Genomes and Genes
Affiliation: National Institutes of Health
- Future of molecular profiling of human hepatocellular carcinomaStephanie Roessler
National Cancer Institute, Laboratory of Human Carcinogenesis, Center for Cancer Research, NIH, 37 Convent Drive, Bldg 37, Rm 3044A, Bethesda, MD 20892 4258, USA
Future Oncol 3:429-39. 2007..Such an approach will provide mechanistic insight into the pathogenesis of HCC, potentially leading to personalized medicine and the identification of new therapeutic targets...
- Integrated metabolite and gene expression profiles identify lipid biomarkers associated with progression of hepatocellular carcinoma and patient outcomesAnuradha Budhu
Liver Carcinogenesis Section, Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA
Gastroenterology 144:1066-1075.e1. 2013..We combined gene expression and metabolic profiling analyses to identify factors associated with outcomes of patients with hepatocellular carcinoma (HCC)...
- Transcriptomic profiling reveals hepatic stem-like gene signatures and interplay of miR-200c and epithelial-mesenchymal transition in intrahepatic cholangiocarcinomaNaoki Oishi
National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
Hepatology 56:1792-803. 2012..NCAM1, a known hepatic stem/progenitor cell marker, was experimentally demonstrated to be a direct target of miR-200c...
- Integrative genomic identification of genes on 8p associated with hepatocellular carcinoma progression and patient survivalStephanie Roessler
Laboratory of Human Carcinogenesis, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
Gastroenterology 142:957-966.e12. 2012..We used an integrative approach to identify HCC driver genes, defined as genes whose copy numbers associate with gene expression and cancer progression...
- A unique metastasis gene signature enables prediction of tumor relapse in early-stage hepatocellular carcinoma patientsStephanie Roessler
Laboratory of Human Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Cancer Res 70:10202-12. 2010....
- Modulation of miR-29 expression by α-fetoprotein is linked to the hepatocellular carcinoma epigenomeSonya Parpart
Laboratory of Human Carcinogenesis, National Cancer Institute, Bethesda, MD Tumor Biology Department, Georgetown University, Washington, DC
Hepatology 60:872-83. 2014..AFP also inhibited transcription of the miR-29a/b-1 locus, and this effect is mediated through c-MYC binding to the transcript of miR-29a/b-1. Furthermore, AFP expression promotes tumor growth of AFP- HCC cells in nude mice...
- iSubgraph: integrative genomics for subgroup discovery in hepatocellular carcinoma using graph mining and mixture modelsBahadir Ozdemir
Department of Computer Science, University of Maryland, College Park, Maryland, United States of America Liver Carcinogenesis Section, Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America
PLoS ONE 8:e78624. 2013..iSubgraph is available as MATLAB code at http://www.cs.umd.edu/~ozdemir/isubgraph/. ..
- Integrative genomic and transcriptomic characterization of matched primary and metastatic liver and colorectal carcinomaStephanie Roessler
1 Laboratory of Human Carcinogenesis, National Cancer Institute, NIH, Bethesda, MD, USA
Int J Biol Sci 11:88-98. 2015..Thus, the metastatic propensity is inherent to the primary tumor and the lack of general metastasis genes necessitates the development of specific treatment modalities. ..
- MicroRNA expression, survival, and response to interferon in liver cancerJunfang Ji
Liver Carcinogenesis Section, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
N Engl J Med 361:1437-47. 2009..Hepatocellular carcinoma is a common and aggressive cancer that occurs mainly in men. We examined microRNA expression patterns, survival, and response to interferon alfa in both men and women with the disease...