Ana I Robles

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi Schedule-dependent synergy between the heat shock protein 90 inhibitor 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin and doxorubicin restores apoptosis to p53-mutant lymphoma cell lines
    Ana I Robles
    Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute and Hematology Branch, National Heart, Lung and Blood Institute, NIH, Bethesda, Maryland 20892, USA
    Clin Cancer Res 12:6547-56. 2006
  2. ncbi rs4919510 in hsa-mir-608 is associated with outcome but not risk of colorectal cancer
    Bríd M Ryan
    Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America
    PLoS ONE 7:e36306. 2012
  3. ncbi HSP90 inhibitor, DMAG, synergizes with radiation of lung cancer cells by interfering with base excision and ATM-mediated DNA repair
    Thuy T Koll
    Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    Mol Cancer Ther 7:1985-92. 2008
  4. ncbi Targeted disruption of Ing2 results in defective spermatogenesis and development of soft-tissue sarcomas
    Motonobu Saito
    Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    PLoS ONE 5:e15541. 2010
  5. ncbi Macrophages, nitric oxide and microRNAs are associated with DNA damage response pathway and senescence in inflammatory bowel disease
    Jane J Sohn
    Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America
    PLoS ONE 7:e44156. 2012
  6. ncbi Novel indenoisoquinolines NSC 725776 and NSC 724998 produce persistent topoisomerase I cleavage complexes and overcome multidrug resistance
    Smitha Antony
    Laboratory of Molecular Pharmacology, National Cancer Institute, NIH, Bethesda, MD 20892 4255, USA
    Cancer Res 67:10397-405. 2007
  7. ncbi MDM2 SNP285 does not antagonize the effect of SNP309 in lung cancer
    Bríd M Ryan
    Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 4258, USA
    Int J Cancer 131:2710-6. 2012
  8. ncbi Molecular analysis reveals heterogeneity of mouse mammary tumors conditionally mutant for Brca1
    Mollie H Wright
    Center for Cancer Research, National Cancer Institute, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Mol Cancer 7:29. 2008
  9. ncbi Genetic variation in microRNA networks: the implications for cancer research
    Bríd M Ryan
    Cancer Prevention Fellowship Program, Center for Cancer Training, National Cancer Institute, National Institutes of Health, 37 Convent Drive, Building 37, Room 3068A, Bethesda, MD 20892 4258, USA
    Nat Rev Cancer 10:389-402. 2010
  10. ncbi Microenvironmental modulation of asymmetric cell division in human lung cancer cells
    Sharon R Pine
    Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 107:2195-200. 2010

