
    ..The relative contributions of tissue vs. endocrine (hepatic) IGF-I to the regulation of growth has been a fundamental question. New gene targeting technologies are providing answers for these questions...
  76. ncbi request reprint Regulation of the splenic somatotropic axis by dietary protein and insulin-like growth factor-I in the rat
    Wilson Mejia-Naranjo
    Department of Chemistry, National University of Colombia, P O Box 14490, Bogota, Colombia
    Growth Horm IGF Res 13:254-63. 2003
    ..These results suggest that in catabolic stress, induced by protein malnutrition the splenic GH/IGF-I axis is an important modulator and contributes to the maintenance of the homeostasis of the immune system...
  77. ncbi request reprint Type 2 diabetes: the role of basal insulin therapy
    Derek LeRoith
    J Fam Pract 53:215-22. 2004
  78. pmc Insulin-like growth factor 1 receptor signaling regulates skin development and inhibits skin keratinocyte differentiation
    Marianna Sadagurski
    Department of Pathology, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    Mol Cell Biol 26:2675-87. 2006
    ..In conclusion, these results reveal that IGF-1R plays an inhibitory role in the regulation of skin development and differentiation...
  79. ncbi request reprint The benefits of tight glycemic control in type 2 diabetes mellitus
    Derek LeRoith
    Division of Endocrinology, Diabetes and Bone Disease, Department of Medicine, Mount Sinai School of Medicine, New York, New York 10024, USA
    Clin Cornerstone 8:S19-29. 2007
    ....