Collaborators

Detail Information

Publications21

  1. ncbi Schedule-dependent synergy between the heat shock protein 90 inhibitor 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin and doxorubicin restores apoptosis to p53-mutant lymphoma cell lines
    Ana I Robles
    Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute and Hematology Branch, National Heart, Lung and Blood Institute, NIH, Bethesda, Maryland 20892, USA
    Clin Cancer Res 12:6547-56. 2006
    ..We aimed to establish the optimal schedule for administration of both drugs in combination and the molecular basis for their interaction...
  2. ncbi rs4919510 in hsa-mir-608 is associated with outcome but not risk of colorectal cancer
    Bríd M Ryan
    Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America
    PLoS ONE 7:e36306. 2012
    ..We therefore investigated the association between a SNP in hsa-mir-608, which lies within the 10q24 locus, and colorectal cancer...
  3. ncbi HSP90 inhibitor, DMAG, synergizes with radiation of lung cancer cells by interfering with base excision and ATM-mediated DNA repair
    Thuy T Koll
    Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    Mol Cancer Ther 7:1985-92. 2008
    ..Thus, administration of HSP90 inhibitors before radiation is critical for optimizing their use as radiosensitizers...
  4. ncbi Targeted disruption of Ing2 results in defective spermatogenesis and development of soft-tissue sarcomas
    Motonobu Saito
    Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    PLoS ONE 5:e15541. 2010
    ..In addition, a bona fide tumor suppressive role of Ing2 is demonstrated by increased incidence of soft-tissue sarcomas in Ing2(-/-) mice...
  5. ncbi Macrophages, nitric oxide and microRNAs are associated with DNA damage response pathway and senescence in inflammatory bowel disease
    Jane J Sohn
    Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America
    PLoS ONE 7:e44156. 2012
    ..In vitro experiments tested the ability of macrophages to induce senescence in primary cells. Inflammation modulating microRNAs were identified in senescence colon tissue for further investigation...
  6. ncbi Novel indenoisoquinolines NSC 725776 and NSC 724998 produce persistent topoisomerase I cleavage complexes and overcome multidrug resistance
    Smitha Antony
    Laboratory of Molecular Pharmacology, National Cancer Institute, NIH, Bethesda, MD 20892 4255, USA
    Cancer Res 67:10397-405. 2007
    ..These gamma-H2AX foci were detectable at pharmacologically relevant doses for up to 24 h and thus could be used as biomarkers for clinical trials (phase 0)...
  7. ncbi MDM2 SNP285 does not antagonize the effect of SNP309 in lung cancer
    Bríd M Ryan
    Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 4258, USA
    Int J Cancer 131:2710-6. 2012
    ....
  8. ncbi Molecular analysis reveals heterogeneity of mouse mammary tumors conditionally mutant for Brca1
    Mollie H Wright
    Center for Cancer Research, National Cancer Institute, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Mol Cancer 7:29. 2008
    ..We examined the expression profiles of original and serially transplanted mammary tumors from Brca1 deficient mice, and tumor derived cell lines to validate their use for preclinical testing and studies of tumor biology...
  9. ncbi Genetic variation in microRNA networks: the implications for cancer research
    Bríd M Ryan
    Cancer Prevention Fellowship Program, Center for Cancer Training, National Cancer Institute, National Institutes of Health, 37 Convent Drive, Building 37, Room 3068A, Bethesda, MD 20892 4258, USA
    Nat Rev Cancer 10:389-402. 2010
    ..In reviewing this new field of cancer biology, we describe the methodological approaches of these studies and make recommendations for which strategies will be most informative in the future...
  10. ncbi Microenvironmental modulation of asymmetric cell division in human lung cancer cells
    Sharon R Pine
    Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 107:2195-200. 2010
    ..The characterization and modulation of asymmetric cell division in lung cancer can provide insight into tumor initiation, growth, and maintenance...
  11. ncbi Accelerated preclinical testing using transplanted tumors from genetically engineered mouse breast cancer models
    Lyuba Varticovski
    Center for Cancer Research, National Cancer Institute, Frederick, Maryland
    Clin Cancer Res 13:2168-77. 2007
    ..Here, we describe and validate a transplantation strategy that circumvents some of these difficulties...
  12. ncbi Functional interaction of tumor suppressor DLC1 and caveolin-1 in cancer cells
    Xiaoli Du
    Laboratory of Cellular Oncology, Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA
    Cancer Res 72:4405-16. 2012
    ....
  13. ncbi A novel ING2 isoform, ING2b, synergizes with ING2a to prevent cell cycle arrest and apoptosis
    Motoko Unoki
    Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, NIH, 37 Convent Dr, Bldg 37, Rm 3068, Bethesda, MD 20892, USA
    FEBS Lett 582:3868-74. 2008
    ..ING2a and ING2b have compensatory roles that protect cells from cell cycle arrest and apoptosis and may be involved in development of chemotherapeutic resistance...
  14. ncbi 3'-UTR and functional secretor haplotypes in mannose-binding lectin 2 are associated with increased colon cancer risk in African Americans
    Krista A Zanetti
    Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA
    Cancer Res 72:1467-77. 2012
    ..33-5.08 and LYQC: OR, 2.28; 95% CI, 1.20-4.30). Similar associations were not observed in Caucasians. Together, our results support the hypothesis that genetic variations in MBL2 increase colon cancer susceptibility in African Americans...
  15. ncbi The p53 tumor suppressor network is a key responder to microenvironmental components of chronic inflammatory stress
    Frank Staib
    Laboratories of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892-4255, USA
    Cancer Res 65:10255-64. 2005
    ..In summary, the inflammatory stress response is a complex, integrated biological network in which p53 is a key molecular node regulating gene expression...
  16. ncbi Harnessing genetically engineered mouse models for preclinical testing
    Ana I Robles
    Laboratory of Human Carcinogenesis, Center for Cancer Research, NCI, NIH, 37 Convent Drive, Room 3060, Bethesda, MD 20892, United States
    Chem Biol Interact 171:159-64. 2008
    ....
  17. ncbi Clinical outcomes and correlates of TP53 mutations and cancer
    Ana I Robles
    Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Cold Spring Harb Perspect Biol 2:a001016. 2010
    ..Here, we describe the strengths and limitations of the most frequently used techniques for determination of p53 status in tumors, as well as the most remarkable latest findings relating to its clinical and epidemiological value...
  18. ncbi Laser capture microdissection and microarray expression analysis of lung adenocarcinoma reveals tobacco smoking- and prognosis-related molecular profiles
    Koh Miura
    Laboratory of Human Carcinogenesis, Biometric Research Branch, Division of Cancer Treatment and Diagnosis National Cancer Institute, NIH, 37 Convent Drive, Bethesda, MD 20892, USA
    Cancer Res 62:3244-50. 2002
    ..g., hBUB3, hZW10, and APC2, contribute to the molecular pathogenesis and tumor progression of tobacco smoke-induced adenocarcinoma of the lung...
  19. ncbi Apoptotic signaling pathways induced by nitric oxide in human lymphoblastoid cells expressing wild-type or mutant p53
    Chun-Qi Li
    Biological Engineering Division and Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139-4307, USA
    Cancer Res 64:3022-9. 2004
    ..Collectively, these data show that NO* exposure activated a complex network of responses leading to p53-dependent apoptosis via both mitochondrial and Fas receptor pathways, which were abrogated in the presence of mutant p53...
  20. ncbi Predicting hepatitis B virus-positive metastatic hepatocellular carcinomas using gene expression profiling and supervised machine learning
    Qing Hai Ye
    Liver Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai, China
    Nat Med 9:416-23. 2003
    ..Thus, osteopontin acts as both a diagnostic marker and a potential therapeutic target for metastatic HCC...
  21. ncbi Nitric oxide is a signaling molecule that regulates gene expression
    Lorne J Hofseth
    College of Pharmacy, University of South Carolina, Columbia, SC 29208, USA
    Methods Enzymol 396:326-40. 2005
    ....